BR112016024357A2 - composições de insulina de ação rápida - Google Patents
composições de insulina de ação rápidaInfo
- Publication number
- BR112016024357A2 BR112016024357A2 BR112016024357A BR112016024357A BR112016024357A2 BR 112016024357 A2 BR112016024357 A2 BR 112016024357A2 BR 112016024357 A BR112016024357 A BR 112016024357A BR 112016024357 A BR112016024357 A BR 112016024357A BR 112016024357 A2 BR112016024357 A2 BR 112016024357A2
- Authority
- BR
- Brazil
- Prior art keywords
- acting insulin
- fast acting
- insulin compositions
- insulin analogue
- insulin
- Prior art date
Links
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title abstract 4
- 239000000203 mixture Substances 0.000 title abstract 3
- 102000004877 Insulin Human genes 0.000 title 1
- 108090001061 Insulin Proteins 0.000 title 1
- 229940125396 insulin Drugs 0.000 title 1
- 239000004026 insulin derivative Substances 0.000 abstract 2
- 101000976075 Homo sapiens Insulin Proteins 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- PBGKTOXHQIOBKM-FHFVDXKLSA-N insulin (human) Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H]1CSSC[C@H]2C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3C=CC(O)=CC=3)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3NC=NC=3)NC(=O)[C@H](CO)NC(=O)CNC1=O)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(=O)N[C@@H](CC(N)=O)C(O)=O)=O)CSSC[C@@H](C(N2)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)CN)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)CC=1C=CC=CC=1)C(C)C)C1=CN=CN1 PBGKTOXHQIOBKM-FHFVDXKLSA-N 0.000 abstract 1
- PAJMKGZZBBTTOY-ZFORQUDYSA-N treprostinil Chemical compound C1=CC=C(OCC(O)=O)C2=C1C[C@@H]1[C@@H](CC[C@@H](O)CCCCC)[C@H](O)C[C@@H]1C2 PAJMKGZZBBTTOY-ZFORQUDYSA-N 0.000 abstract 1
- 229960005032 treprostinil Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
- A61K31/5575—Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
- A61K31/558—Eicosanoids, e.g. leukotrienes or prostaglandins having heterocyclic rings containing oxygen as the only ring hetero atom, e.g. thromboxanes
- A61K31/5585—Eicosanoids, e.g. leukotrienes or prostaglandins having heterocyclic rings containing oxygen as the only ring hetero atom, e.g. thromboxanes having five-membered rings containing oxygen as the only ring hetero atom, e.g. prostacyclin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Inorganic Chemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Emergency Medicine (AREA)
- Dermatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
a presente invenção refere-se a uma composição de insulina humana ou de análogo de insulina que inclui treprostinil e que tem ação farmacocinética mais rápida do que as formulações comerciais de produtos de análogo de insulina existentes.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461990402P | 2014-05-08 | 2014-05-08 | |
| US61/990,402 | 2014-05-08 | ||
| PCT/US2015/029010 WO2015171484A1 (en) | 2014-05-08 | 2015-05-04 | Rapid-acting insulin compositions |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BR112016024357A2 true BR112016024357A2 (pt) | 2017-10-10 |
| BR112016024357B1 BR112016024357B1 (pt) | 2022-08-23 |
Family
ID=53189204
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112016024357-9A BR112016024357B1 (pt) | 2014-05-08 | 2015-05-04 | Composições farmacêuticas compreendendo uma insulina e treprostinil, seu uso, e artigo de fabricação |
Country Status (36)
| Country | Link |
|---|---|
| US (2) | US9439952B2 (pt) |
| EP (3) | EP3536380B8 (pt) |
| JP (1) | JP6050902B2 (pt) |
| KR (1) | KR101858890B1 (pt) |
| CN (1) | CN106456717B (pt) |
| AP (1) | AP2016009525A0 (pt) |
| AR (1) | AR100155A1 (pt) |
| AU (1) | AU2015256355B2 (pt) |
