BR112017002624A2 - sistemas e métodos para a síntese de produtos químicos, incluindo ingredientes farmacêuticos ativos - Google Patents

sistemas e métodos para a síntese de produtos químicos, incluindo ingredientes farmacêuticos ativos

Info

Publication number
BR112017002624A2
BR112017002624A2 BR112017002624A BR112017002624A BR112017002624A2 BR 112017002624 A2 BR112017002624 A2 BR 112017002624A2 BR 112017002624 A BR112017002624 A BR 112017002624A BR 112017002624 A BR112017002624 A BR 112017002624A BR 112017002624 A2 BR112017002624 A2 BR 112017002624A2
Authority
BR
Brazil
Prior art keywords
systems
methods
active pharmaceutical
pharmaceutical ingredients
including active
Prior art date
Application number
BR112017002624A
Other languages
English (en)
Other versions
BR112017002624B1 (pt
Inventor
Stuart MYERSON Allan
Adamo Andrea
R Snead David
Marie REVALOR Eve
M Monbaliu Jean-Christophe
Chen Jie
F Jensen Klavs
BEHNAM Mohsen
Weeranoppanant Nophon
Zhang Ping
Yee WONG Shin
F Jamison Timothy
Stelzer Torsten
Original Assignee
Massachusetts Inst Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Massachusetts Inst Technology filed Critical Massachusetts Inst Technology
Publication of BR112017002624A2 publication Critical patent/BR112017002624A2/pt
Publication of BR112017002624B1 publication Critical patent/BR112017002624B1/pt

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0006—Controlling or regulating processes
    • B01J19/004—Multifunctional apparatus for automatic manufacturing of various chemical products
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0093—Microreactors, e.g. miniaturised or microfabricated reactors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/18—Stationary reactors having moving elements inside
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/14—Quaternary ammonium compounds, e.g. edrophonium, choline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00002—Chemical plants
    • B01J2219/00004—Scale aspects
    • B01J2219/00011—Laboratory-scale plants
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00002—Chemical plants
    • B01J2219/00018—Construction aspects
    • B01J2219/0002—Plants assembled from modules joined together
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00002—Chemical plants
    • B01J2219/00027—Process aspects
    • B01J2219/0004—Processes in series
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00788—Three-dimensional assemblies, i.e. the reactor comprising a form other than a stack of plates
    • B01J2219/00792—One or more tube-shaped elements
    • B01J2219/00795—Spiral-shaped
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00788—Three-dimensional assemblies, i.e. the reactor comprising a form other than a stack of plates
    • B01J2219/00799—Cup-shaped
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00801—Means to assemble
    • B01J2219/00804—Plurality of plates
    • B01J2219/00806—Frames
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00801—Means to assemble
    • B01J2219/0081—Plurality of modules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00801—Means to assemble
    • B01J2219/0081—Plurality of modules
    • B01J2219/00813—Fluidic connections
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00801—Means to assemble
    • B01J2219/0081—Plurality of modules
    • B01J2219/00817—Support structures
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00819—Materials of construction
    • B01J2219/00822—Metal
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00819—Materials of construction
    • B01J2219/00831—Glass
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00819—Materials of construction
    • B01J2219/00833—Plastic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00819—Materials of construction
    • B01J2219/00835—Comprising catalytically active material
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00851—Additional features
    • B01J2219/00871—Modular assembly
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00873—Heat exchange
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00889—Mixing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00905—Separation
    • B01J2219/00907—Separation using membranes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00905—Separation
    • B01J2219/00909—Separation using filters
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00905—Separation
    • B01J2219/00918—Separation by adsorption
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/0095—Control aspects
    • B01J2219/00986—Microprocessor

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Manufacturing & Machinery (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)

Abstract

a presente invenção refere-se a sistemas e métodos para a síntese de produtos químicos, incluindo ingredientes farmacêuticos ativos. alguns dos sistemas e métodos descritos no presente documento têm a capacidade de fabricar múltiplos produtos químicos sem a necessidade de conectar ou desconectar de maneira fluida unidades de operação ao passar da produção de um produto químico à produção de um outro produto químico.
BR112017002624-4A 2014-08-15 2015-08-14 Sistemas para a produção de um produto químico BR112017002624B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462038039P 2014-08-15 2014-08-15
US62/038,039 2014-08-15
PCT/US2015/045220 WO2016025803A1 (en) 2014-08-15 2015-08-14 Systems and methods for synthesizing chemical products, including active pharmaceutical ingredients

