BR112016017152A2 - Monólitos com compostos de reconhecimento fixados, matrizes dos mesmos e usos dos mesmos - Google Patents

Monólitos com compostos de reconhecimento fixados, matrizes dos mesmos e usos dos mesmos

Info

Publication number
BR112016017152A2
BR112016017152A2 BR112016017152A BR112016017152A BR112016017152A2 BR 112016017152 A2 BR112016017152 A2 BR 112016017152A2 BR 112016017152 A BR112016017152 A BR 112016017152A BR 112016017152 A BR112016017152 A BR 112016017152A BR 112016017152 A2 BR112016017152 A2 BR 112016017152A2
Authority
BR
Brazil
Prior art keywords
monoliths
matrixes
recognition compounds
fixed recognition
fixed
Prior art date
Application number
BR112016017152A
Other languages
English (en)
Portuguese (pt)
Inventor
Harbury Pehr
Paidhungat Madan
PRINCE Robin
Original Assignee
Dice Molecules Sv Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dice Molecules Sv Llc filed Critical Dice Molecules Sv Llc
Publication of BR112016017152A2 publication Critical patent/BR112016017152A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1068—Template (nucleic acid) mediated chemical library synthesis, e.g. chemical and enzymatical DNA-templated organic molecule synthesis, libraries prepared by non ribosomal polypeptide synthesis [NRPS], DNA/RNA-polymerase mediated polypeptide synthesis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1065—Preparation or screening of tagged libraries, e.g. tagged microorganisms by STM-mutagenesis, tagged polynucleotides, gene tags
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1093—General methods of preparing gene libraries, not provided for in other subgroups
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
    • C40B50/14—Solid phase synthesis, i.e. wherein one or more library building blocks are bound to a solid support during library creation; Particular methods of cleavage from the solid support
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00306—Reactor vessels in a multiple arrangement
    • B01J2219/00313—Reactor vessels in a multiple arrangement the reactor vessels being formed by arrays of wells in blocks
    • B01J2219/00315—Microtiter plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/00423—Means for dispensing and evacuation of reagents using filtration, e.g. through porous frits
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B01J2219/005—Beads
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B01J2219/00504—Pins
    • B01J2219/00509—Microcolumns
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/0054—Means for coding or tagging the apparatus or the reagents
    • B01J2219/00547—Bar codes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/0054—Means for coding or tagging the apparatus or the reagents
    • B01J2219/00572—Chemical means
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00592—Split-and-pool, mix-and-divide processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00596—Solid-phase processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00639—Making arrays on substantially continuous surfaces the compounds being trapped in or bound to a porous medium
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00639—Making arrays on substantially continuous surfaces the compounds being trapped in or bound to a porous medium
    • B01J2219/00641—Making arrays on substantially continuous surfaces the compounds being trapped in or bound to a porous medium the porous medium being continuous, e.g. porous oxide substrates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/00722—Nucleotides
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
    • C40B50/14—Solid phase synthesis, i.e. wherein one or more library building blocks are bound to a solid support during library creation; Particular methods of cleavage from the solid support
    • C40B50/16—Solid phase synthesis, i.e. wherein one or more library building blocks are bound to a solid support during library creation; Particular methods of cleavage from the solid support involving encoding steps
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B70/00—Tags or labels specially adapted for combinatorial chemistry or libraries, e.g. fluorescent tags or bar codes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Structural Engineering (AREA)
  • Medicinal Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
BR112016017152A 2014-01-28 2015-01-28 Monólitos com compostos de reconhecimento fixados, matrizes dos mesmos e usos dos mesmos BR112016017152A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461932747P 2014-01-28 2014-01-28
US201462006845P 2014-06-02 2014-06-02
PCT/US2015/013382 WO2015116739A1 (en) 2014-01-28 2015-01-28 Monoliths with attached recognition compounds, arrays thereof and uses thereof

Publications (1)

Publication Number Publication Date
BR112016017152A2 true BR112016017152A2 (pt) 2017-08-08

Family

ID=53678148

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112016017152A BR112016017152A2 (pt) 2014-01-28 2015-01-28 Monólitos com compostos de reconhecimento fixados, matrizes dos mesmos e usos dos mesmos

Country Status (15)

