BR112021019233A2 - Método para preparar toxina botulínica - Google Patents

Método para preparar toxina botulínica

Info

Publication number
BR112021019233A2
BR112021019233A2 BR112021019233A BR112021019233A BR112021019233A2 BR 112021019233 A2 BR112021019233 A2 BR 112021019233A2 BR 112021019233 A BR112021019233 A BR 112021019233A BR 112021019233 A BR112021019233 A BR 112021019233A BR 112021019233 A2 BR112021019233 A2 BR 112021019233A2
Authority
BR
Brazil
Prior art keywords
botulinum toxin
preparing
production
time
botulinum
Prior art date
Application number
BR112021019233A
Other languages
English (en)
Inventor
Jin Yun Bum
Young Kim Jae
Sun Nam Jeong
Minjoong Kim
Seungho Kim
Wonil Lee
Original Assignee
Jetema Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jetema Co Ltd filed Critical Jetema Co Ltd
Publication of BR112021019233A2 publication Critical patent/BR112021019233A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/33—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Clostridium (G)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/145—Clostridium
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/24—Metalloendopeptidases (3.4.24)
    • C12Y304/24069—Bontoxilysin (3.4.24.69), i.e. botulinum neurotoxin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Toxicology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

método para preparar toxina botulínica. é revelada uma composição de meio para cultivar clostridium botulinum compreendendo uma peptona de batata, um extrato de levedura e glicose e um método para preparar uma toxina botulínica usando os mesmos. o meio exclui produtos de origem animal e principais alérgenos e permite que a cepa produtora de toxina botulínica alcance o nível máximo de crescimento em um curto período de tempo, proporcionando então efeitos de encurtamento do tempo de produção e reduzindo o custo de produção no processo de produção de toxina botulínica.
BR112021019233A 2019-03-29 2020-03-12 Método para preparar toxina botulínica BR112021019233A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020190036921A KR102209159B1 (ko) 2019-03-29 2019-03-29 독소의 제조방법
PCT/KR2020/003458 WO2020204395A2 (ko) 2019-03-29 2020-03-12 독소의 제조방법

Publications (1)

Publication Number Publication Date
BR112021019233A2 true BR112021019233A2 (pt) 2021-11-30

Family

ID=72666801

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112021019233A BR112021019233A2 (pt) 2019-03-29 2020-03-12 Método para preparar toxina botulínica

Country Status (8)

Country Link
US (1) US20220195412A1 (pt)
EP (1) EP3950951A4 (pt)
KR (1) KR102209159B1 (pt)
CN (1) CN113811616A (pt)
BR (1) BR112021019233A2 (pt)
MX (1) MX2021011744A (pt)
TW (1) TWI748394B (pt)
WO (1) WO2020204395A2 (pt)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20230057586A1 (en) * 2019-08-16 2023-02-23 Janssen Biotech, Inc. Optimized culture media for clostridia bacteria
KR20240041474A (ko) * 2022-09-23 2024-04-01 (주)제테마 보툴리눔 독소 생산성을 증가시키는 방법

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7148041B2 (en) 2003-09-25 2006-12-12 Allergan, Inc. Animal product free media and processes for obtaining a botulinum toxin
WO2006042542A2 (en) * 2004-10-19 2006-04-27 Statens Serum Institut Production of tetanus, diphtheria, and pertussis toxins and toxoids using fermentation media containing no components of animal or soy origin
KR20090120222A (ko) * 2008-05-19 2009-11-24 (주)메디톡스 식물 유래 성분 함유 배지 및 가요성 폐쇄 용기를 이용하여클로스트리디움 보툴리눔 독소를 생산하는 방법
US8236356B2 (en) * 2008-06-11 2012-08-07 Roche Diagnostics Operations, Inc. Growth medium for Clostridium histolyticum
US8129139B2 (en) * 2009-07-13 2012-03-06 Allergan, Inc. Process for obtaining botulinum neurotoxin
KR101729251B1 (ko) * 2015-04-28 2017-04-21 주식회사 대웅 보툴리눔 독소의 제조를 위한 배지 조성물
KR101723167B1 (ko) * 2015-04-28 2017-04-05 주식회사 대웅 보툴리눔 독소의 제조를 위한 배지 조성물
CA3060669A1 (en) * 2017-04-28 2018-11-01 Bonti, Inc. Botulinum neurotoxins production methods
KR102197224B1 (ko) * 2019-03-29 2020-12-31 (주)제테마 배지 조성물
TW202136518A (zh) * 2019-12-20 2021-10-01 瑞士商葛德瑪控股公司 生產肉毒桿菌毒素的方法

Also Published As

Publication number Publication date
EP3950951A2 (en) 2022-02-09
US20220195412A1 (en) 2022-06-23
TW202102681A (zh) 2021-01-16
TWI748394B (zh) 2021-12-01
EP3950951A4 (en) 2023-03-29
KR102209159B1 (ko) 2021-01-29
KR20200114721A (ko) 2020-10-07
CN113811616A (zh) 2021-12-17
WO2020204395A2 (ko) 2020-10-08
WO2020204395A3 (ko) 2020-11-19
MX2021011744A (es) 2022-01-06

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