BR9810832A - Composição farmacêutica contendo como princìpios ativos vitamina d associada a um sal de cálcio, e, processos para a preparação de uma composição farmacêutica, para tratamento de deficiências nutricionais de cálcio e vitamina d na velhice e para reduzir a perda de tecido ósseo ligada à idade e para evitar fraturas femurais e outras fraturas não vertebrais - Google Patents

Composição farmacêutica contendo como princìpios ativos vitamina d associada a um sal de cálcio, e, processos para a preparação de uma composição farmacêutica, para tratamento de deficiências nutricionais de cálcio e vitamina d na velhice e para reduzir a perda de tecido ósseo ligada à idade e para evitar fraturas femurais e outras fraturas não vertebrais

Info

Publication number
BR9810832A
BR9810832A BR9810832-8A BR9810832A BR9810832A BR 9810832 A BR9810832 A BR 9810832A BR 9810832 A BR9810832 A BR 9810832A BR 9810832 A BR9810832 A BR 9810832A
Authority
BR
Brazil
Prior art keywords
vitamin
pharmaceutical composition
calcium
age
composition containing
Prior art date
Application number
BR9810832-8A
Other languages
English (en)
Other versions
BR9810832B1 (pt
Inventor
Maurizio Valleri
Alessandro Tosetti
Original Assignee
Menarini International Operati
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Menarini International Operati filed Critical Menarini International Operati
Publication of BR9810832A publication Critical patent/BR9810832A/pt
Publication of BR9810832B1 publication Critical patent/BR9810832B1/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • A61K31/593—9,10-Secocholestane derivatives, e.g. cholecalciferol, i.e. vitamin D3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates

Abstract

''COMPOSIçãO FARMACêUTICA CONTENDO COMO PRINCìPIOS ATIVOS VITAMINA D ASSOCIADA A UM SAL DE CáLCIO, E, PROCESSOS PARA A PREPARAçãO DE UMA COMPOSIçãO FARMACêUTICA, PARA O TRATAMENTO DE DEFICIêNCIAS NUTRICIONAIS DE CáLCIO E VITAMINA D NA VELHICE E PARA REDUZIR A PERDA DE TECIDO óSSEO LIGADA à IDADE E PARA EVITAR FRATURAS FEMURAIS E OUTRAS FRATURAS NãO VERTEBRAIS''. é descrito aqui uma composição farmacêutica contendo Vitamina D e cálcio, compreendendo um agente de ligação selecionado entre o grupo consistindo de: propileno glicol, um polietileno glicol apresentando peso molecular compreendido entre 300 e 1500, parafina líquida ou óleo de silicone, útil para tratamento de deficiências nutricionais na velhice, de cálcio e Vitamina D.
BRPI9810832-8A 1997-07-30 1998-07-21 composição farmacêutica contendo como princìpios ativos vitamina d associada a um sal de cálcio, e, processos para a preparação de uma composição farmacêutica, para o tratamento de deficiências nutricionais de cálcio e vitamina d na velhice e para reduzir a perda de tecido ósseo ligada à idade e para evitar fraturas femurais e outras fraturas não vertebrais. BR9810832B1 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT97FI000184A ITFI970184A1 (it) 1997-07-30 1997-07-30 Composizioni farmaceutiche contenenti vitamina d e calcio,loro preparazione ed uso terapeutico
PCT/EP1998/004567 WO1999006051A1 (en) 1997-07-30 1998-07-21 Pharmaceutical compositions containing vitamin d and calcium, their preparation and therapeutic use

Publications (2)

Publication Number Publication Date
BR9810832A true BR9810832A (pt) 2000-07-25
BR9810832B1 BR9810832B1 (pt) 2010-11-16

Family

ID=11352223

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI9810832-8A BR9810832B1 (pt) 1997-07-30 1998-07-21 composição farmacêutica contendo como princìpios ativos vitamina d associada a um sal de cálcio, e, processos para a preparação de uma composição farmacêutica, para o tratamento de deficiências nutricionais de cálcio e vitamina d na velhice e para reduzir a perda de tecido ósseo ligada à idade e para evitar fraturas femurais e outras fraturas não vertebrais.

