BR9708780A - "aparelho para detecção magnética da mais alta sensibilidade de analitos ". - Google Patents

"aparelho para detecção magnética da mais alta sensibilidade de analitos ".

Info

Publication number
BR9708780A
BR9708780A BR9708780-7A BR9708780A BR9708780A BR 9708780 A BR9708780 A BR 9708780A BR 9708780 A BR9708780 A BR 9708780A BR 9708780 A BR9708780 A BR 9708780A
Authority
BR
Brazil
Prior art keywords
detection
analytes
magnetization
sample
location
Prior art date
Application number
BR9708780-7A
Other languages
English (en)
Inventor
Lutz Trahms
Wolfhard Semmler
Hans Koch
Hartmut Matz
Roman Koetitz
Dietmar Drung
Werner Weitschies
Original Assignee
Diagnostikforschung Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Diagnostikforschung Inst filed Critical Diagnostikforschung Inst
Publication of BR9708780A publication Critical patent/BR9708780A/pt

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54326—Magnetic particles
    • G01N33/54333—Modification of conditions of immunological binding reaction, e.g. use of more than one type of particle, use of chemical agents to improve binding, choice of incubation time or application of magnetic field during binding reaction
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/0098—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor involving analyte bound to insoluble magnetic carrier, e.g. using magnetic separation
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S505/00—Superconductor technology: apparatus, material, process
    • Y10S505/825—Apparatus per se, device per se, or process of making or operating same
    • Y10S505/842—Measuring and testing
    • Y10S505/843—Electrical
    • Y10S505/845—Magnetometer
    • Y10S505/846—Magnetometer using superconductive quantum interference device, i.e. squid

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Investigating Or Analyzing Materials By The Use Of Magnetic Means (AREA)
  • Measuring Magnetic Variables (AREA)
  • Inspection Of Paper Currency And Valuable Securities (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Patente de Invenção: <B>"APARELHO PARA DETECçãO MAGNéTICA DA MAIS ALTA SENSIBILIDADE DE ANALITOS"<D>. Um aparelho para a medição qualitativa e/ou quantitativa de analitos, em particular em amostras biológicas, por meio de ligação com ligante receptor e tendo um dispositivo de magnetização para a produção de um campo magnético na localização da amostra e com um dispositivo de detecção para medição das propriedades magnéticas da amostra é caracterizado pelo fato de que o dispositivo de magnetização (11', 11") e especialmente disposto com relação ao dispositivo de detecção (71, 8, 9, 10; 16; 20) em uma tal maneira que o campo magnético produzido pelo dispositivo de magnetização (11', 11") na localização da magnetização é atenuado por pelo menos um fator de 10, e preferivelmente por um fator de 1000 ou mais, na localização ocupada pela amostra durante a medição, ou em que um dispositivo de comutação é fornecido com o qual, por toda uma predeterminada duração de tempo e em particular durante a fase de medição do dispositivo de detecção (71, 8, 9, 10; 16), pode-se desativar o campo magnético do dispositivo de magnetização (11; 21) na localização da amostra (12). Nessa maneira, novos tipos de medições para detecção magnetorelaxométrica de analitos ou para a detecção de analitos por meio de medições de remanência podem ser executadas em uma maneira rotineira e económica "in vitro" ou "in vivo".
BR9708780-7A 1996-04-18 1997-03-26 "aparelho para detecção magnética da mais alta sensibilidade de analitos ". BR9708780A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19615254A DE19615254C2 (de) 1996-04-18 1996-04-18 Gerät zur höchstempfindlichen magnetischen Detektion von Analyten
PCT/DE1997/000611 WO1997040377A1 (de) 1996-04-18 1997-03-26 Gerät zur höchstempfindlichen magnetischen detektion von analyten

Publications (1)

Publication Number Publication Date
BR9708780A true BR9708780A (pt) 2000-01-04

Family

ID=7791594

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9708780-7A BR9708780A (pt) 1996-04-18 1997-03-26 "aparelho para detecção magnética da mais alta sensibilidade de analitos ".

