BR112022021511A2 - Composição de pó seco para administração peroral - Google Patents
Composição de pó seco para administração peroralInfo
- Publication number
- BR112022021511A2 BR112022021511A2 BR112022021511A BR112022021511A BR112022021511A2 BR 112022021511 A2 BR112022021511 A2 BR 112022021511A2 BR 112022021511 A BR112022021511 A BR 112022021511A BR 112022021511 A BR112022021511 A BR 112022021511A BR 112022021511 A2 BR112022021511 A2 BR 112022021511A2
- Authority
- BR
- Brazil
- Prior art keywords
- average diameter
- weight
- volume
- dry powder
- composition
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
- A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1611—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4816—Wall or shell material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/485—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4891—Coated capsules; Multilayered drug free capsule shells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/08—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing alicyclic rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Inorganic Chemistry (AREA)
- Virology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Pulmonology (AREA)
- Physiology (AREA)
- Nutrition Science (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Biophysics (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
COMPOSIÇÃO DE PÓ SECO PARA ADMINISTRAÇÃO PERORAL. De acordo com a invenção é fornecida uma forma de dosagem farmacêutica adequada para administração oral no trato gastrointestinal, em que a forma de dosagem compreende uma composição farmacêutica na forma de uma mistura particulada que compreende partículas sólidas de N butiloxicarbonil 3 (4 imidazol 1 ilmetilfenil) 5 iso butiltiofeno 2 sulfonamida (C21), ou um sal farmaceuticamente aceitável do mesmo, misturado por adição com uma mescla de partículas carreadoras com um diâmetro médio baseado em peso e/ou volume, e/ou uma densidade estrutural/de partículas, que é/são semelhantes ao diâmetro médio baseado em peso e/ou volume, e/ou a densidade estrutural/de partículas, das partículas sólidas de C21 e um deslizante, em que a composição está contida dentro de uma cápsula que é adequada para tal administração oral. As partículas carreadoras preferidas têm um diâmetro médio baseado em peso e/ou volume que é inferior a cerca de 100 pm. Os materiais de partículas carreadoras preferidos incluem manitol. Os deslizantes preferidos compreendem sílica coloidal. Tais formas de dosagem encontram utilidade no tratamento de doenças pulmonares, tais como fibrose pulmonar idiopática, sarcoidose e danos nos tecidos induzidos por vírus respiratórios.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB2006079.4A GB202006079D0 (en) | 2020-04-24 | 2020-04-24 | New composition |
PCT/GB2021/050994 WO2021214488A1 (en) | 2020-04-24 | 2021-04-23 | New dry powder composition for peroral administration |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112022021511A2 true BR112022021511A2 (pt) | 2023-01-24 |
Family
ID=71080269
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112022021511A BR112022021511A2 (pt) | 2020-04-24 | 2021-04-23 | Composição de pó seco para administração peroral |
Country Status (17)
Country | Link |
---|---|
US (1) | US11844868B2 (pt) |
EP (2) | EP4389212A2 (pt) |
JP (2) | JP7387903B2 (pt) |
KR (1) | KR20230005220A (pt) |
CN (1) | CN115697309A (pt) |
AU (1) | AU2021260923A1 (pt) |
BR (1) | BR112022021511A2 (pt) |
CA (1) | CA3180646A1 (pt) |
DK (1) | DK4138790T3 (pt) |
GB (1) | GB202006079D0 (pt) |
IL (1) | IL297373A (pt) |
LT (1) | LT4138790T (pt) |
MX (1) | MX2022013070A (pt) |
PL (1) | PL4138790T3 (pt) |
PT (1) | PT4138790T (pt) |
SI (1) | SI4138790T1 (pt) |
