JP7199417B2 - 遺伝子操作されたベンジルイソキノリンアルカロイドエピメラーゼおよびベンジルイソキノリンアルカロイドの生成方法 - Google Patents

遺伝子操作されたベンジルイソキノリンアルカロイドエピメラーゼおよびベンジルイソキノリンアルカロイドの生成方法 Download PDF

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JP7199417B2
JP7199417B2 JP2020505492A JP2020505492A JP7199417B2 JP 7199417 B2 JP7199417 B2 JP 7199417B2 JP 2020505492 A JP2020505492 A JP 2020505492A JP 2020505492 A JP2020505492 A JP 2020505492A JP 7199417 B2 JP7199417 B2 JP 7199417B2
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genetically engineered
epimerase
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benzylisoquinoline
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クリスティーナ ディー． スモルケ
デレク エイチ． ウェルズ
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アンテイア インコーポレイテッド
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    • C12N9/0014—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on the CH-NH2 group of donors (1.4)
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    • C12N9/0026—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on CH-NH groups of donors (1.5)
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    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/10—Nitrogen as only ring hetero atom
    • C12P17/12—Nitrogen as only ring hetero atom containing a six-membered hetero ring
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    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
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    • C12Y105/00—Oxidoreductases acting on the CH-NH group of donors (1.5)
    • C12Y105/01—Oxidoreductases acting on the CH-NH group of donors (1.5) with NAD+ or NADP+ as acceptor (1.5.1)
    • C12Y105/01027—1,2-Dehydroreticulinium reductase (NADPH) (1.5.1.27)
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    • C12Y114/00—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14)
    • C12Y114/19—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14) with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water (1.14.19)
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    • C12Y501/00—Racemaces and epimerases (5.1)
    • C12Y501/01—Racemaces and epimerases (5.1) acting on amino acids and derivatives (5.1.1)

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JP2020505492A 2017-08-03 2018-08-03 遺伝子操作されたベンジルイソキノリンアルカロイドエピメラーゼおよびベンジルイソキノリンアルカロイドの生成方法 Active JP7199417B2 (ja)

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US201762541038P 2017-08-03 2017-08-03
US62/541,038 2017-08-03
PCT/US2018/045222 WO2019028390A1 (en) 2017-08-03 2018-08-03 ALKALOID BENZYLISOQUINOLEIN GENETICALLY MODIFIED EPIMERASES AND METHODS FOR PRODUCING BENZYLISOQUINOLINE ALKALOIDS

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CN110179859B (zh) * 2019-06-27 2021-09-24 香港科技大学深圳研究院 防己提取物及防己诺林碱在制药中的应用
US20230332195A1 (en) * 2019-10-10 2023-10-19 River Stone Biotech Aps Genetically modified host cells producing benzylisoquinoline alkaloids
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CN116463310B (zh) * 2022-11-11 2024-08-20 浙江中医药大学 一种粉防己4’-氧甲基转移酶4’-omt及应用

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US20200157551A1 (en) 2020-05-21
BR112020002050A2 (pt) 2020-09-08
GB2579940A (en) 2020-07-08
US20190078100A1 (en) 2019-03-14
GB2579940B (en) 2022-11-30
US10544420B2 (en) 2020-01-28
WO2019028390A1 (en) 2019-02-07
IL272363A (en) 2020-03-31
US11427827B2 (en) 2022-08-30
GB202002867D0 (en) 2020-04-15

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