BR112016020556A2 - compostos, composição farmacêutica, método de modulação da atividade do receptor de grelina, método para o tratamento de uma doença - Google Patents

compostos, composição farmacêutica, método de modulação da atividade do receptor de grelina, método para o tratamento de uma doença

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Publication number
BR112016020556A2
BR112016020556A2 BR112016020556A BR112016020556A BR112016020556A2 BR 112016020556 A2 BR112016020556 A2 BR 112016020556A2 BR 112016020556 A BR112016020556 A BR 112016020556A BR 112016020556 A BR112016020556 A BR 112016020556A BR 112016020556 A2 BR112016020556 A2 BR 112016020556A2
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BR
Brazil
Prior art keywords
disease
treating
compounds
pharmaceutical composition
receptor activity
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BR112016020556A
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English (en)
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BR112016020556B1 (pt
BR112016020556A8 (pt
Inventor
Guainazzi Angelo
Daina Antoine
Giuliano Claudio
Pietra Claudio
Garcia Rubio Silvina
Original Assignee
Helsinn Healthcare Sa
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Application filed by Helsinn Healthcare Sa filed Critical Helsinn Healthcare Sa
Publication of BR112016020556A2 publication Critical patent/BR112016020556A2/pt
Publication of BR112016020556A8 publication Critical patent/BR112016020556A8/pt
Publication of BR112016020556B1 publication Critical patent/BR112016020556B1/pt

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4453—Non condensed piperidines, e.g. piperocaine only substituted in position 1, e.g. propipocaine, diperodon
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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