BR9508019B1 - Ácido nuclÉico, vetor de expressço, cÉlula hospedeira e composiÇço farmacÊutica. - Google Patents
Ácido nuclÉico, vetor de expressço, cÉlula hospedeira e composiÇço farmacÊutica.Info
- Publication number
- BR9508019B1 BR9508019B1 BRPI9508019-8A BR9508019A BR9508019B1 BR 9508019 B1 BR9508019 B1 BR 9508019B1 BR 9508019 A BR9508019 A BR 9508019A BR 9508019 B1 BR9508019 B1 BR 9508019B1
- Authority
- BR
- Brazil
- Prior art keywords
- nucleic acid
- pharmaceutical composition
- host cell
- expression vector
- pantropic
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/185—Nerve growth factor [NGF]; Brain derived neurotrophic factor [BDNF]; Ciliary neurotrophic factor [CNTF]; Glial derived neurotrophic factor [GDNF]; Neurotrophins, e.g. NT-3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/48—Nerve growth factor [NGF]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Physics & Mathematics (AREA)
- Psychology (AREA)
- Plant Pathology (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US25393794A | 1994-06-03 | 1994-06-03 | |
PCT/US1995/006918 WO1995033829A1 (en) | 1994-06-03 | 1995-06-01 | Pantropic neurotrophic factors |
Publications (2)
Publication Number | Publication Date |
---|---|
BR9508019A BR9508019A (pt) | 1997-09-09 |
BR9508019B1 true BR9508019B1 (pt) | 2012-06-12 |
Family
ID=22962278
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI9508019-8A BR9508019B1 (pt) | 1994-06-03 | 1995-06-01 | Ácido nuclÉico, vetor de expressço, cÉlula hospedeira e composiÇço farmacÊutica. |
Country Status (17)
Country | Link |
---|---|
US (6) | US5728803A (fi) |
EP (1) | EP0763107B1 (fi) |
JP (1) | JPH10501138A (fi) |
CN (1) | CN1159439C (fi) |
AT (1) | ATE280825T1 (fi) |
AU (1) | AU695144B2 (fi) |
BR (1) | BR9508019B1 (fi) |
CA (1) | CA2191064C (fi) |
DE (1) | DE69533698T2 (fi) |
ES (1) | ES2231786T3 (fi) |
FI (1) | FI120237B (fi) |
IL (1) | IL113983A0 (fi) |
MX (1) | MX9605971A (fi) |
NO (1) | NO317938B1 (fi) |
NZ (1) | NZ287762A (fi) |
PT (1) | PT763107E (fi) |
WO (1) | WO1995033829A1 (fi) |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5728803A (en) * | 1994-06-03 | 1998-03-17 | Genentech, Inc. | Pantropic neurotrophic factors |
DE19637718A1 (de) * | 1996-04-01 | 1997-10-02 | Boehringer Mannheim Gmbh | Rekombinante inaktive Core-Streptavidin Mutanten |
CN1268639C (zh) | 1996-11-15 | 2006-08-09 | 基因技术股份有限公司 | 神经营养蛋白的纯化 |
US6391571B1 (en) | 1997-04-01 | 2002-05-21 | Roche Diagnostics Gmbh | Recombinant inactive avidin mutants |
IL132251A0 (en) * | 1997-04-25 | 2001-03-19 | Genentech Inc | Ngf variants |
US6365373B2 (en) | 1997-04-25 | 2002-04-02 | Genentech, Inc. | Nucleic acids encoding NGF variants |
US7452863B1 (en) | 1997-04-29 | 2008-11-18 | Genentech, Inc. | NGF variants |
US6663899B2 (en) | 1997-06-13 | 2003-12-16 | Genentech, Inc. | Controlled release microencapsulated NGF formulation |
US6113947A (en) * | 1997-06-13 | 2000-09-05 | Genentech, Inc. | Controlled release microencapsulated NGF formulation |
US20040120891A1 (en) * | 1998-12-21 | 2004-06-24 | Craig Hill | Compounds for intracellular delivery of therapeutic moieties to nerve cells |
US6652864B1 (en) * | 1998-12-21 | 2003-11-25 | Asilomar Pharmaceuticals, Inc. | Compounds for intracellular delivery of therapeutic moieties to nerve cells |
GB0024550D0 (fi) | 2000-10-06 | 2000-11-22 | Oxford Biomedica Ltd | |
CA2975521A1 (en) * | 2001-05-30 | 2002-12-05 | Genentech, Inc. | Anti-ngf antibodies for the treatment of various disorders |
WO2004016167A1 (en) * | 2002-08-16 | 2004-02-26 | The General Hospital Corporation | Non-invasive functional imaging of peripheral nervous system activation in humans and animals |
EP1589988A2 (en) | 2002-12-20 | 2005-11-02 | Neuronicon ApS | Modulation of activity of neurotrophins |
