BR9905785A - Processo de fermantação para a preparação de ácido d-panto-tênico utilizando cepas da famìlia enterobacteriaceae - Google Patents

Processo de fermantação para a preparação de ácido d-panto-tênico utilizando cepas da famìlia enterobacteriaceae

Info

Publication number
BR9905785A
BR9905785A BR9905785-9A BR9905785A BR9905785A BR 9905785 A BR9905785 A BR 9905785A BR 9905785 A BR9905785 A BR 9905785A BR 9905785 A BR9905785 A BR 9905785A
Authority
BR
Brazil
Prior art keywords
acid
preparation
enterobacteriaceae family
fermentation process
strains
Prior art date
Application number
BR9905785-9A
Other languages
English (en)
Inventor
Mechthild Dr Rieping
Georg Dr Thierbach
Walter Dr Pfefferle
Nicole Dr Dusch
Joern Dr Kalinowski
Alfred Dr Puehler
Original Assignee
Degussa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Degussa filed Critical Degussa
Publication of BR9905785A publication Critical patent/BR9905785A/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P15/00—Preparation of compounds containing at least three condensed carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/02—Amides, e.g. chloramphenicol or polyamides; Imides or polyimides; Urethanes, i.e. compounds comprising N-C=O structural element or polyurethanes

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Patente de Invenção: <B>"PROCESSO DE FERMENTAçãO PARA A PREPARAçãO DE áCIDO D-PANTOTêNICO UTILIZANDO CEPAS DA FAMìLIA ENTEROBACTERIACEAE"<D>. A invenção refere-se a um processo para a preparação de ácido D-pantotênico pela fermentação de microorganismos produtores de ácido D-pantotênico da família Enterobacteriaceae, que é caracterizado pelo fato de que: a) são utilizadas cepas que contêm plasmídeo pFV31 e/ou pFV202, b) o gene panD e opcionalmente outras seq³ências de nucleotídeo que codificam aspartato-1-descarboxilase são amplificados e, em particular, superexpressos nos ditos microorganismos, c) o ácido pantotênico é enriquecido no meio ou nas células dos microorganismos e d) o ácido pantotênico produzido é isolado.
BR9905785-9A 1998-12-01 1999-12-01 Processo de fermantação para a preparação de ácido d-panto-tênico utilizando cepas da famìlia enterobacteriaceae BR9905785A (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19855314A DE19855314A1 (de) 1998-12-01 1998-12-01 Verfahren zur fermentiven Herstellung von D-Pantothensäure unter Verwendung von Stämmen der Familie Enterobacteriaceae

Publications (1)

Publication Number Publication Date
BR9905785A true BR9905785A (pt) 2001-04-24

Family

ID=7889570

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9905785-9A BR9905785A (pt) 1998-12-01 1999-12-01 Processo de fermantação para a preparação de ácido d-panto-tênico utilizando cepas da famìlia enterobacteriaceae

Country Status (13)

