BR9602933B1 - compostos dihidrodibenzo [b,f] azepinas substituÍdas. - Google Patents
compostos dihidrodibenzo [b,f] azepinas substituÍdas.Info
- Publication number
- BR9602933B1 BR9602933B1 BRPI9602933-1B1A BR9602933A BR9602933B1 BR 9602933 B1 BR9602933 B1 BR 9602933B1 BR 9602933 A BR9602933 A BR 9602933A BR 9602933 B1 BR9602933 B1 BR 9602933B1
- Authority
- BR
- Brazil
- Prior art keywords
- dihydrodibenzo
- azepines
- substituted
- compounds
- substituted dihydrodibenzo
- Prior art date
Links
- 150000001538 azepines Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
- C07D223/22—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Vascular Medicine (AREA)
- Psychiatry (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicinal Preparation (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PT101732A PT101732B (pt) | 1995-06-30 | 1995-06-30 | Novas di-hidrodibenzo<b,f>azepinas substituidas processo para a sua preparacao composicoes farmaceuticas que as contem e utilizacao dos novos compostos na preparacao de composicoes farmaceuticas empregues em doencas do sistema nervoso |
Publications (3)
Publication Number | Publication Date |
---|---|
BR9602933A BR9602933A (pt) | 1998-04-28 |
BR9602933B1 true BR9602933B1 (pt) | 2013-06-11 |
BRPI9602933B8 BRPI9602933B8 (pt) | 2022-01-18 |
Family
ID=20085522
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI9602933A BRPI9602933B8 (pt) | 1995-06-30 | 1996-06-28 | Compostos dihidrodibenzo [b,f] azepinas substituídas. |
Country Status (22)
Country | Link |
---|---|
US (1) | US5753646A (pt) |
EP (1) | EP0751129B3 (pt) |
JP (2) | JP3852984B2 (pt) |
KR (1) | KR100376603B1 (pt) |
CN (1) | CN1070853C (pt) |
AR (1) | AR003962A1 (pt) |
AT (1) | ATE173468T3 (pt) |
AU (1) | AU705388B2 (pt) |
BR (1) | BRPI9602933B8 (pt) |
CA (1) | CA2180301C (pt) |
DE (2) | DE122009000049I2 (pt) |
DK (1) | DK0751129T6 (pt) |
ES (1) | ES2124612T7 (pt) |
FR (1) | FR09C0040I2 (pt) |
HU (1) | HU221382B1 (pt) |
NL (1) | NL300406I1 (pt) |
PL (1) | PL185476B1 (pt) |
PT (1) | PT101732B (pt) |
RU (1) | RU2168502C2 (pt) |
SI (1) | SI0751129T1 (pt) |
TR (1) | TR199701734T1 (pt) |
WO (1) | WO1997002250A1 (pt) |
Families Citing this family (46)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9930058D0 (en) | 1999-12-20 | 2000-02-09 | Novartis Ag | Organic compounds |
GB0111566D0 (en) * | 2001-05-11 | 2001-07-04 | Portela & Ca Sa | Method for preparation of (s)-(+)-and (r)-(-)-10,11-dihydro-10-hydroxy-5h-dibenz/b,f/azephine-5-carboxamide |
GB0112812D0 (en) * | 2001-05-25 | 2001-07-18 | Portela & Ca Sa | Mthd for preparation of 10, 11-dihydro-10-hydroxy-5H-dibenz/B,F/azepine-5-c arboxamide and 10,11-dihydro-10-oxo-5H-dibenz/B,F/azepine-5-carb oxamide therefrom |
MXPA04004470A (es) * | 2001-11-12 | 2005-05-16 | Novartis Ag | Monohidroxicarbamazepina para utilizarse en la preparacion de un medicamento para el tratamiento de un trastorno afectivo y de la atencion y dolor neuropatico. |
AU2003266965A1 (en) | 2002-08-06 | 2004-02-25 | Novartis Ag | Use of carboxamides for the treatment of tinnitus |
GB0223224D0 (en) * | 2002-10-07 | 2002-11-13 | Novartis Ag | Organic compounds |
