IL305671A - Methods and preparations for the production of oligodendrocyte progenitor cells - Google Patents

Methods and preparations for the production of oligodendrocyte progenitor cells

Info

Publication number
IL305671A
IL305671A IL305671A IL30567123A IL305671A IL 305671 A IL305671 A IL 305671A IL 305671 A IL305671 A IL 305671A IL 30567123 A IL30567123 A IL 30567123A IL 305671 A IL305671 A IL 305671A
Authority
IL
Israel
Prior art keywords
opcs
pathway
culture media
agonist
antagonist
Prior art date
Application number
IL305671A
Other languages
English (en)
Hebrew (he)
Inventor
Nooshin Amini
Original Assignee
Trailhead Biosystems Inc
Nooshin Amini
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Trailhead Biosystems Inc, Nooshin Amini filed Critical Trailhead Biosystems Inc
Publication of IL305671A publication Critical patent/IL305671A/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C12N5/0622—Glial cells, e.g. astrocytes, oligodendrocytes; Schwann cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C12N5/0623—Stem cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/155—Bone morphogenic proteins [BMP]; Osteogenins; Osteogenic factor; Bone inducing factor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/30—Hormones
    • C12N2501/38—Hormones with nuclear receptors
    • C12N2501/385—Hormones with nuclear receptors of the family of the retinoic acid recptor, e.g. RAR, RXR; Peroxisome proliferator-activated receptor [PPAR]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/40—Regulators of development
    • C12N2501/41—Hedgehog proteins; Cyclopamine (inhibitor)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/40—Regulators of development
    • C12N2501/415—Wnt; Frizzeled
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/70—Enzymes
    • C12N2501/72—Transferases [EC 2.]
    • C12N2501/727—Kinases (EC 2.7.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/45—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from artificially induced pluripotent stem cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/50—Proteins

Landscapes

  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Neurosurgery (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
IL305671A 2021-03-30 2022-01-28 Methods and preparations for the production of oligodendrocyte progenitor cells IL305671A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202163168065P 2021-03-30 2021-03-30
PCT/US2022/014306 WO2022211893A1 (en) 2021-03-30 2022-01-28 Methods and compositions for generating oligodendrocyte progenitor cells

Publications (1)

Publication Number Publication Date
IL305671A true IL305671A (en) 2023-11-01

Family

ID=80446173

Family Applications (1)

Application Number Title Priority Date Filing Date
IL305671A IL305671A (en) 2021-03-30 2022-01-28 Methods and preparations for the production of oligodendrocyte progenitor cells

Country Status (10)

Country Link
US (4) US12385009B2 (https=)
EP (1) EP4314256A1 (https=)
JP (1) JP2024511880A (https=)
KR (1) KR20230161494A (https=)
CN (1) CN117321191A (https=)
AU (1) AU2022247250A1 (https=)
BR (1) BR112023019790A2 (https=)
CA (1) CA3215398A1 (https=)
IL (1) IL305671A (https=)
WO (1) WO2022211893A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2022247250A1 (en) 2021-03-30 2023-11-09 Trailhead Biosystems Inc. Methods and compositions for generating oligodendrocyte progenitor cells
US20250304916A1 (en) 2024-03-11 2025-10-02 Trailhead Biosystems Inc. Methods and compositions for generating vascular leptomeningeal cells

