BR112018004878A2 - - Google Patents
Info
- Publication number
- BR112018004878A2 BR112018004878A2 BR112018004878A BR112018004878A BR112018004878A2 BR 112018004878 A2 BR112018004878 A2 BR 112018004878A2 BR 112018004878 A BR112018004878 A BR 112018004878A BR 112018004878 A BR112018004878 A BR 112018004878A BR 112018004878 A2 BR112018004878 A2 BR 112018004878A2
- Authority
- BR
- Brazil
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57407—Specifically defined cancers
- G01N33/57411—Specifically defined cancers of cervix
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/118—Prognosis of disease development
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/50—Determining the risk of developing a disease
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Organic Chemistry (AREA)
- Analytical Chemistry (AREA)
- Public Health (AREA)
- Biochemistry (AREA)
- Pathology (AREA)
- Microbiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medical Informatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Oncology (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Computational Biology (AREA)
- Evolutionary Biology (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Theoretical Computer Science (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Genetics & Genomics (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1516047.6 | 2015-09-10 | ||
| GBGB1516047.6A GB201516047D0 (en) | 2015-09-10 | 2015-09-10 | Method |
| PCT/EP2016/071471 WO2017042394A1 (en) | 2015-09-10 | 2016-09-12 | "immune checkpoint intervention" in cancer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BR112018004878A2 true BR112018004878A2 (pt) | 2018-10-02 |
| BR112018004878B1 BR112018004878B1 (pt) | 2022-07-05 |
Family
ID=54362973
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112018004878-0A BR112018004878B1 (pt) | 2015-09-10 | 2016-09-12 | Intervenção de ponto de verificação imune no câncer |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US11098121B2 (pt) |
| EP (1) | EP3347039B1 (pt) |
| JP (1) | JP7073254B2 (pt) |
| KR (1) | KR20180081490A (pt) |
| CN (1) | CN108135985A (pt) |
| AU (1) | AU2016319316B2 (pt) |
| BR (1) | BR112018004878B1 (pt) |
| CA (1) | CA2997651A1 (pt) |
| GB (1) | GB201516047D0 (pt) |
| RU (1) | RU2739036C2 (pt) |
| WO (1) | WO2017042394A1 (pt) |
Families Citing this family (41)
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|---|---|---|---|---|
| US9424392B2 (en) | 2005-11-26 | 2016-08-23 | Natera, Inc. | System and method for cleaning noisy genetic data from target individuals using genetic data from genetically related individuals |
| EP2854057B1 (en) | 2010-05-18 | 2018-03-07 | Natera, Inc. | Methods for non-invasive pre-natal ploidy calling |
| US11332793B2 (en) | 2010-05-18 | 2022-05-17 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US11326208B2 (en) | 2010-05-18 | 2022-05-10 | Natera, Inc. | Methods for nested PCR amplification of cell-free DNA |
| US20190010543A1 (en) | 2010-05-18 | 2019-01-10 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US11939634B2 (en) | 2010-05-18 | 2024-03-26 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US11339429B2 (en) | 2010-05-18 | 2022-05-24 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
| US11322224B2 (en) | 2010-05-18 | 2022-05-03 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
| US11332785B2 (en) | 2010-05-18 | 2022-05-17 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
| US10316362B2 (en) | 2010-05-18 | 2019-06-11 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US11408031B2 (en) | 2010-05-18 | 2022-08-09 | Natera, Inc. | Methods for non-invasive prenatal paternity testing |
| US9677118B2 (en) | 2014-04-21 | 2017-06-13 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| CN113774132A (zh) | 2014-04-21 | 2021-12-10 | 纳特拉公司 | 检测染色体片段中的突变和倍性 |
| JP7305300B2 (ja) | 2014-11-05 | 2023-07-10 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 併用免疫療法 |
| MX2017013777A (es) * | 2015-04-27 | 2018-03-27 | Cancer Research Tech Ltd | Metodo para el tratamiento de cancer. |
| WO2016183106A1 (en) | 2015-05-11 | 2016-11-17 | Natera, Inc. | Methods and compositions for determining ploidy |
