BR112019023014A2 - constructos de lamp aperfeiçoados compreendendo antígenos de câncer - Google Patents

constructos de lamp aperfeiçoados compreendendo antígenos de câncer Download PDF

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Publication number
BR112019023014A2
BR112019023014A2 BR112019023014A BR112019023014A BR112019023014A2 BR 112019023014 A2 BR112019023014 A2 BR 112019023014A2 BR 112019023014 A BR112019023014 A BR 112019023014A BR 112019023014 A BR112019023014 A BR 112019023014A BR 112019023014 A2 BR112019023014 A2 BR 112019023014A2
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Prior art keywords
lamp constructs
improved lamp
constructs
cancer antigens
improved
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BR112019023014A
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English (en)
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Heiland Teri
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Immunomic Therapeutics Inc
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Publication of BR112019023014A2 publication Critical patent/BR112019023014A2/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/82—Translation products from oncogenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/64—Medicinal preparations containing antigens or antibodies characterised by the architecture of the carrier-antigen complex, e.g. repetition of carrier-antigen units
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)

Abstract

a presente invenção fornece constructos de lamp aperfeiçoados compreendendo fragmentos específicos do domínio luminal de lamp para liberar antígenos de câncer às células imunes para processamento acentuado. estes constructos de lamp podem ser usados para o tratamento de doenças e, em particular, transtornos hiperproliferativos e/ou câncer. os constructos de lamp aperfeiçoados permitem a apresentação de epítopos tridimensionais adequadamente configurados para a produção de uma resposta imune quando administrados a um indivíduo. os constructos de lamp aperfeiçoados podem ser moléculas multivalentes e/ou podem ser fornecidos como parte de uma vacina multivalente contendo dois ou mais constructos de lamp. os constructos de lamp aperfeiçoados, conforme descrito neste relatório, também podem ser usados para gerar anticorpos quando administrados a um vertebrado não humano.
BR112019023014A 2017-05-02 2018-05-02 constructos de lamp aperfeiçoados compreendendo antígenos de câncer BR112019023014A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762500053P 2017-05-02 2017-05-02
US201762561760P 2017-09-22 2017-09-22
PCT/US2018/030725 WO2018204534A1 (en) 2017-05-02 2018-05-02 Lamp (lysosomal associated membrane protein) constructs comprising cancer antigens

Publications (1)

Publication Number Publication Date
BR112019023014A2 true BR112019023014A2 (pt) 2020-05-19

Family

ID=62528827

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112019023014A BR112019023014A2 (pt) 2017-05-02 2018-05-02 constructos de lamp aperfeiçoados compreendendo antígenos de câncer

Country Status (10)

Country Link
US (1) US20200087365A1 (pt)
EP (1) EP3618854A1 (pt)
JP (3) JP7222915B2 (pt)
KR (2) KR20200016224A (pt)
CN (1) CN110913892A (pt)
AU (1) AU2018263923B9 (pt)
BR (1) BR112019023014A2 (pt)
CA (1) CA3061950A1 (pt)
IL (2) IL270271B2 (pt)
WO (1) WO2018204534A1 (pt)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019222281A1 (en) * 2018-05-15 2019-11-21 Immunomic Therapeutics, Inc Improved lamp constructs comprising allergens
AU2020366515A1 (en) * 2019-10-18 2022-04-21 Immunomic Therapeutics, Inc. Improved lamp constructs comprising cancer antigens
TWI828126B (zh) * 2021-04-27 2024-01-01 中央研究院 用以治療高三酸甘油脂血症或其相關疾病的方法
AU2023254186A1 (en) 2022-04-10 2024-10-17 Immunomic Therapeutics, Inc. Bicistronic lamp constructs comprising immune response enhancing genes and methods of use thereof

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AU2018263923A1 (en) 2019-10-31
EP3618854A1 (en) 2020-03-11
JP2020518613A (ja) 2020-06-25
AU2018263923B2 (en) 2024-08-22
IL270271B (en) 2022-11-01
IL270271A (pt) 2019-12-31
IL297073B2 (en) 2023-12-01
IL297073B1 (en) 2023-08-01
IL270271B2 (en) 2023-03-01
JP2024037951A (ja) 2024-03-19
CN110913892A (zh) 2020-03-24
CA3061950A1 (en) 2018-11-08
KR20200016224A (ko) 2020-02-14
WO2018204534A1 (en) 2018-11-08
IL297073A (en) 2022-12-01
JP7407902B2 (ja) 2024-01-04
US20200087365A1 (en) 2020-03-19
AU2018263923B9 (en) 2024-09-19
JP7222915B2 (ja) 2023-02-15
JP2023036863A (ja) 2023-03-14
KR20240027895A (ko) 2024-03-04

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