MX2022003203A - Polipéptidos de sintasa de ácido tetrahidrocannabinólico (thca) optimizados. - Google Patents

Polipéptidos de sintasa de ácido tetrahidrocannabinólico (thca) optimizados.

Info

Publication number
MX2022003203A
MX2022003203A MX2022003203A MX2022003203A MX2022003203A MX 2022003203 A MX2022003203 A MX 2022003203A MX 2022003203 A MX2022003203 A MX 2022003203A MX 2022003203 A MX2022003203 A MX 2022003203A MX 2022003203 A MX2022003203 A MX 2022003203A
Authority
MX
Mexico
Prior art keywords
engineered variants
tetrahydrocannabinolic acid
methods
thca
optimized
Prior art date
Application number
MX2022003203A
Other languages
English (en)
Spanish (es)
Inventor
Andrew Horwitz
Jeff Ubersax
Darren Platt
Jeff Wong
Original Assignee
Demetrix Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Demetrix Inc filed Critical Demetrix Inc
Publication of MX2022003203A publication Critical patent/MX2022003203A/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004Oxidoreductases (1.)
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/415Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52Genes encoding for enzymes or proenzymes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02Oxygen as only ring hetero atoms
    • C12P17/06Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00Preparation of oxygen-containing organic compounds
    • C12P7/40Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/42Hydroxy-carboxylic acids
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y121/00Oxidoreductases acting on X-H and Y-H to form an X-Y bond (1.21)
    • C12Y121/03Oxidoreductases acting on X-H and Y-H to form an X-Y bond (1.21) with oxygen as acceptor (1.21.3)
    • C12Y121/03007Tetrahydrocannabinolic acid synthase (1.21.3.7)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Botany (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
MX2022003203A 2019-09-18 2020-09-17 Polipéptidos de sintasa de ácido tetrahidrocannabinólico (thca) optimizados. MX2022003203A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962902300P 2019-09-18 2019-09-18
PCT/US2020/051261 WO2021055597A1 (en) 2019-09-18 2020-09-17 Optimized tetrahydrocannabinolic acid (thca) synthase polypeptides

Publications (1)

Publication Number Publication Date
MX2022003203A true MX2022003203A (es) 2022-06-08

Family

ID=72744852

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2022003203A MX2022003203A (es) 2019-09-18 2020-09-17 Polipéptidos de sintasa de ácido tetrahidrocannabinólico (thca) optimizados.

Country Status (9)

Country Link
EP (1) EP4031657A1 (ja)
JP (1) JP2022548904A (ja)
CN (1) CN115038786A (ja)
AU (1) AU2020349513A1 (ja)
BR (1) BR112022004797A2 (ja)
CA (1) CA3152803A1 (ja)
IL (1) IL291328A (ja)
MX (1) MX2022003203A (ja)
WO (1) WO2021055597A1 (ja)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020176547A1 (en) 2019-02-25 2020-09-03 Ginkgo Bioworks, Inc. Biosynthesis of cannabinoids and cannabinoid precursors
WO2023168266A2 (en) * 2022-03-02 2023-09-07 Genomatica, Inc. Flavin-dependent oxidases having cannabinoid synthase activity

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA05003382A (es) 2002-10-04 2005-06-22 Du Pont Proceso para la produccion biologica de 1,3-propanodiol con alto rendimiento.
DK2235190T3 (en) 2007-12-13 2018-07-23 Danisco Us Inc COMPOSITIONS AND PROCEDURES FOR PRODUCING ISOPRENE
EP2279251A2 (en) 2008-04-23 2011-02-02 Danisco US Inc. Isoprene synthase variants for improved microbial production of isoprene
EP3406722A1 (en) 2008-07-02 2018-11-28 Danisco US Inc. Methods for producing isoprene free of c5 hydrocarbons under decoupling conditions and/or safe operating ranges
AU2018256863B2 (en) * 2017-04-27 2024-06-06 Regents Of The University Of California Microorganisms and methods for producing cannabinoids and cannabinoid derivatives
US11149291B2 (en) * 2017-07-12 2021-10-19 Biomedican, Inc. Production of cannabinoids in yeast
CA3123182A1 (en) * 2017-12-14 2019-06-20 Medicinal Genomics Corporation Methods and kits for classifying cannabinoid production in cannabis plants
WO2020069214A2 (en) * 2018-09-26 2020-04-02 Demetrix, Inc. Optimized expression systems for producing cannabinoid synthase polypeptides, cannabinoids, and cannabinoid derivatives

Also Published As

Publication number Publication date
AU2020349513A1 (en) 2022-05-05
IL291328A (en) 2022-05-01
BR112022004797A2 (pt) 2022-06-21
WO2021055597A1 (en) 2021-03-25
CA3152803A1 (en) 2021-03-25
JP2022548904A (ja) 2022-11-22
CN115038786A (zh) 2022-09-09
EP4031657A1 (en) 2022-07-27

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