BR112018005208A2 - Compostos heterocíclicos que contêm benzilamina e composições úteis contra infecção micobacteriana - Google Patents
Compostos heterocíclicos que contêm benzilamina e composições úteis contra infecção micobacterianaInfo
- Publication number
- BR112018005208A2 BR112018005208A2 BR112018005208A BR112018005208A BR112018005208A2 BR 112018005208 A2 BR112018005208 A2 BR 112018005208A2 BR 112018005208 A BR112018005208 A BR 112018005208A BR 112018005208 A BR112018005208 A BR 112018005208A BR 112018005208 A2 BR112018005208 A2 BR 112018005208A2
- Authority
- BR
- Brazil
- Prior art keywords
- compounds containing
- heterocyclic compounds
- compositions useful
- mycobacterial infection
- useful against
- Prior art date
Links
- WGQKYBSKWIADBV-UHFFFAOYSA-N benzylamine Chemical compound NCC1=CC=CC=C1 WGQKYBSKWIADBV-UHFFFAOYSA-N 0.000 title 2
- 206010062207 Mycobacterial infection Diseases 0.000 title 1
- 150000002391 heterocyclic compounds Chemical class 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 208000027531 mycobacterial infectious disease Diseases 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/429—Thiazoles condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Obesity (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Pulmonology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Child & Adolescent Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562220192P | 2015-09-17 | 2015-09-17 | |
| US62/220,192 | 2015-09-17 | ||
| PCT/US2016/052558 WO2017049321A1 (en) | 2015-09-17 | 2016-09-19 | Benzyl amine-containing heterocyclic compounds and compositions useful against mycobacterial infection |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BR112018005208A2 true BR112018005208A2 (pt) | 2018-10-02 |
| BR112018005208B1 BR112018005208B1 (pt) | 2023-12-12 |
Family
ID=58289763
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112018005208-6A BR112018005208B1 (pt) | 2015-09-17 | 2016-09-19 | Compostos heterocíclicos que contêm benzilamina e composições úteis contra infecção micobacteriana |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US10919888B2 (pt) |
| EP (1) | EP3328382A4 (pt) |
| JP (1) | JP7055378B2 (pt) |
| KR (1) | KR20180053386A (pt) |
| CN (1) | CN108348510B (pt) |
| AU (2) | AU2016324598A1 (pt) |
| BR (1) | BR112018005208B1 (pt) |
| CA (1) | CA2998375A1 (pt) |
| CL (1) | CL2018000688A1 (pt) |
| HK (1) | HK1252225A1 (pt) |
| IL (1) | IL257743B (pt) |
| MX (2) | MX2018003294A (pt) |
| PE (1) | PE20181352A1 (pt) |
| WO (1) | WO2017049321A1 (pt) |
| ZA (1) | ZA201802323B (pt) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017049321A1 (en) | 2015-09-17 | 2017-03-23 | Miller Marvin J | Benzyl amine-containing heterocyclic compounds and compositions useful against mycobacterial infection |
| US10858359B2 (en) | 2016-06-07 | 2020-12-08 | Jacobio Pharmaceuticals Co., Ltd. | Heterocyclic ring derivatives useful as SHP2 inhibitors |
| SG11201908820VA (en) | 2017-03-23 | 2019-10-30 | Jacobio Pharmaceuticals Co Ltd | Novel heterocyclic derivatives useful as shp2 inhibitors |
| CN108159049B (zh) * | 2018-02-01 | 2021-01-05 | 中国科学院广州生物医药与健康研究院 | 一种吡啶类化合物的新用途 |
| EP3976031A4 (en) * | 2019-05-28 | 2023-07-12 | Shionogi & Co., Ltd | MEDICATION FOR THE TREATMENT OF MYCOBACTERIAL INFECTION IN THE FORM OF A COMBINATION OF A CYTOCHROME BC1 INHIBITOR WITH CLARITHROMYCIN OR AZITHROMYCIN AND CLOFAZIMIN |
| TW202124379A (zh) * | 2019-09-10 | 2021-07-01 | 日商鹽野義製藥股份有限公司 | 對分枝桿菌感染有用之含苄胺的５，６－雜芳族化合物 |
| MX2022003037A (es) * | 2019-09-13 | 2022-04-07 | Janssen Sciences Ireland Unlimited Co | Compuestos antibacterianos. |