Publications (2)

Publication Number Publication Date
BR112017002624A2 true BR112017002624A2 (pt) 2017-12-05
BR112017002624B1 BR112017002624B1 (pt) 2021-04-13

Family

ID=55304659

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112017002624-4A BR112017002624B1 (pt) 2014-08-15 2015-08-14 Sistemas para a produção de um produto químico

Country Status (9)

Country Link
US (3) US10780410B2 (pt)
EP (1) EP3180118A4 (pt)
JP (4) JP6787881B2 (pt)
KR (3) KR102517182B1 (pt)
AU (3) AU2015301544A1 (pt)
BR (1) BR112017002624B1 (pt)
CA (1) CA2957410C (pt)
MX (2) MX2017002033A (pt)
WO (1) WO2016025803A1 (pt)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102517182B1 (ko) 2014-08-15 2023-04-04 메사추세츠 인스티튜트 오브 테크놀로지 활성 제약 성분을 포함한 화학적 생성물의 합성을 위한 시스템 및 방법
BR112018011117A2 (pt) 2015-12-08 2018-11-21 Massachusetts Inst Technology cristalizador de fluxo dirigido por pressão
US11185839B2 (en) 2016-05-02 2021-11-30 Massachusetts Institute Of Technology Reconfigurable multi-step chemical synthesis system and related components and methods
KR102558187B1 (ko) 2017-02-17 2023-07-24 메사추세츠 인스티튜트 오브 테크놀로지 제약 정제를 비롯한 정제의 제작을 위한 시스템 및 방법
CN110650797B (zh) * 2017-04-06 2022-07-01 斯坦福国际研究院 用于执行多步骤化学反应的模块系统及其使用方法
WO2018200236A1 (en) 2017-04-26 2018-11-01 Massachusetts Institute Of Technology Reconfigurable chemical synthesis systems and methods
JP6967492B2 (ja) * 2018-07-30 2021-11-17 株式会社神戸製鋼所 流体処理システム
GB201911686D0 (en) * 2019-08-15 2019-10-02 Fujifilm Diosynth Biotechnologies Uk Ltd Process for purifying target substances
GB201911687D0 (en) * 2019-08-15 2019-10-02 Fujifilm Diosynth Biotechnologies Uk Ltd Apparatus for purifying a liquid comprising a target substance
US11911719B2 (en) 2019-09-20 2024-02-27 Massachusetts Institute Of Technology Devices and methods for the integrated filtration, drying, and mechanical processing of active pharmaceutical ingredients
CN112834686A (zh) * 2019-11-22 2021-05-25 北方工业大学 一种多功能气体成分循环改变与循环检测装置
CN112834693A (zh) * 2019-11-22 2021-05-25 北方工业大学 一种多功能气体成分动态改变与动态检测装置
KR102320318B1 (ko) * 2019-12-18 2021-11-02 한국전자기술연구원 연속공정을 위한 모듈화 장비

