BR112021020241A2 - Derivados de heteroarila bicíclica como inibidores de ectonucleotídeo pirofosfatase fosfodiesterase 1 - Google Patents
Derivados de heteroarila bicíclica como inibidores de ectonucleotídeo pirofosfatase fosfodiesterase 1Info
- Publication number
- BR112021020241A2 BR112021020241A2 BR112021020241A BR112021020241A BR112021020241A2 BR 112021020241 A2 BR112021020241 A2 BR 112021020241A2 BR 112021020241 A BR112021020241 A BR 112021020241A BR 112021020241 A BR112021020241 A BR 112021020241A BR 112021020241 A2 BR112021020241 A2 BR 112021020241A2
- Authority
- BR
- Brazil
- Prior art keywords
- bicyclic heteroaryl
- inhibitors
- ectonucleotide pyrophosphatase
- heteroaryl derivatives
- phosphodiesterase
- Prior art date
Links
- 108010067341 ectonucleotide pyrophosphatase phosphodiesterase 1 Proteins 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 101000812677 Homo sapiens Nucleotide pyrophosphatase Proteins 0.000 abstract 1
- 102100039306 Nucleotide pyrophosphatase Human genes 0.000 abstract 1
- 101000995829 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) Nucleotide pyrophosphatase Proteins 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000002255 enzymatic effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/69—Boron compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/025—Boronic and borinic acid compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/027—Organoboranes and organoborohydrides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6503—Five-membered rings
- C07F9/65031—Five-membered rings having the nitrogen atoms in the positions 1 and 2
- C07F9/65038—Five-membered rings having the nitrogen atoms in the positions 1 and 2 condensed with carbocyclic rings or carbocyclic ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6503—Five-membered rings
- C07F9/6506—Five-membered rings having the nitrogen atoms in positions 1 and 3
- C07F9/65068—Five-membered rings having the nitrogen atoms in positions 1 and 3 condensed with carbocyclic rings or carbocyclic ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
a presente invenção refere-se a certos compostos de heteroarila bicíclica que inibem a atividade enzimática de ectonucleotídeo pirofosfatase/fosfodiesterase 1 (enpp1) e são, portanto, úteis para o tratamento de doenças e afecções moduladas, pelo menos em parte, por enpp1. em algumas modalidades, os compostos de heteroarila bicíclica incluem aqueles de fórmula (i). são também fornecidas no presente documento composições farmacêuticas contendo tais compostos e processos para preparar tais compostos. (i)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201962833455P | 2019-04-12 | 2019-04-12 | |
US201962881111P | 2019-07-31 | 2019-07-31 | |
PCT/US2020/027700 WO2020210649A1 (en) | 2019-04-12 | 2020-04-10 | Bicyclic heteroaryl derivatives as ectonucleotide pyrophosphatase phosphodiesterase 1 inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112021020241A2 true BR112021020241A2 (pt) | 2021-12-07 |
Family
ID=70465561
