BR112023023149A2 - Precursores de marcação diméricos conjugados via um trislinker e radiotraçadores derivados dos mesmos - Google Patents
Precursores de marcação diméricos conjugados via um trislinker e radiotraçadores derivados dos mesmosInfo
- Publication number
- BR112023023149A2 BR112023023149A2 BR112023023149A BR112023023149A BR112023023149A2 BR 112023023149 A2 BR112023023149 A2 BR 112023023149A2 BR 112023023149 A BR112023023149 A BR 112023023149A BR 112023023149 A BR112023023149 A BR 112023023149A BR 112023023149 A2 BR112023023149 A2 BR 112023023149A2
- Authority
- BR
- Brazil
- Prior art keywords
- trislinker
- radiotracers
- derived
- dimmer
- conjugated via
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/041—Heterocyclic compounds
- A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
- A61K51/0455—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0489—Phosphates or phosphonates, e.g. bone-seeking phosphonates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0491—Sugars, nucleosides, nucleotides, oligonucleotides, nucleic acids, e.g. DNA, RNA, nucleic acid aptamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0497—Organic compounds conjugates with a carrier being an organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2123/00—Preparations for testing in vivo
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Optics & Photonics (AREA)
- Epidemiology (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biophysics (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Paints Or Removers (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
- Treatment And Processing Of Natural Fur Or Leather (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102021114711.5A DE102021114711B4 (de) | 2021-06-08 | 2021-06-08 | Trislinker-konjugierte dimere Markierungsvorläufer und daraus abgeleitete Radiotracer |
| PCT/EP2022/065440 WO2022258637A1 (de) | 2021-06-08 | 2022-06-07 | Trislinker-konjugierte dimere markierungsvorläufer und daraus abgeleitete radiotracer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112023023149A2 true BR112023023149A2 (pt) | 2024-01-23 |
Family
ID=82258261
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112023023149A BR112023023149A2 (pt) | 2021-06-08 | 2022-06-07 | Precursores de marcação diméricos conjugados via um trislinker e radiotraçadores derivados dos mesmos |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20250235566A1 (enExample) |
| EP (1) | EP4351663A1 (enExample) |
| JP (1) | JP2024522200A (enExample) |
| KR (1) | KR20240019301A (enExample) |
| CN (1) | CN117642190A (enExample) |
| AU (1) | AU2022288744A1 (enExample) |
| BR (1) | BR112023023149A2 (enExample) |
| CA (1) | CA3222226A1 (enExample) |
| DE (1) | DE102021114711B4 (enExample) |
| WO (1) | WO2022258637A1 (enExample) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3248367A1 (en) * | 2022-01-14 | 2023-07-20 | Provincial Health Services Authority | Radiolabeled compounds for imaging fibroblast-activating protein (FAP) and treating FAP-related disorders |
| WO2023222558A1 (en) | 2022-05-14 | 2023-11-23 | Zounek Alexis Nikolai | Precursor and theranostic radiotracer with improved tumor retention |
| DE102022116009A1 (de) * | 2022-06-28 | 2023-12-28 | Positron Precision GmbH | Fibroblasten-Aktivierungsprotein adressierender Präkursor und Radiotracer |
| CN115947775B (zh) * | 2023-03-13 | 2023-06-09 | 北京先通国际医药科技股份有限公司 | 一种制备化合物（i）的方法和化合物（i）及其用途 |
| CN117304125A (zh) * | 2023-09-12 | 2023-12-29 | 北京师范大学 | 靶向PSMA的EuK二聚体化合物及其药用盐和应用 |
| WO2025063849A2 (en) * | 2023-09-21 | 2025-03-27 | Erasmus University Medical Center Rotterdam | Dimeric fap targeting agents |
