HUP0303107A2 - Gyulladásos betegségek kezelésére alkalmazható vegyületek, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények - Google Patents
Gyulladásos betegségek kezelésére alkalmazható vegyületek, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítményekInfo
- Publication number
- HUP0303107A2 HUP0303107A2 HU0303107A HUP0303107A HUP0303107A2 HU P0303107 A2 HUP0303107 A2 HU P0303107A2 HU 0303107 A HU0303107 A HU 0303107A HU P0303107 A HUP0303107 A HU P0303107A HU P0303107 A2 HUP0303107 A2 HU P0303107A2
- Authority
- HU
- Hungary
- Prior art keywords
- group
- aryl
- alkyl
- heteroaryl
- formula
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 208000027866 inflammatory disease Diseases 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 12
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 6
- 101100439663 Arabidopsis thaliana CHR7 gene Proteins 0.000 abstract 4
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 4
- 125000003342 alkenyl group Chemical group 0.000 abstract 3
- 125000003118 aryl group Chemical group 0.000 abstract 3
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 3
- 125000004434 sulfur atom Chemical group 0.000 abstract 3
- 125000000304 alkynyl group Chemical group 0.000 abstract 2
- 229910052799 carbon Inorganic materials 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 125000000392 cycloalkenyl group Chemical group 0.000 abstract 2
- 125000001072 heteroaryl group Chemical group 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 125000002950 monocyclic group Chemical group 0.000 abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 2
- 229910052717 sulfur Inorganic materials 0.000 abstract 2
- 125000005018 aryl alkenyl group Chemical group 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000000816 ethylene group Chemical group [H]C([H])([*:1])C([H])([H])[*:2] 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
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- A—HUMAN NECESSITIES
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- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics
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- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
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- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D267/02—Seven-membered rings
- C07D267/08—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D267/10—Seven-membered rings having the hetero atoms in positions 1 and 4 not condensed with other rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
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- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- Public Health (AREA)
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- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
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- Tropical Medicine & Parasitology (AREA)
- Biomedical Technology (AREA)
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Abstract
A találmány szerinti vegyületek (I) általános képletében R1 jelentésealkilcsoport, alkenilcsoport, alkinilcsoport, aril-Y1-, heteroaril-Y1-, aril(O)t-aril-Y1-, aril-(O)t-heteroaril-Y1-, hetero-aril-(O)t-aril-Y1-, heteroaril-(O)t-heteroaril-Y1-, aril-SO2-Y1-, alkil-G-Y1-,heteroaril-G-aril-Y1-, J1-SO2-Y1-, R17O(CO-aIkenil-Y1-, R17NHCO-Y1-,R17NHSO2-Y1-, alkinil-Y1-, alkenil-Y1-, aril-O-Y1-, heteroaril-O-Y1-,alkil-SO2-Y1-, M-Y1-, J1-Y1-, J1-CO-Y1-, aril-CO-Y1 vagy cikloalkilY1- vagy cikloalkenil-Y1-képletű csoport, ahol az alkinilcsoport ésalkinil-Y1-képletű csoport adott esetben -OR17 képletű csoporttalszubsztituálva lehet, az alkenilcsoport adott esetben egy vagy több -COOR17 képletű csoporttal szubsztituálva lehet, és a cikloalkilcsoportés cikloalkenilcsoport adott esetben egy vagy több