BR112022013780A2 - Moléculas de anticorpo para c5ar1 e usos das mesmas - Google Patents

Moléculas de anticorpo para c5ar1 e usos das mesmas

Info

Publication number
BR112022013780A2
BR112022013780A2 BR112022013780A BR112022013780A BR112022013780A2 BR 112022013780 A2 BR112022013780 A2 BR 112022013780A2 BR 112022013780 A BR112022013780 A BR 112022013780A BR 112022013780 A BR112022013780 A BR 112022013780A BR 112022013780 A2 BR112022013780 A2 BR 112022013780A2
Authority
BR
Brazil
Prior art keywords
antibody molecules
c5ar1
anca
treat
prevent
Prior art date
Application number
BR112022013780A
Other languages
English (en)
Inventor
Viswanathan Karthik
Booth Brian
Ramakrishnan Boopathy
Wollacott Andrew
Babcok Gregory
Shriver Zachary
Original Assignee
Visterra Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Visterra Inc filed Critical Visterra Inc
Publication of BR112022013780A2 publication Critical patent/BR112022013780A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/35—Valency
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

MOLÉCULAS DE ANTICORPO PARA C5AR1 E USOS DAS MESMAS. A presente invenção refere-se a moléculas de anticorpo que se ligam especificamente a C5aR1. As moléculas de anticorpo podem ser usadas para tratar, prevenir e/ou diagnosticar distúrbios, tais como a vasculite associada a ANCA.
BR112022013780A 2020-01-13 2021-01-13 Moléculas de anticorpo para c5ar1 e usos das mesmas BR112022013780A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202062960544P 2020-01-13 2020-01-13
PCT/US2021/013284 WO2021146320A1 (en) 2020-01-13 2021-01-13 Antibody molecules to c5ar1 and uses thereof

Publications (1)

Publication Number Publication Date
BR112022013780A2 true BR112022013780A2 (pt) 2022-10-11

Family

ID=74554227

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112022013780A BR112022013780A2 (pt) 2020-01-13 2021-01-13 Moléculas de anticorpo para c5ar1 e usos das mesmas

Country Status (12)

Country Link
US (3) US11773179B2 (pt)
EP (1) EP4090680A1 (pt)
JP (1) JP2023510844A (pt)
KR (1) KR20220160542A (pt)
CN (1) CN115443290A (pt)
AU (1) AU2021207627A1 (pt)
BR (1) BR112022013780A2 (pt)
CA (1) CA3166505A1 (pt)
IL (1) IL294661A (pt)
MX (1) MX2022008659A (pt)
TW (1) TW202140553A (pt)
WO (1) WO2021146320A1 (pt)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW202140553A (zh) 2020-01-13 2021-11-01 美商威特拉公司 C5ar1抗體分子及其用途
TW202246331A (zh) 2021-01-13 2022-12-01 美商威特拉公司 人源化補體５ａ受體１抗體及其使用方法
WO2023129870A2 (en) * 2021-12-29 2023-07-06 Staidson Biopharma Inc. ANTIBODIES SPECIFICALLY RECOGNIZING C5aR1 AND USES THEREOF
CN114315990B (zh) * 2022-03-10 2022-05-27 北京康乐卫士生物技术股份有限公司 新型冠状病毒特异性单克隆抗体的制备及其应用

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Publication number Publication date
IL294661A (en) 2022-09-01
US11773179B2 (en) 2023-10-03
JP2023510844A (ja) 2023-03-15
US20220089764A1 (en) 2022-03-24
CA3166505A1 (en) 2021-07-22
TW202140553A (zh) 2021-11-01
WO2021146320A9 (en) 2021-11-18
US20240076398A1 (en) 2024-03-07
US20240150488A1 (en) 2024-05-09
MX2022008659A (es) 2022-11-10
EP4090680A1 (en) 2022-11-23
WO2021146320A1 (en) 2021-07-22
KR20220160542A (ko) 2022-12-06
WO2021146320A8 (en) 2022-07-28
AU2021207627A1 (en) 2022-08-04
CN115443290A (zh) 2022-12-06

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