BR9807486A - Epìtopos pre-m/m do vìrus da dengue, peptìdios, sintéticos, proteìnas quiméricas e uso das mesmas - Google Patents

Epìtopos pre-m/m do vìrus da dengue, peptìdios, sintéticos, proteìnas quiméricas e uso das mesmas

Info

Publication number
BR9807486A
BR9807486A BR9807486A BR9807486A BR9807486A BR 9807486 A BR9807486 A BR 9807486A BR 9807486 A BR9807486 A BR 9807486A BR 9807486 A BR9807486 A BR 9807486A BR 9807486 A BR9807486 A BR 9807486A
Authority
BR
Brazil
Prior art keywords
peptides
dengue virus
protein
epitopes
demonstrated
Prior art date
Application number
BR9807486A
Other languages
English (en)
Inventor
Susana Vazquez Ramudo
Guadalupe Guzman Tirado
Gerardo Enrique Guillen Nieto
Orlando Luis Pardo Lazo
Glay Chinea Santiago
Ana Beatriz Perez Diaz
Maritza Pupo Antunez
Rosmari Rodriguez Roche
Osvaldo Reyes Acosta
Cubana
Hilda Elisa Garay Perez
Gabriel Padron Palomares
Maylin Alvarez Vera
Luis Morier Diaz
Omaida Perez Insuita
Jose Luis Pelegrino Mar Cotera
Original Assignee
Cigb
Inst De Medicina Tropical Pedr
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cigb, Inst De Medicina Tropical Pedr filed Critical Cigb
Publication of BR9807486A publication Critical patent/BR9807486A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24111—Flavivirus, e.g. yellow fever virus, dengue, JEV
    • C12N2770/24122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
    • G01N2333/08—RNA viruses
    • G01N2333/18—Togaviridae; Flaviviridae
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Patente de Invenção: <B>"EPìTOPOS PRE-M/M DO VìRUSICAS E USO DAS MESMAS"<D>. A presente invenção refere-se a cinco peptídeos sintéticos da proteína pre-M/M do vírus de dengue 2, correspondentes às see 103-124. A resposta imunológica do antipeptídio combinantes também foram obtidas, incluindo regiões da proteína pre-M/M. A presença de epítopos de células B tanto como comundongos como em humanos foi demonstrada nos peptídeos da proteína pre-M/M. Orus da dengue. Respostas proliferativas específicas para vírus foram demonstradas em camundongos imunizados com os peptídios com os peptídios 3-31 e 57-92 não-conjugados. Camundongos imunizados com os peptídios 3-31, 57-92 e 69-93 conjugadores estavam protegidos quando receberam o virús da dengue 2. Assim, foi demonstrada a presença de epítopos seq³ênciais na proteína pre-M/M do vírus da dengue 2, assim como sua relevância na resposta imunológica contra este flavivírus.
BR9807486A 1997-01-15 1998-01-13 Epìtopos pre-m/m do vìrus da dengue, peptìdios, sintéticos, proteìnas quiméricas e uso das mesmas BR9807486A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CU1997013A CU22683A1 (es) 1997-01-15 1997-01-15 Epítopes de la proteína pre-m/m del virus del dengue, péptidos sintéticos, proteínas quiméricas y sus usos
PCT/CU1998/000001 WO1998031814A1 (es) 1997-01-15 1998-01-13 Epitopes de la proteina pre-m/m del virus del dengue, peptidos sinteticos

Publications (1)

Publication Number Publication Date
BR9807486A true BR9807486A (pt) 2000-03-21

Family

ID=5459193

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9807486A BR9807486A (pt) 1997-01-15 1998-01-13 Epìtopos pre-m/m do vìrus da dengue, peptìdios, sintéticos, proteìnas quiméricas e uso das mesmas

Country Status (15)

