BR9814747A - Derivados pleuromutilina atuando comoantimicrobianos - Google Patents

Derivados pleuromutilina atuando comoantimicrobianos

Info

Publication number
BR9814747A
BR9814747A BR9814747-1A BR9814747A BR9814747A BR 9814747 A BR9814747 A BR 9814747A BR 9814747 A BR9814747 A BR 9814747A BR 9814747 A BR9814747 A BR 9814747A
Authority
BR
Brazil
Prior art keywords
antimicrobials
replaced
derivatives acting
pleuromutilin derivatives
derivatives
Prior art date
Application number
BR9814747-1A
Other languages
English (en)
Other versions
BR9814747B1 (pt
Inventor
Valerie Berry
Stephen Dabbs
Colin Henry Frydry
Eric Hunt
Gary Woodnutt
Francis Dominic Sanderson
Original Assignee
Smithkline Beecham Plc
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26312507&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR9814747(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GBGB9722817.5A external-priority patent/GB9722817D0/en
Priority claimed from GBGB9813689.8A external-priority patent/GB9813689D0/en
Application filed by Smithkline Beecham Plc, Smithkline Beecham Corp filed Critical Smithkline Beecham Plc
Publication of BR9814747A publication Critical patent/BR9814747A/pt
Publication of BR9814747B1 publication Critical patent/BR9814747B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/32—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C271/36—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of rings other than six-membered aromatic rings with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/54—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyrrole Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

"DERIVADOS PLEURONUTILINA ATUANDO COMOANTIMICROBIANOS". Derivados de pleuromutilina da fórmula (IA)ou (IB) onde a porção de éster glicólico na posição (14) ésubstituída por R^ 2^(CH~ 2~),~ m~(CH~ 2~)~ n~CH~ 2~COOsendo de uso na terapia antimicrobiana. Nos quais: cada um de ne m está independentemente entre 0, 1 ou 2; X é selecionado de-0-, -S-, -S(O)-, -SO~ 2~-, -CO.O-, -NH-, CONH-, NHCONH- e umaligação; R^ 1^ é vinila ou etila; R^ 2^ é um grupo monocíclico oubicíclico não aromático contendo um ou dois átomos de nitrogêniobásico e anexados através de um átomo de carbono do anel; R^3^ é H ou OH, ou a porção R^ 2^(CH~ 2~),~ m~X(CH~ 2~)~n~CH~ 2~COO na posição 14 de (IA) ou (IB) é substituída por R^a^R^ b^C=CHCOO, onde um de R^ a^ e R^ b^ é hidrogênio e ooutro é R^ 2^ ou R^ a^ e R^ b^ juntos formam R^ 2^; ou um salfarmaceuticamente aceitável do mesmo.
BRPI9814747-1A 1997-10-29 1998-10-27 derivados de pleuromutilina atuando como antimicrobianos. BR9814747B1 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GBGB9722817.5A GB9722817D0 (en) 1997-10-29 1997-10-29 Novel compounds
GB9722817.5 1997-10-29
GB9813689.8 1998-06-25
GBGB9813689.8A GB9813689D0 (en) 1998-06-25 1998-06-25 Novel compounds
PCT/GB1998/003211 WO1999021855A1 (en) 1997-10-29 1998-10-27 Pleuromutilin derivatives as antimicrobials

Publications (2)

Publication Number Publication Date
BR9814747A true BR9814747A (pt) 2001-11-20
BR9814747B1 BR9814747B1 (pt) 2010-12-14

Family

ID=26312507

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI9814747-1A BR9814747B1 (pt) 1997-10-29 1998-10-27 derivados de pleuromutilina atuando como antimicrobianos.

