YU61999A - Postupak za fermentacionu proizvodnju d-pantotenske kiseline uz primenu bakterija korijumskog oblika - Google Patents

Postupak za fermentacionu proizvodnju d-pantotenske kiseline uz primenu bakterija korijumskog oblika

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Publication number
YU61999A
YU61999A YU61999A YU61999A YU61999A YU 61999 A YU61999 A YU 61999A YU 61999 A YU61999 A YU 61999A YU 61999 A YU61999 A YU 61999A YU 61999 A YU61999 A YU 61999A
Authority
YU
Yugoslavia
Prior art keywords
acid
corynebacterium
seq
codes
gene
Prior art date
Application number
YU61999A
Other languages
English (en)
Inventor
Eggeling Lothar
Georg Thierbach
Hermann Sahm
Original Assignee
Degussa-Huls Aktiengesellschaft
Forschungszentrum Julich Gmbh.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Degussa-Huls Aktiengesellschaft, Forschungszentrum Julich Gmbh. filed Critical Degussa-Huls Aktiengesellschaft
Publication of YU61999A publication Critical patent/YU61999A/sh

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93—Ligases (6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1003—Transferases (2.) transferring one-carbon groups (2.1)
    • C12N9/1014—Hydroxymethyl-, formyl-transferases (2.1.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/02—Amides, e.g. chloramphenicol or polyamides; Imides or polyimides; Urethanes, i.e. compounds comprising N-C=O structural element or polyurethanes

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)

Abstract

Pronalazak se odnosi na, rekombinovanu DNK porekla iz corynebacterium-a, koja se može replicirati u mikroorganizmima soja corynebactrium, i koja sadrži bar jednu od sledećih sekvenci nukleotida, izabranih iz grupe: a) koja kodira panB-gen (transferaza ketopantoathidroksi metila), prikazan sa SEQ ID br. 1, b) koja kodira pan C-gen (sintetaza pantotenata), prikazan sa SEQ ID br. 1, posebno panBC-operon, i, u datom slučaju, c) koja kodira ilvD-gen (dehidrataza dihidroksi kiseline), prikazan sa SEQ ID. br. 4, i na jedan postupak za fermentacionu proizvodnju D-pantotenske kiseline uz primenu mikroorganizama soja corynebacterium, kod kojih su navedeni geni pojačani.[The invention refers to the recombinated DNK originating from corynebacterium which can be replicated in microorganisms of specimens of corynebacterium, and which contains at least one of the following sequences of nucleotides, chosen from the group: (a) which codes pan B-gene (transferase of ketopantoathidroxy methile) displayed with SEQ ID No 1, (b) which codes pan C-gene (synthesis of pantothenate), shown with SEQ ID No 2, especially pan BC-operone, and, in the given case, (c) which codes ilv D-gene (dehydratase of dihydroxy acid), shown with SEQ ID No 4, and on one procedure for the fermentativen production of D-pantothenic acid with the application of microorganisms of specimens corynebacterium, where the mentioned genes have been amplified.
YU61999A 1998-12-01 1999-11-26 Postupak za fermentacionu proizvodnju d-pantotenske kiseline uz primenu bakterija korijumskog oblika YU61999A (sh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19855312A DE19855312A1 (de) 1998-12-01 1998-12-01 Verfahren zur fermentativen Herstellung von D-Pantothensäure unter Verwendung coryneformer Bakterien

Publications (1)

Publication Number Publication Date
YU61999A true YU61999A (sh) 2003-02-28

Family

ID=7889568

Family Applications (1)

Application Number Title Priority Date Filing Date
YU61999A YU61999A (sh) 1998-12-01 1999-11-26 Postupak za fermentacionu proizvodnju d-pantotenske kiseline uz primenu bakterija korijumskog oblika

Country Status (13)

