BR9709234A - Composto com atividades antiinflamatórias e imunossupressivas - Google Patents
Composto com atividades antiinflamatórias e imunossupressivasInfo
- Publication number
- BR9709234A BR9709234A BR9709234A BR9709234A BR9709234A BR 9709234 A BR9709234 A BR 9709234A BR 9709234 A BR9709234 A BR 9709234A BR 9709234 A BR9709234 A BR 9709234A BR 9709234 A BR9709234 A BR 9709234A
- Authority
- BR
- Brazil
- Prior art keywords
- inflammatory
- immunosuppressive activities
- immunosuppressive
- activities
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
- C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
- C07C259/10—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to carbon atoms of six-membered aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C275/42—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
- C07D217/16—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/02—Ortho- or ortho- and peri-condensed systems
- C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
- C07C2603/06—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
- C07C2603/10—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
- C07C2603/12—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings only one five-membered ring
- C07C2603/18—Fluorenes; Hydrogenated fluorenes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/56—Ring systems containing bridged rings
- C07C2603/58—Ring systems containing bridged rings containing three rings
- C07C2603/70—Ring systems containing bridged rings containing three rings containing only six-membered rings
- C07C2603/74—Adamantanes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Transplantation (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Plant Substances (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT96MI000968A IT1283637B1 (it) | 1996-05-14 | 1996-05-14 | Composti ad attivita' antinfiammatoria ed immunosoppressiva |
| PCT/EP1997/002407 WO1997043251A1 (en) | 1996-05-14 | 1997-05-12 | Compounds with anti-inflammatory and immunosuppressive activities |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| BR9709234A true BR9709234A (pt) | 1999-08-10 |
| BR9709234B1 BR9709234B1 (pt) | 2009-01-13 |
| BR9709234B8 BR9709234B8 (pt) | 2014-04-15 |
Family
ID=11374259
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI9709234-7B8A BR9709234B8 (pt) | 1996-05-14 | 1997-05-12 | Composto com atividades antiinflamatórias e imunossupressivas. |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US6034096A (pt) |
| EP (1) | EP0901465B1 (pt) |
| JP (1) | JP4108127B2 (pt) |
| CN (1) | CN1105100C (pt) |
| AU (1) | AU713300B2 (pt) |
| BR (1) | BR9709234B8 (pt) |
| CA (1) | CA2254066C (pt) |
| CZ (1) | CZ293233B6 (pt) |
| DE (1) | DE69703207T2 (pt) |
| DK (1) | DK0901465T3 (pt) |
| ES (1) | ES2151267T3 (pt) |
| GR (1) | GR3035128T3 (pt) |
| HU (2) | HUP9902818A3 (pt) |
| IT (1) | IT1283637B1 (pt) |
| PL (1) | PL187527B1 (pt) |
| PT (1) | PT901465E (pt) |
| RU (1) | RU2177473C2 (pt) |
| SK (1) | SK282174B6 (pt) |
| WO (1) | WO1997043251A1 (pt) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2352740A1 (en) | 1998-12-10 | 2000-06-15 | F. Hoffmann-La Roche Ag | Procollagen c-proteinase inhibitors |
| EP1149079B1 (en) * | 1999-02-04 | 2004-04-21 | SK Corporation | Tetrahydro isoquino linealkanol derivatives and pharmaceutical compositions containing same |