Country Status (29)

Country Link
US (1) US7067154B1 (pt)
EP (1) EP0999843B1 (pt)
JP (1) JP4497496B2 (pt)
KR (1) KR100573421B1 (pt)
AT (1) ATE271387T1 (pt)
AU (1) AU8978198A (pt)
BG (1) BG65044B1 (pt)
BR (1) BR9810832B1 (pt)
CA (1) CA2299420C (pt)
CZ (1) CZ297670B6 (pt)
DE (1) DE69825164D1 (pt)
EA (1) EA002492B1 (pt)
EE (1) EE04046B1 (pt)
ES (1) ES2223135T3 (pt)
HK (1) HK1027751A1 (pt)
HU (1) HU226112B1 (pt)
ID (1) ID23504A (pt)
IL (1) IL134268A0 (pt)
IS (1) IS5359A (pt)
IT (1) ITFI970184A1 (pt)
NO (1) NO20000310L (pt)
PL (1) PL189295B1 (pt)
PT (1) PT999843E (pt)
RS (1) RS49703B (pt)
SI (1) SI0999843T1 (pt)
SK (1) SK284873B6 (pt)
TR (1) TR200000261T2 (pt)
UA (1) UA61968C2 (pt)
WO (1) WO1999006051A1 (pt)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040071789A1 (en) * 2002-02-14 2004-04-15 Baron John A Calcium supplementation to reduce prostate cancer risk
ES2192136B1 (es) * 2002-01-04 2005-03-16 Italfarmaco, S.A. Composiciones farmaceuticas para el tratamiento o prevencion de la osteoporosis.
ITFI20030194A1 (it) * 2003-07-17 2005-01-18 Menarini Int Operations Lu Sa Composizione farmaceutiche effervescenti contenenti
US10258576B2 (en) 2004-05-24 2019-04-16 Takeda As Particulate comprising a calcium-containing compound and a sugar alcohol
EP1755578B2 (en) 2004-06-01 2018-11-28 Takeda AS Chewable, suckable and swallowable tablet containing a calcium-containing compound as an active substance
AU2006211023B2 (en) 2005-02-03 2012-05-24 Takeda Nycomed As Fast wet-massing method for the preparation of calcium-containing compositions
EP1845949B1 (en) 2005-02-03 2008-05-21 Nycomed Pharma AS Melt granulation of a composition containing a calcium-containing compound
CA2924200C (en) * 2005-10-12 2017-09-05 Proventiv Therapeutics, Llc Methods and articles for treating 25-hydroxyvitamin d insufficiency and deficiency
EP1962806B1 (en) 2005-12-07 2010-09-01 Nycomed Pharma AS Pre-compacted calcium-containing compositions
UA95093C2 (uk) * 2005-12-07 2011-07-11 Нікомед Фарма Ас Спосіб одержання кальцієвмісної сполуки
MXPA05014091A (es) * 2005-12-20 2007-06-20 Leopoldo De Jesus Espinosa Abdala Composiciones farmaceuticas que comprenden derivados de esteroides sinteticos, minerales y el metabolito activo de la vitamina d, 1,25(oh)2d3 (calcitriol) para la prevencion y tratamiento de la osteoporosis y el control de los sintomas de la menopaus
CA2587805C (en) * 2007-04-25 2014-02-18 The Procter & Gamble Company Improved vitamin d content uniformity in pharmaceutical dosage forms
MX2011004744A (es) 2008-11-17 2011-05-30 Nycomed Pharma As Estabilidad mejorada de disolucion de tabletas de carbonato de calcio.
TR200900878A2 (tr) 2009-02-05 2010-08-23 Bi̇lgi̇ç Mahmut Tek bir dozaj formunda kombine edilen farmasötik formülasyonlar
TR200900880A2 (tr) 2009-02-05 2010-08-23 Bi̇lgi̇ç Mahmut Tek bir dozaj formunda kombine edilen farmasötik bileşimler.
TR200908237A2 (tr) 2009-11-02 2011-05-23 Bi̇lgi̇ç Mahmut Kalsiyum ve D vitamini içeren farmasötik bileşimler.
US20120015913A1 (en) 2010-07-15 2012-01-19 Delansorne Remi Formulations of 14-EPI-Analogues of Vitamin D
JP6554034B2 (ja) * 2013-08-09 2019-07-31 日東薬品工業株式会社 カルシウム剤
CN105166935B (zh) * 2015-09-01 2018-08-31 张伟 一种含有维生素d3的液体制剂及其制备方法
CA3099055A1 (en) 2018-05-02 2019-11-07 Ferring B.V. Improved pharmaceutical formulations
KR102211287B1 (ko) * 2018-12-21 2021-02-03 (주)휴온스 비타민 d 또는 이의 유도체를 포함하는 안정성이 개선된 액상 제제