Country Status (26)

Country Link
US (1) US6123902A (pt)
EP (1) EP0898706B1 (pt)
JP (1) JP2001515585A (pt)
KR (1) KR100305102B1 (pt)
CN (1) CN1105917C (pt)
AT (1) ATE234465T1 (pt)
AU (1) AU718523B2 (pt)
BR (1) BR9708780A (pt)
CA (1) CA2250087C (pt)
CZ (1) CZ293853B6 (pt)
DE (3) DE19615254C2 (pt)
DK (1) DK0898706T3 (pt)
ES (1) ES2192269T3 (pt)
GE (1) GEP20012591B (pt)
HK (1) HK1019249A1 (pt)
HU (1) HUP9901377A3 (pt)
IL (1) IL126067A (pt)
NO (1) NO984856L (pt)
NZ (1) NZ331772A (pt)
PL (1) PL183725B1 (pt)
PT (1) PT898706E (pt)
RU (1) RU2217751C2 (pt)
SK (1) SK283627B6 (pt)
TW (1) TW356519B (pt)
UA (1) UA41476C2 (pt)
WO (1) WO1997040377A1 (pt)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19730497C2 (de) * 1997-07-16 2000-02-10 Heermann Klaus Hinrich Verfahren zum Waschen, zur Separierung und Konzentrierung von Biomolekülen unter Verwendung eines Magnetstifts
US6437563B1 (en) * 1997-11-21 2002-08-20 Quantum Design, Inc. Method and apparatus for making measurements of accumulations of magnetically susceptible particles combined with analytes
FI102906B (fi) * 1998-02-23 1999-03-15 Bio Nobile Oy Menetelmä ja väline aineen siirtämiseksi
US9066695B2 (en) 1998-04-30 2015-06-30 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US6949816B2 (en) * 2003-04-21 2005-09-27 Motorola, Inc. Semiconductor component having first surface area for electrically coupling to a semiconductor chip and second surface area for electrically coupling to a substrate, and method of manufacturing same
US8465425B2 (en) 1998-04-30 2013-06-18 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US6175752B1 (en) 1998-04-30 2001-01-16 Therasense, Inc. Analyte monitoring device and methods of use
US8974386B2 (en) 1998-04-30 2015-03-10 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US8480580B2 (en) 1998-04-30 2013-07-09 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US8688188B2 (en) 1998-04-30 2014-04-01 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US8346337B2 (en) 1998-04-30 2013-01-01 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
EP1198712A2 (de) * 1999-02-17 2002-04-24 Kilian Hennes Verfahren zum darstellen von biologisch aktivierten induktivitätsändernden partikeln sowie vorrichtung dafür
JP4171139B2 (ja) * 1999-07-21 2008-10-22 住友電気工業株式会社 磁性体標識による免疫検査方法とその装置
GB2362588A (en) * 2000-05-23 2001-11-28 Alistair Forrest Air freshening device
US6420868B1 (en) * 2000-06-16 2002-07-16 Honeywell International Inc. Read-out electronics for DC squid magnetic measurements
US6560471B1 (en) 2001-01-02 2003-05-06 Therasense, Inc. Analyte monitoring device and methods of use
FI113297B (fi) * 2001-06-19 2004-03-31 Magnasense Oy Menetelmä ja laitteisto analyyttien kvalitatiiviseksi ja kvantitatiiviseksi osoittamiseksi
DE10210072B4 (de) * 2002-03-08 2005-11-03 Bundesrepublik Deutschland, vertr. d. d. Bundesministerium für Wirtschaft und Arbeit, dieses vertr. d. d. Präsidenten der Physikalisch-Technischen Bundesanstalt Magnetometer
US6724188B2 (en) * 2002-03-29 2004-04-20 Wavbank, Inc. Apparatus and method for measuring molecular electromagnetic signals with a squid device and stochastic resonance to measure low-threshold signals
US20050148863A1 (en) * 2003-12-09 2005-07-07 Toshiro Okamura Magnetic fluid detection device
JP3962385B2 (ja) 2004-03-11 2007-08-22 株式会社日立製作所 免疫検査装置及び免疫検査方法
JP4758713B2 (ja) * 2005-08-30 2011-08-31 旭化成株式会社 磁気センサを用いた測定装置及び測定方法
US8034634B2 (en) * 2005-11-16 2011-10-11 Rex Chih-Yih Hong Ultra-sensitive magnetoreduction measurement system and ultra-sensitive, wash-free assay using the same
JP4676361B2 (ja) * 2006-03-09 2011-04-27 株式会社日立製作所 磁気的免疫検査装置
JP4823726B2 (ja) * 2006-03-17 2011-11-24 国立大学法人豊橋技術科学大学 生体高分子検出方法およびその検出装置
JP4837410B2 (ja) * 2006-03-22 2011-12-14 富士フイルム株式会社 標的化合物の検出方法
DE102006061041B4 (de) * 2006-12-22 2010-05-12 Mesutronic Gerätebau GmbH Einrichtung zur Überwachung eines Produktstromes auf störende Einschlüsse
JP5326138B2 (ja) * 2009-03-31 2013-10-30 国立大学法人豊橋技術科学大学 粉体材料中の磁性異物の検査装置およびその検査方法
JP5560334B2 (ja) * 2010-07-21 2014-07-23 株式会社日立製作所 磁場計測装置
KR101039912B1 (ko) * 2010-08-16 2011-06-09 강학성 매트릭스 구조의 위치판별이 가능한 미세 스틸볼 감지장치
CA2815085C (en) 2010-10-22 2022-06-21 T2 Biosystems, Inc. Nmr systems and methods for the rapid detection of analytes
US8409807B2 (en) 2010-10-22 2013-04-02 T2 Biosystems, Inc. NMR systems and methods for the rapid detection of analytes
JP6414498B2 (ja) * 2015-03-27 2018-10-31 愛知製鋼株式会社 差動型磁気センサ
WO2017127731A1 (en) 2016-01-21 2017-07-27 T2 Biosystems, Inc. Nmr methods and systems for the rapid detection of bacteria
CN108508390B (zh) * 2018-05-28 2020-05-08 哈尔滨工业大学 矢量磁传感器的标定方法及其简便标定方法
SE1950159A1 (en) * 2019-02-11 2020-08-12 Alexei Kalaboukhov Measurement system for magnetic samples
CN111073948A (zh) * 2019-07-04 2020-04-28 山东百多安医疗器械有限公司 一种非接触式细胞弱磁的测定方法
CN113390957A (zh) * 2021-04-27 2021-09-14 杭州电子科技大学 一种基于磁传感探头的防串扰涡流无损探伤检测系统