GB0303613D0 (en) * | 2003-02-17 | 2003-03-19 | Novartis Ag | Use of organic compounds |
CA2514649A1 (en) * | 2003-02-17 | 2004-08-26 | Novartis Ag | Use of s-10 hydroxy-10, 11-dihydro-carbamazepine for the treatment of anxiety and bipolar disorders |
TW200501962A (en) * | 2003-04-01 | 2005-01-16 | Novartis Ag | Use of carbamazepine derivatives for the treatment of agitation in dementia patients |
TW200502222A (en) * | 2003-04-02 | 2005-01-16 | Novartis Ag | Use of 10-hydroxy-10,11-dihydrocarbamazepine derivatives for the treatment of affective disorders |
GB2401605A (en) * | 2003-05-12 | 2004-11-17 | Portela & Ca Sa | Method for racemisation of (S)-(+)- and (R)-(-)-10,11-dihydro-10-hydroxy-5H-dibenz[b,f]azepine-5-carboxamide and optically enriched mixtures thereof |
GB2416167A (en) * | 2004-07-13 | 2006-01-18 | Portela & Ca Sa | Chiral inversion and esterification of (S)- and (R)-10-hydroxy-dibenzazepine carboxamides |
ITMI20042230A1 (it) * | 2004-11-19 | 2005-02-19 | Farchemia Srl | Procedimento per la preparazione della 10,11-diidro-10 idrossi-5h-dibenz-b,f-azepin-5carbossiammide |
GB2422149A (en) * | 2005-01-14 | 2006-07-19 | Portela & Ca Sa | Process for the preparation of 10,11-dihydro-10-hydroxy-5H-dibenz[b,f]azepine-5-carboxamide |
GB0507298D0 (en) | 2005-04-11 | 2005-05-18 | Novartis Ag | Organic compounds |
BRPI0520258A2 (pt) * | 2005-05-06 | 2009-09-15 | Portela & Ca Sa | uso de uma composição farmacêutica, método para preparar uma composição farmacêutica, e, uso de uma quantidade eficaz de acetato de eslicarbazepina |
US20060252745A1 (en) * | 2005-05-06 | 2006-11-09 | Almeida Jose L D | Methods of preparing pharmaceutical compositions comprising eslicarbazepine acetate and methods of use |
EP2384755A1 (en) * | 2005-05-06 | 2011-11-09 | Bial-Portela & CA, S.A. | Eslicarbazepine acetate and methods of use |
GB0515690D0 (en) * | 2005-07-29 | 2005-09-07 | Portela & Ca Sa | Asymmetric catalytic reduction |
GB0517740D0 (en) * | 2005-08-31 | 2005-10-12 | Novartis Ag | Organic compounds |
GB0603008D0 (en) * | 2006-02-14 | 2006-03-29 | Portela & Ca Sa | Method |
GB2437078A (en) * | 2006-04-11 | 2007-10-17 | Portela & Ca Sa | 10-Acyloxy-5H-dibenzo[b,f]azepine-5-carboxamides & their asymmetric hydrogenation to the chiral 10,11-dihydro derivatives |
GB0700773D0 (en) * | 2007-01-15 | 2007-02-21 | Portela & Ca Sa | Drug therapies |
US8372431B2 (en) | 2007-10-26 | 2013-02-12 | Bial-Portela & C.A., S.A. | Pharmaceutical composition comprising licarbazepine acetate |
WO2010113179A2 (en) | 2009-04-02 | 2010-10-07 | Glenmark Generics Limited | A process for the purification of eslicarbazepine acetate |
UA106384C2 (ru) * | 2009-07-27 | 2014-08-26 | БИАЛ-ПОРТЕЛА энд КА., С.А. | ПРИМЕНЕНИЕ ПРОИЗВОДНЫХ 5H-ДИБЕНЗ/б,ф/АЗЕПИН-5-КАРБОКСАМИДА ДЛЯ ЛЕЧЕНИЯ ФИБРОМИАЛГИИ |
WO2011045648A2 (en) | 2009-10-12 | 2011-04-21 | Matrix Laboratories Limited | Process for preparing (s)-(-)-10-acetoxy-10,11-dihydro-5h-dibenz[b,f]azepine-5-carboxamide and its esters thereof |
WO2011091131A2 (en) * | 2010-01-23 | 2011-07-28 | Dr. Reddy's Laboratories Ltd. | Eslicarbazepine acetate and its polymorphs |
