BR9810595A - Medicamentos, compostos de poliidroxibutilpirazina, processo para preparação dos compostos, e, utilização dos compostos. - Google Patents
Medicamentos, compostos de poliidroxibutilpirazina, processo para preparação dos compostos, e, utilização dos compostos.Info
- Publication number
- BR9810595A BR9810595A BR9810595-7A BR9810595A BR9810595A BR 9810595 A BR9810595 A BR 9810595A BR 9810595 A BR9810595 A BR 9810595A BR 9810595 A BR9810595 A BR 9810595A
- Authority
- BR
- Brazil
- Prior art keywords
- radical
- compounds
- represent
- methylene
- choh
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 9
- 239000003814 drug Substances 0.000 title abstract 3
- 229940079593 drug Drugs 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- HZVOZRGWRWCICA-UHFFFAOYSA-N methanediyl Chemical compound [CH2] HZVOZRGWRWCICA-UHFFFAOYSA-N 0.000 abstract 4
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 3
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 2
- 239000004480 active ingredient Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/12—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Plural Heterocyclic Compounds (AREA)
- Cosmetics (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
"MEDICAMENTOS, COMPOSTOS DE POLIIDROXIBUTILPIRAZINA, PROCESSO PARA PREPARAçãO DOS COMPOSTOS, E, UTILIZAçãO DOS COMPOSTOS". Medicamentos contendo, como princípio ativo, pelo menos um composto de fórmula (I): em que, quando (A) R~ 9~ e R~ 10~ representam, cada um, um radical -CH~ 2~OH, e quando R~ 3~ representa um radical metileno, R~ 4~ representa um radical -CHOH- e um dos radicais R~ 1~, R~ 2~, R~ 5~ e R~ 6~ representa um radical carbonila, metileno, -CHF-, -CH(NHR~ 7~)- ou -CH(OR~ 8~) e os outros representam, cada um, um radical -CHOH-, quando R~ 2~ e R~ 5~ representam, cada um, um radical -CHOH-, R~ 3~ representa um radical metileno e R~ 1~, R~ 4~ e R~ 6~ são idênticos e representam, cada um, um radical carbonila, metileno, -CHF-, -CH(NHR~ 7~)- ou -CH(OR~ 8~), quando R~ 1~ e R~ 6~ representam um radical -CHOH-, R~ 3~ representa um radical metileno e R~ 2~, R~ 4~ e R~ 5~ são idênticos e representam, cada um, um radical carbonila, metileno, -CHF-, -CH(NHR~ 7~)- ou -CH(OR~ 8~), quando R~ 1~, R~ 4~, R~ 5~ e R~ 6~ representam, cada um, um radical -CHOH- e -R~ 2~-R~ 3~- representa um radical -CH=CH-, quando (B) R~ 1~, R~ 2~, R~ 4~, R~ 5~ e R~ 6~ representam, cada um, um radical -CHOH-, R~ 3~ representa um radical metileno, R~ 9~ representa um radical -CH~ 2~F ou -CH~ 2~OH, R~ 10~ representa um radical -CH~ 2~F ou -CH~ 2~OH, sendo que R~ 9~ e R~ 10~ não são, ambos, um radical -CH~ 2~OH ou um de seus estereoisómeros ou um sal de um tal composto, os novos compostos de fórmula (I) e seu Processo para preparação.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9709059A FR2766183B1 (fr) | 1997-07-17 | 1997-07-17 | Medicaments contenant des polyhydroxybutylpyrazines, les polyhydroxybutylpyrazines nouvelles et leur preparation |
| PCT/FR1998/001543 WO1999003841A1 (fr) | 1997-07-17 | 1998-07-15 | Polyhydroxybutylpyrazines, leur preparation et medicaments les contenant |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9810595A true BR9810595A (pt) | 2000-09-12 |
Family
ID=9509301
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR9810595-7A BR9810595A (pt) | 1997-07-17 | 1998-07-15 | Medicamentos, compostos de poliidroxibutilpirazina, processo para preparação dos compostos, e, utilização dos compostos. |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US6288066B1 (pt) |
| EP (1) | EP1001942B1 (pt) |
| JP (1) | JP4443033B2 (pt) |
| KR (1) | KR20010021871A (pt) |
| CN (1) | CN1264368A (pt) |
| AT (1) | ATE243683T1 (pt) |
| AU (1) | AU745905B2 (pt) |
| BR (1) | BR9810595A (pt) |
| CA (1) | CA2296725C (pt) |
| CZ (1) | CZ290896B6 (pt) |
| DE (1) | DE69815854T2 (pt) |
| DK (1) | DK1001942T3 (pt) |
| ES (1) | ES2196595T3 (pt) |
| FR (1) | FR2766183B1 (pt) |
| HU (1) | HUP0004661A3 (pt) |
| IL (1) | IL134039A0 (pt) |
| MX (1) | MXPA00000437A (pt) |
| NO (1) | NO20000199L (pt) |
| NZ (1) | NZ502279A (pt) |
| PL (1) | PL338147A1 (pt) |
| PT (1) | PT1001942E (pt) |
| RU (1) | RU2186773C2 (pt) |
| SK (1) | SK462000A3 (pt) |
| WO (1) | WO1999003841A1 (pt) |
| ZA (1) | ZA986336B (pt) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2802816A1 (fr) * | 1999-12-23 | 2001-06-29 | Aventis Pharma Sa | Association de deoxyfructosazine et d'un antidiabetique inhibiteur d'alpha-glucosidase |