| BR (1) | BR112016024357B1 (pt) |
| CA (1) | CA2945188C (pt) |
| CL (1) | CL2016002772A1 (pt) |
| CY (2) | CY1121669T1 (pt) |
| DK (2) | DK3536380T3 (pt) |
| EA (1) | EA031134B1 (pt) |
| ES (2) | ES2733639T3 (pt) |
| HR (2) | HRP20190777T1 (pt) |
| HU (2) | HUE044370T2 (pt) |
| IL (1) | IL248350B (pt) |
| JO (1) | JO3624B1 (pt) |
| LT (2) | LT3140008T (pt) |
| MA (1) | MA39441A1 (pt) |
| ME (1) | ME03384B (pt) |
| MX (1) | MX367521B (pt) |
| NZ (1) | NZ724919A (pt) |
| PE (1) | PE20161408A1 (pt) |
| PH (1) | PH12016502195B1 (pt) |
| PL (2) | PL3536380T3 (pt) |
| PT (2) | PT3140008T (pt) |
| RS (2) | RS58726B1 (pt) |
| SG (1) | SG11201608424WA (pt) |
| SI (2) | SI3536380T1 (pt) |
| TN (1) | TN2016000443A1 (pt) |
| TR (1) | TR201906843T4 (pt) |
| TW (1) | TWI685348B (pt) |
| UA (1) | UA124919C2 (pt) |
| WO (1) | WO2015171484A1 (pt) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2910571B1 (en) | 2008-03-18 | 2016-10-05 | Novo Nordisk A/S | Protease stabilized, acylated insulin analogues |
| PL2919804T3 (pl) | 2012-11-13 | 2018-07-31 | Adocia | Szybko działająca formulacja insuliny zawierająca podstawiony związek anionowy |
| US9505737B2 (en) | 2013-01-11 | 2016-11-29 | Corsair Pharma, Inc. | Treprostinil derivative compounds and methods of using same |
| EP2943479B1 (en) | 2013-01-11 | 2020-04-15 | Corsair Pharma, Inc. | Prodrugs of treprostinil |
| WO2017015760A1 (en) * | 2015-07-28 | 2017-02-02 | Societe De Commercialisation Des Produits De La Recherche Appliquee Socpra Sciences Sante Et Humaines, S.E.C. | A pharmaceutical preparation for improving absorption and postprandial hypoglycemic action of insulin |
| JO3749B1 (ar) | 2015-08-27 | 2021-01-31 | Lilly Co Eli | تركيبات إنسولين سريعة المفعول |
| CN114904100A (zh) * | 2016-01-29 | 2022-08-16 | 曼金德公司 | 干粉吸入器 |
| GB201607918D0 (en) | 2016-05-06 | 2016-06-22 | Arecor Ltd | Novel formulations |
| EP3515430A1 (en) | 2016-09-26 | 2019-07-31 | United Therapeutics Corporation | Treprostinil prodrugs |
| CA3034971A1 (en) | 2016-09-29 | 2018-04-05 | Arecor Limited | A pharmaceutical insulin formulation |
| MX2019006463A (es) | 2016-12-16 | 2019-08-14 | Novo Nordisk As | Composiciones farmaceuticas que contienen insulina. |
| GB201707188D0 (en) | 2017-05-05 | 2017-06-21 | Arecor Ltd | Novel formulations |
| GB201707187D0 (en) | 2017-05-05 | 2017-06-21 | Arecor Ltd | Novel formulations |
| GB201707189D0 (en) | 2017-05-05 | 2017-06-21 | Arecor Ltd | Novel formulations |
| JP6920471B2 (ja) | 2017-06-01 | 2021-08-18 | イーライ リリー アンド カンパニー | 迅速に作用するインスリン組成物 |
| CA3094237A1 (en) | 2018-04-04 | 2019-10-10 | Arecor Limited | Medical infusion pump system for the delivery of an insulin compound |
| IL277720B2 (en) | 2018-04-04 | 2024-03-01 | Arecor Ltd | A medical infusion pump system for administration of an insulin compound |
| US20210093775A1 (en) * | 2018-04-04 | 2021-04-01 | Arecor Limited | Medical infusion pump system for the delivery of an insulin compound |
| FR3083985A1 (fr) | 2018-07-23 | 2020-01-24 | Adocia | Dispositif pour injecter une solution d'insuline(s) |
| WO2019243627A1 (fr) | 2018-06-23 | 2019-12-26 | Adocia | Dispositif pour injecter une solution d'insuline(s) |
| EA202190552A1 (ru) * | 2018-09-18 | 2021-06-18 | Эли Лилли Энд Компани | Эрбуминовая соль трепростинила |
| US10799564B1 (en) | 2019-05-06 | 2020-10-13 | Baxter International Inc. | Insulin premix formulation and product, methods of preparing same, and methods of using same |
| US20220249619A1 (en) * | 2019-07-12 | 2022-08-11 | Novo Nordisk A/S | High concentration insulin formulation |
| AU2020337342A1 (en) | 2019-08-23 | 2022-02-24 | United Therapeutics Corporation | Treprostinil prodrugs |
