BR112017000127A2 - Nova forma polimórfica de cloridrato de n-[2-(6- fluoro-1h-indol-3-il)etil]-3-(2,2,3,3- tetrafluoropropoxi)benzilamina para o tratamento da doença de alzheimer - Google Patents

Nova forma polimórfica de cloridrato de n-[2-(6- fluoro-1h-indol-3-il)etil]-3-(2,2,3,3- tetrafluoropropoxi)benzilamina para o tratamento da doença de alzheimer

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Publication number
BR112017000127A2
BR112017000127A2 BR112017000127A BR112017000127A BR112017000127A2 BR 112017000127 A2 BR112017000127 A2 BR 112017000127A2 BR 112017000127 A BR112017000127 A BR 112017000127A BR 112017000127 A BR112017000127 A BR 112017000127A BR 112017000127 A2 BR112017000127 A2 BR 112017000127A2
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BR
Brazil
Prior art keywords
indol
fluoro
ethyl
benzylamine
tetrafluoropropoxi
Prior art date
Application number
BR112017000127A
Other languages
English (en)
Other versions
BR112017000127B1 (pt
Inventor
Dennis Therkelsen Frans
Lopez De Diego Heidi
Birklund Andersen Kristine
Harold Rock Michael
Original Assignee
H Lundbeck As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=58794010&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR112017000127(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by H Lundbeck As filed Critical H Lundbeck As
Publication of BR112017000127A2 publication Critical patent/BR112017000127A2/pt
Publication of BR112017000127B1 publication Critical patent/BR112017000127B1/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C07D209/16—Tryptamines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

a presente invenção refere-se a uma nova forma polimórfica de cloridrato de n-[2-(6-fluoro-1h-indol-3-il)etil]-3-(2,2,3,3-tetrafluoropropoxi)benzilamina.
BR112017000127-6A 2014-07-04 2015-07-03 Forma polimórfica iii do cloridrato de n-[2-(6-fluoro-1hindol-3-il)etil]-3- (2,2,3,3-tetrafluoropropoxi)benzilamina, processos de preparação da mesma, sua composição farmacêutica e seu uso BR112017000127B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DKPA201400369 2014-07-04
DKPA201400369 2014-07-04
PCT/EP2015/065176 WO2016001398A1 (en) 2014-07-04 2015-07-03 Novel polymorphic form of n-[2-(6-fluoro-lh-indol-3-yl)ethyl]-3-(2,2,3,3-tetrafluoropropoxy)benzylamine hydrochloride for the treatment of alzheimer's

Publications (2)

Publication Number Publication Date
BR112017000127A2 true BR112017000127A2 (pt) 2018-01-23
BR112017000127B1 BR112017000127B1 (pt) 2023-06-27

Family

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Also Published As

Publication number Publication date
PL3164385T3 (pl) 2021-12-20
WO2016001398A1 (en) 2016-01-07
MA40345A (fr) 2021-04-28
JP6643330B2 (ja) 2020-02-12
SG11201610334XA (en) 2017-01-27
PE20170522A1 (es) 2017-05-28
GEP20227368B (en) 2022-03-25
AP2016009643A0 (en) 2016-12-31
CA2951794C (en) 2023-03-07
AR101109A1 (es) 2016-11-23
CR20160605A (es) 2017-04-24
PT3164385T (pt) 2021-10-07
TN2016000549A1 (en) 2018-04-04
PH12016502477B1 (en) 2017-04-10
CO2017000019A2 (es) 2017-05-31
US10071963B2 (en) 2018-09-11
HRP20211596T1 (hr) 2022-01-07
ES2893619T3 (es) 2022-02-09
CA2951794A1 (en) 2016-01-07
NZ727251A (en) 2023-06-30
SV2016005353A (es) 2017-03-23
RU2016151637A3 (pt) 2019-01-28
US20170152227A1 (en) 2017-06-01
TW201625525A (zh) 2016-07-16
AU2015282909B2 (en) 2019-02-07
LT3164385T (lt) 2021-10-11
HRP20211596T8 (hr) 2022-03-04
PH12016502477A1 (en) 2017-04-10
MA40345B1 (fr) 2021-10-29
CN112961095A (zh) 2021-06-15
EP3164385B1 (en) 2021-09-08
DK3164385T3 (da) 2021-10-11
JP2020059724A (ja) 2020-04-16
CN106458889A (zh) 2017-02-22
TWI665188B (zh) 2019-07-11
KR102399374B1 (ko) 2022-05-17
EP3164385A1 (en) 2017-05-10
IL249428A0 (en) 2017-02-28
RS62380B1 (sr) 2021-10-29
IL249428B (en) 2019-10-31
EA035894B1 (ru) 2020-08-27
JP2017519829A (ja) 2017-07-20
CL2017000002A1 (es) 2017-06-23
HUE056368T2 (hu) 2022-02-28
JO3639B1 (ar) 2020-08-27
RU2016151637A (ru) 2018-08-08
MX2016016895A (es) 2017-04-27
DOP2017000001A (es) 2017-03-31
SI3164385T1 (sl) 2021-10-29
UA121547C2 (uk) 2020-06-25
MY190715A (en) 2022-05-12
CN112961094A (zh) 2021-06-15
EA201692485A1 (ru) 2017-05-31
KR20170023019A (ko) 2017-03-02
AU2015282909A1 (en) 2017-01-05
CY1124594T1 (el) 2022-07-22
ECSP17000222A (es) 2017-02-24

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Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]

Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS.

B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 03/07/2015, OBSERVADAS AS CONDICOES LEGAIS