PL3952995T3 - Pochodne bicyklicznych heteroaryli jako inhibitory ekto- pirofosfatazy/fosfodiesterazy nukleotydowej 1 - Google Patents
Pochodne bicyklicznych heteroaryli jako inhibitory ekto- pirofosfatazy/fosfodiesterazy nukleotydowej 1Info
- Publication number
- PL3952995T3 PL3952995T3 PL20722196.1T PL20722196T PL3952995T3 PL 3952995 T3 PL3952995 T3 PL 3952995T3 PL 20722196 T PL20722196 T PL 20722196T PL 3952995 T3 PL3952995 T3 PL 3952995T3
- Authority
- PL
- Poland
- Prior art keywords
- inhibitors
- bicyclic heteroaryl
- heteroaryl derivatives
- ectonucleotide pyrophosphatase
- pyrophosphatase phosphodiesterase
- Prior art date
Links
- 108010067341 ectonucleotide pyrophosphatase phosphodiesterase 1 Proteins 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/69—Boron compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic System
- C07F5/02—Boron compounds
- C07F5/025—Boronic and borinic acid compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic System
- C07F5/02—Boron compounds
- C07F5/027—Organoboranes and organoborohydrides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6503—Five-membered rings
- C07F9/65031—Five-membered rings having the nitrogen atoms in the positions 1 and 2
- C07F9/65038—Five-membered rings having the nitrogen atoms in the positions 1 and 2 condensed with carbocyclic rings or carbocyclic ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6503—Five-membered rings
- C07F9/6506—Five-membered rings having the nitrogen atoms in positions 1 and 3
- C07F9/65068—Five-membered rings having the nitrogen atoms in positions 1 and 3 condensed with carbocyclic rings or carbocyclic ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962833455P | 2019-04-12 | 2019-04-12 | |
| US201962881111P | 2019-07-31 | 2019-07-31 | |
| PCT/US2020/027700 WO2020210649A1 (en) | 2019-04-12 | 2020-04-10 | Bicyclic heteroaryl derivatives as ectonucleotide pyrophosphatase phosphodiesterase 1 inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL3952995T3 true PL3952995T3 (pl) | 2024-03-11 |
Family
ID=70465561
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL20722196.1T PL3952995T3 (pl) | 2019-04-12 | 2020-04-10 | Pochodne bicyklicznych heteroaryli jako inhibitory ekto- pirofosfatazy/fosfodiesterazy nukleotydowej 1 |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US20220362266A1 (pl) |
| EP (2) | EP4249070A3 (pl) |
| JP (1) | JP2022526432A (pl) |
| KR (1) | KR20210151873A (pl) |
| CN (1) | CN114040915A (pl) |
| AU (1) | AU2020272034A1 (pl) |
| CA (1) | CA3136443A1 (pl) |
| DK (1) | DK3952995T3 (pl) |
| ES (1) | ES2960987T3 (pl) |
| FI (1) | FI3952995T3 (pl) |
| HR (1) | HRP20231413T1 (pl) |
| HU (1) | HUE064377T2 (pl) |
| IL (1) | IL286966A (pl) |
| LT (1) | LT3952995T (pl) |
| MX (1) | MX2021012305A (pl) |
| PL (1) | PL3952995T3 (pl) |
| PT (1) | PT3952995T (pl) |
| RS (1) | RS64792B1 (pl) |
| SG (1) | SG11202110888QA (pl) |
| SI (1) | SI3952995T1 (pl) |
| TW (1) | TW202103708A (pl) |
| WO (1) | WO2020210649A1 (pl) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2022164249A1 (ko) * | 2021-01-29 | 2022-08-04 | 주식회사 티씨노바이오사이언스 | 엑토뉴클레오티드 피로포스파타아제-포스포디에스터라아제의 저해 활성을 갖는 신규한 벤조트리아졸 유도체 및 이들의 용도 |
| WO2022197734A1 (en) * | 2021-03-16 | 2022-09-22 | Riboscience Llc | Bicyclic heteroaryl boronate derivatives as ectonucleotide pyrophosphatase phosphodiesterase 1 inhibitors |
| CN116444544A (zh) * | 2022-01-10 | 2023-07-18 | 中国科学院上海药物研究所 | 苯并咪唑类化合物及其医药用途 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4107288A (en) | 1974-09-18 | 1978-08-15 | Pharmaceutical Society Of Victoria | Injectable compositions, nanoparticles useful therein, and process of manufacturing same |
| US5145684A (en) | 1991-01-25 | 1992-09-08 | Sterling Drug Inc. | Surface modified drug nanoparticles |
| DK40192D0 (da) * | 1992-03-26 | 1992-03-26 | Neurosearch As | Imidazolforbindelser, deres fremstilling og anvendelse |
| WO2006125592A2 (en) * | 2005-05-24 | 2006-11-30 | Lek Pharmaceuticals D.D. | Process for the preparation of 2-alkyl-1-((2'-substituted-biphenyl-4-yl)methyl)-imidazole, dihydroimidazole or benzimidazole derivatives |
