BR112018016396A2 - composto, composição farmacêutica, uso de um composto, e, método para tratar um distúrbio - Google Patents
composto, composição farmacêutica, uso de um composto, e, método para tratar um distúrbioInfo
- Publication number
- BR112018016396A2 BR112018016396A2 BR112018016396A BR112018016396A BR112018016396A2 BR 112018016396 A2 BR112018016396 A2 BR 112018016396A2 BR 112018016396 A BR112018016396 A BR 112018016396A BR 112018016396 A BR112018016396 A BR 112018016396A BR 112018016396 A2 BR112018016396 A2 BR 112018016396A2
- Authority
- BR
- Brazil
- Prior art keywords
- compound
- disorder
- treating
- pharmaceutical composition
- compounds
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 5
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 102000003993 Phosphatidylinositol 3-kinases Human genes 0.000 abstract 1
- 108090000430 Phosphatidylinositol 3-kinases Proteins 0.000 abstract 1
- 108091000080 Phosphotransferase Proteins 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 102000020233 phosphotransferase Human genes 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/76—Nitrogen atoms to which a second hetero atom is attached
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Pulmonology (AREA)
- Psychiatry (AREA)
- Reproductive Health (AREA)
- Pregnancy & Childbirth (AREA)
- Pain & Pain Management (AREA)
- Endocrinology (AREA)
- Gynecology & Obstetrics (AREA)
- Immunology (AREA)
- Hospice & Palliative Care (AREA)
- Epidemiology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
a invenção está direcionada a certos novos compostos. especificamente, a invenção está direcionada a compostos da fórmula (i): (i) e sais dos mesmos. os compostos da invenção são inibidores da atividade da cinase, em particular da atividade da pi3 cinase.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB1602527.2 | 2016-02-12 | ||
GBGB1602527.2A GB201602527D0 (en) | 2016-02-12 | 2016-02-12 | Chemical compounds |
PCT/EP2017/052954 WO2017137535A1 (en) | 2016-02-12 | 2017-02-10 | Chemical compounds as inhibitors of kinase activity |
Publications (2)
Publication Number | Publication Date |
---|---|
BR112018016396A2 true BR112018016396A2 (pt) | 2018-12-18 |
BR112018016396B1 BR112018016396B1 (pt) | 2023-11-14 |
Family
ID=55697605
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112018016396-1A BR112018016396B1 (pt) | 2016-02-12 | 2017-02-10 | Composto, composição farmacêutica, e, uso de um composto |
Country Status (15)
Country | Link |
---|---|
US (2) | US10457674B2 (pt) |
EP (1) | EP3414228B1 (pt) |
JP (1) | JP6916195B2 (pt) |
KR (1) | KR20180105726A (pt) |
CN (1) | CN108884046B (pt) |
AR (1) | AR107570A1 (pt) |
AU (1) | AU2017218530A1 (pt) |
BR (1) | BR112018016396B1 (pt) |
CA (1) | CA3013404A1 (pt) |
ES (1) | ES2786948T3 (pt) |
GB (1) | GB201602527D0 (pt) |
RU (1) | RU2018127494A (pt) |
TW (1) | TW201738238A (pt) |
UY (1) | UY37121A (pt) |
WO (1) | WO2017137535A1 (pt) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW201811766A (zh) * | 2016-08-29 | 2018-04-01 | 瑞士商諾華公司 | N-(吡啶-2-基)吡啶-磺醯胺衍生物及其用於疾病治療之用途 |
GB201712081D0 (en) * | 2017-07-27 | 2017-09-13 | Glaxosmithkline Ip Dev Ltd | Chemical compounds |
US10952996B2 (en) * | 2018-12-11 | 2021-03-23 | Theravance Biopharma R&D Ip, Llc | ALK5 inhibitors |
KR102130254B1 (ko) | 2019-10-15 | 2020-07-03 | 주식회사 실리콘사피엔스 | 대상자 고유의 혈관에 대한 혈류 시뮬레이션 방법 및 장치 |
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KR102012398B1 (ko) * | 2009-11-05 | 2019-08-20 | 리젠 파마슈티컬스 소시에떼 아노님 | 신규한 벤조피란 키나제 조절제 |
WO2011080568A2 (en) * | 2009-12-28 | 2011-07-07 | Development Center For Biotechnology | Novel pyrimidine compounds as mtor and p13k inhibitors |
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CN103539777B (zh) * | 2012-07-13 | 2016-03-02 | 广东东阳光药业有限公司 | Pi3激酶调节剂及其使用方法和用途 |
EP2916868B1 (en) * | 2012-11-08 | 2022-05-11 | Rhizen Pharmaceuticals S.A. | Pharmaceutical compositions containing a pde4 inhibitor and a pi3 delta or dual pi3 delta-gamma kinase inhibitor |
CN104402861A (zh) * | 2014-11-07 | 2015-03-11 | 中国人民解放军第二军医大学 | 苯磺酰胺衍生物、制备方法及治疗用途 |
-
2016
- 2016-02-12 GB GBGB1602527.2A patent/GB201602527D0/en not_active Ceased
-
2017
- 2017-02-09 AR ARP170100322A patent/AR107570A1/es unknown
- 2017-02-10 AU AU2017218530A patent/AU2017218530A1/en not_active Abandoned
- 2017-02-10 BR BR112018016396-1A patent/BR112018016396B1/pt active IP Right Grant
- 2017-02-10 CA CA3013404A patent/CA3013404A1/en active Pending
- 2017-02-10 EP EP17704257.9A patent/EP3414228B1/en active Active
- 2017-02-10 UY UY0001037121A patent/UY37121A/es not_active Application Discontinuation
- 2017-02-10 US US16/073,355 patent/US10457674B2/en active Active
- 2017-02-10 WO PCT/EP2017/052954 patent/WO2017137535A1/en active Application Filing
- 2017-02-10 JP JP2018542238A patent/JP6916195B2/ja active Active
- 2017-02-10 KR KR1020187026341A patent/KR20180105726A/ko unknown
- 2017-02-10 RU RU2018127494A patent/RU2018127494A/ru not_active Application Discontinuation
- 2017-02-10 TW TW106104541A patent/TW201738238A/zh unknown
- 2017-02-10 CN CN201780021258.1A patent/CN108884046B/zh active Active
- 2017-02-10 ES ES17704257T patent/ES2786948T3/es active Active
-
2019
- 2019-09-17 US US16/572,917 patent/US10793559B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
KR20180105726A (ko) | 2018-09-28 |
US20200071311A1 (en) | 2020-03-05 |
CA3013404A1 (en) | 2017-08-17 |
ES2786948T3 (es) | 2020-10-14 |
TW201738238A (zh) | 2017-11-01 |
CN108884046A (zh) | 2018-11-23 |
JP6916195B2 (ja) | 2021-08-11 |
BR112018016396B1 (pt) | 2023-11-14 |
US20190040051A1 (en) | 2019-02-07 |
AU2017218530A1 (en) | 2018-08-09 |
EP3414228B1 (en) | 2020-03-18 |
US10793559B2 (en) | 2020-10-06 |
JP2019504858A (ja) | 2019-02-21 |
WO2017137535A1 (en) | 2017-08-17 |
CN108884046B (zh) | 2021-11-09 |
EP3414228A1 (en) | 2018-12-19 |
AR107570A1 (es) | 2018-05-09 |
US10457674B2 (en) | 2019-10-29 |
GB201602527D0 (en) | 2016-03-30 |
RU2018127494A (ru) | 2020-03-12 |
UY37121A (es) | 2017-09-29 |
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