| AU3631500A (en) | 1999-03-19 | 2000-10-09 | Du Pont Pharmaceuticals Company | N-adamant-1-yl-n'-(4-chlorobenzothiazol-2-yl) urea useful in the treatment of inflammation and as an anticancer radiosensitizing agent |
| DE60143098D1 (de) | 2000-05-31 | 2010-10-28 | Santen Pharmaceutical Co Ltd | (Pyridinyl)alkyl-Amide oder -Harnstoffe als TNF-alpha Bildung Inhibitoren |
| JP2004509941A (ja) * | 2000-09-29 | 2004-04-02 | プロリフィクス リミテッド | Ｈｄａｃインヒビターとしてのアミド結合を含むカルバミン酸化合物 |
| ITMI20011733A1 (it) * | 2001-08-07 | 2003-02-07 | Italfarmaco Spa | Derivati dell'acido idrossamico inibitori degli enzimi istone deacetilasi, quali nuovi farmaci antiinfiammatori inibenti la sintesi di citoc |
| PE20030701A1 (es) | 2001-12-20 | 2003-08-21 | Schering Corp | Compuestos para el tratamiento de trastornos inflamatorios |
| WO2003070691A1 (fr) * | 2002-02-21 | 2003-08-28 | Osaka Industrial Promotion Organization | Derive de n-hydroxycarboxamide |
| ITMI20030025A1 (it) | 2003-01-10 | 2004-07-11 | Italfarmaco Spa | Derivati dell'acido idrossammico ad attivita' antinfiammatoria. |
| ITMI20030063A1 (it) * | 2003-01-17 | 2004-07-18 | Italfarmaco Spa | Cloridrato monoidrato dell'estere (6-dietilamminometil-naftalen-2-il)metilico dell'acido (4-idrossicarbammoil-fenil)carbammico. |
| ITMI20030064A1 (it) * | 2003-01-17 | 2004-07-18 | Italfarmaco Spa | Uso dei derivati dell'acido idrossamico per la preparazione |
| US7291744B2 (en) | 2003-11-13 | 2007-11-06 | Bristol-Myers Squibb Company | N-ureidoalkyl-amino compounds as modulators of chemokine receptor activity |
| US9115090B2 (en) * | 2003-12-02 | 2015-08-25 | The Ohio State University Research Foundation | Zn2+-chelating motif-tethered short-chain fatty acids as a novel class of histone deacetylase inhibitors |
| WO2006115509A2 (en) | 2004-06-24 | 2006-11-02 | Novartis Vaccines And Diagnostics Inc. | Small molecule immunopotentiators and assays for their detection |
| ITMI20041347A1 (it) * | 2004-07-05 | 2004-10-05 | Italfarmaco Spa | Derivati di alfa-amminoacidi ad attivita'antiinfiammatoria |
| US20100152188A1 (en) * | 2005-08-05 | 2010-06-17 | Akella Satya Surya Visweswara Srinivas | Novel Heterocyclic Compounds |
| IT1392908B1 (it) | 2008-09-29 | 2012-04-02 | Italfarmaco Spa | Uso degli inibitori delle istone-deacetilasi per la cura di sindromi mieloproliferative philadelphia-negative |
| AU2009305214B2 (en) * | 2008-10-15 | 2015-06-25 | Generics [Uk] Limited | Process for the preparation of vorinostat |
| US8754129B2 (en) | 2008-11-26 | 2014-06-17 | Generics [Uk] Limited | Crystalline vorinostat form VI |
| KR101168801B1 (ko) | 2009-03-27 | 2012-07-25 | 주식회사종근당 | 신규한 하이드록사메이트 유도체, 이의 제조방법, 및 이를 함유하는 약제학적 조성물 |
| IT1396915B1 (it) | 2009-10-23 | 2012-12-20 | Italfarmaco Spa | Dietil-[6-(4-idrossicarbamoil-fenil-carbamoilossimetil)-naftalen-2-il-metil]-ammonio cloruro ed altri derivati della n-idrossi-benzammide per l'uso nel trattamento di infezioni da hiv. |
| IT1397912B1 (it) * | 2010-01-28 | 2013-02-04 | Chemi Spa | Nuovo polimorfo dell'estere 6-dietilamminometil-2-naftilico dell'acido 4-idrossicarbamoil-fenil-carbammico cloridrato. |
| US8217079B2 (en) * | 2010-03-26 | 2012-07-10 | Italfarmaco Spa | Method for treating Philadelphia-negative myeloproliferative syndromes |
| WO2012120262A1 (en) | 2011-03-09 | 2012-09-13 | Larsson Pia | Compounds and methods for improving impaired endogenous fibrinolysis using histone deacetylase inhibitors |
