BR112016028521A2 - métodos para triagem de um neoplasma colorretal ou predisposição para desenvolvimento de um neoplasma colorretal e para análise de metilação de dna, e, composição de oligonucleotídeos - Google Patents

métodos para triagem de um neoplasma colorretal ou predisposição para desenvolvimento de um neoplasma colorretal e para análise de metilação de dna, e, composição de oligonucleotídeos

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Publication number
BR112016028521A2
BR112016028521A2 BR112016028521-2A BR112016028521A BR112016028521A2 BR 112016028521 A2 BR112016028521 A2 BR 112016028521A2 BR 112016028521 A BR112016028521 A BR 112016028521A BR 112016028521 A2 BR112016028521 A2 BR 112016028521A2
Authority
BR
Brazil
Prior art keywords
colorectal neoplasm
methods
predisposition
screening
development
Prior art date
Application number
BR112016028521-2A
Other languages
English (en)
Other versions
BR112016028521B1 (pt
Inventor
Pedersen Suzanne
Lapointe Laurence
Baker Rohan
C. DONAHUE Amber
Peng Yen-Lin
Waldman Frederic
Original Assignee
Quest Diagnostics Investments Incorporated
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Quest Diagnostics Investments Incorporated filed Critical Quest Diagnostics Investments Incorporated
Publication of BR112016028521A2 publication Critical patent/BR112016028521A2/pt
Publication of BR112016028521B1 publication Critical patent/BR112016028521B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/118—Prognosis of disease development
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/154—Methylation markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

é descrita aqui uma combinação de sequências genômicas cujos padrões de metilação têm utilidade para a detecção e diferenciação melhoradas entre neoplasmas colorretais. são adicionalmente descritos métodos, ácidos nucleicos e kits para detectar ou diferenciar entre neoplasmas colorretais.
BR112016028521-2A 2014-06-04 2015-06-03 Métodos para triagem de um neoplasma colorretal e para análise de metilação de dna, e, composição de oligonucleotídeos BR112016028521B1 (pt)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201462007687P 2014-06-04 2014-06-04
US62/007687 2014-06-04
US62/007,687 2014-06-04
PCT/US2015/033968 WO2015187823A2 (en) 2014-06-04 2015-06-03 Methylated markers for colorectal cancer

Publications (2)

Publication Number Publication Date
BR112016028521A2 true BR112016028521A2 (pt) 2018-01-09
BR112016028521B1 BR112016028521B1 (pt) 2023-03-14

Family

ID=54767574

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112016028521-2A BR112016028521B1 (pt) 2014-06-04 2015-06-03 Métodos para triagem de um neoplasma colorretal e para análise de metilação de dna, e, composição de oligonucleotídeos

Country Status (14)

Country Link
US (2) US11486007B2 (pt)
EP (1) EP3152333B1 (pt)
JP (2) JP6722659B2 (pt)
KR (2) KR102461235B1 (pt)
CN (1) CN106574303A (pt)
AU (2) AU2015271697B2 (pt)
BR (1) BR112016028521B1 (pt)
CA (1) CA2951141C (pt)
IL (2) IL280521B (pt)
MX (1) MX370850B (pt)
NZ (1) NZ727493A (pt)
PH (1) PH12016502417A1 (pt)
WO (1) WO2015187823A2 (pt)
ZA (1) ZA201700031B (pt)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2872867C (en) * 2012-05-11 2020-09-15 Clinical Genomics Pty Ltd Diagnostic gene marker panel for colorectal cancer
WO2017129716A1 (en) * 2016-01-29 2017-08-03 Epigenomics Ag Methods for detecting cpg methylation of tumor-derived dna in blood samples
CN110770354B (zh) 2017-04-19 2024-03-19 鹍远基因公司 用于文库构建和序列分析的组合物和方法
CN107164535A (zh) * 2017-07-07 2017-09-15 沈阳宁沪科技有限公司 一种无创高通量甲基化结肠癌诊断、研究和治疗方法
US20210032703A1 (en) * 2018-01-23 2021-02-04 Exellon Medical Technology Method and kit for identifying state of colorectal cancer
WO2019144275A1 (zh) 2018-01-23 2019-08-01 北京艾克伦医疗科技有限公司 鉴定肺癌状态的方法和试剂盒
US11884966B2 (en) 2018-03-15 2024-01-30 Grail, Llc Tissue-specific methylation marker
CN110512001A (zh) * 2018-05-22 2019-11-29 广州市康立明生物科技有限责任公司 肿瘤标志物、甲基化试剂、试剂盒及其应用
CN110283913A (zh) * 2019-07-21 2019-09-27 广州奥百阕谱生物科技有限公司 Rassf1a基因甲基化状态检测试剂盒及其应用
KR102261606B1 (ko) * 2019-11-07 2021-06-07 (주)지노믹트리 대장암 검출 방법
KR102478720B1 (ko) * 2019-11-08 2022-12-19 주식회사 아이엠비디엑스 혈액 기반 대장암 진단용 dna 메틸화 바이오마커 패널
EP3911756A4 (en) * 2020-03-20 2022-08-10 Singlera Health Technologies (Shanghai) Ltd. SCREENING PROCEDURES AND KITS FOR COLORECTAL NEOPLASMA
EP4127215A4 (en) * 2020-03-31 2024-07-10 Freenome Holdings Inc METHODS AND SYSTEMS FOR DETECTING COLORECTAL CANCER BY NUCLEIC ACID METHYLATION ANALYSIS