Country Status (36)

Country Link
US (3) USRE43390E1 (pt)
EP (3) EP1028961B3 (pt)
JP (2) JP4227729B2 (pt)
KR (1) KR100538721B1 (pt)
CN (1) CN1205211C (pt)
AR (1) AR015987A1 (pt)
AT (2) ATE525373T1 (pt)
AU (1) AU742167C (pt)
BR (1) BR9814747B1 (pt)
CA (1) CA2307551C (pt)
CO (1) CO5021129A1 (pt)
CY (2) CY2007028I2 (pt)
CZ (1) CZ298543B6 (pt)
DE (2) DE122007000076I2 (pt)
DK (2) DK1028961T5 (pt)
DZ (1) DZ2634A1 (pt)
EG (1) EG24177A (pt)
ES (2) ES2371205T3 (pt)
FR (1) FR07C0057I2 (pt)
HK (1) HK1031376A1 (pt)
HU (2) HU229792B1 (pt)
IL (2) IL135811A0 (pt)
LU (1) LU91372I2 (pt)
MY (1) MY130665A (pt)
NL (1) NL300304I2 (pt)
NO (3) NO327392B1 (pt)
NZ (1) NZ504203A (pt)
PE (1) PE123299A1 (pt)
PL (2) PL191927B1 (pt)
PT (2) PT1028961E (pt)
SI (2) SI1028961T1 (pt)
TR (1) TR200001203T2 (pt)
TW (1) TWI232861B (pt)
UY (1) UY25225A1 (pt)
WO (1) WO1999021855A1 (pt)
ZA (1) ZA989767B (pt)

Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UY25225A1 (es) * 1997-10-29 2000-12-29 Smithkline Beecham Plc Derivados de pleuromutilina utiles como agentes antimicrobianos
WO2000027790A1 (en) * 1998-11-11 2000-05-18 Smithkline Beecham P.L.C. Mutilin compounds
GB9912657D0 (en) * 1999-06-01 1999-07-28 Smithkline Beecham Plc Novel compounds
GB9918037D0 (en) * 1999-07-30 1999-09-29 Biochemie Gmbh Organic compounds
GB9919839D0 (en) * 1999-08-20 1999-10-27 Smithkline Beecham Plc Novel compounds
CA2405132A1 (en) 2000-04-04 2001-10-11 Smithkline Beecham Plc 2-hydroxy-mutilin carbamate derivatives for antibacterial use
GB0017031D0 (en) 2000-07-11 2000-08-30 Biochemie Gmbh Antimicrobials
GB0017073D0 (en) * 2000-07-11 2000-08-30 Univ London Microorganism
PE20020676A1 (es) 2000-09-13 2002-08-27 Biochemie Gmbh Compuestos de mutilina como antibacterianos
GB0024811D0 (en) 2000-10-10 2000-11-22 Smithkline Beecham Plc Novel compounds
GB0027705D0 (en) * 2000-11-11 2000-12-27 S P A Novel compounds
FR2835186B1 (fr) * 2002-01-28 2006-10-20 Aventis Pharma Sa Nouveaux composes heterocycliques, actifs comme inhibiteurs de beta-lactamases
GB0207495D0 (en) * 2002-03-28 2002-05-08 Biochemie Gmbh Organic compounds
ATE377001T1 (de) * 2002-07-24 2007-11-15 Nabriva Therapeutics Forschung Pleuromutilinderivate als antimikrobielle mittel
GB0218578D0 (en) * 2002-08-09 2002-09-18 Glaxo Group Ltd Novel method
GB0308114D0 (en) * 2003-04-08 2003-05-14 Glaxo Group Ltd Novel compounds
DE602004024417D1 (de) * 2003-09-03 2010-01-14 Glaxo Group Ltd Neues verfahren zur herstellung von pleuromutilinderivaten
US7598267B2 (en) * 2004-05-13 2009-10-06 Glaxo Group Limited Muscarinic acetylcholine receptor antagonists
GB0504314D0 (en) * 2005-03-02 2005-04-06 Glaxo Group Ltd Novel polymorph
WO2006104667A2 (en) * 2005-03-10 2006-10-05 Smithkline Beecham Corporation Novel method
GB0513058D0 (en) * 2005-06-27 2005-08-03 Sandoz Ag Organic compounds
US7790767B2 (en) * 2005-06-27 2010-09-07 Nabriva Therapeutics Forschungs Gmbh Pleuromutilin derivatives containing a hydroxyamino- or acyloxyaminocycloalkyl group
WO2007037518A1 (ja) * 2005-09-29 2007-04-05 Dainippon Sumitomo Pharma Co., Ltd. ムチリン誘導体及びそれを含有する医薬組成物
WO2007079173A2 (en) * 2005-12-30 2007-07-12 Emergent Biosolutions Inc. Novel 2-heteroaryloxy-phenol derivatives as antibacterial agents
JP5293192B2 (ja) 2007-02-09 2013-09-18 アステラス製薬株式会社 アザ架橋環化合物
WO2008117796A1 (ja) * 2007-03-28 2008-10-02 Dainippon Sumitomo Pharma Co., Ltd. 新規ムチリン誘導体
EP2149571A4 (en) 2007-05-24 2010-09-01 Kyorin Seiyaku Kk MUTILINE DERIVATIVE WITH A RINGED, HETEROCYCLIC AND AROMATIC CARBOXYLIC ACID STRUCTURE IN A SUBSTITUTE AT POSITION 14
US20090076071A1 (en) * 2007-09-13 2009-03-19 Protia, Llc Deuterium-enriched retapamulin
US20090234125A1 (en) * 2007-11-26 2009-09-17 Eli Lancry Amorphous retapamulin and processes for preparation thereof
US20090149655A1 (en) * 2007-12-05 2009-06-11 Lilach Hedvati Process for the preparation of Retapamulin and its intermediates
US8278313B2 (en) 2008-03-11 2012-10-02 Abbott Laboratories Macrocyclic spiro pyrimidine derivatives
US8436005B2 (en) 2008-04-03 2013-05-07 Abbott Laboratories Macrocyclic pyrimidine derivatives
WO2010056855A1 (en) * 2008-11-13 2010-05-20 Teva Pharmaceutical Industries Ltd. Preparation of retapamulin via its pleuromutilin-thiol precursor
US20120107854A1 (en) * 2009-03-03 2012-05-03 National Institute Of Radiological Sciences Reagent for measurement of cholinesterase activity
JP5663572B2 (ja) 2009-07-14 2015-02-04 アルバニー モレキュラー リサーチ， インコーポレイテッド ５−ｈｔ３受容体モジュレーター、その作製方法、およびその使用
CN102344397B (zh) * 2011-08-23 2013-09-04 浙江升华拜克生物股份有限公司 一种伐奈莫林盐酸盐的提纯方法
CN103626693B (zh) * 2012-08-28 2016-09-14 中国科学院上海药物研究所 一类截短侧耳素衍生物、其药物组合物及其合成方法与用途
CN103709093B (zh) * 2012-09-28 2016-06-08 山东亨利医药科技有限责任公司 含有并环的截短侧耳素类抗生素
US10258222B2 (en) 2014-07-21 2019-04-16 Endochoice, Inc. Multi-focal, multi-camera endoscope systems
EP3971191A1 (en) * 2016-03-02 2022-03-23 Bill And Melinda Gates Foundation Boron-containing small molecules
US10874679B2 (en) 2016-03-02 2020-12-29 Bill & Melinda Gates Foundation Boron-containing small molecules
CN113845536A (zh) * 2016-03-02 2021-12-28 比尔及梅琳达盖茨基金会 含硼小分子
CN106496085B (zh) * 2016-09-21 2018-01-26 盐城市舜宝化工有限公司 合成盐酸沃尼妙林的中间体化合物以及盐酸沃尼妙林的制备方法
TWI762573B (zh) 2017-02-10 2022-05-01 奧地利商納畢瓦治療有限責任公司 截短側耳素之純化
CN111574395B (zh) * 2020-06-18 2021-07-02 华南农业大学 一种具有酰胺侧链的截短侧耳素衍生物及制备与应用
AT523646B1 (de) 2020-07-21 2021-10-15 Gerd Dr Ascher Pharmazeutische Verbindungen, ihre Anwendung alleine oder in Kombination, zur Prophylaxe und lokalen Initial-Therapie bei bakteriellen und viralen Infektionen, insbesondere Coronaviren
US11155514B1 (en) * 2020-12-19 2021-10-26 Shaanxi University Of Science And Technology Pleuromulin acitretin ester with antibacterial activity and a method of preparing the same
US11332430B1 (en) * 2021-01-25 2022-05-17 Xi'an Taikomed Pharmaceutical Technology Co., Ltd. Pleuromulin lauric acid ester with antibacterial activity and a method of preparing the same
CN112919463B (zh) * 2021-04-09 2021-10-26 南京理工大学 一种利用泰妙菌素废盐制备的活性炭及其制备方法
CN113121355B (zh) * 2021-04-13 2023-05-09 西安康诺化工有限公司 一种截短侧耳素大黄酸酯及其制备方法和应用
CN114736194A (zh) * 2022-03-29 2022-07-12 中牧实业股份有限公司 一种具有抗病原微生物活性的含吡啶季铵盐侧链的截短侧耳素衍生物及其制备方法与应用