WO2011117885A1 (en) * | 2010-03-23 | 2011-09-29 | Intas Pharmaceuticals Limited | Process for preparation of enantiomers of licarbazepine |
EP2383261B1 (en) | 2010-04-23 | 2013-09-04 | Euticals GmbH | Process for the asymmetric hydrogenation of ketones |
WO2011138795A2 (en) * | 2010-05-03 | 2011-11-10 | Msn Laboratories Limited | Process for preparing (s)-10-acetoxy-10,11-dihydro-5h-dibenz[b,f] azepine-5-carboxamide |
JP6133786B2 (ja) | 2010-12-31 | 2017-05-24 | ビアル−ポルテラ エ コンパニア,ソシエダッド アノニマ | エスリカルバゼピンアセテート含有顆粒 |
WO2012121701A1 (en) * | 2011-03-07 | 2012-09-13 | Watson Laboratories, Inc. | Process for the resolution of racemic (±)-10,11-dihydro-10-hydroxy-5h-dibenz[b,f]azepine-5-carboxamide |
US9346760B2 (en) | 2011-03-08 | 2016-05-24 | Jubilant Life Sciences Limited | Process for the preparation of (S)-(+)- or (R)-(-)-10-hydroxy dihydrodibenz[B,F]azepines by enantioselective reduction of 10,11-dihydro-10-OXO-5H-dibenz[B,F]azepines and polymorphs thereof |
DK2697662T3 (en) | 2011-04-13 | 2018-07-30 | Codexis Inc | BIOCATALYTIC PROCEDURE FOR PREPARING ESLICARBAZEPIN AND ANALOGUES THEREOF |
WO2013008194A2 (en) | 2011-07-13 | 2013-01-17 | Ranbaxy Laboratories Limited | Process for the preparation and purification of eslicarbazepine acetate and intermediates thereof |
US9750747B2 (en) | 2011-08-26 | 2017-09-05 | Bail-Portela & Ca, S.A. | Treatments involving eslicarbazepine acetate or eslicarbazepine |
SG11201407300VA (en) * | 2012-05-07 | 2014-12-30 | Cellix Bio Private Ltd | Compositions and methods for the treatment of neurological disorders |
WO2014049550A1 (en) | 2012-09-26 | 2014-04-03 | Ranbaxy Laboratories Limited | Process for the preparation of oxcarbazepine and its use as intermediate in the preparation of eslicarbazepine acetate |
WO2016046835A1 (en) * | 2014-09-26 | 2016-03-31 | Cellix Bio Private Limited | Compositions and methods for the treatment of epilepsy and neurological disorders |
CN105384689B (zh) * | 2014-12-24 | 2017-10-31 | 开封制药(集团)有限公司 | 一种改进的醋酸艾司利卡西平的合成方法 |
EP3064490A1 (en) | 2015-03-06 | 2016-09-07 | F.I.S.- Fabbrica Italiana Sintetici S.p.A. | Improved process for the preparation of eslicarbazepine and eslicarbazepine acetate |
CN105130899A (zh) * | 2015-08-25 | 2015-12-09 | 安徽省新星药物开发有限责任公司 | 一种醋酸艾司利卡西平的合成方法 |
WO2017103876A1 (en) | 2015-12-18 | 2017-06-22 | Jubilant Generics Limited | Solid oral dosage forms of eslicarbazepine |
CN106588773B (zh) * | 2016-11-10 | 2019-09-27 | 北京现代药物代谢研究院 | 一种脑靶向艾司利卡西平酯类前药及其应用 |
CA3224977A1 (en) | 2018-09-28 | 2020-04-02 | Griffith University | Agents and methods for modulating pathogen activity using ligands of complement receptor 3 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH500196A (de) * | 1969-03-10 | 1970-12-15 | Ciba Geigy Ag | Verfahren zur Herstellung von neuen Azepinderivaten |
CH505101A (de) * | 1969-03-31 | 1971-03-31 | Ciba Geigy Ag | Verfahren zur Herstellung von neuen Azepinderivaten |
FI75561C (fi) * | 1979-10-30 | 1988-07-11 | Ciba Geigy Ag | Foerfarande foer framstaellning av 5- karbamoyl-10-oxo-10,11-dihydro-5h-dibens/b,f/azepin och daertill noedvaendiga mellanprodukter. |
