CA2188264A1 - Isolated nucleic acid molecule coding for fibroblast activation protein .alpha. and uses thereof - Google Patents

Isolated nucleic acid molecule coding for fibroblast activation protein .alpha. and uses thereof

Info

Publication number
CA2188264A1
CA2188264A1 CA002188264A CA2188264A CA2188264A1 CA 2188264 A1 CA2188264 A1 CA 2188264A1 CA 002188264 A CA002188264 A CA 002188264A CA 2188264 A CA2188264 A CA 2188264A CA 2188264 A1 CA2188264 A1 CA 2188264A1
Authority
CA
Canada
Prior art keywords
alpha
nucleic acid
acid molecule
activation protein
isolated nucleic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002188264A
Other languages
French (fr)
Other versions
CA2188264C (en
Inventor
Wolfgang J. Rettig
Matthew J. Scanlan
Pilar Garin-Chesa
Lloyd J. Old
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ludwig Institute for Cancer Research Ltd
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/230,491 external-priority patent/US5587299A/en
Application filed by Individual filed Critical Individual
Publication of CA2188264A1 publication Critical patent/CA2188264A1/en
Application granted granted Critical
Publication of CA2188264C publication Critical patent/CA2188264C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70517—CD8
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/06—Preparation of peptides or proteins produced by the hydrolysis of a peptide bond, e.g. hydrolysate products
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/026—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a baculovirus

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The invention describes the identification and isolation of nucleic acid molecules which code for fibroblast activation protein alpha, or "FAP.alpha.". Various applications of the isolated molecules are also described.
CA002188264A 1994-04-20 1995-04-19 Isolated nucleic acid molecule coding for fibroblast activation protein .alpha. and uses thereof Expired - Fee Related CA2188264C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/230,491 US5587299A (en) 1994-04-20 1994-04-20 Isolated nucleic acid molecule coding for fibroblast activation protein alpha and uses thereof
US08/230,491 1994-04-20
PCT/US1995/004860 WO1995029233A1 (en) 1994-04-20 1995-04-19 ISOLATED NUCLEIC ACID MOLECULE CODING FOR FIBROBLAST ACTIVATION PROTEIN α AND USES THEREOF

Publications (2)

Publication Number Publication Date
CA2188264A1 true CA2188264A1 (en) 1995-11-02
CA2188264C CA2188264C (en) 2006-07-25

Family

ID=36707436

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002188264A Expired - Fee Related CA2188264C (en) 1994-04-20 1995-04-19 Isolated nucleic acid molecule coding for fibroblast activation protein .alpha. and uses thereof

Country Status (1)

Country Link
CA (1) CA2188264C (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9587176B2 (en) 2011-02-25 2017-03-07 Fort Hills Energy L.P. Process for treating high paraffin diluted bitumen
US9676684B2 (en) 2011-03-01 2017-06-13 Fort Hills Energy L.P. Process and unit for solvent recovery from solvent diluted tailings derived from bitumen froth treatment
US10226717B2 (en) 2011-04-28 2019-03-12 Fort Hills Energy L.P. Method of recovering solvent from tailings by flashing under choked flow conditions

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9587176B2 (en) 2011-02-25 2017-03-07 Fort Hills Energy L.P. Process for treating high paraffin diluted bitumen
US9676684B2 (en) 2011-03-01 2017-06-13 Fort Hills Energy L.P. Process and unit for solvent recovery from solvent diluted tailings derived from bitumen froth treatment
US10226717B2 (en) 2011-04-28 2019-03-12 Fort Hills Energy L.P. Method of recovering solvent from tailings by flashing under choked flow conditions

Also Published As

Publication number Publication date
CA2188264C (en) 2006-07-25

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Legal Events

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MKLA Lapsed

Effective date: 20150420