BR112022021613A2 - Métodos para gerar células tímicas in vitro - Google Patents

Métodos para gerar células tímicas in vitro

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Publication number
BR112022021613A2
BR112022021613A2 BR112022021613A BR112022021613A BR112022021613A2 BR 112022021613 A2 BR112022021613 A2 BR 112022021613A2 BR 112022021613 A BR112022021613 A BR 112022021613A BR 112022021613 A BR112022021613 A BR 112022021613A BR 112022021613 A2 BR112022021613 A2 BR 112022021613A2
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BR
Brazil
Prior art keywords
cells
vitro
methods
thymic
generate
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BR112022021613A
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English (en)
Inventor
Parent Audrey
Hebrok Matthias
Stuart Anderson Mark
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Univ California
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Publication date
Application filed by Univ California filed Critical Univ California
Publication of BR112022021613A2 publication Critical patent/BR112022021613A2/pt

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    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
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    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/065—Thymocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/26—Lymph; Lymph nodes; Thymus; Spleen; Splenocytes; Thymocytes
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    • C12N2502/13—Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
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    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
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  • Health & Medical Sciences (AREA)
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Abstract

MÉTODOS PARA GERAR CÉLULAS TÍMICAS IN VITRO. A presente descrição fornece métodos melhorados para gerar células progenitoras epiteliais tímicas (TEP) a partir de células tronco pluripotentes (PS) in vitro. Também são fornecidas populações de células in vitro isoladas, composições e sistemas compreendendo células TEP produzidas in vitro. São fornecidas composições e sistemas de populações celulares de células epiteliais tímicas e subpopulações das mesmas, bem como células formadas durante diferentes estágios de diferenciação de células PS em células epiteliais tímicas e subpopulações das mesmas.
BR112022021613A 2020-04-28 2021-04-27 Métodos para gerar células tímicas in vitro BR112022021613A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063016527P 2020-04-28 2020-04-28
US202163147126P 2021-02-08 2021-02-08
PCT/US2021/029457 WO2021222297A1 (en) 2020-04-28 2021-04-27 Methods for generating thymic cells in vitro

Publications (1)

Publication Number Publication Date
BR112022021613A2 true BR112022021613A2 (pt) 2022-12-06

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ID=78332192

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112022021613A BR112022021613A2 (pt) 2020-04-28 2021-04-27 Métodos para gerar células tímicas in vitro

Country Status (11)

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US (1) US20230159887A1 (pt)
EP (1) EP4142754A4 (pt)
JP (1) JP2023524213A (pt)
KR (1) KR20230004690A (pt)
CN (1) CN115461446A (pt)
AU (1) AU2021262770A1 (pt)
BR (1) BR112022021613A2 (pt)
CA (1) CA3179236A1 (pt)
IL (1) IL297082A (pt)
MX (1) MX2022013500A (pt)
WO (1) WO2021222297A1 (pt)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018229179A1 (en) * 2017-06-14 2018-12-20 Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) Methods for purifying endoderm and pancreatic endoderm cells derived from human embryonic stem cells
WO2024091676A1 (en) * 2022-10-28 2024-05-02 The Regents Of The University Of Colorado, A Body Corporate Compositions and methods for accelerated production of thymic cells from pluripotent stem cells
US11983164B1 (en) * 2022-11-17 2024-05-14 Bank Of America Corporation System and method for data community detection via data network telemetry

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL156200A0 (en) * 2000-12-22 2003-12-23 Univ Edinburgh Thymic epithelial progenitor cells and pharmaceutical compositions containing the same
AU2003233271A1 (en) * 2002-06-14 2003-12-31 Norwood Immunology Ltd Thymic epithelial cells with progenitor capacity
JPWO2010143529A1 (ja) * 2009-06-09 2012-11-22 国立大学法人名古屋大学 多能性幹細胞を胸腺上皮へ分化誘導する方法
CA3173076A1 (en) * 2013-02-27 2014-09-04 The Regents Of The University Of California Generation of thymic epithelial progenitor cells in vitro
US11898166B2 (en) * 2017-09-20 2024-02-13 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services In vitro generation of thymic organoid from human pluripotent stem cells
EP3841195A1 (en) * 2018-08-20 2021-06-30 Propagenix Inc. Epithelial cell spheroids
AU2020253429A1 (en) * 2019-04-01 2021-09-09 The Trustees Of Columbia University In The City Of New York Methods of promoting thymic epithelial cell and thymic epithelial cell progenitor differentiation of pluripotent stem cells
KR20220004126A (ko) * 2019-04-26 2022-01-11 더 리젠츠 오브 더 유니버시티 오브 콜로라도, 어 바디 코포레이트 유도 다능성 줄기 세포로부터 생체내에서 기능적이고 환자-특이적인 흉선 조직의 생성

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KR20230004690A (ko) 2023-01-06
CN115461446A (zh) 2022-12-09
EP4142754A4 (en) 2024-06-12
IL297082A (en) 2022-12-01
MX2022013500A (es) 2022-11-16
AU2021262770A1 (en) 2022-11-17
EP4142754A1 (en) 2023-03-08
WO2021222297A1 (en) 2021-11-04
JP2023524213A (ja) 2023-06-09
US20230159887A1 (en) 2023-05-25
CA3179236A1 (en) 2021-11-04

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