CH649080A5 (de) * | 1981-04-16 | 1985-04-30 | Ciba Geigy Ag | 5h-dibenz(b,f)azepin-5-carboxamide als mittel zur prophylaxe und behandlung von zerebraler leistungsinsuffizienz. |
DD218889B3 (de) * | 1983-11-09 | 1992-11-05 | Dresden Arzneimittel | Verfahren zur herstellung neuer 5-carbamoyl-10,11-dihydro-5h-dibenz|b,f¨azepine |
US5466683A (en) * | 1994-08-25 | 1995-11-14 | Teva Pharmaceutical Industries Ltd. | Water-soluble analogs of carbamazepine |
-
1995
- 1995-06-30 PT PT101732A patent/PT101732B/pt not_active IP Right Cessation
-
1996
- 1996-06-27 HU HU9900172A patent/HU221382B1/hu active Protection Beyond IP Right Term
- 1996-06-27 AU AU63106/96A patent/AU705388B2/en not_active Expired
- 1996-06-27 KR KR1019970709780A patent/KR100376603B1/ko not_active IP Right Cessation
- 1996-06-27 US US08/673,819 patent/US5753646A/en not_active Expired - Lifetime
- 1996-06-27 RU RU98101463/04A patent/RU2168502C2/ru active Protection Beyond IP Right Term
- 1996-06-27 WO PCT/GB1996/001565 patent/WO1997002250A1/en active IP Right Grant
- 1996-06-27 PL PL96324313A patent/PL185476B1/pl unknown
- 1996-06-27 AR ARP960103352A patent/AR003962A1/es active IP Right Grant
- 1996-06-27 CN CN96196397A patent/CN1070853C/zh not_active Expired - Lifetime
- 1996-06-27 TR TR97/01734T patent/TR199701734T1/xx unknown
- 1996-06-28 DE DE122009000049C patent/DE122009000049I2/de active Active
- 1996-06-28 EP EP96110490.8A patent/EP0751129B3/en not_active Expired - Lifetime
- 1996-06-28 DE DE69600985.4T patent/DE69600985T3/de not_active Expired - Lifetime
- 1996-06-28 AT AT96110490T patent/ATE173468T3/de unknown
- 1996-06-28 SI SI9630030T patent/SI0751129T1/xx unknown
- 1996-06-28 DK DK96110490.8T patent/DK0751129T6/da active
- 1996-06-28 ES ES96110490T patent/ES2124612T7/es active Active
- 1996-06-28 BR BRPI9602933A patent/BRPI9602933B8/pt not_active IP Right Cessation
- 1996-07-01 JP JP17146096A patent/JP3852984B2/ja not_active Expired - Lifetime
- 1996-07-02 CA CA002180301A patent/CA2180301C/en not_active Expired - Lifetime
-
2003
- 2003-12-25 JP JP2003428815A patent/JP2004256516A/ja active Pending
-
2009
- 2009-08-26 NL NL300406C patent/NL300406I1/nl unknown
- 2009-08-26 FR FR09C0040C patent/FR09C0040I2/fr active Active
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FB34 | Technical and formal requirements: requirement - article 34 of industrial property law | ||
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Free format text: INPI-52400.003239/10 SECAO JUDICIARIA DO RIO DE JANEIRO - 38A VARA FEDERAL PROCESSO NO 2010.51.01.805360-1 AUTOR: BIAL PORTELA E CA, S/A REU: INSTITUTO NACIONAL DA PROPRIEDADE INDUSTRIAL - INPI EMENTA: A HIPOTESE CONSISTE EM DECIDIR SE A INVENCAO EM COMENTO POSSUI OS REQUISITOS LEGAIS DE PATENTEABILIDADE, QUAIS SEJAM: NOVIDADE, ATIVIDADE INVENTIVA E APLICACAO INDUSTRIAL; OBEDIENCIA AOS ARTIGOS 8O, 11, 13 E 15 DA LEI NO 9.279/96. ACORDAO: VISTO E RELATADOS ESTES AUTOS, EM QUE SAO PARTES AS ACIMA INDICADAS, ACORDAM OS MEMBROS DA PRIMEIRA TURMA ESPECIALIZADA DO TRIBUNAL REGIONAL FEDERAL DA 2A REGIAO, POR UNANIMIDADE, EM NEGAR PROVIMENTO A REMESSA NECESSARIA, NOS TERMOS DO VOTO RELATOR. |
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