EA200901240A1 - Соединения 4-пиперидинилмочевины (варианты), фармацевтическая композиция на их основе (варианты) и способ лечения заболевания, опосредованного растворимой эпоксидгидролазой, посредством названных соединений (варианты) - Google Patents
Соединения 4-пиперидинилмочевины (варианты), фармацевтическая композиция на их основе (варианты) и способ лечения заболевания, опосредованного растворимой эпоксидгидролазой, посредством названных соединений (варианты)Info
- Publication number
- EA200901240A1 EA200901240A1 EA200901240A EA200901240A EA200901240A1 EA 200901240 A1 EA200901240 A1 EA 200901240A1 EA 200901240 A EA200901240 A EA 200901240A EA 200901240 A EA200901240 A EA 200901240A EA 200901240 A1 EA200901240 A1 EA 200901240A1
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- EA
- Eurasian Patent Office
- Prior art keywords
- mediated
- solvable
- epoxydrohydrolose
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- distribution
- Prior art date
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C07D211/58—Nitrogen atoms attached in position 4
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
- C07D211/96—Sulfur atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Obesity (AREA)
- Physical Education & Sports Medicine (AREA)
- Endocrinology (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Urology & Nephrology (AREA)
- Pulmonology (AREA)
- Gastroenterology & Hepatology (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Pyridine Compounds (AREA)
Abstract
Описаны соединения мочевины из стереоизомера или фармацевтически приемлемая соль и композиции, которые ингибируют растворимую эпоксидгидролазу (sEH), способы получения соединения и композиций и способы лечения пациентов с помощью данных соединений и композиций. Соединения, композиции и способы используют для лечения ряда sEH-опосредованных заболеваний, включая гипертензивные, сердечно-сосудистые, воспалительные, легочные и связанные с диабетом заболевания.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US89463707P | 2007-03-13 | 2007-03-13 | |
PCT/US2007/082012 WO2008112022A1 (en) | 2007-03-13 | 2007-10-19 | 4 -pi peridinylurea compounds as soluble epoxide hydrolase inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
EA200901240A1 true EA200901240A1 (ru) | 2010-02-26 |
Family
ID=39205255
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200901240A EA200901240A1 (ru) | 2007-03-13 | 2007-10-19 | Соединения 4-пиперидинилмочевины (варианты), фармацевтическая композиция на их основе (варианты) и способ лечения заболевания, опосредованного растворимой эпоксидгидролазой, посредством названных соединений (варианты) |
Country Status (12)
Country | Link |
---|---|
US (1) | US20080227780A1 (ru) |
EP (1) | EP2132176A1 (ru) |
JP (1) | JP2010521456A (ru) |
CN (1) | CN101679258A (ru) |
AU (1) | AU2007349176A1 (ru) |
BR (1) | BRPI0721451A2 (ru) |
CA (1) | CA2680360A1 (ru) |
EA (1) | EA200901240A1 (ru) |
IL (1) | IL200667A0 (ru) |
MX (1) | MX2009009754A (ru) |
TW (1) | TW200837055A (ru) |
WO (1) | WO2008112022A1 (ru) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2010507587A (ja) * | 2006-10-20 | 2010-03-11 | アレテ セラピューティクス, インコーポレイテッド | 可溶性エポキシドヒドロラーゼ阻害剤 |
US20090247521A1 (en) * | 2007-12-28 | 2009-10-01 | Arete Therapeutics, Inc. | Soluble epoxide hydrolase inhibitors for the treatment of endothelial dysfunction |
WO2009129508A1 (en) * | 2008-04-18 | 2009-10-22 | Arete Therapeutics, Inc. | Soluble epoxide hydrolase inhibitors |
US20100063583A1 (en) * | 2008-08-29 | 2010-03-11 | Arete Therapeutics, Inc. | Use of soluble epoxide hydrolase inhibitors in the treatment of inflammatory vascular diseases |
EP2528604B1 (en) * | 2010-01-29 | 2017-11-22 | The Regents of the University of California | Acyl piperidine inhibitors of soluble epoxide hydrolase |
EP2582709B1 (de) | 2010-06-18 | 2018-01-24 | Sanofi | Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen |
EP2567959B1 (en) | 2011-09-12 | 2014-04-16 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
WO2013065712A1 (ja) * | 2011-10-31 | 2013-05-10 | 東レ株式会社 | ジアザスピロウレア誘導体及びその医薬用途 |
CN104093708B (zh) * | 2012-02-01 | 2016-11-09 | 加利福尼亚大学董事会 | 可溶性环氧化物水解酶的酰基哌啶抑制剂 |
JPWO2015046405A1 (ja) * | 2013-09-26 | 2017-03-09 | 東レ株式会社 | 鎮痛剤 |
TW201601724A (zh) * | 2013-09-26 | 2016-01-16 | Toray Industries | 肺性高血壓之治療劑或預防劑 |
TWI703130B (zh) * | 2014-03-07 | 2020-09-01 | 瑞士商赫爾辛保健股份有限公司 | 對位取代的不對稱脲及其醫療用途 |
WO2015188060A1 (en) * | 2014-06-06 | 2015-12-10 | The Scripps Research Institute | FLUOROSULFONYL sEH INHIBITORS |