| BR112014018975A2 (pt) | 2012-02-03 | 2018-05-08 | Italfarmaco Spa | Cloreto de dietil- [6-(4- hidroxicarbamoil-fenil- carbamoiloxi-metil) - naftalen- 2-il-metil] - amônio para uso no tratamento de distrofia muscular |
| ITUB20155193A1 (it) | 2015-11-03 | 2017-05-03 | Italfarmaco Spa | Sospensioni orali di Givinostat fisicamente e chimicamente stabili |
| WO2018054960A1 (en) | 2016-09-21 | 2018-03-29 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for predicting and treating resistance to chemotherapy in npm-alk(+) alcl |
| IT201900003281A1 (it) * | 2019-03-06 | 2020-09-06 | Chemi Spa | Processo per preparare {6-[(dietilammino)metil]naftalen-2-il}metil [4-(idrossicarbamoil)fenil]carbammato ad elevata purezza |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2800498A (en) * | 1954-09-12 | 1957-07-23 | Lab Dausse | Carbamates of dialkylaminoalkyl p-aminobenzoates |
| NO134946C (pt) * | 1970-09-09 | 1977-01-12 | Ciba Geigy Ag | |
| US3804888A (en) * | 1971-05-17 | 1974-04-16 | Morton Norwich Products Inc | 2-p-nitrobenzamidoacetohydroxamic acid |
| US3728380A (en) * | 1971-05-17 | 1973-04-17 | Morton Norwich Products Inc | P-chlorobenzamidoacetohydroxamic acid |
| FR2354315A1 (fr) * | 1976-06-10 | 1978-01-06 | Eisai Co Ltd | Nouveaux derives d'acide hydroxamique et medicaments en contenant |
| IL60888A (en) * | 1978-06-16 | 1984-07-31 | Yeda Res & Dev | Substrates and process for the quantitative assay of enzymes |
| JPS5668650A (en) * | 1979-11-07 | 1981-06-09 | Otsuka Pharmaceut Co Ltd | Benzoic acid amide derivative |
| GB8506870D0 (en) * | 1985-03-16 | 1985-04-17 | Wellcome Found | Aryl derivatives |
| US4792560A (en) * | 1985-04-03 | 1988-12-20 | Rorer Pharmaceutical Corporation | Quinoline hydroxamates and their use as modulators of arachidonic acid metabolic pathways |
| US4711900A (en) * | 1986-07-23 | 1987-12-08 | E. R. Squibb & Sons, Inc. | Certain arylalkyl or pyridylalkyl hydroxamates useful for treating allergies and asthma |
| US4681894A (en) * | 1986-09-26 | 1987-07-21 | Ortho Pharmaceutical Corporation | Hydroxamic acids and esters |
| US5280015A (en) * | 1990-09-05 | 1994-01-18 | The United States Of America As Represented By The Department Of Health And Human Services | 2-substituted adenosines and 2-substituted adenosine 5'-carboxamides |
-
1996
- 1996-05-14 IT IT96MI000968A patent/IT1283637B1/it active IP Right Grant
-
1997
- 1997-05-12 CN CN97195410A patent/CN1105100C/zh not_active Expired - Lifetime
- 1997-05-12 CZ CZ19983667A patent/CZ293233B6/cs not_active IP Right Cessation
- 1997-05-12 AU AU28964/97A patent/AU713300B2/en not_active Expired
- 1997-05-12 BR BRPI9709234-7B8A patent/BR9709234B8/pt not_active IP Right Cessation
- 1997-05-12 SK SK1579-98A patent/SK282174B6/sk not_active IP Right Cessation
- 1997-05-12 CA CA002254066A patent/CA2254066C/en not_active Expired - Lifetime
- 1997-05-12 RU RU98122430/04A patent/RU2177473C2/ru active
- 1997-05-12 PT PT97923053T patent/PT901465E/pt unknown
- 1997-05-12 HU HU9902818A patent/HUP9902818A3/hu unknown
- 1997-05-12 WO PCT/EP1997/002407 patent/WO1997043251A1/en active IP Right Grant
- 1997-05-12 DK DK97923053T patent/DK0901465T3/da active
- 1997-05-12 ES ES97923053T patent/ES2151267T3/es not_active Expired - Lifetime
- 1997-05-12 EP EP97923053A patent/EP0901465B1/en not_active Expired - Lifetime
- 1997-05-12 DE DE69703207T patent/DE69703207T2/de not_active Expired - Lifetime
