BR9900565A - Inibidores de ciclooxigenase-2 de benzimidazol. - Google Patents
Inibidores de ciclooxigenase-2 de benzimidazol.Info
- Publication number
- BR9900565A BR9900565A BR9900565-4A BR9900565A BR9900565A BR 9900565 A BR9900565 A BR 9900565A BR 9900565 A BR9900565 A BR 9900565A BR 9900565 A BR9900565 A BR 9900565A
- Authority
- BR
- Brazil
- Prior art keywords
- alkyl
- halo
- heteroaryl
- phenyl
- hydrogen
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Abstract
Patente de Invenção: <B>"INIBIDORES DE CICLOOXIGENASE-2 DE BENZIMIDAZOL"<D>. Esta invenção proporciona um composto da fórmula seguinte: ou os seus sais farmaceuticamente aceitáveis, em que <B>Ar<D> é heteroarila; <B>X^ 1^<D> e <B>X^ 2^<D> são independentemente selecionados dentre halo, alquila C1-C~ 4~, hidróxi, alcóxi C1-C~ 4~, amino, alcanoíla C1-C~ 4~, carbóxi, carbamoíla, ciano, nitro, mercapto, (alquil C1-C~ 4~)tio, (alquil C1-C~ 4~)sulfinila, (alquil C1-C~ 4~)sulfonila, aminossulfonila ou semelhantes; <B>R^ 1^<D> é selecionado dentre hidrogênio, alquila C1-C~ 4~ linear ou ramificada, cicloalquila C3-C8, cicloalquenila C~ 4~-C8; fenila, heteroarila e semelhantes; <B>R^ 2^<D> e <B>R^ 3^<D> são independentemente selecionados dentre hidrogênio, halo, alquila C1-C~ 4~, fenila e semelhantes; ou <B>R^ 1^<D> e <B>R^ 2^<D> podem formar, em conjunto com o átomo de carbono ao qual eles estão ligados, um anel cicloalquila C~ 5~-C~ 7~; e m e n são independentemente 0, 1, 2 ou 3. Tais compostos e composições farmacêuticas que contêm tais compostos são úteis como agentes analgésicos e antiinflamatórios.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IB9800164 | 1998-02-11 | ||
US09/244,875 US6310079B1 (en) | 1998-02-11 | 1999-02-05 | Benzimidazole cyclooxygenase-2 inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
BR9900565A true BR9900565A (pt) | 2000-05-02 |
Family
ID=26318715
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9900565-4A BR9900565A (pt) | 1998-02-11 | 1999-02-10 | Inibidores de ciclooxigenase-2 de benzimidazol. |
Country Status (10)
Country | Link |
---|---|
US (3) | US6310079B1 (pt) |
EP (1) | EP0937722B1 (pt) |
JP (1) | JP3256513B2 (pt) |
AT (1) | ATE220066T1 (pt) |
BR (1) | BR9900565A (pt) |
CA (1) | CA2261426C (pt) |
DE (1) | DE69901969T2 (pt) |
DK (1) | DK0937722T3 (pt) |
ES (1) | ES2175901T3 (pt) |
PT (1) | PT937722E (pt) |
Families Citing this family (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040072889A1 (en) * | 1997-04-21 | 2004-04-15 | Pharmacia Corporation | Method of using a COX-2 inhibitor and an alkylating-type antineoplastic agent as a combination therapy in the treatment of neoplasia |
JP3256513B2 (ja) | 1998-02-11 | 2002-02-12 | ファイザー製薬株式会社 | ベンゾイミダゾールシクロオキシゲナーゼ−2阻害剤 |
AU2001267826A1 (en) * | 2000-06-29 | 2002-01-08 | Shionogi And Co., Ltd. | Remedies for alzheimer's disease |
ATE375171T1 (de) * | 2000-06-29 | 2007-10-15 | Anthera Pharmaceuticals Inc | Heilmittel für krebs |
US20060167074A1 (en) * | 2001-06-19 | 2006-07-27 | Norbert Muller | Methods and compositions for the treatment of psychiatric disorders |
DE10129320A1 (de) * | 2001-06-19 | 2003-04-10 | Norbert Mueller | Verwendung von COX-2 Inhibitoren zur Behandlung von Schizophrenie, wahnhaften Störungen, affektiven Störungen oder Ticstörungen |
US20030220374A1 (en) * | 2002-01-14 | 2003-11-27 | Pharmacia Corporation | Compositions and methods of treatment involving peroxisome proliferator-activated receptor-gamma agonists and cyclooxygenase-2 selective inhibitors |