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2073271A1 (en) * 1969-12-11 1971-10-01 Boivin Jean Calcium salt - vitamin d2 compn - for treatment of decalcification of
ZA813205B (en) * 1980-12-05 1983-03-30 Smith Kline French Lab Dosage units
DK8603837A (pt) * 1985-08-13 1987-02-14
US5624683A (en) * 1986-08-06 1997-04-29 Eisai Co., Ltd. Sustained-release multi-granule tablet
JPH05505935A (ja) * 1990-02-05 1993-09-02 ボード オブ リージェンツ，ザ ユニバーシティ オブ テキサス システム ビタミン，ミネラルおよび他の有利な補給剤の徐放性処方
CA2080818A1 (en) * 1990-05-16 1991-11-17 Zbigniew Walaszek Formula and method for the prevention and treatment of hypercholesterolemia and cellular hyerproliferative disorders
RO113611B1 (ro) * 1990-08-03 1998-09-30 Asta Pharma Ag Preparate solide de ifosfamida, administrate oral si procedeu de obtinere
IL103224A (en) * 1992-09-18 1998-08-16 Teva Pharma Stabilized pharmaceutical compositions containing derivatives of vitamins d2 and d3
FR2724844B1 (fr) 1994-09-23 1997-01-24 Innothera Lab Sa Association therapeutique vitamino-calcique, son procede d'obtention et son utilisation
IL115241A (en) * 1994-09-26 2000-08-31 American Cyanamid Co Calcium dietary supplement
FR2760639B1 (fr) * 1997-03-14 2000-09-22 Innothera Lab Sa Association therapeutique mineralo-vitaminique sous forme de preparation unitaire liquide buvable

Also Published As

Publication number Publication date
BR9810832B1 (pt) 2010-11-16
SK284873B6 (sk) 2006-01-05
ES2223135T3 (es) 2005-02-16
BG104057A (en) 2000-07-31
ATE271387T1 (de) 2004-08-15
CA2299420C (en) 2009-04-21
SI0999843T1 (en) 2005-02-28
EP0999843A1 (en) 2000-05-17
HK1027751A1 (en) 2001-01-23
JP2001511453A (ja) 2001-08-14
TR200000261T2 (tr) 2000-09-21
EP0999843B1 (en) 2004-07-21
EE200000054A (et) 2000-10-16
CZ297670B6 (cs) 2007-02-28
NO20000310D0 (no) 2000-01-21
PL338237A1 (en) 2000-10-09
IS5359A (is) 2000-01-24
UA61968C2 (en) 2003-12-15
ID23504A (id) 2000-04-27
CZ2000199A3 (cs) 2000-05-17
DE69825164D1 (de) 2004-08-26
EE04046B1 (et) 2003-06-16
US7067154B1 (en) 2006-06-27
ITFI970184A1 (it) 1999-01-30
IL134268A0 (en) 2001-04-30
JP4497496B2 (ja) 2010-07-07
PT999843E (pt) 2004-11-30
NO20000310L (no) 2000-01-21
CA2299420A1 (en) 1999-02-11
KR20010022319A (ko) 2001-03-15
HU226112B1 (en) 2008-04-28
PL189295B1 (pl) 2005-07-29
KR100573421B1 (ko) 2006-04-26
RS49703B (sr) 2007-12-31
YU3700A (sh) 2002-11-15
WO1999006051A1 (en) 1999-02-11
HUP0100539A2 (hu) 2001-08-28
AU8978198A (en) 1999-02-22
BG65044B1 (bg) 2007-01-31
SK802000A3 (en) 2000-07-11
EA200000181A1 (ru) 2000-10-30
EA002492B1 (ru) 2002-06-27