| GB201516047D0 (en) | 2015-09-10 | 2015-10-28 | Cancer Rec Tech Ltd | Method |
| US11485996B2 (en) | 2016-10-04 | 2022-11-01 | Natera, Inc. | Methods for characterizing copy number variation using proximity-litigation sequencing |
| US10011870B2 (en) | 2016-12-07 | 2018-07-03 | Natera, Inc. | Compositions and methods for identifying nucleic acid molecules |
| ES2971298T3 (es) * | 2017-01-18 | 2024-06-04 | Icahn School Med Mount Sinai | Neoantígenos y usos de los mismos para el tratamiento del cáncer |
| CN110799196B (zh) * | 2017-03-31 | 2024-02-13 | 行动基因(智财)有限公司 | 致免疫性的癌症特异抗原决定位的排名系统 |
| GB201710815D0 (en) * | 2017-07-05 | 2017-08-16 | Francis Crick Inst Ltd | Method |
| AU2018298971A1 (en) * | 2017-07-14 | 2020-01-16 | Cancer Research Technology Limited | Analysis of HLA alleles in tumours and the uses thereof |
| US11293066B2 (en) * | 2017-07-18 | 2022-04-05 | Institut Gustave Roussy | Method for assessing the response to PD-1/PDL-1 targeting drugs |
| JP7072825B2 (ja) * | 2017-09-13 | 2022-05-23 | 三菱電機ソフトウエア株式会社 | コピー数計測装置、コピー数計測プログラムおよびコピー数計測方法 |
| USD844652S1 (en) * | 2017-11-26 | 2019-04-02 | Jan Magnus Edman | Display screen with graphical user interface |
| JP7299169B2 (ja) * | 2017-12-01 | 2023-06-27 | イルミナ インコーポレイテッド | 体細胞突然変異のクローン性を決定するための方法及びシステム |
| CN112469730A (zh) * | 2018-05-10 | 2021-03-09 | 加利福尼亚大学董事会 | 用于治疗癌症的ccl21和检查点抑制剂 |
| US11525159B2 (en) | 2018-07-03 | 2022-12-13 | Natera, Inc. | Methods for detection of donor-derived cell-free DNA |
| US11427873B2 (en) | 2018-08-10 | 2022-08-30 | Omniseq, Inc. | Methods and systems for assessing proliferative potential and resistance to immune checkpoint blockade |
| CN111383713B (zh) * | 2018-12-29 | 2023-08-01 | 北京安诺优达医学检验实验室有限公司 | ctDNA检测分析装置及方法 |
| WO2020159987A1 (en) * | 2019-01-28 | 2020-08-06 | Board Of Regents, The University Of Texas System | Metal chelator combination therapy for the treatment of cancer |
| WO2020201362A2 (en) * | 2019-04-02 | 2020-10-08 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods of predicting and preventing cancer in patients having premalignant lesions |
| WO2020218322A1 (ja) * | 2019-04-23 | 2020-10-29 | 国立大学法人東北大学 | 血中ケモカインを用いた免疫チェックポイント阻害薬の治療効果予測 |
| CN111394454B (zh) * | 2020-01-06 | 2023-03-14 | 江苏省肿瘤防治研究所（江苏省肿瘤医院） | 一种免疫相关生物标志物及其在头颈部鳞状细胞癌预后诊断中的应用 |
| US20230037966A1 (en) * | 2020-01-07 | 2023-02-09 | The Trustees Of The University Of Pennsylvania | Source specific exosomes for determining avoidance of cancer treatment and avoidance of checkpoint inhibitor therapies |
| US20230047716A1 (en) * | 2020-01-07 | 2023-02-16 | Korea Advanced Institute Of Science And Technology | Method and system for screening neoantigens, and uses thereof |
| EP3868897A1 (en) * | 2020-02-20 | 2021-08-25 | Worldwide Innovative Network | Method for improving the treatment with immune checkpoint blockade therapy |
| CN112735513B (zh) * | 2021-01-04 | 2021-11-19 | 江苏先声医疗器械有限公司 | 基于dna甲基化谱的肿瘤免疫检查点抑制剂治疗有效性评估模型的构建方法 |
| GB202104715D0 (en) * | 2021-04-01 | 2021-05-19 | Achilles Therapeutics Uk Ltd | Identification of clonal neoantigens and uses thereof |
| EP4365204A1 (en) * | 2021-06-30 | 2024-05-08 | Novacellum Inc. | Method for preparing sample containing tumor cells circulating in blood |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| AU7696487A (en) | 1986-07-03 | 1988-01-29 | Bio-Rad Laboratories, Inc. | Peptide fragments of organ-specific neoantigens |
| US5670325A (en) * | 1996-08-14 | 1997-09-23 | Exact Laboratories, Inc. | Method for the detection of clonal populations of transformed cells in a genomically heterogeneous cellular sample |
| EP1762575A1 (en) | 2005-09-12 | 2007-03-14 | Ganymed Pharmaceuticals AG | Identification of tumor-associated antigens for diagnosis and therapy |
| CA2742529C (en) | 2008-11-03 | 2016-05-17 | Stichting Het Nederlands Kanker Instituut | Detecting antigen responsive cells in a sample |
| WO2010144192A1 (en) | 2009-05-05 | 2010-12-16 | Children's Medical Center Corporation | Prognosis indicators for solid human tumors |
| US8176660B2 (en) | 2009-07-30 | 2012-05-15 | Nike, Inc. | Customizable stud for an article of footwear |
| CN102740887B (zh) | 2009-09-30 | 2015-04-15 | 斯隆凯特林防癌纪念中心 | 用于治疗癌症的组合免疫疗法 |