US20030212138A1 (en) * | 2002-01-14 | 2003-11-13 | Pharmacia Corporation | Combinations of peroxisome proliferator-activated receptor-alpha agonists and cyclooxygenase-2 selective inhibitors and therapeutic uses therefor |
JP2006505522A (ja) * | 2002-08-08 | 2006-02-16 | スミスクライン ビーチャム コーポレーション | チオフェン化合物 |
US20040147581A1 (en) * | 2002-11-18 | 2004-07-29 | Pharmacia Corporation | Method of using a Cox-2 inhibitor and a 5-HT1A receptor modulator as a combination therapy |
ES2341240T3 (es) | 2002-12-13 | 2010-06-17 | Warner-Lambert Company Llc | Ligando alfa-2-delta para tratar los sintomas del tracto urinario inferior. |
US20040220155A1 (en) * | 2003-03-28 | 2004-11-04 | Pharmacia Corporation | Method of providing a steroid-sparing benefit with a cyclooxygenase-2 inhibitor and compositions therewith |
PL2266584T3 (pl) | 2003-05-07 | 2013-02-28 | Osteologix As | Kompozycja ze strontem i witaminą D do profilaktyki i/lub leczenia chorób chrząstki i/lub kości |
JP4354984B2 (ja) | 2003-05-07 | 2009-10-28 | オステオロジックス エイ/エス | 水溶性ストロンチウム塩を用いる軟骨/骨症状の治療 |
US20050014729A1 (en) * | 2003-07-16 | 2005-01-20 | Pharmacia Corporation | Method for the treatment or prevention of dermatological disorders with a cyclooxygenase-2 inhibitor alone and in combination with a dermatological treatment agent and compositions therewith |
US20050119262A1 (en) * | 2003-08-21 | 2005-06-02 | Pharmacia Corporation | Method for preventing or treating an optic neuropathy with a cox-2 inhibitor and an intraocular pressure reducing agent |
US20050113409A1 (en) * | 2003-09-03 | 2005-05-26 | Pharmacia Corporation | Method for the prevention or treatment of pain, inflammation and inflammation-related disorders with a Cox-2 selective inhibitor in combination with a nitric oxide-donating agent and compositions therewith |
US7449462B2 (en) | 2004-01-22 | 2008-11-11 | Pfizer, Inc. | Triazole derivatives which inhibit vasopressin antagonistic activity |
JP2007519720A (ja) | 2004-01-28 | 2007-07-19 | スミスクライン ビーチャム コーポレーション | チアゾール化合物 |
CA2563963A1 (en) * | 2004-04-28 | 2005-11-10 | Pfizer Inc. | 3-heterocyclyl-4-phenyl-triazole derivatives as inhibitors of the vasopressin v1a receptor |
CN101142184A (zh) * | 2004-10-12 | 2008-03-12 | 解码遗传Ehf公司 | 用于阻塞性动脉疾病的磺酰胺迫位取代的双环化合物 |
US7442716B2 (en) | 2004-12-17 | 2008-10-28 | Merck Frosst Canada Ltd. | 2-(phenyl or heterocyclic)-1H-phenantrho[9,10-d]imidazoles as mPGES-1 inhibitors |
EP1828143B1 (en) * | 2004-12-17 | 2013-03-20 | Merck Frosst Canada Ltd. | 2-(phenyl or heterocyclic)-1h-phenantrho[9,10-d]imidazoles as mpges-1 inhibitors |
WO2006121887A2 (en) * | 2005-05-05 | 2006-11-16 | Cook Biotech Incorporated | Implantable materials and methods for inhibiting tissue adhesion formation |
WO2007112093A2 (en) * | 2006-03-23 | 2007-10-04 | Synta Pharmaceuticals Corp. | Benzimidazolyl-pyridine compounds for inflammation and immune-related uses |
WO2007124589A1 (en) * | 2006-05-02 | 2007-11-08 | Merck Frosst Canada Ltd. | Methods for treating or preventing neoplasias |
ES2689484T3 (es) | 2006-07-05 | 2018-11-14 | Fibrotech Therapeutics Pty Ltd | Compuestos terapéuticos |
SI2125021T1 (sl) | 2006-12-22 | 2011-09-30 | Recordati Ireland Ltd | Kombinirano zdravljenje bolezni spodnjega urinarnega trakta z alfa2delta ligandi in NSAR |