Family Cites Families (66)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2441498A (en) 1943-07-15 1948-05-11 Astra Apotekarnes Kem Fab Alkyl glycinanilides
US2421714A (en) 1944-04-18 1947-06-03 Parke Davis & Co Dialkylaminoalkyl benzhydryl ethers and salts thereof
IE64511B1 (en) * 1988-03-11 1995-08-09 Takeda Chemical Industries Ltd Automated synthesizing apparatus
US5275741A (en) * 1989-05-11 1994-01-04 Eniricerche S.P.A. Reactor for photooxidations in an aqueous environment
US5259812A (en) * 1992-09-23 1993-11-09 Kleinsek Don A Clean room and clean room containment center
JPH06167500A (ja) * 1992-11-27 1994-06-14 Tosoh Corp アミノ酸配列の決定に用いられる装置
US6638482B1 (en) 1993-11-01 2003-10-28 Nanogen, Inc. Reconfigurable detection and analysis apparatus and method
US5580523A (en) * 1994-04-01 1996-12-03 Bard; Allen J. Integrated chemical synthesizers
US20050042149A1 (en) 1994-04-01 2005-02-24 Integrated Chemical Synthesizers, Inc. Nanoscale chemical synthesis
US6558633B1 (en) * 1994-09-21 2003-05-06 Isis Pharmaceuticals, Inc. Chemical reaction apparatus and methods
JP3630376B2 (ja) * 1994-11-04 2005-03-16 千代田化工建設株式会社 マイクロ・ケミカルプロセス・モジュール及び自律式分散型プロセス・プラント
DE29703788U1 (de) 1997-03-03 1997-06-26 Bürkert Werke GmbH & Co., 74653 Ingelfingen Modularer Steuerblock für die Analysentechnik
US6749814B1 (en) * 1999-03-03 2004-06-15 Symyx Technologies, Inc. Chemical processing microsystems comprising parallel flow microreactors and methods for using same
DE19959249A1 (de) 1999-12-08 2001-07-19 Inst Mikrotechnik Mainz Gmbh Modulares Mikroreaktionssystem
WO2001054663A2 (en) 2000-01-31 2001-08-02 Collaborative Technologies, Inc. Surfactant free topical compositions and method for rapid preparation thereof
US7435392B2 (en) * 2000-02-03 2008-10-14 Acclavis, Llc Scalable continuous production system
US7241423B2 (en) 2000-02-03 2007-07-10 Cellular Process Chemistry, Inc. Enhancing fluid flow in a stacked plate microreactor
US20030017467A1 (en) 2000-02-18 2003-01-23 Aclara Biosciences, Inc. Multiple-site sample-handling apparatus and method
IL135843A0 (en) * 2000-04-28 2001-05-20 Ende Michael Method for production of enhanced traceable and immunising drinking water and other liquids and gases, and devices for use thereof
DE20009234U1 (de) 2000-05-23 2000-08-24 Buerkert Werke Gmbh & Co Fluidisches Anschlusssystem
JP2004508919A (ja) 2000-05-24 2004-03-25 セルラー　プロセス　ケミストリー　インコーポレイテッド マイクロリアクタを組み入れたモジュラ式化学生産システム
JP2004501665A (ja) 2000-07-03 2004-01-22 ゼオトロン　コーポレイション 光生成試薬を用いて化学反応を行なうためのデバイスおよび方法
AU2001283076A1 (en) 2000-08-14 2002-02-25 Chevron U.S.A. Inc. Use of microchannel reactors in combinatorial chemistry
DE10041853C1 (de) * 2000-08-25 2002-02-28 Gmd Gmbh Konfigurierbares Mikroreaktornetzwerk
US6376729B1 (en) * 2000-12-04 2002-04-23 Fina Technology, Inc. Multi-phase alkylation process
WO2003080232A1 (en) 2002-03-22 2003-10-02 Morphochem Aktiengesellschaft für kombinatorische Chemie Methods and systems for discovery of chemical compounds and their syntheses
US7108789B2 (en) * 2002-07-29 2006-09-19 Calgon Carbon Corporation High performance continuous reaction/separation process using a continuous liquid-solid contactor
US20040136873A1 (en) 2003-01-09 2004-07-15 Argonaut Technologies, Inc. Modular reactor system
US8075778B2 (en) 2003-03-25 2011-12-13 Massachusetts Institute Of Technology Fluid separation
DE10361003B3 (de) 2003-12-23 2005-07-28 Hte Ag The High Throughput Experimentation Company Vorrichtung und Verfahren zur Druck- und Flusskontrolle in Parallelreaktoren
US20050175519A1 (en) * 2004-02-06 2005-08-11 Rogers William A.Jr. Microchannel compression reactor
US7582263B2 (en) 2005-01-27 2009-09-01 Octrolix Bv Universal interface for a micro-fluidic chip
JP2006239638A (ja) * 2005-03-07 2006-09-14 Ebara Corp 混合器および混合方法
DE102005028897A1 (de) 2005-06-17 2006-12-28 Eckert & Ziegler Eurotope Gmbh Anordnung und Verfahren zur Verarbeitung von chemischen Stoffen, Computerprogramm zur Steuerung einer solchen Anordnung sowie ein entsprechendes computerlesbares Speichermedium
