BR112021018704B1 - Derivado de heteroarila, método para produção do mesmo, e composição farmacêutica compreendendo a mesma como componente eficaz - Google Patents

Derivado de heteroarila, método para produção do mesmo, e composição farmacêutica compreendendo a mesma como componente eficaz Download PDF

Info

Publication number
BR112021018704B1
BR112021018704B1 BR112021018704-9A BR112021018704A BR112021018704B1 BR 112021018704 B1 BR112021018704 B1 BR 112021018704B1 BR 112021018704 A BR112021018704 A BR 112021018704A BR 112021018704 B1 BR112021018704 B1 BR 112021018704B1
Authority
BR
Brazil
Prior art keywords
amino
acrylamide
pyrimidin
isoxazolidin
methoxyphenyl
Prior art date
Application number
BR112021018704-9A
Other languages
English (en)
Portuguese (pt)
Other versions
BR112021018704A2 (fr
Inventor
Youn Ho Lee
Nam Doo Kim
Ju Hee Kang
Se In Kang
Hwan Kim
Seung Su Kim
Ji Yoon Seok
Yi Kyung Ko
Da Eun Kim
Ah Reum Han
Min Seok Ryu
Dong Keun Hwang
Eun Hwa Ko
Hwan Geun Choi
Sun Hwa Lee
Jung Beom Son
Original Assignee
Voronoi Inc.
Voronoibio Inc.
B2Sbio Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Voronoi Inc., Voronoibio Inc., B2Sbio Inc filed Critical Voronoi Inc.
Publication of BR112021018704A2 publication Critical patent/BR112021018704A2/pt
Publication of BR112021018704B1 publication Critical patent/BR112021018704B1/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5386—1,4-Oxazines, e.g. morpholine spiro-condensed or forming part of bridged ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/08—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
BR112021018704-9A 2019-03-19 2020-03-19 Derivado de heteroarila, método para produção do mesmo, e composição farmacêutica compreendendo a mesma como componente eficaz BR112021018704B1 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
KR10-2019-0031269 2019-03-19
KR20190031269 2019-03-19
KR20190134472 2019-10-28
KR10-2019-0134472 2019-10-28
PCT/KR2020/095044 WO2020190119A1 (fr) 2019-03-19 2020-03-19 Dérivé hétéroaryle, son procédé de production et composition pharmaceutique le comprenant en tant que constituant efficace

Publications (2)

Publication Number Publication Date
BR112021018704A2 BR112021018704A2 (fr) 2021-11-23
BR112021018704B1 true BR112021018704B1 (pt) 2023-01-10

Family

ID=72521153

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112021018704-9A BR112021018704B1 (pt) 2019-03-19 2020-03-19 Derivado de heteroarila, método para produção do mesmo, e composição farmacêutica compreendendo a mesma como componente eficaz

Country Status (15)

Country Link
US (2) US20220162203A1 (fr)
EP (1) EP3943491A4 (fr)
JP (2) JP7109013B2 (fr)
KR (2) KR102318875B1 (fr)
CN (3) CN114605400A (fr)
AU (2) AU2020240382B2 (fr)
BR (1) BR112021018704B1 (fr)
CA (1) CA3134261A1 (fr)
IL (2) IL299831A (fr)
MA (1) MA55380A (fr)
MX (1) MX2021011160A (fr)
NZ (1) NZ781366A (fr)
SG (1) SG11202110376XA (fr)
WO (1) WO2020190119A1 (fr)
ZA (1) ZA202107889B (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20220289733A1 (en) * 2019-03-19 2022-09-15 Voronoi Inc. Heteroaryl derivative, method for producing same, and pharmaceutical composition comprising same as effective component
NZ781366A (en) 2019-03-19 2022-08-26 Voronoi Inc Heteroaryl derivative, method for producing same, and pharmaceutical composition comprising same as effective component
TW202227425A (zh) * 2020-09-18 2022-07-16 南韓商沃若諾伊生物公司 雜芳基衍生物、彼之製法、及包含彼作為活性成份之藥學組成物
KR20220085735A (ko) * 2020-12-14 2022-06-22 보로노이바이오 주식회사 아이소옥사졸리딘 유도체 화합물 및 이의 용도
BR112023021111A2 (pt) 2021-04-13 2023-12-19 Nuvalent Inc Composto, composição farmacêutica, método de tratamento de câncer, método para inibir seletivamente her2, método de regulação de um nível de her2, método para aumentar um nível de her2, método de diminuição da fosforilação de her2
KR20220152508A (ko) * 2021-05-07 2022-11-16 보로노이바이오 주식회사 헤테로아릴 유도체, 이를 제조하는 방법, 및 이를 유효성분으로 포함하는 약학적 조성물
JP2024519626A (ja) * 2021-05-17 2024-05-21 ボロノイ インコーポレイテッド ヘテロアリール誘導体化合物およびその用途｛Ｈｅｔｅｒｏａｒｙｌ ｄｅｒｉｖａｔｉｖｅ ｃｏｍｐｏｕｎｄｓ，ａｎｄ ｕｓｅｓ ｔｈｅｒｅｏｆ｝
KR102563834B1 (ko) * 2021-06-28 2023-08-04 순천대학교 산학협력단 세포자멸사를 유도하는 신규한 화합물 및 이를 포함하는 항암용 조성물
WO2024096624A1 (fr) * 2022-11-03 2024-05-10 Voronoi Inc. Sels de fumarate, tartrate, malate et de citrate d'un inhibiteur d'egfr
WO2024097848A1 (fr) 2022-11-03 2024-05-10 Oric Pharmaceuticals, Inc. Sels de malonate et de glycolate d'un inhibiteur d'egfr
KR20240075718A (ko) * 2022-11-15 2024-05-29 보로노이 주식회사 헤테로아릴 유도체 화합물 및 이의 용도

Family Cites Families (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1506962B1 (fr) 2000-10-20 2008-07-02 Eisai R&D Management Co., Ltd. Hétérocycles aromatiques contenant de l'azote
EP1678147B1 (fr) 2003-09-15 2012-08-08 Lead Discovery Center GmbH Derives d'aminopyrimidine a disubstitution 4,6 actifs sur le plan pharmaceutique en tant que modulateurs des proteine kinases
EP1901747A2 (fr) 2005-05-25 2008-03-26 Ingenium Pharmaceuticals AG Inhibiteurs du cdk bases sur des pyrimidines destines au traitement de la douleur
US7569561B2 (en) 2006-02-22 2009-08-04 Boehringer Ingelheim International Gmbh 2,4-diaminopyrimidines useful for treating cell proliferation diseases
JP2010522188A (ja) 2007-03-20 2010-07-01 スミスクライン ビーチャム コーポレーション 化合物
TWI377944B (en) 2007-06-05 2012-12-01 Hanmi Holdings Co Ltd Novel amide derivative for inhibiting the growth of cancer cells
JP2011102241A (ja) 2008-03-04 2011-05-26 Dainippon Sumitomo Pharma Co Ltd 新規１−アミノカルボニルピペリジン誘導体
EP2467142B1 (fr) 2009-08-17 2016-09-21 Memorial Sloan-Kettering Cancer Center Dérivés 2-(pyrimidin-5-yl)-thiopyrimidine en tant que modulateurs Hsp70 and Hsc70 pour le traitement de maladies proliferatives
KR101401664B1 (ko) 2011-11-15 2014-06-11 중앙대학교 산학협력단 신경줄기세포 분화조절제용 신규 피리미딘-2,4-디아민 유도체 및 이의 의학적 용도
PL2804861T3 (pl) 2012-01-20 2018-08-31 Genosco Podstawione związki pirymidyny i ich zastosowanie jako inhibitory SYK
WO2013169401A1 (fr) 2012-05-05 2013-11-14 Ariad Pharmaceuticals, Inc. Composés pour inhiber la prolifération cellulaire dans les cancers induits par l'egfr
KR102194611B1 (ko) 2012-10-04 2020-12-23 유니버시티 오브 유타 리서치 파운데이션 티로신 수용체 키나아제 btk 억제제로서 치환된 n-(3-(피리미딘-4-일)페닐)아크릴아미드 유사체
EP2769722A1 (fr) 2013-02-22 2014-08-27 Ruprecht-Karls-Universität Heidelberg Composés utilisés pour inhiber un assemblage de capside du VIH
EA028033B1 (ru) 2013-03-14 2017-09-29 Новартис Аг 3-пиримидин-4-ил-оксазолидин-2-оны в качестве ингибиторов мутантного idh
PT3037424T (pt) 2013-08-22 2017-12-18 Taiho Pharmaceutical Co Ltd Novo composto substituído com quinolina
ES2742305T3 (es) 2013-10-21 2020-02-13 Merck Patent Gmbh Compuestos de heteroarilo como inhibidores de BTK y sus usos
KR20150047855A (ko) 2013-10-25 2015-05-06 한미약품 주식회사 단백질 카이네이즈 억제 효과를 갖는 2-사이아노-아크릴아마이드 유도체
US20170166598A1 (en) 2014-05-13 2017-06-15 Ariad Pharmaceuticals, Inc. Heteroaryl compounds for kinase inhibition
SI3157916T1 (sl) 2014-06-19 2019-05-31 Ariad Pharmaceuticals, Inc. Heteroarilne spojine za zaviranja kinaze
RU2702631C2 (ru) * 2014-10-11 2019-10-09 Шанхай Хэнсох Биомедикал Ко., Лтд. Ингибитор egfr и его получение и применение
KR102662358B1 (ko) * 2014-10-13 2024-04-30 주식회사유한양행 Egfr 돌연변이 키나아제 활성을 조절하기 위한 화합물 및 조성물
EP3206691B1 (fr) * 2014-10-14 2018-09-19 Sunshine Lake Pharma Co., Ltd. Composés hétéroaryle substitués et leurs méthodes d'utilisation
TWI739753B (zh) 2015-07-16 2021-09-21 大陸商正大天晴藥業集團股份有限公司 苯胺嘧啶衍生物及其用途
CN106478607B (zh) * 2015-08-28 2019-05-24 广东东阳光药业有限公司 取代的杂芳基化合物及其组合物和用途
CN106132957B (zh) * 2015-08-31 2018-06-12 无锡双良生物科技有限公司 2-芳胺基吡啶、嘧啶或三嗪衍生物及其制备方法和用途
WO2017096301A1 (fr) 2015-12-04 2017-06-08 Denali Therapeutics Inc. Inhibiteurs dérivés d'isoxazolidine de protéine kinase 1 interagissant avec un récepteur (ripk 1)
US10435388B2 (en) * 2016-01-07 2019-10-08 Cs Pharmatech Limited Selective inhibitors of clinically important mutants of the EGFR tyrosine kinase
WO2017156527A1 (fr) 2016-03-11 2017-09-14 H. Lee Moffitt Cancer Center And Research Institute, Inc. Inhibiteurs des kinases aurora et des janus kinases pour la prévention de la maladie du greffon contre l'hôte
US11072607B2 (en) 2016-12-16 2021-07-27 Genentech, Inc. Inhibitors of RIP1 kinase and methods of use thereof
US11352352B2 (en) * 2017-06-13 2022-06-07 Beijing Adamadle Biotechnology Limited Liability Company Aminopyrimidine compound, preparation method therefor and use thereof
CA3068854A1 (fr) * 2017-07-05 2019-01-10 Cs Pharmatech Limited Inhibiteurs selectifs de mutants cliniquement importants de la tyrosine kinase de l'egfr
WO2019081486A1 (fr) 2017-10-24 2019-05-02 Bayer Aktiengesellschaft Dérivés de 4h-pyrrolo[3,2-c]pyridin-4-one
CN108191774B (zh) 2018-01-31 2022-05-24 中国药科大学 一类杂环化合物、其制备方法和用途
TWI798334B (zh) 2018-01-31 2023-04-11 大陸商迪哲（江蘇）醫藥股份有限公司 Ｅｒｂｂ／ｂｔｋ抑制劑
KR20190108079A (ko) 2018-03-13 2019-09-23 보로노이바이오 주식회사 2,4,5-치환된 피리미딘 유도체, 이의 제조방법 및 이를 유효성분으로 포함하는 암의 예방 또는 치료용 약학적 조성물
KR20190108080A (ko) 2018-03-13 2019-09-23 보로노이바이오 주식회사 2,4,5-치환된 피리미딘 유도체, 이의 제조방법 및 이를 유효성분으로 포함하는 암 또는 염증질환의 예방 또는 치료용 약학적 조성물
US20210309640A1 (en) 2018-05-14 2021-10-07 ARIAD Pharmaceuticals, Inc, Pharmaceutical salts of pyrimidine derivatives and method of treating disorders
CN109280048A (zh) 2018-11-16 2019-01-29 江西科技师范大学 一种含取代苯基丙烯酰胺结构的嘧啶类化合物及其应用
CN109608394A (zh) 2018-12-03 2019-04-12 湖南大学 氮杂芳胺类化合物的合成方法和氮杂芳胺类化合物
NZ781366A (en) * 2019-03-19 2022-08-26 Voronoi Inc Heteroaryl derivative, method for producing same, and pharmaceutical composition comprising same as effective component