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112021020241A BR112021020241A2 (pt) | 2019-04-12 | 2020-04-10 | Derivados de heteroarila bicíclica como inibidores de ectonucleotídeo pirofosfatase fosfodiesterase 1 |
Country Status (22)
Country | Link |
---|---|
EP (2) | EP3952995B1 (pt) |
JP (1) | JP2022526432A (pt) |
KR (1) | KR20210151873A (pt) |
CN (1) | CN114040915A (pt) |
AU (1) | AU2020272034A1 (pt) |
BR (1) | BR112021020241A2 (pt) |
CA (1) | CA3136443A1 (pt) |
DK (1) | DK3952995T3 (pt) |
ES (1) | ES2960987T3 (pt) |
FI (1) | FI3952995T3 (pt) |
HR (1) | HRP20231413T1 (pt) |
HU (1) | HUE064377T2 (pt) |
IL (1) | IL286966A (pt) |
LT (1) | LT3952995T (pt) |
MX (2) | MX2021012305A (pt) |
PL (1) | PL3952995T3 (pt) |
PT (1) | PT3952995T (pt) |
RS (1) | RS64792B1 (pt) |
SG (1) | SG11202110888QA (pt) |
SI (1) | SI3952995T1 (pt) |
TW (1) | TW202103708A (pt) |
WO (1) | WO2020210649A1 (pt) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MX2023008761A (es) * | 2021-01-29 | 2023-08-22 | Txinno Bioscience Inc | Derivado de benzotriazol novedoso que posee actividad inhibitoria contra la ectonucleotido pirofosfatasa - fosfodiesterasa y uso del mismo. |
US20240209005A1 (en) * | 2021-03-16 | 2024-06-27 | Riboscience Llc | Bicyclic heteroaryl boronate derivatives as ectonucleotide pyrophosphatase phosphodiesterase 1 inhibitors |
CN116444544A (zh) * | 2022-01-10 | 2023-07-18 | 中国科学院上海药物研究所 | 苯并咪唑类化合物及其医药用途 |
US20240208997A1 (en) * | 2022-11-09 | 2024-06-27 | Boehringer Ingelheim International Gmbh | Cyclic benzimidazole derivatives as cgas inhibitors |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4107288A (en) | 1974-09-18 | 1978-08-15 | Pharmaceutical Society Of Victoria | Injectable compositions, nanoparticles useful therein, and process of manufacturing same |
US5145684A (en) | 1991-01-25 | 1992-09-08 | Sterling Drug Inc. | Surface modified drug nanoparticles |
DK40192D0 (da) * | 1992-03-26 | 1992-03-26 | Neurosearch As | Imidazolforbindelser, deres fremstilling og anvendelse |
EP1885714B1 (en) * | 2005-05-24 | 2014-01-15 | LEK Pharmaceuticals d.d. | Process for the preparation of 2-alkyl-1-((2'-substituted-biphenyl-4-yl)methyl)-imidazole, dihydroimidazole or benzimidazole derivatives |
CN100427488C (zh) * | 2005-10-21 | 2008-10-22 | 上海东升新材料有限公司 | 腺嘌呤类衍生物及其合成方法 |
JO3598B1 (ar) * | 2006-10-10 | 2020-07-05 | Infinity Discovery Inc | الاحماض والاسترات البورونية كمثبطات اميد هيدروليز الحامض الدهني |
EP3246034A1 (en) * | 2008-03-06 | 2017-11-22 | Anacor Pharmaceuticals, Inc. | Boron-containing small molecules as anti-inflammatory agents |
SI2558577T1 (sl) * | 2010-04-16 | 2019-05-31 | Nuevolution A/S | Bifunkcionalni kompleksi in metode za pripravo in uporabo takšnih kompleksov |
MX2013013331A (es) * | 2011-05-17 | 2014-10-17 | Principia Biopharma Inc | Derivados de azaindol como inhibidores de tirosina-cinasas. |
WO2016055582A1 (en) | 2014-10-08 | 2016-04-14 | Thomas Helledays Stiftelse För Medicinsk Forskning | Heterocyclic compounds as dctpp1 modulators |
UA121775C2 (uk) * | 2015-07-31 | 2020-07-27 | Пфайзер Інк. | 1,1,1-трифтор-3-гідроксипропан-2-ілкарбаматні похідні та 1,1,1-трифтор-4-гідроксибутан-2-ілкарбаматні похідні як інгібітори magl |
