BR9711540A - Inibidores de protease proteìnico estabilizados e variantes dos mesmos - Google Patents

Inibidores de protease proteìnico estabilizados e variantes dos mesmos

Info

Publication number
BR9711540A
BR9711540A BR9711540-1A BR9711540A BR9711540A BR 9711540 A BR9711540 A BR 9711540A BR 9711540 A BR9711540 A BR 9711540A BR 9711540 A BR9711540 A BR 9711540A
Authority
BR
Brazil
Prior art keywords
variants
protease inhibitors
protein stabilized
stabilized protease
inhibitors
Prior art date
Application number
BR9711540-1A
Other languages
English (en)
Inventor
Paul Elliott Correa
Charles Winston Saunders
Michael Laskowski Jr
Original Assignee
Protector & Gamble Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Protector & Gamble Company filed Critical Protector & Gamble Company
Publication of BR9711540A publication Critical patent/BR9711540A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Detergent Compositions (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Patente de Invenção: <B>"INIBIDORES DE PROTEASE PROTEINáCEOS ESTABILIZADOS E VARIANTES DOS MESMOS"<D>. A presente invenção refere-se a inibidores da protease de proteína e suas variantes, bem como aos genes codificando as variantes referidas. Esta invenção também refere-se a composições compreendendo as variantes referidas.
BR9711540-1A 1996-09-24 1997-09-23 Inibidores de protease proteìnico estabilizados e variantes dos mesmos BR9711540A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2694496P 1996-09-24 1996-09-24
PCT/US1997/016355 WO1998013387A1 (en) 1996-09-24 1997-09-23 Stabilized proteinaceous protease inhibitors and variants thereof

Publications (1)

Publication Number Publication Date
BR9711540A true BR9711540A (pt) 2001-06-19

Family

ID=21834705

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9711540-1A BR9711540A (pt) 1996-09-24 1997-09-23 Inibidores de protease proteìnico estabilizados e variantes dos mesmos

Country Status (10)

Country Link
US (1) US6579698B1 (pt)
EP (1) EP0929577B1 (pt)
JP (1) JP2000506394A (pt)
AR (1) AR009819A1 (pt)
AT (1) ATE242270T1 (pt)
BR (1) BR9711540A (pt)
CA (1) CA2266323A1 (pt)
DE (1) DE69722639T2 (pt)
DK (1) DK0929577T3 (pt)
WO (1) WO1998013387A1 (pt)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2332564A1 (en) * 1998-06-26 2000-01-13 The Procter & Gamble Company Stabilized variants of streptomyces subtilisin inhibitor
WO2000001831A2 (en) * 1998-07-07 2000-01-13 The Procter & Gamble Company Proteases fused with variants of streptomyces subtilisin inhibitor
US20040038845A1 (en) * 2000-08-21 2004-02-26 Pedersen Poul Erik Method for production of a protease-inhibitor complex
WO2006035821A1 (ja) * 2004-09-29 2006-04-06 Kao Corporation 口腔用組成物
US7759299B2 (en) * 2006-07-24 2010-07-20 Ecolab Inc. Warewashing composition for use in automatic dishwashing machines
US20080090745A1 (en) * 2006-10-13 2008-04-17 Fox Bryan P Expression of Streptomyces subtilism inhibitor (SSI) proteins in Bacillus and Streptomyces sp.
EP2412792A1 (en) * 2010-07-29 2012-02-01 The Procter & Gamble Company Liquid detergent composition
JP2012180514A (ja) * 2011-02-10 2012-09-20 Sanyo Chem Ind Ltd 液体洗剤組成物
JP5953312B2 (ja) * 2011-10-12 2016-07-20 三洋化成工業株式会社 タンパク質性プロテアーゼインヒビター並びにこれを含有するタンパク質溶液及び洗剤組成物
JP6214382B2 (ja) * 2013-12-19 2017-10-18 花王株式会社 衣料用洗浄剤組成物
DE102022205593A1 (de) * 2022-06-01 2023-12-07 Henkel Ag & Co. Kgaa Wasch- und reinigungsmittel mit verbesserter enzymstabilität