WO2010012745A2 (en) * | 2008-07-29 | 2010-02-04 | Boehringer Ingelheim International Gmbh | Benzimidazoles |
CN105153188B (zh) | 2009-10-22 | 2018-06-01 | 法博太科制药有限公司 | 抗纤维化剂的稠环类似物 |
US11014873B2 (en) | 2017-02-03 | 2021-05-25 | Certa Therapeutics Pty Ltd. | Anti-fibrotic compounds |
CN111587292A (zh) * | 2018-01-07 | 2020-08-25 | 纽克莱克斯有限公司 | 用于检测癌症相关突变的试剂盒和方法 |
WO2022195579A1 (en) | 2021-03-15 | 2022-09-22 | Saul Yedgar | Hyaluronic acid-conjugated dipalmitoyl phosphatidyl ethanolamine in combination with non-steroidal anti-inflammatory drugs (nsaids) for treating or alleviating inflammatory diseases |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5013795B2 (pt) | 1972-12-12 | 1975-05-22 | ||
JPS5975257A (ja) | 1982-10-23 | 1984-04-27 | Ricoh Co Ltd | 電子写真用感光体 |
GB8307865D0 (en) * | 1983-03-22 | 1983-04-27 | Fujisawa Pharmaceutical Co | Benzimidazole derivatives |
US4812460A (en) * | 1986-03-25 | 1989-03-14 | Boehringer Ingelheim Pharmaceutical, Inc. | 3-[2-(3',5'-di-t-butyl-4'-hydroxyphenyl)ethenyl]pyridine |
JPH06759B2 (ja) * | 1989-09-22 | 1994-01-05 | ファイザー製薬株式会社 | 新規なベンゾイミダゾール化合物 |
JPH03219232A (ja) | 1990-01-24 | 1991-09-26 | Konica Corp | 分光増感されたハロゲン化銀写真感光材料 |
JPH06194780A (ja) | 1992-12-24 | 1994-07-15 | Konica Corp | ハロゲン化銀写真乳剤 |
JP3219232B2 (ja) | 1995-08-14 | 2001-10-15 | シャープ株式会社 | 液晶表示装置 |
DE69727199T2 (de) * | 1996-12-09 | 2004-11-18 | Pfizer Inc. | Benzimidazol-Verbindungen |
JP2001512453A (ja) | 1997-02-13 | 2001-08-21 | グラックス グループ リミテッド | ベンゾイミダゾール誘導体 |
JP3256513B2 (ja) | 1998-02-11 | 2002-02-12 | ファイザー製薬株式会社 | ベンゾイミダゾールシクロオキシゲナーゼ−2阻害剤 |
-
1999
- 1999-02-02 JP JP02490799A patent/JP3256513B2/ja not_active Expired - Fee Related
- 1999-02-04 AT AT99300824T patent/ATE220066T1/de not_active IP Right Cessation
- 1999-02-04 DK DK99300824T patent/DK0937722T3/da active
- 1999-02-04 DE DE69901969T patent/DE69901969T2/de not_active Expired - Fee Related
- 1999-02-04 EP EP99300824A patent/EP0937722B1/en not_active Expired - Lifetime
- 1999-02-04 ES ES99300824T patent/ES2175901T3/es not_active Expired - Lifetime
- 1999-02-04 PT PT99300824T patent/PT937722E/pt unknown
- 1999-02-05 US US09/244,875 patent/US6310079B1/en not_active Expired - Fee Related
- 1999-02-09 CA CA002261426A patent/CA2261426C/en not_active Expired - Fee Related
- 1999-02-10 BR BR9900565-4A patent/BR9900565A/pt not_active Application Discontinuation
-
2001
- 2001-08-08 US US09/924,351 patent/US6713482B2/en not_active Expired - Fee Related
-
2004
- 2004-02-05 US US10/773,937 patent/US20040181062A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US6310079B1 (en) | 2001-10-30 |
US6713482B2 (en) | 2004-03-30 |
US20030013886A1 (en) | 2003-01-16 |
EP0937722A1 (en) | 1999-08-25 |
PT937722E (pt) | 2002-10-31 |
JP3256513B2 (ja) | 2002-02-12 |
JPH11263788A (ja) | 1999-09-28 |
CA2261426C (en) | 2002-09-24 |
ES2175901T3 (es) | 2002-11-16 |
US20040181062A1 (en) | 2004-09-16 |
DK0937722T3 (da) | 2002-07-22 |
EP0937722B1 (en) | 2002-07-03 |
CA2261426A1 (en) | 1999-08-11 |
ATE220066T1 (de) | 2002-07-15 |
DE69901969D1 (de) | 2002-08-08 |
DE69901969T2 (de) | 2002-10-24 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
B15K | Others concerning applications: alteration of classification |
Ipc: C07D 401/04 (2008.04), C07D 403/04 (2008.04), A61K |
|
B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: INDEFIRO O PRESENTE PEDIDO DE PATENTE DE ACORDO COM ART. 8O DA LPI. |
|
B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL. |