BR112020002351A2 - di-hidro-oxadiazinonas - Google Patents

di-hidro-oxadiazinonas Download PDF

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Publication number
BR112020002351A2
BR112020002351A2 BR112020002351-5A BR112020002351A BR112020002351A2 BR 112020002351 A2 BR112020002351 A2 BR 112020002351A2 BR 112020002351 A BR112020002351 A BR 112020002351A BR 112020002351 A2 BR112020002351 A2 BR 112020002351A2
Authority
BR
Brazil
Prior art keywords
group
oxadiazin
dihydro
trifluoromethyl
phenyl
Prior art date
Application number
BR112020002351-5A
Other languages
English (en)
Portuguese (pt)
Inventor
Manuel ELLERMANN
Heidi Greulich
Xiaoyun Wu
Matthew Meyerson
Alex Burgin
Stefan Nikolaus GRADL
Charlotte Christine Kopitz
Martin Lange
Adrian Tersteegen
Philip Lienau
Christa Hegele-Hartung
Detlev Sülzle
Timothy A. Lewis
Original Assignee
Bayer Aktiengesellschaft
Bayer Pharma Aktiengesellschaft
The Broad Institute, Inc
Dana-Farber Cancer Institute, Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Aktiengesellschaft, Bayer Pharma Aktiengesellschaft, The Broad Institute, Inc, Dana-Farber Cancer Institute, Inc filed Critical Bayer Aktiengesellschaft
Publication of BR112020002351A2 publication Critical patent/BR112020002351A2/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines having two or more nitrogen atoms in the same ring, e.g. oxadiazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
    • C07D273/02—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00 having two nitrogen atoms and only one oxygen atom
    • C07D273/04—Six-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/10—Spiro-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Catalysts (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
BR112020002351-5A 2017-08-04 2018-08-02 di-hidro-oxadiazinonas BR112020002351A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762541627P 2017-08-04 2017-08-04
US62/541,627 2017-08-04
PCT/EP2018/071039 WO2019025562A1 (en) 2017-08-04 2018-08-02 DIHYDROOXADIAZINONES

Publications (1)

Publication Number Publication Date
BR112020002351A2 true BR112020002351A2 (pt) 2020-09-08

Family

ID=63207725

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112020002351-5A BR112020002351A2 (pt) 2017-08-04 2018-08-02 di-hidro-oxadiazinonas

Country Status (26)

Country Link
US (3) US11427553B2 (cg-RX-API-DMAC7.html)
EP (1) EP3661517B1 (cg-RX-API-DMAC7.html)
JP (2) JP7676141B2 (cg-RX-API-DMAC7.html)
KR (1) KR20200036914A (cg-RX-API-DMAC7.html)
CN (1) CN111212647B (cg-RX-API-DMAC7.html)
AR (1) AR112402A1 (cg-RX-API-DMAC7.html)
AU (1) AU2018309356B2 (cg-RX-API-DMAC7.html)
BR (1) BR112020002351A2 (cg-RX-API-DMAC7.html)
CA (1) CA3071800A1 (cg-RX-API-DMAC7.html)
CL (1) CL2020000303A1 (cg-RX-API-DMAC7.html)
CO (1) CO2020001242A2 (cg-RX-API-DMAC7.html)
CR (1) CR20200057A (cg-RX-API-DMAC7.html)
CU (1) CU24608B1 (cg-RX-API-DMAC7.html)
EA (1) EA202090448A1 (cg-RX-API-DMAC7.html)
EC (1) ECSP20008441A (cg-RX-API-DMAC7.html)
IL (1) IL272098B2 (cg-RX-API-DMAC7.html)
JO (1) JOP20200024A1 (cg-RX-API-DMAC7.html)
MA (1) MA49750A (cg-RX-API-DMAC7.html)
MX (1) MX2020001404A (cg-RX-API-DMAC7.html)
PE (1) PE20200936A1 (cg-RX-API-DMAC7.html)
PH (1) PH12020500134A1 (cg-RX-API-DMAC7.html)
SG (1) SG11201913775UA (cg-RX-API-DMAC7.html)
TW (1) TWI791581B (cg-RX-API-DMAC7.html)
UA (1) UA125731C2 (cg-RX-API-DMAC7.html)
UY (1) UY37832A (cg-RX-API-DMAC7.html)
WO (1) WO2019025562A1 (cg-RX-API-DMAC7.html)

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TW202031677A (zh) 2018-11-01 2020-09-01 美商博得學院股份有限公司 Ｐｄｅ３調節劑反應性癌症之鑑定
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AU2020215088A1 (en) 2019-02-01 2021-07-22 Bayer Aktiengesellschaft 1,2,4-triazin-3(2H)-one compounds for the treatment of hyperproliferative diseases
CN117279644A (zh) 2021-03-03 2023-12-22 拜耳股份有限公司 用于治疗肉瘤的取代的3,6-二氢-2h-1,3,4-噁二嗪-2-酮
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CN117903077B (zh) * 2023-01-13 2024-09-03 上海超阳药业有限公司 二氢噁二嗪酮化合物及其应用
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TW202031677A (zh) 2018-11-01 2020-09-01 美商博得學院股份有限公司 Ｐｄｅ３調節劑反應性癌症之鑑定
AU2020215088A1 (en) 2019-02-01 2021-07-22 Bayer Aktiengesellschaft 1,2,4-triazin-3(2H)-one compounds for the treatment of hyperproliferative diseases

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Publication number Publication date
CU20200008A7 (es) 2020-11-30
KR20200036914A (ko) 2020-04-07
WO2019025562A1 (en) 2019-02-07
US11773070B2 (en) 2023-10-03
PE20200936A1 (es) 2020-09-17
IL272098A (en) 2020-03-31
CL2020000303A1 (es) 2020-11-13
CR20200057A (es) 2020-06-16
EP3661517B1 (en) 2023-09-13
CN111212647B (zh) 2024-05-14
CO2020001242A2 (es) 2020-02-18
US12258323B2 (en) 2025-03-25
UY37832A (es) 2019-02-28
US11427553B2 (en) 2022-08-30
AR112402A1 (es) 2019-10-23
PH12020500134A1 (en) 2021-01-25
CN111212647A (zh) 2020-05-29
AU2018309356A1 (en) 2020-01-30
CA3071800A1 (en) 2019-02-07
ECSP20008441A (es) 2020-05-29
JP2023115065A (ja) 2023-08-18
MX2020001404A (es) 2020-03-12
JOP20200024A1 (ar) 2020-02-02
MA49750A (fr) 2020-06-10
IL272098B1 (en) 2023-03-01
TWI791581B (zh) 2023-02-11
TW201917126A (zh) 2019-05-01
JP7676141B2 (ja) 2025-05-14
EP3661517A1 (en) 2020-06-10
US20220396554A1 (en) 2022-12-15
AU2018309356B2 (en) 2022-12-15
JP2020529439A (ja) 2020-10-08
CU24608B1 (es) 2022-06-06
SG11201913775UA (en) 2020-01-30
EA202090448A1 (ru) 2020-05-21
UA125731C2 (uk) 2022-05-25
IL272098B2 (en) 2023-07-01
US20200369633A1 (en) 2020-11-26
US20230017200A1 (en) 2023-01-19

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Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2786 DE 28-05-2024 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.