| CN100427488C (zh) * | 2005-10-21 | 2008-10-22 | 上海东升新材料有限公司 | 腺嘌呤类衍生物及其合成方法 |
| JO3598B1 (ar) * | 2006-10-10 | 2020-07-05 | Infinity Discovery Inc | الاحماض والاسترات البورونية كمثبطات اميد هيدروليز الحامض الدهني |
| RU2547441C2 (ru) * | 2008-03-06 | 2015-04-10 | Анакор Фармасьютикалз, Инк. | Борсодержащие малые молекулы в качестве противовоспалительных агентов |
| US11225655B2 (en) * | 2010-04-16 | 2022-01-18 | Nuevolution A/S | Bi-functional complexes and methods for making and using such complexes |
| EP2710006A1 (en) * | 2011-05-17 | 2014-03-26 | Principia Biopharma Inc. | Azaindole derivatives as tyrosine kinase inhibitors |
| AU2015329955A1 (en) * | 2014-10-08 | 2017-05-11 | Thomas Helledays Stiftelse For Medicinsk Forskning | Heterocyclic compounds as DCTPP1 modulators |
| BR112018000041A2 (pt) * | 2015-07-31 | 2018-09-04 | Pfizer Inc. | Derivados de carbamato de 1,1,1-trifluoro-3- hidroxipropan-2-ila e derivados de carbamato de 1,1,1-trifluoro-4-hidroxibutan-2-ila como inibidores de magl |
| MX2019007256A (es) * | 2016-12-22 | 2019-11-18 | Mavupharma Inc | Inhibidores de las fosfodiesterasas y métodos de tratamiento microbiano. |
| WO2018119325A1 (en) * | 2016-12-22 | 2018-06-28 | Mavupharma, Inc. | Compositions and methods of enhancing or augmenting type i ifn production |
| US10487084B2 (en) * | 2017-08-16 | 2019-11-26 | Bristol-Myers Squibb Company | Toll-like receptor 7 (TLR7) agonists having a heterobiaryl moiety, conjugates thereof, and methods and uses therefor |
| WO2019096113A1 (zh) * | 2017-11-14 | 2019-05-23 | 深圳市塔吉瑞生物医药有限公司 | 一种氘代的含硼的化合物及药物组合物和用途 |
-
2020
- 2020-04-10 EP EP23187601.2A patent/EP4249070A3/en active Pending
- 2020-04-10 US US17/264,684 patent/US20220362266A1/en active Pending
- 2020-04-10 DK DK20722196.1T patent/DK3952995T3/da active
- 2020-04-10 WO PCT/US2020/027700 patent/WO2020210649A1/en active Application Filing
- 2020-04-10 CA CA3136443A patent/CA3136443A1/en active Pending
- 2020-04-10 FI FIEP20722196.1T patent/FI3952995T3/fi active
- 2020-04-10 CN CN202080028332.4A patent/CN114040915A/zh active Pending
- 2020-04-10 PL PL20722196.1T patent/PL3952995T3/pl unknown
- 2020-04-10 LT LTEPPCT/US2020/027700T patent/LT3952995T/lt unknown
- 2020-04-10 RS RS20231040A patent/RS64792B1/sr unknown
- 2020-04-10 ES ES20722196T patent/ES2960987T3/es active Active
- 2020-04-10 PT PT207221961T patent/PT3952995T/pt unknown
- 2020-04-10 JP JP2021559932A patent/JP2022526432A/ja active Pending
- 2020-04-10 TW TW109112260A patent/TW202103708A/zh unknown
- 2020-04-10 EP EP20722196.1A patent/EP3952995B1/en active Active
- 2020-04-10 SI SI202030281T patent/SI3952995T1/sl unknown
- 2020-04-10 KR KR1020217036122A patent/KR20210151873A/ko unknown
- 2020-04-10 SG SG11202110888QA patent/SG11202110888QA/en unknown
- 2020-04-10 HR HRP20231413TT patent/HRP20231413T1/hr unknown
- 2020-04-10 HU HUE20722196A patent/HUE064377T2/hu unknown
- 2020-04-10 AU AU2020272034A patent/AU2020272034A1/en active Pending
- 2020-04-10 MX MX2021012305A patent/MX2021012305A/es unknown
-
2021
- 2021-10-04 IL IL286966A patent/IL286966A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2020272034A1 (en) | 2021-10-28 |
| US20220362266A1 (en) | 2022-11-17 |
| TW202103708A (zh) | 2021-02-01 |
| EP4249070A2 (en) | 2023-09-27 |
| SG11202110888QA (en) | 2021-10-28 |
| SI3952995T1 (sl) | 2023-12-29 |
| PT3952995T (pt) | 2023-10-25 |
| IL286966A (en) | 2021-12-01 |
| ES2960987T3 (es) | 2024-03-07 |
| HUE064377T2 (hu) | 2024-03-28 |
| RS64792B1 (sr) | 2023-11-30 |
| JP2022526432A (ja) | 2022-05-24 |
| CA3136443A1 (en) | 2020-10-15 |
| DK3952995T3 (da) | 2023-10-30 |
| WO2020210649A1 (en) | 2020-10-15 |
| CN114040915A (zh) | 2022-02-11 |
| HRP20231413T1 (hr) | 2024-02-16 |
| MX2021012305A (es) | 2021-11-12 |
| EP3952995B1 (en) | 2023-09-20 |
| KR20210151873A (ko) | 2021-12-14 |
| EP3952995A1 (en) | 2022-02-16 |
| FI3952995T3 (fi) | 2023-10-26 |
| LT3952995T (lt) | 2023-11-10 |
| EP4249070A3 (en) | 2024-04-17 |
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