hidroxilcsoporttalvagy alkilcsoporttal szubsztituálva lehet, R2 jelentése hidrogénatomvagy alkilcsoport, amely adott esetben hidroxilcsoporttalszubsztituálva lehet, R3 jelentése hidrogénatom vagy alkilcsoport,vagy R1 és R2 jelentése a kapcsolódó nitrogénatommal együtt J2csoport, ahol a nitrogénatom jelentése X1 vagy X2 csoport, t értéke 0vagy 1, X jelentése etiléncsoport vagy CReRf képletű csoport, ahol Reés Rf jelentése egymástól függetlenül hidrogénatom vagy alkilcsoportvagy Re és Rf jelentése a kapcsolódó szénatommal együttcikloalkilcsoport, R4 és R5 jelentése egymástól függetlenülhidrogénatom vagy alkilcsoport, Z jelentése közvetlen kötés, CO, SO2,CR10R7(CH2)n, (CH2)nCR10R7, CHR7(CH2)nO, CHR7(CH2)nS, CHR7(CH2)nOCO,CHR7(CH2)nCO, COCHR7(CH2)n vagy SO2CHR7(CH2)n képletű csoport, R6jelentése alkilcsoport, alkenilcsoport, arilcsoport, heteroaril-csoport, arilalkenil-csoport, cianocsoport vagy -Y2-J3 képletűcsoport, R7 jelentése hidrogénatom, alkilcsoport, CONR8R9 vagy COO-(alkil) képletű csoport, a és b értéke 1 vagy 2, ahol a+b értéke 2vagy 3, G jelentése -SO2-, -SO2NR18-, -NR18SO2-, -NR18CO-, -CO- vagy -CONR18- képletű csoport, n értéke 0-4, M jelentése cikloalkil-csoportvagy cikloalkenil-csoport, amely monociklusos arilcsoporttal vagymonociklusos heteroaril-csoporttal fúzionálva van, J1, J2 és J3jelentése egymástól függetlenül (K) képletű csoport, ahol X1 jelentéseoxigénatom, NR11 vagy kénatom, X2 jelentése CH2, oxigénatom, NR12 vagykénatom, m1 értéke 1-3, m2 értéke 1-3, azzal a megszorítással, hogym1+m2 értéke 3-5, azzal a további megszorítással, hogy ha X1 és X2jelentése egyidejűleg oxigénatom, NR11, NR12 vagy kénatom, akkor m1 ésm2 értéke legalább 2, Y1, Y2 és Y3 jelentése egymástól függetlenülközvetlen kötés vagy -(CH2)pCRcRd(CH2)q- képletű csoport, ahol Rc ésRd jelentése egymástól függetlenül hidrogénatom vagy alkilcsoport vagyRc és Rd jelentése a kapcsolódó szénatommal együtt cikloalkilcsoport,p és q értéke egymástól függetlenül 0-5, ahol p+q értéke 0-5. Atalálmány kiterjed a fenti vegyületek előállítására, ezeke
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0023973A GB0023973D0 (en) | 2000-09-29 | 2000-09-29 | Therapeutically useful compounds |
| GB0107643A GB0107643D0 (en) | 2001-03-27 | 2001-03-27 | Therapeutically useful compounds |
| PCT/GB2001/004350 WO2002026723A1 (en) | 2000-09-29 | 2001-09-28 | Compounds useful in the treatment of inflammatory diseases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HUP0303107A2 true HUP0303107A2 (hu) | 2004-03-01 |
Family
ID=26245081
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0303107A HUP0303107A2 (hu) | 2000-09-29 | 2001-09-28 | Gyulladásos betegségek kezelésére alkalmazható vegyületek, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US7157457B2 (hu) |
| EP (2) | EP1586567A1 (hu) |
| JP (1) | JP5069392B2 (hu) |
| KR (1) | KR20030040510A (hu) |
| CN (1) | CN1478084A (hu) |
| AR (1) | AR037080A1 (hu) |
| AT (1) | ATE345331T1 (hu) |
| AU (1) | AU2001290146A1 (hu) |
| BR (1) | BR0114321A (hu) |
| CA (1) | CA2423305A1 (hu) |
| CZ (1) | CZ20031194A3 (hu) |
| DE (1) | DE60124576T2 (hu) |
| ES (1) | ES2275729T3 (hu) |
| HU (1) | HUP0303107A2 (hu) |
| IL (1) | IL155092A0 (hu) |
| MX (1) | MXPA03002813A (hu) |
| NO (1) | NO20031443L (hu) |
| NZ (1) | NZ525055A (hu) |
| PL (1) | PL362984A1 (hu) |
| WO (1) | WO2002026723A1 (hu) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0207450D0 (en) * | 2002-03-28 | 2002-05-08 | Glaxo Group Ltd | Novel compounds |
| US6858596B2 (en) | 2000-08-05 | 2005-02-22 | Smithkline Beecham Corporation | Formulation containing anti-inflammatory androstane derivative |
| US6750210B2 (en) | 2000-08-05 | 2004-06-15 | Smithkline Beecham Corporation | Formulation containing novel anti-inflammatory androstane derivative |