RS64027B1 (sr) | 2016-03-22 | 2023-03-31 | Helsinn Healthcare Sa | Benzenesulfonil-asimetrične uree i njihove medicinske upotrebe |
US20200317813A1 (en) | 2016-05-25 | 2020-10-08 | Johann Wolfgang Goethe-Universitat Frankfurt Am Main | Treatment and diagnosis of non-proliferative diabetic retinopathy |
WO2019222267A1 (en) * | 2018-05-15 | 2019-11-21 | The Scripps Research Institute | Abhd12 inhibitors and methods of making and using same |
EP3584236A1 (en) * | 2018-06-20 | 2019-12-25 | Universitat de Barcelona | Polycyclic compounds soluble epoxide hydrolase inhibitors |
CN111423396B (zh) * | 2020-04-30 | 2023-01-06 | 沈阳药科大学 | 一种sEH抑制剂及其制备方法和应用 |
CN113831301B (zh) * | 2020-06-08 | 2023-06-06 | 沈阳药科大学 | 苯并噻唑类衍生物及其用途 |
US11766419B2 (en) | 2021-01-08 | 2023-09-26 | Banasthali Vidyapith | Mebeverine as soluble epoxide hydrolase inhibitor |
CN113402447B (zh) * | 2021-06-22 | 2022-10-18 | 沈阳药科大学 | 一种sEH抑制剂或其药学上可接受的组合物及其制备方法和应用 |
CN115677567A (zh) * | 2022-11-15 | 2023-02-03 | 大唐环境产业集团股份有限公司 | 一种4-氨基-1-哌啶丙醇的合成方法 |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5189036A (en) * | 1990-06-20 | 1993-02-23 | Schering Ag | Imidazolylbenzoyl substituted heterocycles |
AU1208397A (en) * | 1995-12-28 | 1997-07-28 | Takeda Chemical Industries Ltd. | Diphenylmethane derivatives as mip-1alpha/rantes receptor antagonists |
US6531506B1 (en) * | 1996-08-13 | 2003-03-11 | Regents Of The University Of California | Inhibitors of epoxide hydrolases for the treatment of hypertension |
JPH1171350A (ja) * | 1997-06-17 | 1999-03-16 | Takeda Chem Ind Ltd | ヒドロキシピペリジン化合物およびその剤 |
JPH11130757A (ja) * | 1997-10-24 | 1999-05-18 | Teijin Ltd | フェニルアルキル環状ジアミン誘導体およびその医薬としての用途 |
AU3716499A (en) * | 1998-04-21 | 1999-11-08 | Aventis Pharma Limited | Substituted diamines and their use as cell adhesion inhibitors |
HUP0303107A2 (hu) * | 2000-09-29 | 2004-03-01 | Glaxo Group Ltd. | Gyulladásos betegségek kezelésére alkalmazható vegyületek, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények |
US7122544B2 (en) * | 2000-12-06 | 2006-10-17 | Signal Pharmaceuticals, Llc | Anilinopyrimidine derivatives as IKK inhibitors and compositions and methods related thereto |
WO2003024451A1 (de) * | 2001-09-08 | 2003-03-27 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | 2-(2-phenylethyl)-benzimidazol-5-carboxamid- derivative und ihre verwendung als tryptase_ inhibitoren |
GT200500281A (es) * | 2004-10-22 | 2006-04-24 | Novartis Ag | Compuestos organicos. |
MX2008000115A (es) * | 2005-06-20 | 2008-03-18 | Schering Corp | Derivados de piperidina utiles como antagonistas de histamina h3. |
EP1909796A4 (en) * | 2005-07-12 | 2009-11-11 | Univ California | USE OF CIS-EPOXYICICATURATOIC ACIDS AND SOLUBLE HYDROLASE EPOXY INHIBITORS TO ATTENUATE VIEW DISORDERS |
WO2007030761A2 (en) * | 2005-09-08 | 2007-03-15 | Smithkline Beecham Corporation | Acyclic 1,4-diamines and uses thereof |
AR059826A1 (es) * | 2006-03-13 | 2008-04-30 | Univ California | Inhibidores de urea conformacionalmente restringidos de epoxido hidrolasa soluble |
AP2009004763A0 (en) * | 2006-07-05 | 2009-02-28 | Pfizer Prod Inc | Pyrazole derivatives as cytochrome P450 inhibitors |
-
2007
- 2007-10-19 US US11/875,658 patent/US20080227780A1/en not_active Abandoned
- 2007-10-19 EA EA200901240A patent/EA200901240A1/ru unknown
- 2007-10-19 WO PCT/US2007/082012 patent/WO2008112022A1/en active Application Filing
- 2007-10-19 CN CN200780052107A patent/CN101679258A/zh active Pending
- 2007-10-19 CA CA002680360A patent/CA2680360A1/en not_active Abandoned
- 2007-10-19 EP EP07863439A patent/EP2132176A1/en not_active Withdrawn
- 2007-10-19 BR BRPI0721451-0A patent/BRPI0721451A2/pt not_active Application Discontinuation
- 2007-10-19 TW TW096139429A patent/TW200837055A/zh unknown
- 2007-10-19 MX MX2009009754A patent/MX2009009754A/es not_active Application Discontinuation
- 2007-10-19 JP JP2009553567A patent/JP2010521456A/ja active Pending
- 2007-10-19 AU AU2007349176A patent/AU2007349176A1/en not_active Abandoned
-
2009
- 2009-09-01 IL IL200667A patent/IL200667A0/en unknown
Also Published As
Publication number | Publication date |
---|---|
US20080227780A1 (en) | 2008-09-18 |
MX2009009754A (es) | 2009-09-24 |
JP2010521456A (ja) | 2010-06-24 |
AU2007349176A1 (en) | 2008-09-18 |
CA2680360A1 (en) | 2008-09-18 |
WO2008112022A1 (en) | 2008-09-18 |
BRPI0721451A2 (pt) | 2014-03-25 |
EP2132176A1 (en) | 2009-12-16 |
WO2008112022A8 (en) | 2009-10-08 |
TW200837055A (en) | 2008-09-16 |
IL200667A0 (en) | 2010-05-17 |
CN101679258A (zh) | 2010-03-24 |
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