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4060542A (en) * 1969-07-25 1977-11-29 Biochemie Gesellschaft M.B.H. 14-Desoxy-14 thiocyanato-acetoxy-mutilin
US4208326A (en) 1971-10-05 1980-06-17 Sandoz Ltd. Pleuromutilin esters
US3919290A (en) 1972-10-03 1975-11-11 Sandoz Ltd Substituted 14-desoxy-mutilins
CH575375A5 (pt) 1972-05-25 1976-05-14 Sandoz Ag
US4032530A (en) 1971-10-05 1977-06-28 Sandoz Ltd. Certain pleuromutilins
BE789629A (fr) * 1971-10-05 1973-04-03 Sandoz Sa Nouveaux derives de la pleuromutiline, leur preparation et leurapplication en therapeutique
CH593912A5 (en) 1972-07-07 1977-12-30 Sandoz Ag Pleuromutilin derivs. - prepd. by acylating derivs. contg. a (4)-hydroxyalkyl-(1)-piperazinyl gp.
DE2404046C3 (de) 1974-01-29 1984-07-26 Henkel KGaA, 4000 Düsseldorf Verwendung von Carboxyl- bzw. Carboxylat- und Hydroxylgruppen aufweisenden Polymeren als Hautfeuchthaltemittel
US3987194A (en) 1975-05-12 1976-10-19 E. R. Squibb & Sons, Inc. Use of pleuromutilin derivatives for the treatment of swine dysentery
CH619450A5 (pt) 1976-01-15 1980-09-30 Sandoz Ag
US4130709A (en) 1977-12-08 1978-12-19 Eli Lilly And Company Pleuromutilin glycoside derivatives
GB2025930B (en) * 1978-06-01 1983-02-09 Sandoz Ltd Process for the production of pleuromutilin derivatives
EP0013768B1 (en) * 1979-01-12 1984-02-01 Sandoz Ag New pleuromutilin derivatives, their production and pharmaceutical compositions containing them
JPS5594359A (en) * 1979-01-12 1980-07-17 Sandoz Ag Novel pleuromutilin derivatives*their manufacture and use
FR2502951B1 (fr) 1981-04-06 1985-12-06 Sandoz Sa Compositions pharmaceutiques topiques sous forme d'une micro-emulsion
DE3405632A1 (de) * 1984-02-17 1985-08-22 Sandoz-Patent-GmbH, 7850 Lörrach Neue pleuromutilinderivate, verfahren zu ihrer herstellung und ihre verwendung
EP0153277B1 (de) * 1984-02-17 1987-08-26 Sandoz Ag Neue Pleuromutilinderivate, Verfahren zu ihrer Herstellung und ihre Verwendung
AT400674B (de) 1991-07-24 1996-02-26 Biochemie Gmbh Pharmazeutische pleuromutilin-zubereitung
GB9201751D0 (en) 1992-01-28 1992-03-11 Smithkline Beecham Plc Compounds
AT397654B (de) 1992-05-04 1994-06-27 Biochemie Gmbh Neue pleuromutilinderivate, ihre verwendung und verfahren zu ihrer herstellung
EE9700141A (et) 1994-12-23 1997-12-15 Dr. Karl Thomae Gmbh Piperasiinderivaadid, neid sisaldavad ravimid, nende kasutamine ja valmistamise meetod
BR9612426A (pt) * 1996-01-03 1999-07-13 Smithkline Beecham Plc Derivados carbomoilóxi e sua aplicação como antibacterianos
HUP0001741A3 (en) * 1996-08-02 2000-11-28 Smithkline Beecham Plc Azabicyclic carbamoyloxy mutilin derivatives for antibacterial use, process for preparing them, pharmaceuticals contg. them and their use
TR199900733T2 (xx) 1996-10-01 1999-07-21 Smithkline Beecham Corporation Patojenik organizmalar ile nasofarinksin kolonizasyonu ile ilgili bakteriyal enfeksiyonlar�n tedavisi i�in bir ilac�n imalat�nda mupirosin kullan�m�.
UY25225A1 (es) * 1997-10-29 2000-12-29 Smithkline Beecham Plc Derivados de pleuromutilina utiles como agentes antimicrobianos
DE602004024417D1 (de) 2003-09-03 2010-01-14 Glaxo Group Ltd Neues verfahren zur herstellung von pleuromutilinderivaten
GB0504314D0 (en) 2005-03-02 2005-04-06 Glaxo Group Ltd Novel polymorph