EP1917097A2 (en) 2005-07-05 2008-05-07 Massachusetts Institute of Technology (MIT) Microfluidic separators for multiphase fluid-flow based on membranes
US7641860B2 (en) 2006-06-01 2010-01-05 Nanotek, Llc Modular and reconfigurable multi-stage microreactor cartridge apparatus
US7854902B2 (en) 2006-08-23 2010-12-21 Nanotek, Llc Modular and reconfigurable multi-stage high temperature microreactor cartridge apparatus and system for using same
US8594848B2 (en) * 2006-11-28 2013-11-26 Lester F. Ludwig Reconfigurable chemical process systems
US20100324157A1 (en) * 2006-12-29 2010-12-23 Bauman Richard F High throughput fischer-tropsch catalytic process development method
WO2008091694A2 (en) 2007-01-23 2008-07-31 Siemens Medical Solutions Usa, Inc. Fully-automated microfluidic system for the synthesis of radiolabeled biomarkers for positron emission tomography
NZ579525A (en) 2007-03-08 2011-12-22 Virent Inc Synthesis of liquid fuels and chemicals from oxygenated hydrocarbons
US8046086B2 (en) * 2007-05-15 2011-10-25 Fisher-Rosemount Systems, Inc. Methods and systems for batch processing and execution in a process system
WO2008150451A2 (en) * 2007-05-30 2008-12-11 Velocys, Inc. Oxidative coupling of methane
BE1017763A5 (nl) * 2007-09-24 2009-06-02 Proviron Holding Bioreactor.
FR2925480B1 (fr) * 2007-12-21 2011-07-01 Gervais Danone Sa Procede d'enrichissement d'une eau en oxygene par voie electrolytique, eau ou boisson enrichie en oxygene et utilisations
DE102008004397A1 (de) 2008-01-14 2009-07-16 Evonik Degussa Gmbh Verfahren zur Verminderung des Gehaltes von Elementen, wie Bor, in Halogensilanen sowie Anlage zur Durchführung des Verfahrens
HU230862B1 (hu) 2008-04-28 2018-10-29 DARHOLDING Vagyonkezelő Kft Berendezés és eljárás nanorészecskék folyamatos üzemű előállítására
US8951480B2 (en) 2008-08-19 2015-02-10 The Regents Of The University Of California Modular radiochemistry synthesis system
GB0909154D0 (en) * 2008-09-25 2009-07-08 Nanomaterials Tech Pte Ltd A process for making particles for delivery of drug nanoparticles
SG172325A1 (en) 2008-12-23 2011-07-28 Xoma Technology Ltd Flexible manufacturing system
BRPI0925048B8 (pt) 2009-05-07 2021-06-22 Gea Pharma Systems Ltd módulo para produção de comprimidos e método para a produção contínua de comprimidos
TW201114481A (en) 2009-05-11 2011-05-01 Corning Inc Modular reactor and system
WO2010144037A1 (en) 2009-06-09 2010-12-16 Ge Healthcare Bio-Sciences Ab Automated fluid handling system
US8426630B2 (en) 2009-08-31 2013-04-23 Florida State University Research Foundation Method and apparatus for continuous flow synthesis of ibuprofen
US8066873B2 (en) 2010-03-26 2011-11-29 Kaw Eros G Floating bioreactor system
CA2793723A1 (en) 2010-03-31 2011-10-06 Ge Healthcare Bio-Sciences Ab A parallel separation system
US8287762B2 (en) 2010-04-02 2012-10-16 Air Products And Chemicals, Inc. Operation of staged membrane oxidation reactor systems
US20120076692A1 (en) 2010-09-23 2012-03-29 Siemens Medical Solutions Usa, Inc. Modular Component Synthesis Unit
KR102027596B1 (ko) 2010-12-06 2019-10-01 타폰 바이오시스템즈, 인코포레이티드 생물학적 산물을 위한 연속 처리 방법
US9927788B2 (en) * 2011-05-19 2018-03-27 Fisher-Rosemount Systems, Inc. Software lockout coordination between a process control system and an asset management system
US20120325469A1 (en) 2011-06-27 2012-12-27 Olson Stephen W Process and system for treating produced water and flowback water from oil and gas operations
MX2014001835A (es) 2011-08-15 2014-02-27 Abbott Lab Procedimiento para fabricar beta-hidroxi-beta-metilbutirato y sales del mismo.
US9751957B2 (en) * 2012-02-15 2017-09-05 Cydex Pharmaceuticals, Inc. Manufacturing process for cyclodextrin derivatives
JP6167500B2 (ja) 2012-10-19 2017-07-26 トヨタ自動車株式会社 コンロッド
KR102517182B1 (ko) 2014-08-15 2023-04-04 메사추세츠 인스티튜트 오브 테크놀로지 활성 제약 성분을 포함한 화학적 생성물의 합성을 위한 시스템 및 방법
US11185839B2 (en) 2016-05-02 2021-11-30 Massachusetts Institute Of Technology Reconfigurable multi-step chemical synthesis system and related components and methods