Country Link
US (1) US6184006B1 (pt)
EP (1) EP1006193A3 (pt)
JP (1) JP2000166578A (pt)
KR (1) KR20000047840A (pt)
CN (1) CN1128882C (pt)
BR (1) BR9905785A (pt)
DE (1) DE19855314A1 (pt)
HU (1) HUP9904446A2 (pt)
ID (1) ID25769A (pt)
IL (1) IL133215A0 (pt)
SK (1) SK163999A3 (pt)
YU (1) YU61899A (pt)
ZA (1) ZA997405B (pt)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19855313A1 (de) * 1998-12-01 2000-06-08 Degussa Verfahren zur fermentativen Herstellung von D-Pantothensäure durch Verstärkung des panD-Gens in Mikroorganismen
US8232081B2 (en) * 1999-09-21 2012-07-31 Basf Se Methods and microorganisms for production of panto-compounds
IL156613A0 (en) * 2001-01-19 2004-01-04 Basf Ag Processes for enhanced production of pantothenate
US7244593B2 (en) * 2001-01-19 2007-07-17 Basf Aktiengesellschaft Microorganisms and processes for enhanced production of pantothenate
DE10112102A1 (de) * 2001-03-14 2002-09-19 Degussa Verfahren zur fermentativen Herstellung von D-Pantothensäure und/oder deren Salzen
US6623944B2 (en) 2001-03-14 2003-09-23 Degussa Ag Process for preparation of D-pantothenic acid and/or salts thereof
MXPA04006894A (es) * 2002-01-18 2004-10-15 Cargill Inc Alanina 2,3 - aminomutasa.
WO2004005525A2 (en) * 2002-07-03 2004-01-15 Basf Aktiengesellschaft Microorganisms and processes for enhanced production of pantothenate
EP1786831A4 (en) 2004-07-30 2008-01-23 Cargill Inc Alanine 2,3-aminomutases
DE102005048818A1 (de) 2005-10-10 2007-04-12 Degussa Ag Mikrobiologische Herstellung von 3-Hydroxypropionsäure
JP2014087259A (ja) * 2011-02-22 2014-05-15 Ajinomoto Co Inc Ｌ−システイン生産菌及びｌ−システインの製造法
CN106676051B (zh) * 2016-10-31 2019-07-05 中国科学院微生物研究所 一种制备高效合成泛酸基因工程菌的方法及其应用
CN109913398B (zh) * 2019-03-14 2020-07-31 浙江工业大学 无需β-丙氨酸添加的高产泛酸的基因工程菌、构建及应用
CN109868254B (zh) * 2019-03-14 2021-02-19 浙江工业大学 一种高产泛酸的基因工程菌、构建方法及应用
CN115595314A (zh) * 2022-03-07 2023-01-13 中国科学院微生物研究所（Cn） 表达天冬氨酸脱氢酶的工程菌及发酵生产维生素b5的方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0493060A3 (en) * 1990-12-25 1993-04-14 Takeda Chemical Industries, Ltd. Production method of d-pantothenic acid and plasmids and microorganisms thereof
JP3710497B2 (ja) * 1992-09-25 2005-10-26 ビーエーエスエフ アクチェンゲゼルシャフト Ｄ−パント酸、ｄ−パントテン酸およびそれらの塩の製造法
SK30598A3 (en) * 1995-09-13 1999-01-11 Takeda Chemical Industries Ltd Process for producing d-pantoic acid and d-pantothenic acid or salts thereof
DE19846499A1 (de) * 1998-10-09 2000-04-20 Degussa Verfahren zur Herstellung von Pantothensäure durch Verstärkung von für Ketopantoat-Reduktase kodierenden Nukleotidsequenzen
DE19855313A1 (de) * 1998-12-01 2000-06-08 Degussa Verfahren zur fermentativen Herstellung von D-Pantothensäure durch Verstärkung des panD-Gens in Mikroorganismen
JP2004534501A (ja) * 1999-06-25 2004-11-18 ビーエーエスエフ アクチェンゲゼルシャフト 代謝経路タンパク質をコードするコリネバクテリウム−グルタミカム遺伝子
EP1083225A1 (de) * 1999-09-09 2001-03-14 Degussa-Hüls Aktiengesellschaft Verfahren zur fermentativen Herstellung von D-Pantothensäure unter Verwendung coryneformer Bakterien

Also Published As

Publication number Publication date
ID25769A (id) 2000-11-02
IL133215A0 (en) 2001-03-19
KR20000047840A (ko) 2000-07-25
EP1006193A2 (de) 2000-06-07
JP2000166578A (ja) 2000-06-20
EP1006193A3 (de) 2003-09-17
ZA997405B (en) 2000-06-08
CN1128882C (zh) 2003-11-26
US6184006B1 (en) 2001-02-06
YU61899A (sh) 2003-02-28
DE19855314A1 (de) 2000-06-08
SK163999A3 (en) 2000-07-11
HUP9904446A2 (hu) 2000-11-28
HU9904446D0 (en) 2000-01-28
CN1259576A (zh) 2000-07-12

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Legal Events

Date Code Title Description
FA10 Dismissal: dismissal - article 33 of industrial property law
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]