Country Link
US (1) US6383488B1 (pt)
EP (1) EP0966535B1 (pt)
JP (1) JP3647048B2 (pt)
CN (1) CN1198933C (pt)
AT (1) ATE284444T1 (pt)
AU (1) AU743414B2 (pt)
BR (1) BR9807486A (pt)
CA (1) CA2277816A1 (pt)
CU (1) CU22683A1 (pt)
DE (1) DE69828032T2 (pt)
ES (1) ES2235310T3 (pt)
HK (1) HK1025999A1 (pt)
MY (1) MY120971A (pt)
NO (1) NO993468L (pt)
WO (1) WO1998031814A1 (pt)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CU23245A1 (es) * 2001-07-16 2007-10-17 Inst De Medicina Tropical Pedr CADENAS QUIMéRICAS CODIFICANTES PARA PROTEINAS INDUCTORAS DE EFECTOS CONTRA VIRUS. PREPARADOS UTILIZANDO PROTEINAS QUIMéRICAS
AU2002356690B2 (en) * 2001-12-04 2008-07-24 Bavarian Nordic A/S Flavivirus NS1 subunit vaccine
EP1454988A1 (en) * 2003-03-03 2004-09-08 Institut National De La Sante Et De La Recherche Medicale (Inserm) Infectious flavivirus pseudo-particles containing functional prM-E envelope proteins
US7281274B2 (en) * 2003-10-16 2007-10-09 Lmp Media Llc Electronic media distribution system
IN2012DN03294A (pt) * 2004-07-27 2015-10-23 Government Of The Us Secretary Of The Dept Of Health And Human Services Ct S For Disease Control And
CU23578A1 (es) * 2005-09-16 2010-09-30 Ct Ingenieria Genetica Biotech Proteína de la cápsida del virus dengue inductora de respuesta protectora y composición vacunal
CU23630A1 (es) 2006-10-30 2011-02-24 Ct Ingenieria Genetica Biotech Moléculas peptídicas quiméricas con propiedades antivirales contra los virus de la familia flaviviridae
WO2009024534A2 (en) * 2007-08-17 2009-02-26 Intercell Ag Japanese encephalitis virus (jev) and tick-borne encephalitis virus (tbev) peptides stimulating human t cell responses
CU20080028A6 (es) 2008-02-29 2011-02-24 Ct Ingenieria Genetica Biotech Compuestos químicos obtenidos in silico para la preparación de composiciones farmacéuticas para atenuar o inhibir la infección por virus dengue y otros flavivirus
CN108610416B (zh) * 2008-10-13 2022-01-14 生物医学研究所 登革热病毒中和抗体及其用途
CN101921310B (zh) * 2009-06-15 2014-03-12 温州医学院 登革病毒特异性hla-a2限制性表位肽及应用
WO2011133112A1 (en) * 2010-04-20 2011-10-27 National University Of Singapore Cell penetrating peptide derived from the premembrane protein of flavivirus
BR112013030637A2 (pt) * 2011-05-26 2018-06-12 Inst De Medicina Molecular peptídeo derivado do vírus da dengue (denv) e métodos para a inibição da replicação de flavivírus
CU24188B1 (es) * 2012-12-27 2016-07-29 Ct De Ingeniería Genética Y Biotecnología Composición vacunal contra el virus dengue
KR20160027019A (ko) * 2013-06-26 2016-03-09 더 유니버시티 오브 노쓰 캐롤라이나 엣 채플 힐 뎅기 바이러스 백신에 대한 방법 및 조성물
TWI769185B (zh) 2016-10-27 2022-07-01 海樂源有限公司 登革熱類病毒顆粒、抗登革熱病毒抗體、及含其之組合物
CN116082499B (zh) * 2021-11-08 2023-10-27 东莞市朋志生物科技有限公司 一种抗登革ns1蛋白的抗体及其应用

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996040933A1 (en) * 1995-06-07 1996-12-19 The Government Of The United States Of America, Represented By The Secretary Department Of Health And Human Services Infectious dengue 2 virus pdk-53 as quadravalent vaccine

Also Published As

Publication number Publication date
DE69828032T2 (de) 2005-12-01
EP0966535A1 (en) 1999-12-29
AU5649998A (en) 1998-08-07
ATE284444T1 (de) 2004-12-15
JP3647048B2 (ja) 2005-05-11
CN1198933C (zh) 2005-04-27
ES2235310T3 (es) 2005-07-01
DE69828032D1 (de) 2005-01-13
NO993468L (no) 1999-09-14
AU743414B2 (en) 2002-01-24
US6383488B1 (en) 2002-05-07
MY120971A (en) 2005-12-30
CN1249781A (zh) 2000-04-05
WO1998031814A1 (es) 1998-07-23
CA2277816A1 (en) 1998-07-23
CU22683A1 (es) 2001-07-20
NO993468D0 (no) 1999-07-14
EP0966535B1 (en) 2004-12-08
HK1025999A1 (en) 2000-12-01
JP2001508457A (ja) 2001-06-26

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Legal Events

Date Code Title Description
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B11B Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements