BR112021001878A2 - métodos de terapia genética para o controle da função do órgão - Google Patents
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Classifications
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
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- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
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- A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70571—Receptors; Cell surface antigens; Cell surface determinants for neuromediators, e.g. serotonin receptor, dopamine receptor
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
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- C12N2750/14141—Use of virus, viral particle or viral elements as a vector
- C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
Landscapes
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- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
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| US201862712669P | 2018-07-31 | 2018-07-31 | |
| US62/712,669 | 2018-07-31 | ||
| PCT/US2019/044290 WO2020028466A1 (en) | 2018-07-31 | 2019-07-31 | Gene therapy methods to control organ function |
Publications (1)
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| BR112021001878A2 true BR112021001878A2 (pt) | 2021-04-27 |
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| BR112021001878-6A BR112021001878A2 (pt) | 2018-07-31 | 2019-07-31 | métodos de terapia genética para o controle da função do órgão |
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| Country | Link |
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| US (1) | US20210301306A1 (https=) |
| EP (1) | EP3829718A4 (https=) |
| JP (2) | JP2021533126A (https=) |
| KR (1) | KR20210052450A (https=) |
| CN (1) | CN113301956B (https=) |
| AU (1) | AU2019315445A1 (https=) |
| BR (1) | BR112021001878A2 (https=) |
| CA (1) | CA3108324A1 (https=) |
| EA (1) | EA202190358A1 (https=) |
| IL (1) | IL280531A (https=) |
| MX (1) | MX2021001336A (https=) |
| PH (1) | PH12021550243A1 (https=) |
| SG (1) | SG11202101042SA (https=) |
| WO (1) | WO2020028466A1 (https=) |
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| US20150111918A1 (en) | 2012-03-08 | 2015-04-23 | Medtronic Ardian Luxembourg S.a.r.l | Immune system neuromodulation and associated systems and methods |
| EP3226795B1 (en) | 2014-12-03 | 2020-08-26 | Metavention, Inc. | Systems for modulating nerves or other tissue |
| US10524859B2 (en) | 2016-06-07 | 2020-01-07 | Metavention, Inc. | Therapeutic tissue modulation devices and methods |
| CN115707773A (zh) * | 2021-08-20 | 2023-02-21 | 中国科学院深圳先进技术研究院 | 一种利用交感神经控制血管内皮细胞异质性的方法 |
| WO2023019565A1 (zh) * | 2021-08-20 | 2023-02-23 | 中国科学院深圳先进技术研究院 | 一种利用交感神经控制血管内皮细胞异质性的方法 |
| CN116019909B (zh) * | 2022-09-16 | 2025-07-29 | 上海市第十人民医院 | 一种CRISPR/Cas9纳米系统 |
| CN116115758B (zh) * | 2022-11-22 | 2024-12-03 | 上海市内分泌代谢病研究所 | Gabaa受体作为靶点在制备或筛选降血脂、治疗肥胖和/或改善代谢的药物中的应用 |
| CN121313878A (zh) * | 2024-12-04 | 2026-01-13 | 良渚实验室 | 治疗帕金森病的化学遗传学基因治疗新方案 |
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| US4797368A (en) | 1985-03-15 | 1989-01-10 | The United States Of America As Represented By The Department Of Health And Human Services | Adeno-associated virus as eukaryotic expression vector |
| US4863457A (en) | 1986-11-24 | 1989-09-05 | Lee David A | Drug delivery device |
| US5378475A (en) | 1991-02-21 | 1995-01-03 | University Of Kentucky Research Foundation | Sustained release drug delivery devices |
| US5814618A (en) | 1993-06-14 | 1998-09-29 | Basf Aktiengesellschaft | Methods for regulating gene expression |
| US5464758A (en) | 1993-06-14 | 1995-11-07 | Gossen; Manfred | Tight control of gene expression in eucaryotic cells by tetracycline-responsive promoters |
| US5443505A (en) | 1993-11-15 | 1995-08-22 | Oculex Pharmaceuticals, Inc. | Biocompatible ocular implants |
| US6342390B1 (en) | 1994-11-23 | 2002-01-29 | The United States Of America As Represented By The Secretary Of Health And Human Services | Lipid vesicles containing adeno-associated virus rep protein for transgene integration and gene therapy |
| FR2814642B1 (fr) | 2000-10-03 | 2005-07-01 | Ass Pour Le Dev De La Rech En | Souris transgenique pour la recombinaison ciblee mediee par la cre-er modifiee |
| US6723551B2 (en) | 2001-11-09 | 2004-04-20 | The United States Of America As Represented By The Department Of Health And Human Services | Production of adeno-associated virus in insect cells |
| JP2009523006A (ja) * | 2004-05-07 | 2009-06-18 | アプレラ コーポレイション | 脈管疾患に関連する遺伝的多型、その検出方法および使用 |
| ES2525067T3 (es) * | 2005-04-07 | 2014-12-17 | The Trustees Of The University Of Pennsylvania | Método de incremento de la función de un vector de AAV |
| EP2561073B1 (en) * | 2010-04-23 | 2016-08-24 | University of Massachusetts | Cns targeting aav vectors and methods of use thereof |
| KR20150020250A (ko) * | 2012-06-19 | 2015-02-25 | 유니버시티 오브 플로리다 리서치 파운데이션, 인코포레이티드 | 당뇨병을 치료하기 위한 조성물 및 방법 |
| GB201403684D0 (en) * | 2014-03-03 | 2014-04-16 | King S College London | Vector |
| EP3200830B1 (en) * | 2014-10-03 | 2020-09-09 | University of Massachusetts | High efficiency library-identified aav vectors |
| AU2016324317A1 (en) * | 2015-09-17 | 2018-03-08 | Coda Biotherapeutics, Inc. | Compositions and methods for treating neurological disorders |
| CA3011939A1 (en) * | 2016-02-02 | 2017-08-10 | University Of Massachusetts | Method to enhance the efficiency of systemic aav gene delivery to the central nervous system |
| US20170218842A1 (en) * | 2016-02-02 | 2017-08-03 | General Electric Company | Adjusting Airflow Distortion in Gas Turbine Engine |
| CA3014732A1 (en) * | 2016-03-09 | 2017-09-14 | Fadi ASSAF | Using dreadd for neuronal modulation in treating neuronal |
| MA44546B1 (fr) * | 2016-06-15 | 2021-03-31 | Univ California | Virus adéno-associés variants et procédés d'utilisation |
| WO2018008770A1 (ja) * | 2016-07-06 | 2018-01-11 | 国立研究開発法人国立循環器病研究センター | 末梢神経を操作する方法、脳および脊髄を除く臓器などにおいて神経細胞機能を変化させる機能を発生させる方法、および新規疾病の予防または治療方法、ならびに末梢神経投与用医薬 |
| MX2022004812A (es) * | 2019-10-22 | 2023-02-23 | Applied Genetic Tech Corporation | Sistemas de virus adeno-asociados (aav) para el tratamiento de enfermedades o trastornos neurodegenerativos asociados a la progranulina. |
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| KR20210052450A (ko) | 2021-05-10 |
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| EA202190358A1 (ru) | 2021-05-04 |
| CA3108324A1 (en) | 2020-02-06 |
| JP2024041871A (ja) | 2024-03-27 |
| JP2021533126A (ja) | 2021-12-02 |
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