| US6759398B2 (en) | 2000-08-05 | 2004-07-06 | Smithkline Beecham Corporation | Anti-inflammatory androstane derivative |
| US6777400B2 (en) | 2000-08-05 | 2004-08-17 | Smithkline Beecham Corporation | Anti-inflammatory androstane derivative compositions |
| US6777399B2 (en) | 2000-08-05 | 2004-08-17 | Smithkline Beecham Corporation | Anti-inflammatory androstane derivative compositions |
| US6787532B2 (en) | 2000-08-05 | 2004-09-07 | Smithkline Beecham Corporation | Formulation containing anti-inflammatory androstane derivatives |
| US6858593B2 (en) | 2000-08-05 | 2005-02-22 | Smithkline Beecham Corporation | Anti-inflammatory androstane derivative compositions |
| GB0207439D0 (en) * | 2002-03-28 | 2002-05-08 | Glaxo Group Ltd | Novel compounds |
| TW200400035A (en) | 2002-03-28 | 2004-01-01 | Glaxo Group Ltd | Novel compounds |
| GB0207447D0 (en) * | 2002-03-28 | 2002-05-08 | Glaxo Group Ltd | Novel compounds |
| GB0207449D0 (en) * | 2002-03-28 | 2002-05-08 | Glaxo Group Ltd | Novel compounds |
| GB0207436D0 (en) * | 2002-03-28 | 2002-05-08 | Glaxo Group Ltd | Novel compounds |
| GB0207432D0 (en) | 2002-03-28 | 2002-05-08 | Glaxo Group Ltd | Novel compounds |
| GB0211759D0 (en) * | 2002-05-22 | 2002-07-03 | Glaxo Group Ltd | Novel compounds |
| GB0212357D0 (en) * | 2002-05-29 | 2002-07-10 | Glaxo Group Ltd | Novel compounds |
| GB2389530B (en) | 2002-06-14 | 2007-01-10 | Cipla Ltd | Pharmaceutical compositions |
| US6919356B2 (en) | 2002-09-26 | 2005-07-19 | Bristol Myers Squibb Company | N-substituted heterocyclic amines as modulators of chemokine receptor activity |
| DE60329831D1 (de) * | 2003-06-10 | 2009-12-10 | Biondi Ricardo Miguel | Verwendung einer Verbingung gemäss Formel I zur Herstellung einer pharmazeutischen Zubereitung |
| BRPI0413330A (pt) | 2003-08-29 | 2006-10-10 | Ranbaxy Lab Ltd | inibidores de fosfodiesterase do tipo iv, composição farmacêutica contendo os mesmos e processo para sua preparação |
| EP1801108B9 (en) | 2004-09-08 | 2013-11-20 | Mitsubishi Tanabe Pharma Corporation | Morpholine compounds for the treatment of inflammations |
| EP1992628A1 (en) | 2007-05-18 | 2008-11-19 | Glaxo Group Limited | Derivatives and analogs of N-ethylquinolones and N-ethylazaquinolones |
| EP1958947A1 (en) | 2007-02-15 | 2008-08-20 | Ranbaxy Laboratories Limited | Inhibitors of phosphodiesterase type 4 |
| EA200901240A1 (ru) * | 2007-03-13 | 2010-02-26 | Эрет Терэпьютикс, Инк. | Соединения 4-пиперидинилмочевины (варианты), фармацевтическая композиция на их основе (варианты) и способ лечения заболевания, опосредованного растворимой эпоксидгидролазой, посредством названных соединений (варианты) |
| US8273766B2 (en) | 2007-04-04 | 2012-09-25 | Kowa Company, Ltd. | Tetrahydroisoquinoline compound |
| KR20100093104A (ko) | 2007-12-05 | 2010-08-24 | 아스트라제네카 아베 | 항비만제로서의 피페라진 |
| WO2009071668A2 (en) | 2007-12-05 | 2009-06-11 | Biovitrum Ab (Publ) | Piperazine derivatives and their use as leptin receptor modulators |
| JP2015500221A (ja) | 2011-12-01 | 2015-01-05 | グラクソ グループ リミテッドＧｌａｘｏ Ｇｒｏｕｐ Ｌｉｍｉｔｅｄ | 眼疾患の治療および予防方法 |
| FR3022142B1 (fr) | 2014-06-16 | 2019-07-12 | Universite Paul Sabatier - Toulouse Iii | Inhibition de la chimiokine ccl7 ou de son recepteur ccr3 pour le traitement et le diagnostic du cancer de la prostate |
| EA031589B1 (ru) | 2014-08-22 | 2019-01-31 | Глэксосмитклайн Интеллекчуал Проперти Дивелопмент Лимитед | Трициклические азотсодержащие соединения для лечения инфекции, вызываемой neisseria gonorrhoeae |
| WO2018134731A1 (en) | 2017-01-17 | 2018-07-26 | Glaxosmithkline Intellectual Property Development Limited | Non peptidic heterobivalent molecules for treating inflammatory diseases |
| TW202140550A (zh) | 2020-01-29 | 2021-11-01 | 瑞士商諾華公司 | 使用抗ｔｓｌｐ抗體治療炎性或阻塞性氣道疾病之方法 |