WO (1) | WO2021214488A1 (pt) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB202201723D0 (en) | 2022-02-10 | 2022-03-30 | Vicore Pharma Ab | New use |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE9800550D0 (sv) | 1998-02-24 | 1998-02-24 | A & Science Invest Ab | A pharmaceutical preparation comprising an angiotensin II type 2 receptor agonist, and use thereof |
AU2002257970B2 (en) | 2001-05-31 | 2007-08-02 | Vicore Pharma Ab | Tricyclic compounds useful as angiotensin II agonists |
JP2008502699A (ja) | 2004-06-14 | 2008-01-31 | セプラコール・インコーポレイテッド | 肺疾患治療方法、及びそのための組成物 |
PE20060777A1 (es) | 2004-12-24 | 2006-10-06 | Boehringer Ingelheim Int | Derivados de indolinona para el tratamiento o la prevencion de enfermedades fibroticas |
WO2008073927A1 (en) * | 2006-12-12 | 2008-06-19 | Gilead Colorado, Inc. | Ambrisentan combined with a renin inhibitor for hypertensive disorder |
AU2012206945B2 (en) * | 2011-01-11 | 2015-02-19 | Dimerix Bioscience Pty Ltd | Combination therapy |
MX2017010993A (es) * | 2015-03-02 | 2018-04-11 | Vicore Pharma Ab | Agonista del receptor de angiotensina ii para tratar la fibrosis pulmonar. |
WO2017221012A1 (en) | 2016-06-21 | 2017-12-28 | Vicore Pharma Ab | Methods and compositions for preventing or reducing the risk of cancer treatment-related cardiotoxicity |
GB201710906D0 (en) | 2017-07-06 | 2017-08-23 | Vicore Pharma Ab | Compounds and methods for treating peripheral neuropathy |
US11931341B2 (en) * | 2018-03-22 | 2024-03-19 | University Of Lowa Research Foundation | Compositions and methods for the treatment and prevention of muscular dystrophy |
GB201818164D0 (en) | 2018-11-07 | 2018-12-19 | Vicore Pharma Ab | New composition |
-
2020
- 2020-04-24 GB GBGB2006079.4A patent/GB202006079D0/en not_active Ceased
-
2021
- 2021-04-23 SI SI202130130T patent/SI4138790T1/sl unknown
- 2021-04-23 BR BR112022021511A patent/BR112022021511A2/pt unknown
- 2021-04-23 EP EP24154507.8A patent/EP4389212A2/en active Pending
- 2021-04-23 EP EP21724012.6A patent/EP4138790B1/en active Active
- 2021-04-23 IL IL297373A patent/IL297373A/en unknown
- 2021-04-23 LT LTEPPCT/GB2021/050994T patent/LT4138790T/lt unknown
- 2021-04-23 PT PT217240126T patent/PT4138790T/pt unknown
- 2021-04-23 WO PCT/GB2021/050994 patent/WO2021214488A1/en active Search and Examination
- 2021-04-23 PL PL21724012.6T patent/PL4138790T3/pl unknown
- 2021-04-23 KR KR1020227039916A patent/KR20230005220A/ko active Search and Examination
- 2021-04-23 AU AU2021260923A patent/AU2021260923A1/en active Pending
- 2021-04-23 MX MX2022013070A patent/MX2022013070A/es unknown
- 2021-04-23 CA CA3180646A patent/CA3180646A1/en active Pending
- 2021-04-23 DK DK21724012.6T patent/DK4138790T3/da active
- 2021-04-23 JP JP2022540540A patent/JP7387903B2/ja active Active
- 2021-04-23 CN CN202180042663.8A patent/CN115697309A/zh active Pending
-
2022
- 2022-03-17 US US17/696,984 patent/US11844868B2/en active Active
-
2023
- 2023-11-15 JP JP2023194557A patent/JP2024020417A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
PT4138790T (pt) | 2024-04-01 |
AU2021260923A1 (en) | 2022-12-08 |
US11844868B2 (en) | 2023-12-19 |
SI4138790T1 (sl) | 2024-05-31 |
IL297373A (en) | 2022-12-01 |
EP4138790A1 (en) | 2023-03-01 |
JP7387903B2 (ja) | 2023-11-28 |
US20220202726A1 (en) | 2022-06-30 |
KR20230005220A (ko) | 2023-01-09 |
JP2023503178A (ja) | 2023-01-26 |
WO2021214488A1 (en) | 2021-10-28 |
CA3180646A1 (en) | 2021-10-28 |
DK4138790T3 (en) | 2024-03-11 |
LT4138790T (lt) | 2024-04-10 |
GB202006079D0 (en) | 2020-06-10 |
CN115697309A (zh) | 2023-02-03 |
JP2024020417A (ja) | 2024-02-14 |
EP4138790B1 (en) | 2024-01-31 |
MX2022013070A (es) | 2022-11-30 |
PL4138790T3 (pl) | 2024-06-10 |
EP4389212A2 (en) | 2024-06-26 |
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