Country Link
US (1) US6177264B1 (sh)
EP (1) EP1006189A3 (sh)
JP (1) JP2000166580A (sh)
KR (1) KR20000047833A (sh)
CN (1) CN1256313A (sh)
BR (1) BR9905783A (sh)
DE (1) DE19855312A1 (sh)
HU (1) HUP9904448A3 (sh)
ID (1) ID25933A (sh)
IL (1) IL133185A0 (sh)
SK (1) SK164099A3 (sh)
YU (1) YU61999A (sh)
ZA (1) ZA997407B (sh)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19907567B4 (de) * 1999-02-22 2007-08-09 Forschungszentrum Jülich GmbH Verfahren zur mikrobiellen Herstellung von L-Valin
CN1420931A (zh) * 1999-09-21 2003-05-28 Basf公司 制备泛化合物的方法和微生物
US8232081B2 (en) * 1999-09-21 2012-07-31 Basf Se Methods and microorganisms for production of panto-compounds
DE10026758A1 (de) * 2000-05-30 2001-12-06 Degussa Verfahren zur fermentativen Herstellung von D-Pantothensäure unter Verwendung corymeformer Bakterien
DE10030702A1 (de) 2000-06-23 2002-01-03 Degussa Verfahren zur fermentativen Herstellung von D-Pantothensäure unter Verwendung coryneformer Bakterien
EE200300112A (et) * 2000-09-20 2005-04-15 Basf Aktiengesellschaft D-pantoteenhapet ja/või selle sooli sisaldav loomasöödalisand, saamismeetod, kasutamine
DE10047142A1 (de) * 2000-09-23 2002-04-11 Degussa Verfahren zur fermentativen Herstellung von D-Pantothensäure unter Verwendung coryneformer Bakterien
US6911329B2 (en) 2000-09-23 2005-06-28 Degussa Ag Process for the fermentative preparation of D-pantothenic acid using coryneform bacteria
AU2001291825A1 (en) * 2000-09-30 2002-04-15 Degussa A.G. Process for the fermentative preparation of d-pantothenic acid using coryneform bacteria
IL156708A0 (en) * 2001-01-19 2004-01-04 Basf Ag Microorganisms and process for enhanced production of pantothenate
MXPA03006342A (es) 2001-01-19 2004-12-03 Basf Antiengesellschaft Procesos para una produccion incrementada de pantotenato.
CA2473716A1 (en) * 2002-01-18 2003-07-31 Cargill, Incorporated Alanine 2,3- aminomutase
US20040048343A1 (en) * 2002-01-19 2004-03-11 Theron Hermann Method and microorganisms for the production of 3-(2-hydroxy-3-methyl-butyrylamino)-propionic acid (hmbpa)
AU2003251792A1 (en) * 2002-07-03 2004-01-23 Basf Aktiengesellschaft Microorganisms and processes for enhanced production of pantothenate
DE10344200A1 (de) * 2003-09-22 2005-05-04 Basf Ag Verfahren zur Herstellung eines D-Pantothensäure und/oder deren Salze enthaltendes Tierfuttersupplement
EP2292749A3 (en) 2004-07-30 2011-12-21 Novozymes A/S Alanine 2, 3 aminomutases
US8273558B2 (en) 2005-10-26 2012-09-25 Butamax(Tm) Advanced Biofuels Llc Fermentive production of four carbon alcohols
EP3301182B1 (en) 2005-10-26 2020-03-18 Butamax (TM) Advanced Biofuels LLC Fermentative production of four carbon alcohols
US9303225B2 (en) 2005-10-26 2016-04-05 Butamax Advanced Biofuels Llc Method for the production of isobutanol by recombinant yeast
DE112007001179T5 (de) 2006-05-16 2009-04-02 Dsm Ip Assets B.V. Verfahren zur Herstellung von Panthenol
AU2009296218A1 (en) * 2008-09-29 2010-04-01 Butamax(Tm) Advanced Biofuels Llc Enhanced dihydroxy-acid dehydratase activity in lactic acid bacteria
BRPI0913682A2 (pt) * 2008-09-29 2020-08-11 Butamax Advanced Biofuels Llc método para identificar enzimas dihidróxi-ácido desidratase (dhad) [2fe-2s], célula hospedeira microbiana recombinante, método para a produção de isobutanol e método para a conversão de 2,3-dihidróxiisovalerato
CA2735945A1 (en) 2008-09-29 2010-04-01 Butamaxtm Advanced Biofuels Llc Increased heterologous fe-s enzyme activity in yeast
EP2483400A1 (en) 2009-09-29 2012-08-08 Butamax(tm) Advanced Biofuels LLC Improved flux to acetolactate-derived products in lactic acid bacteria
EP2536821B1 (en) 2010-02-17 2018-06-13 Butamax(TM) Advanced Biofuels LLC Improving activity of fe-s cluster requiring proteins
US9650624B2 (en) 2012-12-28 2017-05-16 Butamax Advanced Biofuels Llc DHAD variants for butanol production
WO2014151190A1 (en) 2013-03-15 2014-09-25 Butamax Advanced Biofuels Llc Dhad variants and methods of screening
CN106676051B (zh) * 2016-10-31 2019-07-05 中国科学院微生物研究所 一种制备高效合成泛酸基因工程菌的方法及其应用
CN109868254B (zh) * 2019-03-14 2021-02-19 浙江工业大学 一种高产泛酸的基因工程菌、构建方法及应用
CN110317768B (zh) * 2019-07-10 2020-09-04 江南大学 一种消减4-甲基苯酚的乳酸菌及其在酿造体系中的应用
KR102389327B1 (ko) * 2020-07-01 2022-04-20 씨제이제일제당 (주) 3-메틸-2-옥소뷰타노에이트 하이드록시 메틸트랜스퍼라아제의 활성이 강화된 미생물, 및 이의 용도
KR102589135B1 (ko) * 2021-05-10 2023-10-12 씨제이제일제당 (주) 3-메틸-2-옥소뷰타노에이트 하이드록시 메틸트랜스퍼라아제의 활성이 강화된 미생물, 및 이의 용도
CN114149981B (zh) * 2021-12-09 2024-02-02 浙江工业大学 一种比活提高的泛酸合成酶突变体及其应用
KR20240118944A (ko) * 2023-01-27 2024-08-06 씨제이제일제당 (주) 아르카노박테리움 포시시마일 유래 판토에이트-베타-알라닌 리가아제의 활성이 강화된 미생물 및 이의 용도
KR20240118943A (ko) * 2023-01-27 2024-08-06 씨제이제일제당 (주) 글루타미시박터 할로피토콜라 유래 판토에이트-베타-알라닌 리가아제의 활성이 강화된 미생물 및 이의 용도