| AU2020356630A1 (en) * | 2019-09-26 | 2022-03-31 | The Global Alliance For Tb Drug Development, Inc. | Thiazole carboxamide compounds and use thereof for the treatment of mycobacterial infections |
| WO2022119899A1 (en) * | 2020-12-02 | 2022-06-09 | Shionogi & Co., Ltd. | A medicament for treating mycobacterial infection characterized by combining a cytochrome bc1 inhibitor with clarithromycin or azithromycin |
| CN117396475A (zh) * | 2021-03-16 | 2024-01-12 | 爱尔兰詹森科学公司 | 抗菌化合物 |
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| WO2017049321A1 (en) | 2015-09-17 | 2017-03-23 | Miller Marvin J | Benzyl amine-containing heterocyclic compounds and compositions useful against mycobacterial infection |
| MA45375A (fr) | 2016-06-16 | 2019-04-24 | Janssen Sciences Ireland Unlimited Co | Composés hétérocycliques utilisés en tant qu'agents antibacteriens |
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| CN108159049B (zh) | 2018-02-01 | 2021-01-05 | 中国科学院广州生物医药与健康研究院 | 一种吡啶类化合物的新用途 |
| US20210009583A1 (en) | 2018-03-12 | 2021-01-14 | University Of Notre Dame Du Lac | Deuterated imidazopyridines |
| CN108358917B (zh) | 2018-04-24 | 2020-06-19 | 北京市结核病胸部肿瘤研究所 | 含有碱性稠环片段的咪唑并[1,2-a]吡啶-3-酰胺类化合物及其制备方法 |
| MX2022003037A (es) | 2019-09-13 | 2022-04-07 | Janssen Sciences Ireland Unlimited Co | Compuestos antibacterianos. |
-
2016
- 2016-09-19 WO PCT/US2016/052558 patent/WO2017049321A1/en active Application Filing
- 2016-09-19 CA CA2998375A patent/CA2998375A1/en active Pending
- 2016-09-19 US US15/760,939 patent/US10919888B2/en active Active
- 2016-09-19 MX MX2018003294A patent/MX2018003294A/es unknown
- 2016-09-19 KR KR1020187010743A patent/KR20180053386A/ko not_active Application Discontinuation
- 2016-09-19 IL IL257743A patent/IL257743B/en unknown
- 2016-09-19 CN CN201680063042.7A patent/CN108348510B/zh active Active
- 2016-09-19 BR BR112018005208-6A patent/BR112018005208B1/pt active IP Right Grant
- 2016-09-19 AU AU2016324598A patent/AU2016324598A1/en not_active Abandoned
- 2016-09-19 JP JP2018514425A patent/JP7055378B2/ja active Active
- 2016-09-19 PE PE2018000402A patent/PE20181352A1/es unknown
- 2016-09-19 EP EP16847573.9A patent/EP3328382A4/en not_active Withdrawn
-
2018
- 2018-03-15 CL CL2018000688A patent/CL2018000688A1/es unknown
- 2018-03-15 MX MX2021000189A patent/MX2021000189A/es unknown
- 2018-04-10 ZA ZA2018/02323A patent/ZA201802323B/en unknown
- 2018-09-06 HK HK18111462.6A patent/HK1252225A1/zh unknown
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2020
- 2020-12-28 US US17/135,927 patent/US11820767B2/en active Active
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2021
- 2021-06-14 AU AU2021203931A patent/AU2021203931A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CN108348510A (zh) | 2018-07-31 |
| CL2018000688A1 (es) | 2018-11-16 |
| EP3328382A1 (en) | 2018-06-06 |
| ZA201802323B (en) | 2019-01-30 |
| KR20180053386A (ko) | 2018-05-21 |
| AU2021203931A1 (en) | 2021-07-08 |
| CA2998375A1 (en) | 2017-03-23 |
| BR112018005208B1 (pt) | 2023-12-12 |
| PE20181352A1 (es) | 2018-08-22 |
| RU2018111768A (ru) | 2019-10-17 |
| MX2021000189A (es) | 2021-03-25 |
| MX2018003294A (es) | 2019-04-25 |
| EP3328382A4 (en) | 2018-12-19 |
| IL257743B (en) | 2022-08-01 |
| HK1252225A1 (zh) | 2019-05-24 |
| AU2016324598A1 (en) | 2018-03-15 |
| CN108348510B (zh) | 2022-01-04 |
| US20210198254A1 (en) | 2021-07-01 |
| JP7055378B2 (ja) | 2022-04-18 |
| JP2018532723A (ja) | 2018-11-08 |
| WO2017049321A1 (en) | 2017-03-23 |
| US10919888B2 (en) | 2021-02-16 |
| RU2018111768A3 (pt) | 2020-02-20 |
| US11820767B2 (en) | 2023-11-21 |
| US20180265506A1 (en) | 2018-09-20 |
| IL257743A (en) | 2018-04-30 |
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