| WO2025087229A1 (zh) * | 2023-10-27 | 2025-05-01 | 四川科伦博泰生物医药股份有限公司 | 一类喹啉结构的配体化合物及其放射性或非放射性标记物以及应用 |
| WO2025125335A1 (en) | 2023-12-13 | 2025-06-19 | Radiovaxx Gmbh | Cytotoxic or radiopharmaceutical compound with sulfur fluoride exchange group |
| CN120136958A (zh) * | 2023-12-13 | 2025-06-13 | 无锡诺宇医药科技有限公司 | Fap靶向放射性药物 |
| WO2025125621A1 (en) | 2023-12-14 | 2025-06-19 | Radiovaxx Gmbh | Cancer-associated protein-targeted strong or covalently binding precursor compounds and radiotracers |
| WO2025146433A1 (en) | 2024-01-05 | 2025-07-10 | Radiovaxx Gmbh | Precursor and theranostic radiotracer with prolonged tumor retention |
| TW202535358A (zh) * | 2024-01-11 | 2025-09-16 | 大陸商上海復星醫藥產業發展有限公司 | 一種ｆａｐ結合化合物、金屬錯合物及其用途 |
| CN118271393B (zh) * | 2024-05-31 | 2024-09-03 | 中国药科大学 | 一种靶向fap的二聚化合物及其探针和应用 |
| EP4696686A1 (en) * | 2024-08-15 | 2026-02-18 | Tetrakit Technologies ApS | Fapi theranostic compounds assembled with tetrazine ligation |
| CN119060093B (zh) * | 2024-08-26 | 2025-09-05 | 广州医科大学附属第一医院（广州呼吸中心） | 一种靶向成纤维细胞激活蛋白的抑制剂类放射性探针及其制备方法和应用 |
| CN119060094B (zh) * | 2024-08-26 | 2025-09-05 | 广州医科大学附属第一医院（广州呼吸中心） | 一种靶向成纤维细胞激活蛋白的抑制剂类放射性探针及其制备方法和应用 |
| CN118955353A (zh) * | 2024-10-14 | 2024-11-15 | 南京恒远科技开发有限公司 | 一种(s)-4,4-二氟-1-甘氨酰吡咯烷-2-氰基的合成方法 |
| CN119679977B (zh) * | 2024-12-16 | 2025-09-05 | 山东第一医科大学附属肿瘤医院(山东省肿瘤防治研究院、山东省肿瘤医院) | 一种Al18F示踪剂一体化冻干粉的制备方法、试剂盒及其应用 |
| CN119409613B (zh) * | 2025-01-03 | 2025-04-11 | 南京恒远科技开发有限公司 | (s)-[2-(2-氰基-4,4-二氟吡咯烷-1-基)-2-氧代-乙基]氨基甲酸叔丁酯的合成方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3456700A1 (en) | 2013-10-18 | 2019-03-20 | Deutsches Krebsforschungszentrum | Labeled inhibitors of prostate specific membrane antigen (psma), their use as imaging agents and pharmaceutical agents for the treatment of prostate cancer |
| DE102018126558A1 (de) * | 2018-10-24 | 2020-04-30 | Helmholtz-Zentrum Dresden - Rossendorf E.V. | Markierungsvorläufer mit Quadratsäure-Kopplung |
| US11167048B2 (en) * | 2018-12-14 | 2021-11-09 | The Curators Of The University Of Missouri | Dual targeting ligand for cancer diagnosis and treatment |
| CN114502528B (zh) * | 2019-09-20 | 2024-09-06 | 墨尔本大学 | 成像和治疗组合物 |
| DE102021101216A1 (de) * | 2021-01-21 | 2022-07-21 | Johannes Gutenberg-Universität Mainz, Körperschaft des öffentlichen Rechts | Markierungsvorläufer und Radiotracer zur nuklearmedizinischen Diagnose und Therapie von Prostatakrebs induzierten Knochenmetastasen |
| CN113880810B (zh) * | 2021-09-24 | 2023-02-28 | 厦门大学 | 一种核素标记的配合物及其制备方法和应用 |
-
2021
- 2021-06-08 DE DE102021114711.5A patent/DE102021114711B4/de active Active
-
2022
- 2022-06-07 WO PCT/EP2022/065440 patent/WO2022258637A1/de not_active Ceased
- 2022-06-07 BR BR112023023149A patent/BR112023023149A2/pt unknown
- 2022-06-07 JP JP2023576067A patent/JP2024522200A/ja active Pending
- 2022-06-07 AU AU2022288744A patent/AU2022288744A1/en active Pending
- 2022-06-07 EP EP22734235.9A patent/EP4351663A1/de active Pending
- 2022-06-07 KR KR1020247000764A patent/KR20240019301A/ko active Pending
- 2022-06-07 US US18/567,891 patent/US20250235566A1/en active Pending
- 2022-06-07 CN CN202280040063.2A patent/CN117642190A/zh active Pending
- 2022-06-07 CA CA3222226A patent/CA3222226A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CA3222226A1 (en) | 2022-12-15 |
| DE102021114711A1 (de) | 2022-12-08 |
| WO2022258637A1 (de) | 2022-12-15 |
| CN117642190A (zh) | 2024-03-01 |
| AU2022288744A9 (en) | 2023-12-21 |
| JP2024522200A (ja) | 2024-06-11 |
| DE102021114711B4 (de) | 2023-11-02 |
| AU2022288744A1 (en) | 2023-12-14 |
| KR20240019301A (ko) | 2024-02-14 |
| EP4351663A1 (de) | 2024-04-17 |
| US20250235566A1 (en) | 2025-07-24 |
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