BR112023019790A2 - Métodos e composições para geração de células progenitoras de oligodendrócitos - Google Patents
Métodos e composições para geração de células progenitoras de oligodendrócitosInfo
- Publication number
- BR112023019790A2 BR112023019790A2 BR112023019790A BR112023019790A BR112023019790A2 BR 112023019790 A2 BR112023019790 A2 BR 112023019790A2 BR 112023019790 A BR112023019790 A BR 112023019790A BR 112023019790 A BR112023019790 A BR 112023019790A BR 112023019790 A2 BR112023019790 A2 BR 112023019790A2
- Authority
- BR
- Brazil
- Prior art keywords
- progenitor cells
- methods
- oligodendrocyte progenitor
- compositions
- opcs
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0618—Cells of the nervous system
- C12N5/0622—Glial cells, e.g. astrocytes, oligodendrocytes; Schwann cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0618—Cells of the nervous system
- C12N5/0623—Stem cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/155—Bone morphogenic proteins [BMP]; Osteogenins; Osteogenic factor; Bone inducing factor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/30—Hormones
- C12N2501/38—Hormones with nuclear receptors
- C12N2501/385—Hormones with nuclear receptors of the family of the retinoic acid recptor, e.g. RAR, RXR; Peroxisome proliferator-activated receptor [PPAR]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/40—Regulators of development
- C12N2501/41—Hedgehog proteins; Cyclopamine (inhibitor)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/40—Regulators of development
- C12N2501/415—Wnt; Frizzeled
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/70—Enzymes
- C12N2501/72—Transferases [EC 2.]
- C12N2501/727—Kinases (EC 2.7.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/45—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from artificially induced pluripotent stem cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2533/00—Supports or coatings for cell culture, characterised by material
- C12N2533/50—Proteins
Landscapes
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Neurosurgery (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Neurology (AREA)
- Developmental Biology & Embryology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163168065P | 2021-03-30 | 2021-03-30 | |
| PCT/US2022/014306 WO2022211893A1 (en) | 2021-03-30 | 2022-01-28 | Methods and compositions for generating oligodendrocyte progenitor cells |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112023019790A2 true BR112023019790A2 (pt) | 2023-11-07 |
Family
ID=80446173
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112023019790A BR112023019790A2 (pt) | 2021-03-30 | 2022-01-28 | Métodos e composições para geração de células progenitoras de oligodendrócitos |
Country Status (10)
| Country | Link |
|---|---|
| US (4) | US12385009B2 (https=) |
| EP (1) | EP4314256A1 (https=) |
| JP (1) | JP2024511880A (https=) |
| KR (1) | KR20230161494A (https=) |
| CN (1) | CN117321191A (https=) |
| AU (1) | AU2022247250A1 (https=) |
| BR (1) | BR112023019790A2 (https=) |
| CA (1) | CA3215398A1 (https=) |
| IL (1) | IL305671A (https=) |
| WO (1) | WO2022211893A1 (https=) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2022247250A1 (en) | 2021-03-30 | 2023-11-09 | Trailhead Biosystems Inc. | Methods and compositions for generating oligodendrocyte progenitor cells |
| US20250304916A1 (en) | 2024-03-11 | 2025-10-02 | Trailhead Biosystems Inc. | Methods and compositions for generating vascular leptomeningeal cells |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2028268A1 (en) | 2007-08-20 | 2009-02-25 | Université Libre De Bruxelles | Generation of neuronal cells from pluripotent stem cells |
| US8227247B2 (en) * | 2007-12-20 | 2012-07-24 | Wisconsin Alumni Research Foundation | Method of generating myelinating oligodendrocytes |
| DK2980209T3 (en) | 2011-05-20 | 2018-04-23 | Mclean Hospital Corp | NEURONAL PROGENITOR CELLS AND APPLICATIONS |
| WO2013163228A1 (en) | 2012-04-24 | 2013-10-31 | International Stem Cell Corporation | Derivation of neural stem cells and dopaminergic neurons from human pluripotent stem cells |
| JP6541577B2 (ja) * | 2013-02-06 | 2019-07-10 | ユニバーシティー オブ ロチェスター | ミエリン障害の治療のための誘導多能性細胞由来オリゴデンドロサイト前駆細胞 |
| CA2899507A1 (en) | 2013-03-14 | 2014-09-25 | The Regents Of The University Of California | In vitro production of medial ganglionic eminence precursor cells |
| EP3031908B1 (en) | 2013-08-06 | 2018-12-05 | Takeda Pharmaceutical Company Limited | Method for producing dopaminergic neurons |