US20080260722A1 (en) * | 2004-12-30 | 2008-10-23 | The Johns Hopkins University Johns Hopkins Technology Transfer | Method for High Efficiency Survival/Proliferation of Human Embyonic Stem Cells and Human Embryo Survival in Culture |
DK3225251T3 (da) | 2006-12-21 | 2020-03-16 | H Lundbeck As | Modulering af pro-neurotrofinaktivitet |
WO2009062149A1 (en) * | 2007-11-08 | 2009-05-14 | Creighton University | Methods for maintaining inner ear neurons |
US8447409B2 (en) * | 2008-10-15 | 2013-05-21 | Cochlear Limited | Electroneural interface for a medical implant |
US8259461B2 (en) * | 2008-11-25 | 2012-09-04 | Micron Technology, Inc. | Apparatus for bypassing faulty connections |
MX359070B (es) | 2010-12-01 | 2018-09-13 | Alderbio Holdings Llc | Composiciones anti-ngf y uso de las mismas. |
US9078878B2 (en) | 2010-12-01 | 2015-07-14 | Alderbio Holdings Llc | Anti-NGF antibodies that selectively inhibit the association of NGF with TrkA, without affecting the association of NGF with p75 |
US11214610B2 (en) | 2010-12-01 | 2022-01-04 | H. Lundbeck A/S | High-purity production of multi-subunit proteins such as antibodies in transformed microbes such as Pichia pastoris |
US9067988B2 (en) | 2010-12-01 | 2015-06-30 | Alderbio Holdings Llc | Methods of preventing or treating pain using anti-NGF antibodies |
US9539324B2 (en) | 2010-12-01 | 2017-01-10 | Alderbio Holdings, Llc | Methods of preventing inflammation and treating pain using anti-NGF compositions |
US9884909B2 (en) | 2010-12-01 | 2018-02-06 | Alderbio Holdings Llc | Anti-NGF compositions and use thereof |
EP4292649A3 (en) | 2016-03-18 | 2024-02-21 | Staidson(Beijing) Biopharmaceuticals Co., Ltd. | Fusion protein comprising nerve growth factor and preparation method and use thereof |
CN112409471B (zh) * | 2016-04-13 | 2022-07-29 | 舒泰神(北京)生物制药股份有限公司 | 低痛神经生长因子突变体 |
CN110183536B (zh) * | 2018-02-22 | 2021-01-15 | 中国科学院遗传与发育生物学研究所 | 一种复合支架材料及其应用 |
CA3105879A1 (en) | 2018-07-18 | 2020-01-23 | Manzanita Pharmaceuticals, Inc. | Conjugates for delivering an anti-cancer agent to nerve cells, methods of use and methods of making thereof |
CN110812532A (zh) * | 2019-08-20 | 2020-02-21 | 中山大学 | 一种靶向促进皮质脊髓束连接以修复脊髓损伤的组织工程支架的构建方法 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5169764A (en) * | 1990-08-08 | 1992-12-08 | Regeneron Pharmaceuticals, Inc. | Multitrophic and multifunctional chimeric neurotrophic factors, and nucleic acids and plasmids encoding the chimeras |
US5488099A (en) * | 1992-03-06 | 1996-01-30 | Persson, Deceased; Hakan B. | Multifunctional chimeric neurotrophic factors |
US5349055A (en) * | 1992-03-06 | 1994-09-20 | Persson Hakan B | Nerve growth factor having altered receptor binding specificities |
WO1993025684A1 (en) * | 1992-06-12 | 1993-12-23 | Regeneron Pharmaceuticals, Inc. | Therapeutic and diagnostic methods based on neurotrophin-4 expression |
US5753225A (en) | 1993-12-03 | 1998-05-19 | The Regents Of The University Of California | Antibodies that mimic actions of neurotrophins |
AU1282895A (en) * | 1993-12-29 | 1995-07-17 | Sumitomo Pharmaceuticals Company, Limited | Novel human ciliary neurotrophic factor |
US7144983B1 (en) * | 1997-02-03 | 2006-12-05 | Genentech, Inc. | Pantropic neurotrophic factors |
US5728803A (en) * | 1994-06-03 | 1998-03-17 | Genentech, Inc. | Pantropic neurotrophic factors |
-
1995
- 1995-05-12 US US08/440,049 patent/US5728803A/en not_active Expired - Lifetime
- 1995-05-15 US US08/441,513 patent/US5981480A/en not_active Expired - Lifetime
- 1995-06-01 NZ NZ287762A patent/NZ287762A/xx not_active IP Right Cessation
- 1995-06-01 AU AU26592/95A patent/AU695144B2/en not_active Expired
- 1995-06-01 CN CNB951933817A patent/CN1159439C/zh not_active Expired - Lifetime