Also Published As

Publication number Publication date
CA2957410C (en) 2023-07-04
AU2021286269A1 (en) 2022-01-06
BR112017002624B1 (pt) 2021-04-13
AU2019268159A1 (en) 2019-12-12
KR20170042330A (ko) 2017-04-18
EP3180118A4 (en) 2018-04-04
MX2017002033A (es) 2017-08-14
AU2019268159B2 (en) 2022-01-13
EP3180118A1 (en) 2017-06-21
JP2023123614A (ja) 2023-09-05
AU2015301544A1 (en) 2017-03-02
US20200368710A1 (en) 2020-11-26
MX2021014747A (es) 2022-01-18
KR20220044863A (ko) 2022-04-11
WO2016025803A8 (en) 2016-03-17
KR102482164B1 (ko) 2022-12-29
JP6787881B2 (ja) 2020-11-18
US20180207604A1 (en) 2018-07-26
CA2957410A1 (en) 2016-02-18
KR20230049755A (ko) 2023-04-13
KR102517182B1 (ko) 2023-04-04
AU2021286269B2 (en) 2023-07-20
WO2016025803A1 (en) 2016-02-18
US20230201787A1 (en) 2023-06-29
KR102558427B1 (ko) 2023-07-24
JP2020099903A (ja) 2020-07-02
JP7042518B2 (ja) 2022-03-28
US11565230B2 (en) 2023-01-31
JP2021193137A (ja) 2021-12-23
US10780410B2 (en) 2020-09-22
JP2017530096A (ja) 2017-10-12

Similar Documents

Publication Publication Date Title
BR112017002624A2 (pt) sistemas e métodos para a síntese de produtos químicos, incluindo ingredientes farmacêuticos ativos
MX2020003825A (es) Formas de dosificacion solidas de palbociclib.
PH12018500899A1 (en) Compositions and methods for inhibiting arginase activity
CL2020001852A1 (es) Procesos de preparación de s-ketamina o clorhidrato de s-ketamina o productos derivados de éste. (divisional solicitud 201901066)
MX2022015755A (es) Profarmacos de hormona paratiroidea (pth).
PH12016500486A1 (en) Aza-pyridone compounds and uses thereof
GB2546432A (en) Apertured fibrous structures and methods for making same
PH12016502586A1 (en) Lipid comprising docosapentaenoic acid
CR20140430A (es) Complejos de polielectrolitos que comprenden natamicina y/o fosfito para mejora de biocida
EA033163B1 (ru) Ингибиторы глутаминазы
TW201613859A (en) Analogs of PRIDOPIDINE, their preparation and use
MX2014011825A (es) INHIBIDORES DE ISOXAZOL ß-LACTAMASA.
PH12016500492A1 (en) Pyridazinone compounds and uses thereof
MX2017011655A (es) Compuestos de aza-piridona y usos de estos.
MX2019002057A (es) Formas solidas de mesilato de cenicriviroc y procesos para elaborar formas sólidas de mesilato de cenicriviroc.
MX2016013029A (es) Compuestos de indanona sustituidos como modulares de gpr119 para el tratamiento de diabetes, obesidad, dislipidemia y trastornos relacionados.
BR112017022391A2 (pt) composições e métodos para a fiscalização de câncer de próstata
TR201901228T4 (tr) Vortioksetin piroglutamat.
MX2017002323A (es) Variantes de desintegrina y usos farmaceuticos de las mismas.
IN2014CH00840A (pt)
EA201692020A1 (ru) Пролекарственные средства янтарной кислоты для применения в лечении лактоацидоза или индуцируемого лекарственными средствами побочного действия вследствие связанных с комплексом i нарушений окислительного фосфорилирования в митохондриях
WO2016055647A3 (fr) Procede de preparation de plasma universel
PH12017502017A1 (en) Pharmaceutical compositions
BR112016030057A2 (pt) composição de diagnóstico para identificação de líquido aminiótico
BR112017022340A2 (pt) 2-tiopirimidinonas

Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 14/08/2015, OBSERVADAS AS CONDICOES LEGAIS.