| FR2802813A1 (fr) * | 1999-12-23 | 2001-06-29 | Aventis Pharma Sa | Association de deoxyfructosazine et d'un antidiabetique de la famille des biguandes |
| FR2802815A1 (fr) * | 1999-12-23 | 2001-06-29 | Aventis Pharma Sa | Association de deoxyfructosazine et d'un antidiabetique agoniste du recepteur gamma-active par le proliferateur de peroxisome |
| US6794506B2 (en) * | 2000-07-21 | 2004-09-21 | Elan Pharmaceuticals, Inc. | 3-(heteroaryl) alanine derivatives-inhibitors of leukocyte adhesion mediated by VLA-4 |
| DE102005047647A1 (de) * | 2005-10-05 | 2007-04-12 | Merck Patent Gmbh | a,a'-Dihydroxyketonderivate und deren Verwendung als UV-Filter |
| WO2008122329A1 (en) * | 2007-03-19 | 2008-10-16 | Dsm Ip Assets B.V. | Uv-filter compounds |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2744365B1 (fr) * | 1996-02-06 | 1998-02-27 | Inst Malgache Rech Appl | Melanges isolables a partir de graines d'eugenia jambolana lamarck, leur preparation et l'utilisation de ces melanges et certains de leurs constituants comme medicaments |
-
1997
- 1997-07-17 FR FR9709059A patent/FR2766183B1/fr not_active Expired - Fee Related
-
1998
- 1998-07-15 CZ CZ2000121A patent/CZ290896B6/cs not_active IP Right Cessation
- 1998-07-15 AT AT98939677T patent/ATE243683T1/de not_active IP Right Cessation
- 1998-07-15 NZ NZ502279A patent/NZ502279A/en unknown
- 1998-07-15 ES ES98939677T patent/ES2196595T3/es not_active Expired - Lifetime
- 1998-07-15 RU RU2000103447/04A patent/RU2186773C2/ru not_active IP Right Cessation
- 1998-07-15 DK DK98939677T patent/DK1001942T3/da active
- 1998-07-15 JP JP2000503066A patent/JP4443033B2/ja not_active Expired - Fee Related
- 1998-07-15 DE DE69815854T patent/DE69815854T2/de not_active Expired - Lifetime
- 1998-07-15 MX MXPA00000437A patent/MXPA00000437A/es not_active IP Right Cessation
- 1998-07-15 HU HU0004661A patent/HUP0004661A3/hu unknown
- 1998-07-15 CA CA002296725A patent/CA2296725C/fr not_active Expired - Fee Related
- 1998-07-15 KR KR1020007000435A patent/KR20010021871A/ko not_active Application Discontinuation
- 1998-07-15 PT PT98939677T patent/PT1001942E/pt unknown
- 1998-07-15 AU AU88103/98A patent/AU745905B2/en not_active Ceased
- 1998-07-15 EP EP98939677A patent/EP1001942B1/fr not_active Expired - Lifetime
- 1998-07-15 PL PL98338147A patent/PL338147A1/xx not_active Application Discontinuation
- 1998-07-15 CN CN98807197A patent/CN1264368A/zh active Pending
- 1998-07-15 BR BR9810595-7A patent/BR9810595A/pt not_active IP Right Cessation
- 1998-07-15 IL IL13403998A patent/IL134039A0/xx unknown
- 1998-07-15 SK SK46-2000A patent/SK462000A3/sk unknown
- 1998-07-15 WO PCT/FR1998/001543 patent/WO1999003841A1/fr not_active Application Discontinuation
- 1998-07-16 ZA ZA986336A patent/ZA986336B/xx unknown
-
2000
- 2000-01-14 NO NO20000199A patent/NO20000199L/no not_active Application Discontinuation
- 2000-01-18 US US09/484,342 patent/US6288066B1/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| DK1001942T3 (da) | 2003-10-20 |
| MXPA00000437A (es) | 2002-04-17 |
| DE69815854T2 (de) | 2004-05-13 |
| HUP0004661A2 (hu) | 2001-11-28 |
| CZ290896B6 (cs) | 2002-11-13 |
| CN1264368A (zh) | 2000-08-23 |
| JP4443033B2 (ja) | 2010-03-31 |
| AU745905B2 (en) | 2002-04-11 |
| ZA986336B (en) | 1999-01-27 |
| US6288066B1 (en) | 2001-09-11 |
| NO20000199D0 (no) | 2000-01-14 |
| PT1001942E (pt) | 2003-11-28 |
| ATE243683T1 (de) | 2003-07-15 |
| SK462000A3 (en) | 2000-06-12 |
| PL338147A1 (en) | 2000-09-25 |
| CZ2000121A3 (cs) | 2000-05-17 |
| WO1999003841A1 (fr) | 1999-01-28 |
| NZ502279A (en) | 2002-04-26 |
| NO20000199L (no) | 2000-01-14 |
| IL134039A0 (en) | 2001-04-30 |
| ES2196595T3 (es) | 2003-12-16 |
| FR2766183B1 (fr) | 1999-08-27 |
| JP2001510185A (ja) | 2001-07-31 |
| EP1001942B1 (fr) | 2003-06-25 |
| FR2766183A1 (fr) | 1999-01-22 |
| KR20010021871A (ko) | 2001-03-15 |
| CA2296725A1 (fr) | 1999-01-28 |
| DE69815854D1 (de) | 2003-07-31 |
| CA2296725C (fr) | 2008-11-18 |
| HUP0004661A3 (en) | 2001-12-28 |
| AU8810398A (en) | 1999-02-10 |
| RU2186773C2 (ru) | 2002-08-10 |
| EP1001942A1 (fr) | 2000-05-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| TC | Change of name | ||
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 7A,8A E 9A ANUIDADES. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1909 DE 07/08/2007. |