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3710497B2 (ja) * 1992-09-25 2005-10-26 ビーエーエスエフ アクチェンゲゼルシャフト Ｄ−パント酸、ｄ−パントテン酸およびそれらの塩の製造法
DE19855313A1 (de) * 1998-12-01 2000-06-08 Degussa Verfahren zur fermentativen Herstellung von D-Pantothensäure durch Verstärkung des panD-Gens in Mikroorganismen
DE19907567B4 (de) * 1999-02-22 2007-08-09 Forschungszentrum Jülich GmbH Verfahren zur mikrobiellen Herstellung von L-Valin
JP2004534501A (ja) * 1999-06-25 2004-11-18 ビーエーエスエフ アクチェンゲゼルシャフト 代謝経路タンパク質をコードするコリネバクテリウム−グルタミカム遺伝子

Also Published As

Publication number Publication date
DE19855312A1 (de) 2000-06-08
HUP9904448A2 (hu) 2000-11-28
JP2000166580A (ja) 2000-06-20
ZA997407B (en) 2000-06-07
KR20000047833A (ko) 2000-07-25
HUP9904448A3 (en) 2004-06-28
US6177264B1 (en) 2001-01-23
IL133185A0 (en) 2001-03-19
SK164099A3 (en) 2000-07-11
CN1256313A (zh) 2000-06-14
EP1006189A3 (de) 2003-09-17
BR9905783A (pt) 2001-04-24
HU9904448D0 (en) 2000-01-28
ID25933A (id) 2000-11-16
EP1006189A2 (de) 2000-06-07

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