Also Published As

Publication number Publication date
FR07C0057I1 (pt) 2007-12-14
DE69826704D1 (de) 2004-11-04
CN1205211C (zh) 2005-06-08
DK1930330T3 (da) 2011-12-12
KR100538721B1 (ko) 2005-12-26
PE123299A1 (es) 2000-02-05
EP1930330B1 (en) 2011-09-21
LU91372I2 (fr) 2007-12-24
CN1283197A (zh) 2001-02-07
DE69826704T2 (de) 2005-10-06
ATE525373T1 (de) 2011-10-15
IL135811A (en) 2006-12-31
BR9814747B1 (pt) 2010-12-14
HUP0004040A1 (hu) 2001-05-28
PL197672B1 (pl) 2008-04-30
ES2371205T3 (es) 2011-12-28
PT1930330E (pt) 2011-10-31
DE122007000076I2 (de) 2010-03-25
JP2001521033A (ja) 2001-11-06
EP1028961B1 (en) 2004-09-29
TR200001203T2 (tr) 2000-08-21
EP1930330A1 (en) 2008-06-11
CA2307551A1 (en) 1999-05-06
NL300304I2 (nl) 2008-03-03
CY2007028I1 (el) 2009-11-04
NO327392B1 (no) 2009-06-22
CY2007028I2 (el) 2009-11-04
DE122007000076I1 (de) 2008-02-14
DK1028961T5 (da) 2009-03-09
TWI232861B (en) 2005-05-21
HK1031376A1 (en) 2001-06-15
ES2229538T7 (es) 2009-06-18
USRE43390E1 (en) 2012-05-15
DZ2634A1 (fr) 2003-03-08
CZ20001551A3 (cs) 2001-01-17
EP1028961A1 (en) 2000-08-23
NO2009023I2 (no) 2012-12-03
NO20002173D0 (no) 2000-04-27
NL300304I1 (nl) 2008-01-02
JP2009040789A (ja) 2009-02-26
IL135811A0 (en) 2001-05-20
WO1999021855A1 (en) 1999-05-06
JP4227729B2 (ja) 2009-02-18
AU9636198A (en) 1999-05-17
MY130665A (en) 2007-07-31
HUP0004040A3 (en) 2001-08-28
HU229792B1 (en) 2014-07-28
SI1930330T1 (sl) 2011-12-30
CZ298543B6 (cs) 2007-10-31
FR07C0057I2 (fr) 2008-05-16
KR20010031654A (ko) 2001-04-16
US6281226B1 (en) 2001-08-28
AU742167C (en) 2003-08-07
PT1028961E (pt) 2005-01-31
ES2229538T3 (es) 2005-04-16
ATE277925T1 (de) 2004-10-15
SI1028961T1 (en) 2005-02-28
LU91372I9 (pt) 2019-01-02
DK1028961T3 (da) 2005-01-03
AU742167B2 (en) 2001-12-20
CO5021129A1 (es) 2001-03-27
AR015987A1 (es) 2001-05-30
PL191927B1 (pl) 2006-07-31
DE69826704T3 (de) 2009-07-23
EP1028961B3 (en) 2008-12-03
PL340254A1 (en) 2001-01-29
NO20002173L (no) 2000-06-05
USRE39128E1 (en) 2006-06-13
CA2307551C (en) 2007-01-30
NO2009023I1 (no) 2009-10-12
EG24177A (en) 2008-09-28
EP1452534A1 (en) 2004-09-01
NZ504203A (en) 2002-11-26
NO20091344L (no) 2000-06-05
ZA989767B (en) 2000-04-28
UY25225A1 (es) 2000-12-29
CY1112062T1 (el) 2015-11-04
HUS1400060I1 (hu) 2016-09-28