Also Published As

Publication number Publication date
AU2020240382A1 (en) 2021-11-11
CN115838369A (zh) 2023-03-24
US20220162203A1 (en) 2022-05-26
WO2020190119A1 (fr) 2020-09-24
BR112021018704A2 (fr) 2021-11-23
EP3943491A4 (fr) 2022-11-23
CN114605400A (zh) 2022-06-10
JP7394298B2 (ja) 2023-12-08
AU2020240382B2 (en) 2022-08-25
JP2022125283A (ja) 2022-08-26
ZA202107889B (en) 2024-02-28
KR20210130123A (ko) 2021-10-29
IL286471A (en) 2021-12-01
EP3943491A1 (fr) 2022-01-26
KR102564533B1 (ko) 2023-08-08
JP7109013B2 (ja) 2022-07-29
AU2022211789A1 (en) 2022-08-25
AU2022211789B2 (en) 2024-06-27
IL286471B2 (en) 2023-08-01
JP2022522250A (ja) 2022-04-14
MX2021011160A (es) 2022-02-10
US20220073505A1 (en) 2022-03-10
IL299831A (en) 2023-03-01
CN113993866B (zh) 2022-10-28
IL286471B1 (en) 2023-04-01
MA55380A (fr) 2022-01-26
CA3134261A1 (fr) 2020-09-24
KR102318875B1 (ko) 2021-11-01
NZ781366A (en) 2022-08-26
CN113993866A (zh) 2022-01-28
SG11202110376XA (en) 2021-10-28
KR20200111644A (ko) 2020-09-29
US11466000B2 (en) 2022-10-11

Similar Documents

Publication Publication Date Title
BR112021018704B1 (pt) Derivado de heteroarila, método para produção do mesmo, e composição farmacêutica compreendendo a mesma como componente eficaz
HUE033177T2 (en) Pyrazine is a carboxamide compound
CN117255792A (zh) 杂芳基衍生物、其制备方法以及包括其作为活性成分的药物组合物
CN113853375B (zh) 含n杂芳基衍生物及包含其作为活性成分的用于预防或治疗癌症的药物组合物
KR102607051B1 (ko) 헤테로아릴 유도체 화합물 및 이의 용도
KR20230143959A (ko) 헤테로아릴 유도체 및 이의 용도
CN116194111A (zh) 杂芳基衍生物、其制备方法、及包含其作为活性成分的药物组合物
KR102682516B1 (ko) 퀴놀린 구조를 갖는 pan-kit 키나제 억제제 및 이의 용도
US20220289733A1 (en) Heteroaryl derivative, method for producing same, and pharmaceutical composition comprising same as effective component
CA3188077A1 (fr) Inhibiteur d'egfr, son procede de preparation et son utilisation
TW202212335A (zh) 雜芳基衍生物、其製備方法、及含彼作為活性成份之藥學組成物
NZ790920A (en) Heteroaryl derivative, method for producing the same, and pharmaceutical composition comprising same as effective component
EA044405B1 (ru) N-содержащее производное гетероарила и фармацевтическая композиция, содержащая его в качестве активного ингредиента для предупреждения или лечения рака
KR20240109270A (ko) Egfr 단백질 분해용 화합물 및 이의 용도
EA041448B1 (ru) Гетероарильное производное и содержащая его фармацевтическая композиция

Legal Events

Date Code Title Description
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 19/03/2020, OBSERVADAS AS CONDICOES LEGAIS