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7718364B2 (en) * 2003-03-25 2010-05-18 John Wayne Cancer Institute DNA markers for management of cancer
CN101160411B (zh) * 2005-04-15 2014-05-14 Epi基因组股份公司 分析细胞增殖性病症的方法和核酸
US20090317810A1 (en) * 2006-04-17 2009-12-24 Epigenomics Ag Methods and nucleic acids for the detection of colorectal cell proliferative disorders
EP2479283B1 (en) 2006-04-17 2016-06-22 Epigenomics AG Methods and nucleic acids for the detection of colorectal cell proliferative disorders
WO2008011620A2 (en) * 2006-07-21 2008-01-24 Epigenomics Ag Methods and nucleic acids for analyses of cellular proliferative disorders
EP2255017A1 (en) * 2008-03-18 2010-12-01 Epigenomics AG A method for optimizing and validating an assay for determining the presence or absence of a medical condition
BR122020021163B1 (pt) * 2010-09-13 2021-03-16 Clinical Genomics Pty. Ltd. métodos de triagem de início ou predisposição para início de neoplasma do intestino grosso ou monitoramento do progresso de neoplasma em indivíduo
BR112014000443B1 (pt) * 2011-07-08 2021-03-23 Epigenomics Ag Métodos para determinação do prognóstico de um indivíduo com câncer
CA2872867C (en) 2012-05-11 2020-09-15 Clinical Genomics Pty Ltd Diagnostic gene marker panel for colorectal cancer
ES2778028T3 (es) * 2012-05-18 2020-08-07 Clinical Genomics Pty Ltd Un método de cribado para cáncer colorrectal
CN103789428B (zh) * 2014-01-22 2015-04-15 北京神源德生物科技有限公司 引物对及其应用及检测sept9dna甲基化状态的试剂盒

Also Published As

Publication number Publication date
JP6722659B2 (ja) 2020-07-15
MX2016015934A (es) 2017-09-01
IL280521A (en) 2021-03-01
US20230212685A1 (en) 2023-07-06
IL280521B (en) 2022-07-01
EP3152333A4 (en) 2018-01-03
US20170191135A1 (en) 2017-07-06
JP2017516504A (ja) 2017-06-22
KR20220150423A (ko) 2022-11-10
EP3152333A2 (en) 2017-04-12
EP3152333B1 (en) 2019-09-11
KR102587812B1 (ko) 2023-10-10
ZA201700031B (en) 2020-05-27
IL249365A0 (en) 2017-02-28
AU2022200667A1 (en) 2022-02-24
KR20170052532A (ko) 2017-05-12
JP7000504B2 (ja) 2022-02-04
WO2015187823A2 (en) 2015-12-10
CA2951141C (en) 2021-11-30
AU2015271697B2 (en) 2021-11-04
PH12016502417A1 (en) 2017-02-27
BR112016028521B1 (pt) 2023-03-14
CN106574303A (zh) 2017-04-19
US11486007B2 (en) 2022-11-01
KR102461235B1 (ko) 2022-10-28
MX370850B (es) 2020-01-08
NZ727493A (en) 2023-07-28
IL249365B (en) 2021-02-28
WO2015187823A3 (en) 2016-03-17
CA2951141A1 (en) 2015-12-10
AU2022200667B2 (en) 2024-09-19
JP2020191876A (ja) 2020-12-03
AU2015271697A1 (en) 2017-01-12

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