BR112018067323A2 - micro-organismos e métodos para a coprodução de etileno glicol e três compostos de carbono - Google Patents

micro-organismos e métodos para a coprodução de etileno glicol e três compostos de carbono

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Publication number
BR112018067323A2
BR112018067323A2 BR112018067323A BR112018067323A BR112018067323A2 BR 112018067323 A2 BR112018067323 A2 BR 112018067323A2 BR 112018067323 A BR112018067323 A BR 112018067323A BR 112018067323 A BR112018067323 A BR 112018067323A BR 112018067323 A2 BR112018067323 A2 BR 112018067323A2
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Prior art keywords
carbon compounds
meg
production
methods
recombinant microorganisms
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BR112018067323A
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English (en)
Inventor
Fernanda Beraldi Zeidler Ane
Johannes Koch Daniel
Pedersen Parizzi Lucas
Schreiner Lopes Mateus
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Braskem Sa
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Application filed by Braskem Sa filed Critical Braskem Sa
Publication of BR112018067323A2 publication Critical patent/BR112018067323A2/pt

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0008—Oxidoreductases (1.) acting on the aldehyde or oxo group of donors (1.2)
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/13—Transferases (2.) transferring sulfur containing groups (2.8)
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/90—Isomerases (5.)
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    • C12P5/00—Preparation of hydrocarbons or halogenated hydrocarbons
    • C12P5/02—Preparation of hydrocarbons or halogenated hydrocarbons acyclic
    • C12P5/026—Unsaturated compounds, i.e. alkenes, alkynes or allenes
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    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
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    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
    • C12P7/18—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic polyhydric
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    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/24—Preparation of oxygen-containing organic compounds containing a carbonyl group
    • C12P7/26—Ketones
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    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/24—Preparation of oxygen-containing organic compounds containing a carbonyl group
    • C12P7/26—Ketones
    • C12P7/28—Acetone-containing products
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    • C12Y—ENZYMES
    • C12Y102/00—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2)
    • C12Y102/01—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2) with NAD+ or NADP+ as acceptor (1.2.1)
    • C12Y102/01021—Glycolaldehyde dehydrogenase (1.2.1.21)
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    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/01—Phosphotransferases with an alcohol group as acceptor (2.7.1)
    • C12Y207/01047—D-Ribulokinase (2.7.1.47)
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    • C12Y—ENZYMES
    • C12Y208/00—Transferases transferring sulfur-containing groups (2.8)
    • C12Y208/03—CoA-transferases (2.8.3)
    • C12Y208/03008—Acetate CoA-transferase (2.8.3.8)
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    • C12Y—ENZYMES
    • C12Y401/00—Carbon-carbon lyases (4.1)
    • C12Y401/02—Aldehyde-lyases (4.1.2)
    • C12Y401/02013—Fructose-bisphosphate aldolase (4.1.2.13)
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    • C12Y—ENZYMES
    • C12Y501/00—Racemaces and epimerases (5.1)
    • C12Y501/03—Racemaces and epimerases (5.1) acting on carbohydrates and derivatives (5.1.3)
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    • C12P2203/00—Fermentation products obtained from optionally pretreated or hydrolyzed cellulosic or lignocellulosic material as the carbon source
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y203/00—Acyltransferases (2.3)
    • C12Y203/01—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C12Y203/01009—Acetyl-CoA C-acetyltransferase (2.3.1.9)
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y401/00—Carbon-carbon lyases (4.1)
    • C12Y401/01—Carboxy-lyases (4.1.1)
    • C12Y401/01004—Acetoacetate decarboxylase (4.1.1.4)

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

o presente pedido refere-se a micro-organismos recombinantes úteis na biossíntese de monoetileno glicol (meg) e um ou mais compostos de três carbonos tais como acetona, isopropanol ou propeno. o meg e um ou mais compostos de três carbonos aqui descritos são úteis como material de partida para a produção de outros compostos ou como produtos finais para uso industrial e doméstico. o pedido ainda refere-se a micro-organismos recombinantes que coexpressam uma via de ramificação c2 e uma via de ramificação c3 para a produção de meg e um ou mais compostos de três carbonos. também são fornecidos métodos de produção de meg e um ou mais compostos de três carbonos utilizando os micro-organismos recombinantes, assim como composições compreendendo os micro-organismos recombinantes e/ou opcionalmente os produtos meg e um ou mais compostos de três carbonos.
BR112018067323A 2016-03-09 2017-03-08 micro-organismos e métodos para a coprodução de etileno glicol e três compostos de carbono BR112018067323A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662305814P 2016-03-09 2016-03-09
US201662430742P 2016-12-06 2016-12-06
PCT/US2017/021421 WO2017156166A1 (en) 2016-03-09 2017-03-08 Microorganisms and methods for the co-production of ethylene glycol and three carbon compounds

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US (3) US10774347B2 (pt)
EP (1) EP3426789A4 (pt)
JP (1) JP7050691B2 (pt)
KR (1) KR20190004258A (pt)
CN (1) CN109312373B (pt)
AU (1) AU2017231728B2 (pt)
BR (1) BR112018067323A2 (pt)
WO (1) WO2017156166A1 (pt)

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US20180179558A1 (en) 2018-06-28
US20170260551A1 (en) 2017-09-14
AU2017231728B2 (en) 2021-12-16
EP3426789A4 (en) 2020-01-08
US10774348B2 (en) 2020-09-15
US20180023101A1 (en) 2018-01-25
CN109312373A (zh) 2019-02-05
EP3426789A1 (en) 2019-01-16
US10941424B2 (en) 2021-03-09
US10774347B2 (en) 2020-09-15
CN109312373B (zh) 2022-07-19
AU2017231728A1 (en) 2018-08-30
JP7050691B2 (ja) 2022-04-08
WO2017156166A1 (en) 2017-09-14
KR20190004258A (ko) 2019-01-11
JP2019507604A (ja) 2019-03-22

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