| GB202004814D0 (en) | 2020-04-01 | 2020-05-13 | Arecor Ltd | Novel formulations |
| CN115916212A (zh) | 2020-04-17 | 2023-04-04 | 联合治疗公司 | 曲前列尼尔用于治疗间质性肺病 |
| CN116113415A (zh) | 2020-06-09 | 2023-05-12 | 联合治疗公司 | 曲前列尼尔的富马酰基二酮哌啶前药 |
| TW202214292A (zh) * | 2020-06-30 | 2022-04-16 | 大陸商江蘇恆瑞醫藥股份有限公司 | 速效胰島素組成物及其醫藥用途 |
| WO2022132655A1 (en) | 2020-12-14 | 2022-06-23 | United Therapeutics Corporation | Methods of treating disease with treprostinil prodrugs |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2740953A1 (de) | 1977-09-12 | 1979-03-22 | Thera Ges Fuer Patente | Verwendung von prostaglandinen zur senkung des blutzuckerspiegels |
| JPH10251146A (ja) * | 1997-03-11 | 1998-09-22 | Toray Ind Inc | 糖尿病性神経障害の治療方法 |
| MXPA04001560A (es) * | 2001-08-28 | 2004-05-17 | Lilly Co Eli | Premezclas de glp-1 e insulina basal. |
| JP5599543B2 (ja) * | 2002-05-07 | 2014-10-01 | ノヴォ ノルディスク アー／エス | 単量体インスリン及びアシル化インスリンを含む可溶性製剤 |
| KR101186029B1 (ko) * | 2004-04-12 | 2012-09-27 | 유나이티드 쎄러퓨틱스 코포레이션 | 신경병증성 당뇨병성 족부 궤양을 치료하기 위한트레프로스티닐의 용도 |
| US20090054473A1 (en) * | 2007-08-22 | 2009-02-26 | Gilead Colorado, Inc. | Therapy for complications of diabetes |
| WO2010023666A2 (en) | 2008-08-28 | 2010-03-04 | Medingo Ltd. | Device and method for enhanced subcutaneous insulin absorption |
| CN102164487A (zh) * | 2008-09-25 | 2011-08-24 | 阿拉迪姆公司 | 曲前列素的深肺部递送 |
| PL2340033T3 (pl) | 2009-06-26 | 2014-03-31 | Novo Nordisk As | Preparat zawierający insulinę, nikotynamid i argininę |
| US9492422B2 (en) * | 2009-11-13 | 2016-11-15 | Toray Industries, Inc. | Therapeutic or prophylactic agent for diabetes |
| KR20140030125A (ko) | 2010-12-14 | 2014-03-11 | 노보 노르디스크 에이/에스 | 인슐린, 니코틴아미드 및 아미노산을 포함하는 제제 |
| CN103857413A (zh) * | 2011-08-12 | 2014-06-11 | 阿森迪斯药物股份有限公司 | 载体连接的曲罗尼尔前药 |
| US9381247B2 (en) * | 2012-04-16 | 2016-07-05 | Biodel Inc. | Magnesium compositions for modulating the pharmacokinetics and pharmacodynamics of insulin and insulin analogs, and injection site pain |
| WO2015031709A1 (en) | 2013-08-30 | 2015-03-05 | Perosphere, Inc. | Rapid acting injectable formulations comprising a peptide and a vasodilatory agent |
| WO2015120457A1 (en) | 2014-02-10 | 2015-08-13 | Biodel Inc. | Stabilized ultra-rapid-acting insulin formulations |
-
2015
- 2015-04-21 JO JOP/2015/0079A patent/JO3624B1/ar active
- 2015-04-21 TW TW104112752A patent/TWI685348B/zh active
- 2015-04-22 AR ARP150101208A patent/AR100155A1/es not_active Application Discontinuation
- 2015-05-04 SG SG11201608424WA patent/SG11201608424WA/en unknown
- 2015-05-04 PT PT15723388T patent/PT3140008T/pt unknown
- 2015-05-04 KR KR1020167031043A patent/KR101858890B1/ko active IP Right Grant
- 2015-05-04 DK DK19161129.2T patent/DK3536380T3/da active
- 2015-05-04 HU HUE15723388 patent/HUE044370T2/hu unknown
- 2015-05-04 BR BR112016024357-9A patent/BR112016024357B1/pt active IP Right Grant
- 2015-05-04 CN CN201580024110.4A patent/CN106456717B/zh active Active
- 2015-05-04 LT LTEP15723388.3T patent/LT3140008T/lt unknown
- 2015-05-04 AP AP2016009525A patent/AP2016009525A0/en unknown
- 2015-05-04 LT LTEP19161129.2T patent/LT3536380T/lt unknown
- 2015-05-04 EP EP19161129.2A patent/EP3536380B8/en active Active
- 2015-05-04 HU HUE19161129A patent/HUE055742T2/hu unknown
- 2015-05-04 TN TN2016000443A patent/TN2016000443A1/en unknown
- 2015-05-04 EP EP21183262.1A patent/EP3943155A1/en not_active Withdrawn
- 2015-05-04 NZ NZ724919A patent/NZ724919A/en unknown
- 2015-05-04 EA EA201691911A patent/EA031134B1/ru active Protection Beyond IP Right Term
- 2015-05-04 CA CA2945188A patent/CA2945188C/en active Active
- 2015-05-04 MX MX2016014643A patent/MX367521B/es active IP Right Grant
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