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6390765A (ja) * 1986-10-03 1988-04-21 Nippon Telegr & Teleph Corp <Ntt> Ｓｑｕｉｄ免疫測定法
US4913883A (en) * 1987-07-20 1990-04-03 Hitachi, Ltd. Particle agglutination immunoassay apparatus
JP2938918B2 (ja) * 1990-01-25 1999-08-25 ティーディーケイ株式会社 磁気微粒子の粒度測定方法
US5408178A (en) * 1991-05-17 1995-04-18 Vanderbilt University Apparatus and method for imaging the structure of diamagnetic and paramagnetic objects
JP3081902B2 (ja) * 1991-11-07 2000-08-28 工業技術院長 磁場検出回路
US5329165A (en) * 1992-05-26 1994-07-12 Midwest Superconductivity, Inc. Selectively switchable superconducting electromagnetic shield
JP3204542B2 (ja) * 1992-07-24 2001-09-04 株式会社東芝 磁場源測定装置
US5532592A (en) * 1993-02-02 1996-07-02 Conductus, Inc. Squid control apparatus with non-cryogenic flux-locked loop disposed in close proximity to the squid
US5486457A (en) * 1993-08-25 1996-01-23 Children's Medical Center Corporation Method and system for measurement of mechanical properties of molecules and cells
DE19503664C2 (de) * 1995-01-27 1998-04-02 Schering Ag Magnetorelaxometrische Detektion von Analyten
DE19508772C2 (de) * 1995-03-01 1998-01-29 Schering Ag Verfahren und Verbindungen zur Detektion von Analyten mittels Remanenzmessung und deren Verwendung
JPH0984777A (ja) * 1995-09-25 1997-03-31 Toshiba Corp 生体磁場計測装置