| CN111269340B (zh) * | 2020-03-31 | 2020-12-29 | 台州学院 | 一种以1-甲烷磺酰哌嗪为配体的螯合树脂及其制备方法和应用 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3087763B2 (ja) * | 1990-11-30 | 2000-09-11 | 三井化学株式会社 | 新規な複素環式化合物およびそれを含有する医薬組成物 |
| JPH04247074A (ja) * | 1991-02-01 | 1992-09-03 | Yoshitomi Pharmaceut Ind Ltd | ４−モルホリノ安息香酸誘導体の製造法 |
| JPH04270272A (ja) * | 1991-02-25 | 1992-09-25 | Yoshitomi Pharmaceut Ind Ltd | アミノアルキルモルホリン誘導体の製造法 |
| WO1995031431A1 (fr) * | 1994-05-18 | 1995-11-23 | Nisshin Flour Milling Co., Ltd. | Nouveau derive de diaminomethylidene |
| US5753654A (en) * | 1994-05-18 | 1998-05-19 | Nisshin Flour Milling Co., Ltd. | Diaminomethylidene derivatives |
| EP2295436A1 (de) * | 1997-11-12 | 2011-03-16 | Bayer Schering Pharma AG | 2-Phenyl-substituierte Imidazotriazinone als Phosphodiesterase V Inhibitoren |
| JP3593037B2 (ja) | 1998-11-20 | 2004-11-24 | エフ．ホフマン−ラ ロシュ アーゲー | ピロリジン誘導体ｃｃｒ−３受容体アンタゴニスト |
| WO2000035876A1 (en) * | 1998-12-18 | 2000-06-22 | Du Pont Pharmaceuticals Company | 2-substituted-4-nitrogen heterocycles as modulators of chemokine receptor activity |
| EP1156807A4 (en) * | 1998-12-18 | 2002-04-03 | Du Pont Pharm Co | N-UREIDOALKYL-PIPERIDINES FOR USE AS MODULATORS OF THE ACTIVITY OF CHIMIOKIN RECEPTORS |
-
2001
- 2001-09-28 AU AU2001290146A patent/AU2001290146A1/en not_active Abandoned
- 2001-09-28 DE DE60124576T patent/DE60124576T2/de not_active Expired - Lifetime
- 2001-09-28 ES ES01970027T patent/ES2275729T3/es not_active Expired - Lifetime
- 2001-09-28 CA CA002423305A patent/CA2423305A1/en not_active Abandoned
- 2001-09-28 BR BR0114321-2A patent/BR0114321A/pt not_active IP Right Cessation
- 2001-09-28 CN CNA018196489A patent/CN1478084A/zh active Pending
- 2001-09-28 AR ARP010104603A patent/AR037080A1/es not_active Application Discontinuation
- 2001-09-28 AT AT01970027T patent/ATE345331T1/de not_active IP Right Cessation
- 2001-09-28 IL IL15509201A patent/IL155092A0/xx unknown
- 2001-09-28 EP EP05076503A patent/EP1586567A1/en not_active Withdrawn
- 2001-09-28 NZ NZ525055A patent/NZ525055A/en unknown
- 2001-09-28 WO PCT/GB2001/004350 patent/WO2002026723A1/en not_active Application Discontinuation
- 2001-09-28 US US10/381,871 patent/US7157457B2/en not_active Expired - Lifetime
- 2001-09-28 EP EP01970027A patent/EP1324991B1/en not_active Expired - Lifetime
- 2001-09-28 HU HU0303107A patent/HUP0303107A2/hu unknown
- 2001-09-28 PL PL01362984A patent/PL362984A1/xx not_active Application Discontinuation
- 2001-09-28 CZ CZ20031194A patent/CZ20031194A3/cs unknown
- 2001-09-28 JP JP2002531107A patent/JP5069392B2/ja not_active Expired - Lifetime
- 2001-09-28 KR KR10-2003-7004593A patent/KR20030040510A/ko not_active Application Discontinuation
- 2001-09-28 MX MXPA03002813A patent/MXPA03002813A/es unknown
-
2003
- 2003-03-28 NO NO20031443A patent/NO20031443L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ATE345331T1 (de) | 2006-12-15 |
| JP2004509953A (ja) | 2004-04-02 |
| EP1586567A1 (en) | 2005-10-19 |
| CN1478084A (zh) | 2004-02-25 |
| IL155092A0 (en) | 2003-10-31 |
| BR0114321A (pt) | 2003-07-01 |
| NO20031443D0 (no) | 2003-03-28 |
| US20040058907A1 (en) | 2004-03-25 |
| CA2423305A1 (en) | 2002-04-04 |
| EP1324991B1 (en) | 2006-11-15 |
| NZ525055A (en) | 2004-09-24 |
| DE60124576D1 (de) | 2006-12-28 |
| PL362984A1 (en) | 2004-11-15 |
| ES2275729T3 (es) | 2007-06-16 |
| US7157457B2 (en) | 2007-01-02 |
| JP5069392B2 (ja) | 2012-11-07 |
| AR037080A1 (es) | 2004-10-20 |
| AU2001290146A1 (en) | 2002-04-08 |
| CZ20031194A3 (cs) | 2003-08-13 |
| DE60124576T2 (de) | 2007-06-21 |
| MXPA03002813A (es) | 2003-10-15 |
| WO2002026723A1 (en) | 2002-04-04 |
| EP1324991A1 (en) | 2003-07-09 |
| NO20031443L (no) | 2003-05-26 |
| KR20030040510A (ko) | 2003-05-22 |
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