Similar Documents

Publication Publication Date Title
BR9814747A (pt) Derivados pleuromutilina atuando comoantimicrobianos
IE861820L (en) 2-hydroxy-2-phenylethylaminotetralines
EP0423714A3 (en) Hair revitalizing agent
HU9603298D0 (en) Meterocyclic compounds having tachykinin receptor antagonist activity, their preparation and their use
PT1235826E (pt) Acrilamidas de quinuclidina
ES2179071T3 (es) Agentes vasodilatadores perifericos que comprenden como principio activo derivados de la piperidina 4-amino n-acilada.
TW336939B (en) Lipopeptide derivatives, a process for their preparation and their use
IL114894A (en) Pyrrolidine derivatives as endothelin antagonists, pharmaceutical compositions containing them, and their use in the preparation of medicaments
HK1011967A1 (en) Amide derivatives having anti-hyper cholesteremic activity their preparation and their therapeutic uses
ES2149305T3 (es) Compuestos de dibenzoxazepina sustituidos, composiciones farmaceuticas y procedimientos de uso.
PL338415A1 (en) Application of physiologically compatible vanadium compounds, salts and complexes
IL114785A0 (en) Pyrrolocarbazoles their preparation and pharmaceutical compositions containing them
MY106314A (en) New tetrazole derivatives, process for their preparation and their use
CA2245490A1 (en) 3,4-disubstituted phenylethanolaminotetralincarboxamide derivatives
ES2124256T3 (es) Arilmorfolina, preparacion y uso.
CA2041330A1 (en) Percutaneously Absorbable Eperisone or Tolperisone Preparation
IL82564A0 (en) Synergistin derivatives,their preparation and pharmaceutical compositions which contain them
ATE285771T1 (de) Diaminotrifluoromethylpyrimidinderivate enthaltende antikrebs-zusammensetzung
DK0913151T3 (da) Anti-helicobacter Pylori-præparater indeholdende 1-methylcarbapenemderivater som den aktive bestanddel
ATE184282T1 (de) Cyclopropan-derivate und diese enthaltende antivirale mittel
MY132436A (en) Use of allylamine derivatives such as terbinafine, in the manufacture of a medicament for the treatment of helicobacter pylori infection of associated diseases
MX9707610A (es) Derivados de fenoxietilamina que tienen una afinidad elevada hacia el receptor 5-ht1a, su procedimiento de preparacion, su aplicacion como medicamento y las composiciones farmaceuticas que los contienen.
TW362972B (en) Use of lower alkanoyl L-carnitines to produce a medicament suitable for the therapeutic treatment of retinopathies
BR7901571U (pt) Guardanapo odontológico
MX9709299A (es) Uso de las l-carnitinas de alcanoilo inferior para producir un medicamento apropiado para el tratamiento terapeutico de retinopatias.

Legal Events

Date Code Title Description
B06G Technical and formal requirements: other requirements [chapter 6.7 patent gazette]

Free format text: SUSPENSAO DO ANDAMENTO DO PEDIDO DE PATENTE PARA QUE SEJA COMPLEMENTADA A RETRIBUICAO EQUIVALENTE AO PEDIDO DE EXAME DE 20 ( VINTE ) REIVINDICACOES ( QUADRO REIVINDICATORIO MODIFICADO SOB PETICAO NO 020060133895, DE 29/08/2006), VISTO QUE A RETRIBUICAO PAGA ATRAVES DA PETICAO NO 052593, DE 29/10/2001, REFERE-SE A 16 ( DEZESSEIS ) REIVINDICACOES

B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 14/12/2010, OBSERVADAS AS CONDICOES LEGAIS.

B25D Requested change of name of applicant approved

Owner name: SMITHKLINE BEECHAM P.L.C. (GB) , GLAXOSMITHKLINE L

Free format text: NOME ALTERADO DE: SMITHKLINE BEECHAM CORPORATION

B21A Patent or certificate of addition expired [chapter 21.1 patent gazette]

Free format text: PATENTE EXTINTA EM 14.12.2020