- 1997-05-12 JP JP54050597A patent/JP4108127B2/ja not_active Expired - Lifetime
- 1997-05-12 US US09/180,606 patent/US6034096A/en not_active Expired - Lifetime
- 1997-05-12 HU HU9902818D patent/HU225650B1/hu unknown
- 1997-05-12 PL PL97329873A patent/PL187527B1/pl unknown
-
2000
- 2000-12-19 GR GR20000402810T patent/GR3035128T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU713300B2 (en) | 1999-11-25 |
| DK0901465T3 (da) | 2000-12-18 |
| DE69703207T2 (de) | 2001-02-01 |
| CZ366798A3 (cs) | 1999-06-16 |
| AU2896497A (en) | 1997-12-05 |
| BR9709234B1 (pt) | 2009-01-13 |
| BR9709234B8 (pt) | 2014-04-15 |
| US6034096A (en) | 2000-03-07 |
| CA2254066A1 (en) | 1997-11-20 |
| IT1283637B1 (it) | 1998-04-23 |
| CN1221403A (zh) | 1999-06-30 |
| EP0901465A1 (en) | 1999-03-17 |
| PL329873A1 (en) | 1999-04-12 |
| CN1105100C (zh) | 2003-04-09 |
| SK282174B6 (sk) | 2001-11-06 |
| RU2177473C2 (ru) | 2001-12-27 |
| ES2151267T3 (es) | 2000-12-16 |
| JP4108127B2 (ja) | 2008-06-25 |
| ITMI960968A1 (it) | 1997-11-14 |
| EP0901465B1 (en) | 2000-09-27 |
| JP2000510472A (ja) | 2000-08-15 |
| CZ293233B6 (cs) | 2004-03-17 |
| CA2254066C (en) | 2007-09-11 |
| PT901465E (pt) | 2001-01-31 |
| GR3035128T3 (en) | 2001-04-30 |
| WO1997043251A1 (en) | 1997-11-20 |
| ITMI960968A0 (pt) | 1996-05-14 |
| PL187527B1 (pl) | 2004-07-30 |
| DE69703207D1 (de) | 2000-11-02 |
| HU225650B1 (en) | 2007-05-29 |
| SK157998A3 (en) | 1999-04-13 |
| HUP9902818A3 (en) | 2001-10-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
| B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
| B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
| B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 13/01/2009, OBSERVADAS AS CONDICOES LEGAIS. |
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| B22O | Other matters related to patents and certificates of addition of invention: legal action concerning patent |
Free format text: INPI-52400.061587/2013 ORIGEM: JUIZO DA 013A VARA FEDERAL DO RIO DE JANEIRO PROCESSO NO 0132263-70.2013.4.02.5101 ACAO DE NULIDADE DAS PATENTES SUBMETIDAS AO MAILBOX (ART. 229, PARAGRAFO UNICO DA LPI); ALTERNATIVAMENTE, A DECRETACAO DA NULIDADE PARCIAL PARA CORRECAO DO PRAZO DE VIGENCIA; SUBSIDIARIAMENTE, CASO SE ENTENDA NAO SER O CASO DE NULIDADE, A CORRECAO DO ATO ADMINISTRATIVO PARA ADEQUACAO DA VIGENCIA DAS PATENTES. AUTOR: INSTITUTO NACIONAL DA PROPRIEDADE INDUSTRIAL - INPI REU: GILEAD SCIENCES, INC, HRISSANTHI IKONOMIDOU, INNOGENETICS N.V., ISTITUTO NAZIONALE PRE LO STUDIO E LA, CURA DEI TUMORI, ITALFARMACO S.P.A. |
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| B19A | Notification of judicial decision: notification of judicial decision |
Free format text: INPI-0132263-70.2013.4.02.5101 SECAO JUDICIARIA DO RIO DE JANEIRO-13A VARA FEDERAL DO RIO DE JANEIRO PROCESSO NO52400.061587/2013-47 AUTOR:INPI-INSTITUTO NACIONAL DE PROPRIEDADE INDUSTRIAL REU(S):GILEAD SCIENCES INC.,HRISSANTHI IKONOMIDOU, INNOGENTICS NV, ISTITUTO NAZIONALE PER LO STUDIO E LA CURA DEI TUMORI E ITALFARMACO SPA DECISAO:HOMOLOGO O ACORDO FIRMADO PELAS PARTES JULGANDO EXTINTO O PROCESSO COM RESOLUCAO DE MERITO, FORTE NO ART.269, III DO CODIGO DE PROCESSO CIVIL. |
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| B16C | Correction of notification of the grant [chapter 16.3 patent gazette] |
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