| ES2788863T3 (es) | 2010-05-14 | 2020-10-23 | Massachusetts Gen Hospital | Composiciones de neoantígenos específicos de un tumor para uso en el tratamiento de tumores |
| BR112013029834A8 (pt) | 2011-05-24 | 2022-10-18 | Biontech Ag | vacinas individualizadas para câncer |
| WO2012159643A1 (en) * | 2011-05-24 | 2012-11-29 | Biontech Ag | Individualized vaccines for cancer |
| CN104662171B (zh) | 2012-07-12 | 2018-07-13 | 普瑟姆尼股份有限公司 | 个性化癌症疫苗和过继免疫细胞治疗 |
| US20150197785A1 (en) | 2012-08-10 | 2015-07-16 | The Broad Institute, Inc. | Methods and apparatus for analyzing and quantifying dna alterations in cancer |
| DK2904111T3 (en) | 2012-10-01 | 2018-03-12 | Adaptive Biotechnologies Corp | Immune competence evaluation of adaptive immune receptor diversity and clonality characterization |
| CA2886684C (en) | 2012-10-10 | 2023-09-19 | Sangamo Biosciences, Inc. | T cell modifying compounds and uses thereof |
| WO2014168874A2 (en) | 2013-04-07 | 2014-10-16 | The Broad Institute, Inc. | Compositions and methods for personalized neoplasia vaccines |
| US10188712B2 (en) | 2013-07-30 | 2019-01-29 | Biontech Ag | Tumor antigens for determining cancer therapy |
| WO2015014375A1 (en) | 2013-07-30 | 2015-02-05 | Biontech Ag | Tumor antigens for determining cancer therapy |
| GB201319446D0 (en) | 2013-11-04 | 2013-12-18 | Immatics Biotechnologies Gmbh | Personalized immunotherapy against several neuronal and brain tumors |
| CA2932798C (en) | 2013-12-06 | 2022-09-20 | The Broad Institute, Inc. | Formulations for neoplasia vaccines |
| CN106456724A (zh) | 2013-12-20 | 2017-02-22 | 博德研究所 | 使用新抗原疫苗的联合疗法 |
| BR112016015399A2 (pt) * | 2014-01-02 | 2017-10-24 | Memorial Sloan Kettering Cancer Center | método, método de tratamento de um sujeito, método de melhorar a eficácia da terapia do câncer, método para tratamento do câncer, método de tratamento de um câncer e método de definição de uma assinatura de resposta para uma terapia de modulador do ponto de checagem imunológico |
| CN113694193A (zh) * | 2014-11-13 | 2021-11-26 | 约翰·霍普金斯大学 | 检查点阻断和微卫星不稳定性 |
| MA40737A (fr) | 2014-11-21 | 2017-07-04 | Memorial Sloan Kettering Cancer Center | Déterminants de la réponse d'un cancer à une immunothérapie par blocage de pd-1 |
| NZ734144A (en) | 2014-12-31 | 2023-06-30 | Checkmate Pharmaceuticals Inc | Combination tumor immunotherapy |
| WO2016145578A1 (en) | 2015-03-13 | 2016-09-22 | Syz Cell Therapy Co. | Methods of cancer treatment using activated t cells |
| TWI755158B (zh) | 2015-03-17 | 2022-02-11 | 德商英麥提克生物技術股份有限公司 | 用於抗胰臟癌與其他癌症的免疫治療的新穎胜肽及胜肽的組合 |
| PT3273992T (pt) | 2015-03-23 | 2020-08-21 | Jounce Therapeutics Inc | Anticorpos para icos |
| MX2017013777A (es) | 2015-04-27 | 2018-03-27 | Cancer Research Tech Ltd | Metodo para el tratamiento de cancer. |
| CA2992578A1 (en) | 2015-07-14 | 2017-01-19 | Victor Velculescu | Neoantigen analysis |
| GB201516047D0 (en) | 2015-09-10 | 2015-10-28 | Cancer Rec Tech Ltd | Method |
| US10597466B2 (en) | 2015-12-02 | 2020-03-24 | Fred Hutchinson Cancer Research Center | Circular tandem repeat proteins |
| CA3048202A1 (en) | 2015-12-23 | 2017-06-29 | Moonshot Pharma Llc | Methods for inducing an immune response by inhibition of nonsense mediated decay |
-
2015
- 2015-09-10 GB GBGB1516047.6A patent/GB201516047D0/en not_active Ceased
-
2016
- 2016-09-12 RU RU2018112516A patent/RU2739036C2/ru active
- 2016-09-12 BR BR112018004878-0A patent/BR112018004878B1/pt active IP Right Grant
- 2016-09-12 US US15/758,165 patent/US11098121B2/en active Active
- 2016-09-12 JP JP2018512548A patent/JP7073254B2/ja active Active
- 2016-09-12 CN CN201680052459.3A patent/CN108135985A/zh active Pending
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| WO2017042394A1 (en) | 2017-03-16 |
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| US20180251553A1 (en) | 2018-09-06 |
| GB201516047D0 (en) | 2015-10-28 |
| EP3347039A1 (en) | 2018-07-18 |
| RU2018112516A (ru) | 2019-10-10 |
| CA2997651A1 (en) | 2017-03-16 |
| JP7073254B2 (ja) | 2022-05-23 |
| AU2016319316B2 (en) | 2022-09-08 |
| RU2739036C2 (ru) | 2020-12-21 |
| JP2018527935A (ja) | 2018-09-27 |
| EP3347039B1 (en) | 2021-08-11 |
| CN108135985A (zh) | 2018-06-08 |
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