BR112020002050A2 - epimerases engenheiradas alcaloides benzilisoquinolina e métodos de produção de alcaloides benzilisoquinolina - Google Patents
epimerases engenheiradas alcaloides benzilisoquinolina e métodos de produção de alcaloides benzilisoquinolina Download PDFInfo
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- BR112020002050A2 BR112020002050A2 BR112020002050-8A BR112020002050A BR112020002050A2 BR 112020002050 A2 BR112020002050 A2 BR 112020002050A2 BR 112020002050 A BR112020002050 A BR 112020002050A BR 112020002050 A2 BR112020002050 A2 BR 112020002050A2
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- engineered
- epimerase
- alkaloid
- benzylisoquinoline
- enzyme
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- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
- C12N9/0014—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on the CH-NH2 group of donors (1.4)
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- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
- C12N9/0026—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on CH-NH groups of donors (1.5)
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- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/10—Nitrogen as only ring hetero atom
- C12P17/12—Nitrogen as only ring hetero atom containing a six-membered hetero ring
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- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
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- C12Y105/01—Oxidoreductases acting on the CH-NH group of donors (1.5) with NAD+ or NADP+ as acceptor (1.5.1)
- C12Y105/01027—1,2-Dehydroreticulinium reductase (NADPH) (1.5.1.27)
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- C12Y114/19—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14) with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water (1.14.19)
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- C12Y501/00—Racemaces and epimerases (5.1)
- C12Y501/01—Racemaces and epimerases (5.1) acting on amino acids and derivatives (5.1.1)
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- Biophysics (AREA)
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- Proteomics, Peptides & Aminoacids (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762541038P | 2017-08-03 | 2017-08-03 | |
| US62/541,038 | 2017-08-03 | ||
| PCT/US2018/045222 WO2019028390A1 (en) | 2017-08-03 | 2018-08-03 | ALKALOID BENZYLISOQUINOLEIN GENETICALLY MODIFIED EPIMERASES AND METHODS FOR PRODUCING BENZYLISOQUINOLINE ALKALOIDS |
Publications (1)
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| BR112020002050A2 true BR112020002050A2 (pt) | 2020-09-08 |
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| BR112020002050-8A BR112020002050A2 (pt) | 2017-08-03 | 2018-08-03 | epimerases engenheiradas alcaloides benzilisoquinolina e métodos de produção de alcaloides benzilisoquinolina |
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| Country | Link |
|---|---|
| US (2) | US10544420B2 (https=) |
| JP (1) | JP7199417B2 (https=) |
| BR (1) | BR112020002050A2 (https=) |
| GB (1) | GB2579940B (https=) |
| IL (1) | IL272363A (https=) |
| WO (1) | WO2019028390A1 (https=) |
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| EP3475426A4 (en) | 2016-06-27 | 2020-08-19 | Serturner Corp. | POLYNUCLEOTIDES AND POLYPEPTIDES USEFUL FOR THE MANUFACTURE OF ALKALOID COMPOUNDS |
| WO2019028390A1 (en) | 2017-08-03 | 2019-02-07 | Antheia, Inc. | ALKALOID BENZYLISOQUINOLEIN GENETICALLY MODIFIED EPIMERASES AND METHODS FOR PRODUCING BENZYLISOQUINOLINE ALKALOIDS |
| US20200325509A1 (en) * | 2017-09-08 | 2020-10-15 | Intrexon Corporation | Microorganisms and Methods in the Fermentation of Benzylisoquinoline Alkaloids |
| WO2019157383A2 (en) * | 2018-02-08 | 2019-08-15 | Antheia, Inc. | Methods of producing morphinan alkaloids and derivatives |
| WO2020198373A1 (en) * | 2019-03-26 | 2020-10-01 | Antheia, Inc. | Methods of improving production of morphinan alkaloids and derivatives |
| EP3988663A4 (en) * | 2019-06-24 | 2023-08-02 | Ishikawa Prefectural Public University Corporation | Production method of (r)-reticulin |
| CN110179859B (zh) * | 2019-06-27 | 2021-09-24 | 香港科技大学深圳研究院 | 防己提取物及防己诺林碱在制药中的应用 |
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