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3324534A1 (de) 1983-07-07 1985-01-17 Ciba-Geigy Ag, Basel Modifizierte protease-inhibitoren, verfahren zu ihrer herstellung und daraus bereitete pharmazeutische mittel
US4801537A (en) 1984-06-08 1989-01-31 Genex Corporation Vector for expression of polypeptides in bacilli
US4760130A (en) * 1984-12-06 1988-07-26 Synergen Biologicals, Inc. Serine protease inhibitors and methods for isolation of same
EP0253870B1 (en) 1986-01-03 1993-03-31 Genetics Institute, Inc. Method for producing factor viii:c-type proteins
US5180667A (en) 1988-03-07 1993-01-19 Ciba-Geigy Corporation Genes encoding eglin C mutants
ATE103930T1 (de) 1988-03-07 1994-04-15 Ciba Geigy Ag Modifizierte proteine.
US5039446A (en) 1988-07-01 1991-08-13 Genencor International, Inc. Liquid detergent with stabilized enzyme
JPH0648988B2 (ja) 1988-07-26 1994-06-29 工業技術院長 トロンビン阻害物質の製造法
WO1990002175A1 (en) 1988-08-16 1990-03-08 Novo Nordisk A/S A method of producing polypeptides by culturing eukaryotic cells in the presence of protease inhibitors
US5550042A (en) 1989-03-06 1996-08-27 The Board Of Regents Of The University Of Texas System Serine protease mutants of the chymotrypsin superfamily resistant to inhibition by their cognate inhibitors and genes encoding the same and serine protease inhibitor mutants and genes encoding the same
JPH0399099A (ja) 1989-09-12 1991-04-24 Tsumura & Co ポリペプチドおよび該ポリペプチドを有効成分とするプロテアーゼ阻害剤
DK204290D0 (da) 1990-08-24 1990-08-24 Novo Nordisk As Enzymatisk detergentkomposition og fremgangsmaade til enzymstabilisering
US5674833A (en) 1990-09-18 1997-10-07 Novo Nordisk A/S Detergent compositions containing protease and novel inhibitors for use therein
DK223790D0 (da) * 1990-09-18 1990-09-18 Novo Nordisk As Proteaseholdig detergentkomposition
US5178789A (en) 1991-06-27 1993-01-12 Genencor International, Inc. Liquid detergent with stabilized enzyme
US5527487A (en) 1991-11-27 1996-06-18 Novo Nordisk A/S Enzymatic detergent composition and method for enzyme stabilization
US5371198A (en) 1991-12-16 1994-12-06 Novo Nordisk A/S Method for protection of proteolysis-susceptible protein during protein production in a fluid medium
DK23692D0 (da) 1992-02-25 1992-02-25 Novo Nordisk As Detergentkomposition
US5623059A (en) 1992-03-09 1997-04-22 Novo Nordisk A/S Method for protection of proteolysis-susceptible protein during protein production in a fluid medium
DK43192D0 (da) 1992-03-31 1992-03-31 Novo Nordisk As Detergentkomposition
WO1995002055A1 (en) 1993-07-09 1995-01-19 Michael Laskowski Novel protein inhibitors of serine proteinases (e.g. furin) derived from turkey ovomucoid third domain
US5616485A (en) 1993-12-23 1997-04-01 Cangene Corporation Streptomyces proteases and improved streptomyces strains for expression of peptides and polypeptides
JPH0838191A (ja) 1994-05-27 1996-02-13 Japan Energy Corp プロテア−ゼインヒビタ−ｓｓｉと異種蛋白質との融合蛋白質の製造方法
AU7476296A (en) 1995-10-25 1997-05-15 Arris Pharmaceutical Corporation Novel subtilisin inhibitors

Also Published As

Publication number Publication date
DK0929577T3 (da) 2003-10-06
EP0929577B1 (en) 2003-06-04
CA2266323A1 (en) 1998-04-02
EP0929577A1 (en) 1999-07-21
WO1998013387A1 (en) 1998-04-02
DE69722639D1 (de) 2003-07-10
DE69722639T2 (de) 2004-04-29
ATE242270T1 (de) 2003-06-15
JP2000506394A (ja) 2000-05-30
AR009819A1 (es) 2000-05-03
US6579698B1 (en) 2003-06-17

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 6A,7A E 8A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1836 DE 14/03/2006.