BR112022004797A2 - Polipeptídeos otimizados de ácido tetra-hidrocanabinólico (thca) sintase - Google Patents
Polipeptídeos otimizados de ácido tetra-hidrocanabinólico (thca) sintaseInfo
- Publication number
- BR112022004797A2 BR112022004797A2 BR112022004797A BR112022004797A BR112022004797A2 BR 112022004797 A2 BR112022004797 A2 BR 112022004797A2 BR 112022004797 A BR112022004797 A BR 112022004797A BR 112022004797 A BR112022004797 A BR 112022004797A BR 112022004797 A2 BR112022004797 A2 BR 112022004797A2
- Authority
- BR
- Brazil
- Prior art keywords
- tetrahydrocannabinolic acid
- thca
- optimized
- engineered variants
- methods
- Prior art date
Links
- 229920001184 polypeptide Polymers 0.000 title abstract 4
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 4
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 4
- UCONUSSAWGCZMV-HZPDHXFCSA-N Delta(9)-tetrahydrocannabinolic acid Chemical compound C([C@H]1C(C)(C)O2)CC(C)=C[C@H]1C1=C2C=C(CCCCC)C(C(O)=O)=C1O UCONUSSAWGCZMV-HZPDHXFCSA-N 0.000 title abstract 2
- 238000000034 method Methods 0.000 abstract 3
- 108030003705 Tetrahydrocannabinolic acid synthases Proteins 0.000 abstract 2
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 2
- 229930003827 cannabinoid Natural products 0.000 abstract 2
- 239000003557 cannabinoid Substances 0.000 abstract 2
- 108020004707 nucleic acids Proteins 0.000 abstract 2
- 102000039446 nucleic acids Human genes 0.000 abstract 2
- 150000007523 nucleic acids Chemical class 0.000 abstract 2
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 1
- 229940065144 cannabinoids Drugs 0.000 abstract 1
- 238000012216 screening Methods 0.000 abstract 1
- 238000006467 substitution reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/02—Oxygen as only ring hetero atoms
- C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
- C12P7/42—Hydroxy-carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y121/00—Oxidoreductases acting on X-H and Y-H to form an X-Y bond (1.21)
- C12Y121/03—Oxidoreductases acting on X-H and Y-H to form an X-Y bond (1.21) with oxygen as acceptor (1.21.3)
- C12Y121/03007—Tetrahydrocannabinolic acid synthase (1.21.3.7)
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Botany (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962902300P | 2019-09-18 | 2019-09-18 | |
| PCT/US2020/051261 WO2021055597A1 (en) | 2019-09-18 | 2020-09-17 | Optimized tetrahydrocannabinolic acid (thca) synthase polypeptides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112022004797A2 true BR112022004797A2 (pt) | 2022-06-21 |
Family
ID=72744852
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112022004797A BR112022004797A2 (pt) | 2019-09-18 | 2020-09-17 | Polipeptídeos otimizados de ácido tetra-hidrocanabinólico (thca) sintase |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP4031657A1 (ja) |
| JP (1) | JP2022548904A (ja) |
| CN (1) | CN115038786A (ja) |
| AU (1) | AU2020349513A1 (ja) |
| BR (1) | BR112022004797A2 (ja) |
| CA (1) | CA3152803A1 (ja) |
| IL (1) | IL291328A (ja) |
| MX (1) | MX2022003203A (ja) |
| WO (1) | WO2021055597A1 (ja) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2020176547A1 (en) | 2019-02-25 | 2020-09-03 | Ginkgo Bioworks, Inc. | Biosynthesis of cannabinoids and cannabinoid precursors |
| WO2023168266A2 (en) * | 2022-03-02 | 2023-09-07 | Genomatica, Inc. | Flavin-dependent oxidases having cannabinoid synthase activity |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE60335574D1 (de) | 2002-10-04 | 2011-02-10 | Du Pont | Verfahren zur biologischen herstellung von 1,3-propandiol mit hoher ausbeute |
| CN102027124B (zh) | 2007-12-13 | 2015-11-25 | 丹尼斯科美国公司 | 用于生产异戊二烯的组合物和方法 |
| EP2279251A2 (en) | 2008-04-23 | 2011-02-02 | Danisco US Inc. | Isoprene synthase variants for improved microbial production of isoprene |
| ES2716231T3 (es) | 2008-07-02 | 2019-06-11 | Danisco Us Inc | Procedimientos para producir isopreno |
| ES2898272T3 (es) * | 2017-04-27 | 2022-03-04 | Univ California | Microorganismos y métodos para producir cannabinoides y derivados de cannabinoides |
| US11149291B2 (en) * | 2017-07-12 | 2021-10-19 | Biomedican, Inc. | Production of cannabinoids in yeast |
| EP3724322A1 (en) * | 2017-12-14 | 2020-10-21 | Medicinal Genomics Corporation | Methods and kits for classifying cannabinoid production in cannabis plants |
| WO2020069214A2 (en) * | 2018-09-26 | 2020-04-02 | Demetrix, Inc. | Optimized expression systems for producing cannabinoid synthase polypeptides, cannabinoids, and cannabinoid derivatives |
-
2020
- 2020-09-17 CN CN202080078001.1A patent/CN115038786A/zh active Pending
- 2020-09-17 BR BR112022004797A patent/BR112022004797A2/pt not_active Application Discontinuation
- 2020-09-17 EP EP20786122.0A patent/EP4031657A1/en not_active Withdrawn
- 2020-09-17 CA CA3152803A patent/CA3152803A1/en active Pending
- 2020-09-17 AU AU2020349513A patent/AU2020349513A1/en active Pending
- 2020-09-17 WO PCT/US2020/051261 patent/WO2021055597A1/en unknown
- 2020-09-17 MX MX2022003203A patent/MX2022003203A/es unknown
- 2020-09-17 JP JP2022517341A patent/JP2022548904A/ja active Pending
-
2022
- 2022-03-13 IL IL291328A patent/IL291328A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA3152803A1 (en) | 2021-03-25 |
| EP4031657A1 (en) | 2022-07-27 |
| IL291328A (en) | 2022-05-01 |
| CN115038786A (zh) | 2022-09-09 |
| WO2021055597A1 (en) | 2021-03-25 |
| MX2022003203A (es) | 2022-06-08 |
| AU2020349513A1 (en) | 2022-05-05 |
| JP2022548904A (ja) | 2022-11-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B11A | Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing | ||
| B11Y | Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette] |