Similar Documents

Publication Publication Date Title
BR9810832A (pt) Composição farmacêutica contendo como princìpios ativos vitamina d associada a um sal de cálcio, e, processos para a preparação de uma composição farmacêutica, para tratamento de deficiências nutricionais de cálcio e vitamina d na velhice e para reduzir a perda de tecido ósseo ligada à idade e para evitar fraturas femurais e outras fraturas não vertebrais
Einhorn Enhancement of fracture-healing.
NO2014010I1 (no) Radium 223 salt slik som Radium 223 diklorid
BR9813373A (pt) Composto, processo para a preparação do mesmo, composição farmacêutica, processo para a preparação da mesma, uso de um composto, e, processos para efetuar imunossupressão e para tratar ou reduzir o risco de uma doença das vias aérias obstrutiva reversìvel em um paciente
BR0206985A (pt) Anticorpos modificados e métodos de uso
IL141141A0 (en) Targeting pharmaceutical agents to injured tissues
EP0804595A4 (pt)
KR860006988A (ko) 뼈 골절의 국소요법을 위한 비타민 d유도체로 구성된 방법과 조성물들
BRPI0413574A (pt) aplicação de polipeptìdeos da famìlia cupredoxina na terapia do cáncer
PT2009025E (pt) Método de inibição da actividade dos osteoclastos
BR0010531A (pt) Composições e usos de et743 para tratamento de câncer
SE9802528D0 (sv) Bone tissue restoring composition
EP0347899A3 (en) Pharmaceutical compositions on egg shell basis and their preparation and use
ATE198418T1 (de) Pharmazeutische zusammensetzung zur förderung der gewebeheilung und -regenerierung und darreichungssatz
Claassen et al. Cartilage canals in human thyroid cartilage characterized by immunolocalization of collagen types I, II, pro-III, IV and X
McIlwraith et al. Principles of Musculoskeletal Disease: Joint injuries and disease and osteoarthritis
RU2211708C2 (ru) Способ приготовления биоактивного костно-пластического материала "костма"
RU96107872A (ru) Крем для кожи лица "talita"
Pshenisnov et al. The fate of free, pedicled and free vascularized cancellous iliac bone grafts and the effect on the healing of femoral osteotomy: an experimental study
Shinjo et al. Clinical application of hydroxyapatite fillers for pyogenic osteomyelitis
Rozzell Biomaterials Research in West Germany: An Assessment
Nagi et al. S ince the introduction of replacement arthroplasty as a viable option for painful deformed hips, the indications have been expanded to include younger patients with higher demands on their hips. This has
Ratliff et al. Dislocation of the Proximal Tibiofibular Joint
Dickson et al. The use of sulfathiazole in the treatment of subacute and chronic osteomyelitis: Frank D. Dickson MD (1882-1964), Rex L. Diveley MD, Richard Kiene MD. The 4th president of the AAOS 1935 (FDD).
SHANDS et al. PROGRESS IN ORTHOPEDIC SURGERY FOR 1946 A Review Prepared by an Editorial Board of the American Academy of Orthopaedic Surgeons: XXI. RESEARCH

Legal Events

Date Code Title Description
B12F Other appeals [chapter 12.6 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B15K Others concerning applications: alteration of classification

Free format text: ALTERADA DE INT.CL: A61K 47/10, A61K 47/30, A61K 47/44, A61K 9/16, A61K 9/20, A61K 31/59, A61K 31/592, A61K 31/593, A61K 33/06, A61P 3/02, A61P 3/14, A61P 19/08, A61P 19/10

Ipc: A61K 47/10 (2009.01), A61K 47/30 (2009.01), A61K 4

B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 16/11/2010, OBSERVADAS AS CONDICOES LEGAIS.

B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time

Free format text: REFERENTE A 16A ANUIDADE.

B24J Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12)

Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2264 DE 27-05-2014 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.