| WO2015069736A1 (en) | 2013-11-08 | 2015-05-14 | The Mclean Hospital Corporation | METHODS FOR EFFICIENT GENERATION OF GABAergic INTERNEURONS FROM PLURIPOTENT STEM CELLS |
| ES2939807T3 (es) | 2014-03-21 | 2023-04-27 | Fujifilm Cellular Dynamics Inc | Producción de neuronas dopaminérgicas del mesencéfalo y métodos para su utilización |
| PL3145517T3 (pl) | 2014-05-22 | 2021-04-06 | New York Stem Cell Foundation, Inc. | Funkcjonalne oligodendrocyty pochodzące z pluripotencjalnych komórek macierzystych oraz sposoby ich otrzymywania i stosowania |
| WO2016103269A1 (en) | 2014-12-23 | 2016-06-30 | Ramot At Tel-Aviv University Ltd. | Populations of neural progenitor cells and methods of producing and using same |
| JP6998772B2 (ja) | 2015-04-09 | 2022-02-04 | ビオラミナ アーベー | 神経変性疾患の処置における使用のための幹細胞由来のドパミン作用性細胞を生成するための方法および組成物 |
| US10973930B2 (en) | 2016-02-18 | 2021-04-13 | The Penn State Research Foundation | Generating GABAergic neurons in brains |
| KR101870240B1 (ko) | 2016-04-12 | 2018-06-22 | 서울대학교산학협력단 | 지방줄기세포에서 신경줄기세포, 신경세포 및 가바성 신경세포로의 분화 유도 방법 |
| GB201610748D0 (en) | 2016-06-20 | 2016-08-03 | Koninklijke Nederlandse Akademie Van Wetenschappen | Improved diffrentation method |
| JP2020519237A (ja) | 2017-04-13 | 2020-07-02 | ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー | ヒトオリゴデンドロサイトを作製しインビトロでの髄鞘形成を研究するための個別化された神経系３ｄ培養系 |
| US11702629B2 (en) | 2017-05-08 | 2023-07-18 | Regents Of The University Of Minnesota | Acceleration of stem cell differentiation |
| US12365872B2 (en) | 2018-09-19 | 2025-07-22 | Lineage Cell Therapeutics, Inc. | Methods for differentiating pluripotent stem cells in dynamic suspension culture |
| CN110042082B (zh) | 2019-04-19 | 2020-11-27 | 安徽中盛溯源生物科技有限公司 | 视网膜色素上皮细胞及其制备方法和应用 |
| WO2020219696A1 (en) * | 2019-04-26 | 2020-10-29 | The Regents Of The University Of California | Devices and methods for generating oligodendrocyte progenitor cells |
| EP4021477A4 (en) | 2019-08-29 | 2023-12-13 | Memorial Sloan Kettering Cancer Center | METHOD FOR GENERATING AND ISOLATING MID-DOPAMINE NEURONS |
| CN115151633A (zh) | 2019-12-09 | 2022-10-04 | 威斯康星校友研究基金会 | 多潜能干细胞衍生的多巴胺能亚型神经元祖细胞的体外扩增 |
| GB202006792D0 (en) | 2020-05-07 | 2020-06-24 | Ericson Lars Johan | Method and uses thereof |
| AU2022247250A1 (en) | 2021-03-30 | 2023-11-09 | Trailhead Biosystems Inc. | Methods and compositions for generating oligodendrocyte progenitor cells |
| US20230027059A1 (en) | 2021-07-19 | 2023-01-26 | Trallhead Biosystems Inc. | Methods and compositions for generating human midbrain neural progenitor cells |
| CN113564122B (zh) | 2021-08-05 | 2022-04-08 | 呈诺再生医学科技(珠海横琴新区)有限公司 | 人诱导性多能干细胞向少突胶质细胞分化的方法，试剂盒以及应用 |
| WO2023075913A1 (en) | 2021-10-29 | 2023-05-04 | Trailhead Biosystems Inc. | Methods and compositions for generating human forebrain neural progenitor cells and for maturation thereof to parvalbumin+ interneurons |
| JP2025524856A (ja) | 2022-07-21 | 2025-08-01 | トレイルヘッド バイオシステムズ インコーポレイテッド | 神経前駆細胞からヒト中脳ドーパミン作動性ニューロンを作製するための方法および組成物 |
| KR20250047348A (ko) | 2022-08-08 | 2025-04-03 | 트레일헤드 바이오시스템즈 인크. | 희소돌기아교세포 전구 세포를 생성하기 위한 방법 및 조성물 |
-
2022
- 2022-01-28 AU AU2022247250A patent/AU2022247250A1/en active Pending
- 2022-01-28 BR BR112023019790A patent/BR112023019790A2/pt unknown
- 2022-01-28 CN CN202280024768.5A patent/CN117321191A/zh active Pending
- 2022-01-28 CA CA3215398A patent/CA3215398A1/en active Pending
- 2022-01-28 WO PCT/US2022/014306 patent/WO2022211893A1/en not_active Ceased
- 2022-01-28 KR KR1020237036765A patent/KR20230161494A/ko not_active Withdrawn
- 2022-01-28 US US17/587,552 patent/US12385009B2/en active Active
- 2022-01-28 EP EP22705629.8A patent/EP4314256A1/en active Pending
- 2022-01-28 JP JP2023560985A patent/JP2024511880A/ja active Pending
- 2022-01-28 IL IL305671A patent/IL305671A/en unknown
-
2024
- 2024-01-25 US US18/422,961 patent/US20240158743A1/en not_active Abandoned
- 2024-01-25 US US18/423,155 patent/US20240158744A1/en not_active Abandoned
-
2025
- 2025-07-30 US US19/284,888 patent/US20260055366A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CN117321191A (zh) | 2023-12-29 |
| WO2022211893A1 (en) | 2022-10-06 |
| CA3215398A1 (en) | 2022-10-06 |
| AU2022247250A1 (en) | 2023-11-09 |
| US12385009B2 (en) | 2025-08-12 |
| US20260055366A1 (en) | 2026-02-26 |
| JP2024511880A (ja) | 2024-03-15 |
| US20220315891A1 (en) | 2022-10-06 |
| US20240158744A1 (en) | 2024-05-16 |
| WO2022211893A9 (en) | 2022-12-08 |
| EP4314256A1 (en) | 2024-02-07 |
| US20240158743A1 (en) | 2024-05-16 |
| IL305671A (en) | 2023-11-01 |
| KR20230161494A (ko) | 2023-11-27 |
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