- 1995-06-01 WO PCT/US1995/006918 patent/WO1995033829A1/en active IP Right Grant
- 1995-06-01 JP JP8501183A patent/JPH10501138A/ja active Pending
- 1995-06-01 BR BRPI9508019-8A patent/BR9508019B1/pt not_active IP Right Cessation
- 1995-06-01 AT AT95921550T patent/ATE280825T1/de active
- 1995-06-01 MX MX9605971A patent/MX9605971A/es active IP Right Grant
- 1995-06-01 CA CA002191064A patent/CA2191064C/en not_active Expired - Lifetime
- 1995-06-01 ES ES95921550T patent/ES2231786T3/es not_active Expired - Lifetime
- 1995-06-01 DE DE69533698T patent/DE69533698T2/de not_active Expired - Lifetime
- 1995-06-01 IL IL11398395A patent/IL113983A0/xx not_active IP Right Cessation
- 1995-06-01 PT PT95921550T patent/PT763107E/pt unknown
- 1995-06-01 EP EP95921550A patent/EP0763107B1/en not_active Expired - Lifetime
-
1996
- 1996-12-02 NO NO19965123A patent/NO317938B1/no not_active IP Right Cessation
- 1996-12-03 FI FI964833A patent/FI120237B/fi not_active IP Right Cessation
-
1997
- 1997-02-03 US US08/794,028 patent/US6503728B1/en not_active Expired - Fee Related
- 1997-04-25 US US08/845,541 patent/US6333310B1/en not_active Expired - Lifetime
-
2006
- 2006-05-30 US US11/443,576 patent/US7528233B2/en not_active Expired - Fee Related
-
2009
- 2009-03-10 US US12/401,483 patent/US7935671B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
DE69533698T2 (de) | 2006-02-09 |
EP0763107A1 (en) | 1997-03-19 |
NO317938B1 (no) | 2005-01-10 |
ES2231786T3 (es) | 2005-05-16 |
NO965123L (no) | 1997-02-03 |
BR9508019A (pt) | 1997-09-09 |
CN1159439C (zh) | 2004-07-28 |
DE69533698D1 (de) | 2004-12-02 |
FI964833A (fi) | 1996-12-03 |
CA2191064A1 (en) | 1995-12-14 |
IL113983A0 (en) | 1995-10-31 |
EP0763107B1 (en) | 2004-10-27 |
US5981480A (en) | 1999-11-09 |
US6333310B1 (en) | 2001-12-25 |
PT763107E (pt) | 2005-02-28 |
US6503728B1 (en) | 2003-01-07 |
US7935671B2 (en) | 2011-05-03 |
AU695144B2 (en) | 1998-08-06 |
ATE280825T1 (de) | 2004-11-15 |
FI964833A0 (fi) | 1996-12-03 |
NZ287762A (en) | 1999-01-28 |
US7528233B2 (en) | 2009-05-05 |
US20060270838A1 (en) | 2006-11-30 |
US20100184656A1 (en) | 2010-07-22 |
WO1995033829A1 (en) | 1995-12-14 |
US5728803A (en) | 1998-03-17 |
JPH10501138A (ja) | 1998-02-03 |
CA2191064C (en) | 2009-11-03 |
MX9605971A (es) | 1997-12-31 |
AU2659295A (en) | 1996-01-04 |
FI120237B (fi) | 2009-08-14 |
CN1153528A (zh) | 1997-07-02 |
NO965123D0 (no) | 1996-12-02 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EG | Technical examination (opinion): publication of technical examination (opinion) | ||
B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 12/06/2012, OBSERVADAS AS CONDICOES LEGAIS. |
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B22O | Other matters related to patents and certificates of addition of invention: legal action concerning patent |
Free format text: INPI-52400.061552/2013 ORIGEM: JUIZO DA 013A VARA FEDERAL DO RIO DE JANEIRO PROCESSO NO 0132261-03.2013.4.02.5101 ACAO DE NULIDADE DAS PATENTES SUBMETIDAS AO MAILBOX (ART. 229, PARAGRAFO UNICO DA LPI); ALTERNATIVAMENTE, A DECRETACAO DA NULIDADE PARCIAL PARA CORRECAO DO PRAZO DE VIGENCIA; SUBSIDIARIAMENTE, CASO SE ENTENDA NAO SER O CASO DE NULIDADE, A CORRECAO DO ATO ADMINISTRATIVO PARA ADEQUACAO DA VIGENCIA DAS PATENTES. AUTOR: INSTITUTO NACIONAL DA PROPRIEDADE INDUSTRIAL - INPI REU: ELI LILLY AND COMPANY (NZ) LIMITED, ELI LILLY AND COMPANY, F. HOFFMANN-LA ROCHE AG., GENENTECH, INC. E HOECHST AKTIENGESELLSCHAFT |
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B21B | Extinction acc. art. 78, item ii - on waiver by the patentee, without prejudice to the rights of third parties |
Free format text: SOLICITADA ATRAVES DA PETICAO 860130004810, DE 17/10/2013 |