BR112019012618A2 (pt) * | 2016-12-22 | 2019-11-26 | Mavupharma Inc | inibidores de fosfodiesterase e métodos de tratamento microbiano |
JP2020504745A (ja) * | 2016-12-22 | 2020-02-13 | マブファーマ,インク. | I型ifn産生を増強または増大する組成物および方法 |
US10487084B2 (en) * | 2017-08-16 | 2019-11-26 | Bristol-Myers Squibb Company | Toll-like receptor 7 (TLR7) agonists having a heterobiaryl moiety, conjugates thereof, and methods and uses therefor |
WO2019096113A1 (zh) * | 2017-11-14 | 2019-05-23 | 深圳市塔吉瑞生物医药有限公司 | 一种氘代的含硼的化合物及药物组合物和用途 |
-
2020
- 2020-04-10 SI SI202030281T patent/SI3952995T1/sl unknown
- 2020-04-10 LT LTEPPCT/US2020/027700T patent/LT3952995T/lt unknown
- 2020-04-10 CA CA3136443A patent/CA3136443A1/en active Pending
- 2020-04-10 JP JP2021559932A patent/JP2022526432A/ja active Pending
- 2020-04-10 FI FIEP20722196.1T patent/FI3952995T3/fi active
- 2020-04-10 CN CN202080028332.4A patent/CN114040915A/zh active Pending
- 2020-04-10 SG SG11202110888QA patent/SG11202110888QA/en unknown
- 2020-04-10 WO PCT/US2020/027700 patent/WO2020210649A1/en active Application Filing
- 2020-04-10 PT PT207221961T patent/PT3952995T/pt unknown
- 2020-04-10 EP EP20722196.1A patent/EP3952995B1/en active Active
- 2020-04-10 BR BR112021020241A patent/BR112021020241A2/pt unknown
- 2020-04-10 KR KR1020217036122A patent/KR20210151873A/ko unknown
- 2020-04-10 TW TW109112260A patent/TW202103708A/zh unknown
- 2020-04-10 AU AU2020272034A patent/AU2020272034A1/en active Pending
- 2020-04-10 EP EP23187601.2A patent/EP4249070A3/en active Pending
- 2020-04-10 HU HUE20722196A patent/HUE064377T2/hu unknown
- 2020-04-10 RS RS20231040A patent/RS64792B1/sr unknown
- 2020-04-10 PL PL20722196.1T patent/PL3952995T3/pl unknown
- 2020-04-10 DK DK20722196.1T patent/DK3952995T3/da active
- 2020-04-10 ES ES20722196T patent/ES2960987T3/es active Active
- 2020-04-10 HR HRP20231413TT patent/HRP20231413T1/hr unknown
- 2020-04-10 MX MX2021012305A patent/MX2021012305A/es unknown
-
2021
- 2021-10-04 IL IL286966A patent/IL286966A/en unknown
- 2021-10-07 MX MX2023011065A patent/MX2023011065A/es unknown
Also Published As
Publication number | Publication date |
---|---|
HUE064377T2 (hu) | 2024-03-28 |
LT3952995T (lt) | 2023-11-10 |
ES2960987T3 (es) | 2024-03-07 |
CA3136443A1 (en) | 2020-10-15 |
AU2020272034A1 (en) | 2021-10-28 |
CN114040915A (zh) | 2022-02-11 |
WO2020210649A1 (en) | 2020-10-15 |
RS64792B1 (sr) | 2023-11-30 |
SG11202110888QA (en) | 2021-10-28 |
TW202103708A (zh) | 2021-02-01 |
EP3952995B1 (en) | 2023-09-20 |
FI3952995T3 (fi) | 2023-10-26 |
KR20210151873A (ko) | 2021-12-14 |
PT3952995T (pt) | 2023-10-25 |
HRP20231413T1 (hr) | 2024-02-16 |
SI3952995T1 (sl) | 2023-12-29 |
DK3952995T3 (da) | 2023-10-30 |
MX2021012305A (es) | 2021-11-12 |
EP3952995A1 (en) | 2022-02-16 |
MX2023011065A (es) | 2023-09-28 |
IL286966A (en) | 2021-12-01 |
PL3952995T3 (pl) | 2024-03-11 |
JP2022526432A (ja) | 2022-05-24 |
EP4249070A2 (en) | 2023-09-27 |
EP4249070A3 (en) | 2024-04-17 |
US20220362266A1 (en) | 2022-11-17 |
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