Also Published As

Publication number Publication date
IL126067A (en) 2001-08-26
PT898706E (pt) 2003-07-31
NZ331772A (en) 2000-04-28
IL126067A0 (en) 1999-05-09
RU2217751C2 (ru) 2003-11-27
UA41476C2 (uk) 2001-09-17
CZ333898A3 (cs) 1999-04-14
PL183725B1 (pl) 2002-07-31
DE29780349U1 (de) 1999-04-01
WO1997040377A1 (de) 1997-10-30
EP0898706A1 (de) 1999-03-03
NO984856D0 (no) 1998-10-16
JP2001515585A (ja) 2001-09-18
DE19615254A1 (de) 1997-10-23
ATE234465T1 (de) 2003-03-15
HK1019249A1 (en) 2000-01-28
DK0898706T3 (da) 2003-04-22
GEP20012591B (en) 2001-11-26
CZ293853B6 (cs) 2004-08-18
DE59709508D1 (de) 2003-04-17
HUP9901377A3 (en) 2002-11-28
SK283627B6 (sk) 2003-10-07
CA2250087C (en) 2003-12-02
US6123902A (en) 2000-09-26
KR20000005555A (ko) 2000-01-25
NO984856L (no) 1998-12-04
CN1216613A (zh) 1999-05-12
TW356519B (en) 1999-04-21
KR100305102B1 (ko) 2001-11-05
AU2885497A (en) 1997-11-12
SK143598A3 (en) 1999-05-07
DE19615254C2 (de) 1999-03-11
ES2192269T3 (es) 2003-10-01
AU718523B2 (en) 2000-04-13
CN1105917C (zh) 2003-04-16
PL328792A1 (en) 1999-02-15
CA2250087A1 (en) 1997-10-30
EP0898706B1 (de) 2003-03-12
HUP9901377A2 (hu) 1999-08-30

Similar Documents

Publication Publication Date Title
BR9708780A (pt) &#34;aparelho para detecção magnética da mais alta sensibilidade de analitos &#34;.
EP0805215A3 (en) Diagnostic methods and probes
EP0350546A3 (en) Instrument and method for noninvasive testing for glucose and other body fluid constituents
BR8302286A (pt) Aperfeicoamento em processo para determinacao da presenca de um analisador em uma amostra, aparelho de diagnostico inteiramente calibrado e kit para uso em um ensaio diagnostico
BR9811406A (pt) Dispositivo para detenção da presença de pelo menos um analito em uma amostra biológica, kit para detenção da presença de pelo menos um analito em uma amostra biológica, e, processo de detecção da presença de pelo menos um analito em uma amostra biológica
ATE214805T1 (de) System zur bestimmung mindestens eines parameters mindestens einer probe einer physiologischen flüssigkeit und kassette dafür
BR9611461A (pt) Aparelho de coleta de amostras, kit para a detecçao de um analisado em uma amostra, uso do aparelho de coleta de amostra e do kit e processo para detectar um analisado em uma amostra.
CY1105245T1 (el) Μεθοδος προεπεξepγασιας δειγματος για επιμετρηση χοληστepολης και μεθοδος επιμετρησης χοληστepολης σε συγκεκριμενες λιποπρωτεϊνες χρησιμοποιωντας αυτη τη μεθοδο
KR950703148A (ko) 모니터링 방법(Monitoring Method)
ATE128231T1 (de) Testkit zur bestimmung eines analyten in einer pastösen probe, insbesondere in stuhl.
BR9306422A (pt) Aparelho para puxar amostra de fluído teste para recipiente conjunto de lámina reutilizável para análise com microscópio aparelho para puxar amostra de fluído de teste através de conjunto de lámina
BR0101432A (pt) Método e equipamento para determinação donúmero de partìculas magnéticas dentro de umaamostra e método de realização de um teste deligação
CA2283154A1 (en) Method and apparatus for measurement of blood substitutes
KR960705211A (ko) 체액내 bpi의 정량 방법(method for quantifying bpi in body fluids)
BR9505536A (pt) Dispositivo de coleta de amostra e processo para e detecção de pelo menos uma substância que reage especificamente em um líquido teste
DE59007017D1 (de) Messvorrichtung zur Bestimmung der dielektrischen Eigenschaften von Stoffen.
ES2123818T3 (es) Procedimiento para medir las variaciones metaplasicas de los epitelocitos mucosecretores.
ES2089153T3 (es) Procedimiento para la medida rapida de componentes trazas.
Benoit et al. Guidelines for conducting early life stage toxicity tests with Japanese Medaka'Oryzias latipes'.
Lutmer et al. Analysis of α-lipoprotein cholesterol in 50 μl of plasma
Pappas et al. High-resolution proton nuclear magnetic resonance spectroscopy in the detection and quantitation of ethanol in human serum
PL330220A1 (en) Method of eliminating disturbances caused by haemoglobing while analysing medical samples
DE59307781D1 (de) Probenaufnahmeeinrichtung für die Blutgerinnungsmessung
SE8501645D0 (sv) Anordning for kalibrering av en metanordningfor konstaterande av oljespar i vatten
Ng et al. The ChemPro-1000: An Evaluation Using Measurements of Sodium, Potassium, and Chloride

Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 9A E 10A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1882 DE 30/01/2007.