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EP2028268A1 (en) 2007-08-20 2009-02-25 Université Libre De Bruxelles Generation of neuronal cells from pluripotent stem cells
US8227247B2 (en) * 2007-12-20 2012-07-24 Wisconsin Alumni Research Foundation Method of generating myelinating oligodendrocytes
DK2980209T3 (en) 2011-05-20 2018-04-23 Mclean Hospital Corp NEURONAL PROGENITOR CELLS AND APPLICATIONS
WO2013163228A1 (en) 2012-04-24 2013-10-31 International Stem Cell Corporation Derivation of neural stem cells and dopaminergic neurons from human pluripotent stem cells
JP6541577B2 (ja) * 2013-02-06 2019-07-10 ユニバーシティー オブ ロチェスター ミエリン障害の治療のための誘導多能性細胞由来オリゴデンドロサイト前駆細胞
CA2899507A1 (en) 2013-03-14 2014-09-25 The Regents Of The University Of California In vitro production of medial ganglionic eminence precursor cells
EP3031908B1 (en) 2013-08-06 2018-12-05 Takeda Pharmaceutical Company Limited Method for producing dopaminergic neurons
WO2015069736A1 (en) 2013-11-08 2015-05-14 The Mclean Hospital Corporation METHODS FOR EFFICIENT GENERATION OF GABAergic INTERNEURONS FROM PLURIPOTENT STEM CELLS
ES2939807T3 (es) 2014-03-21 2023-04-27 Fujifilm Cellular Dynamics Inc Producción de neuronas dopaminérgicas del mesencéfalo y métodos para su utilización
PL3145517T3 (pl) 2014-05-22 2021-04-06 New York Stem Cell Foundation, Inc. Funkcjonalne oligodendrocyty pochodzące z pluripotencjalnych komórek macierzystych oraz sposoby ich otrzymywania i stosowania
WO2016103269A1 (en) 2014-12-23 2016-06-30 Ramot At Tel-Aviv University Ltd. Populations of neural progenitor cells and methods of producing and using same
JP6998772B2 (ja) 2015-04-09 2022-02-04 ビオラミナ アーベー 神経変性疾患の処置における使用のための幹細胞由来のドパミン作用性細胞を生成するための方法および組成物
US10973930B2 (en) 2016-02-18 2021-04-13 The Penn State Research Foundation Generating GABAergic neurons in brains
KR101870240B1 (ko) 2016-04-12 2018-06-22 서울대학교산학협력단 지방줄기세포에서 신경줄기세포, 신경세포 및 가바성 신경세포로의 분화 유도 방법
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JP2020519237A (ja) 2017-04-13 2020-07-02 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー ヒトオリゴデンドロサイトを作製しインビトロでの髄鞘形成を研究するための個別化された神経系３ｄ培養系
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WO2020219696A1 (en) * 2019-04-26 2020-10-29 The Regents Of The University Of California Devices and methods for generating oligodendrocyte progenitor cells
EP4021477A4 (en) 2019-08-29 2023-12-13 Memorial Sloan Kettering Cancer Center METHOD FOR GENERATING AND ISOLATING MID-DOPAMINE NEURONS
CN115151633A (zh) 2019-12-09 2022-10-04 威斯康星校友研究基金会 多潜能干细胞衍生的多巴胺能亚型神经元祖细胞的体外扩增
GB202006792D0 (en) 2020-05-07 2020-06-24 Ericson Lars Johan Method and uses thereof
AU2022247250A1 (en) 2021-03-30 2023-11-09 Trailhead Biosystems Inc. Methods and compositions for generating oligodendrocyte progenitor cells
US20230027059A1 (en) 2021-07-19 2023-01-26 Trallhead Biosystems Inc. Methods and compositions for generating human midbrain neural progenitor cells
CN113564122B (zh) 2021-08-05 2022-04-08 呈诺再生医学科技(珠海横琴新区)有限公司 人诱导性多能干细胞向少突胶质细胞分化的方法，试剂盒以及应用
WO2023075913A1 (en) 2021-10-29 2023-05-04 Trailhead Biosystems Inc. Methods and compositions for generating human forebrain neural progenitor cells and for maturation thereof to parvalbumin+ interneurons
JP2025524856A (ja) 2022-07-21 2025-08-01 トレイルヘッド バイオシステムズ インコーポレイテッド 神経前駆細胞からヒト中脳ドーパミン作動性ニューロンを作製するための方法および組成物
KR20250047348A (ko) 2022-08-08 2025-04-03 트레일헤드 바이오시스템즈 인크. 희소돌기아교세포 전구 세포를 생성하기 위한 방법 및 조성물

Also Published As

Publication number Publication date
CN117321191A (zh) 2023-12-29
WO2022211893A1 (en) 2022-10-06
CA3215398A1 (en) 2022-10-06
AU2022247250A1 (en) 2023-11-09
US12385009B2 (en) 2025-08-12
BR112023019790A2 (pt) 2023-11-07
US20260055366A1 (en) 2026-02-26
JP2024511880A (ja) 2024-03-15
US20220315891A1 (en) 2022-10-06
US20240158744A1 (en) 2024-05-16
WO2022211893A9 (en) 2022-12-08
EP4314256A1 (en) 2024-02-07
US20240158743A1 (en) 2024-05-16
KR20230161494A (ko) 2023-11-27

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