Country Link
US (3) US10358641B2 (https=)
EP (1) EP3099799B1 (https=)
JP (1) JP6602772B2 (https=)
KR (1) KR20160122174A (https=)
CN (1) CN106459978B (https=)
AU (1) AU2015211020A1 (https=)
BR (1) BR112016017152A2 (https=)
CA (1) CA2940526A1 (https=)
DK (1) DK3099799T3 (https=)
ES (1) ES2732054T3 (https=)
IL (1) IL246784A0 (https=)
MX (1) MX369674B (https=)
RU (1) RU2016132972A (https=)
SG (2) SG11201606921PA (https=)
WO (1) WO2015116739A1 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6564369B2 (ja) 2013-12-09 2019-08-21 デュレクト コーポレイション 薬学的活性剤複合体、ポリマー複合体、ならびにこれらを伴う組成物及び方法
JP7033923B2 (ja) * 2016-01-08 2022-03-11 株式会社ジーンデザイン ゾル－ゲル法で作製される無機多孔質体を用いた核酸合成用担体
US20170348666A1 (en) * 2016-06-05 2017-12-07 Dice Molecules Sv, Llc Methods of routing, compositions and uses thereof
WO2020037194A1 (en) * 2018-08-17 2020-02-20 Sierra Biosystems, Inc. Row-independent oligonucleotide synthesis
CN110724623A (zh) * 2019-09-10 2020-01-24 深圳市百迈生命科学有限公司 1536孔固相合成与萃取板

Family Cites Families (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1123878A (en) 1966-08-23 1968-08-14 Ici Ltd Synthesis of norbornene derivatives
US4889632A (en) 1987-12-10 1989-12-26 Ceskoslovenska Akademie Ved Macroporous polymeric membranes for the separation of polymers and a method of their application
JPH06502667A (ja) 1990-10-26 1994-03-24 ジンタ・インコーポレイテッド オリゴマーの固相合成用非芳香族有機ポリマー試薬
US5539082A (en) 1993-04-26 1996-07-23 Nielsen; Peter E. Peptide nucleic acids
DK51092D0 (da) 1991-05-24 1992-04-15 Ole Buchardt Oligonucleotid-analoge betegnet pna, monomere synthoner og fremgangsmaade til fremstilling deraf samt anvendelser deraf
US5281368A (en) 1992-03-31 1994-01-25 Exxon Chemical Patents Inc. Norbornene polymerization initiators and process for preparing same
US5605793A (en) 1994-02-17 1997-02-25 Affymax Technologies N.V. Methods for in vitro recombination
WO1999005320A1 (en) * 1997-07-22 1999-02-04 Rapigene, Inc. Multiple functionalities within an array element and uses thereof
WO1999064480A1 (en) 1998-06-12 1999-12-16 Waters Investments Limited Novel ion exchange porous resins for solid phase extraction and chromatography
US6238565B1 (en) 1998-09-16 2001-05-29 Varian, Inc. Monolithic matrix for separating bio-organic molecules
EP1123305A1 (en) * 1998-10-19 2001-08-16 The Board Of Trustees Of The Leland Stanford Junior University Dna-templated combinatorial library chemistry
US6919181B2 (en) * 2002-03-25 2005-07-19 Agilent Technologies, Inc. Methods for generating ligand arrays
US7473367B2 (en) 2002-06-26 2009-01-06 Dionex Corporation Monolithic column
EP1601433A4 (en) * 2003-01-17 2006-03-29 Univ Northeastern CLOSE MONOLYTHIC I.D. CAPILLARY COLUMNS FOR A HIGHLY EFFECTIVE SEPARATION AND ACCURATE SENSITIVITY ANALYSIS OF BIOMOLECULES
US20050095602A1 (en) * 2003-11-04 2005-05-05 West Jason A. Microfluidic integrated microarrays for biological detection
EP1719816B1 (en) 2004-02-12 2011-06-01 GL Sciences Incorporated Mechanism of separating and purifying dna
US7897378B2 (en) 2004-03-18 2011-03-01 Roche Molecular Systems, Inc. Method and device for purifying nucleic acids
JP2006015333A (ja) * 2004-05-31 2006-01-19 Showa Denko Kk 有機ポリマーモノリス、その製造方法、およびその用途
EP1786552A1 (en) * 2004-08-27 2007-05-23 Applera Corporation Method of making polymer monolith composite substrate and resulting substrate as well as beads and bead array
WO2006047791A2 (en) * 2004-10-27 2006-05-04 The Board Of Trustees Of The Leland Stanford Junior University Dna-templated combinatorial library device and method for use
US8394492B1 (en) 2004-10-28 2013-03-12 The United States Of America As Represented By The United States National Aeronautics And Space Administration Surface modified aerogel monoliths
CN101400993A (zh) 2005-11-10 2009-04-01 阿普尔拉股份有限公司 包括多孔聚合物电极的微流体系统
DE102005059315A1 (de) 2005-12-09 2007-06-14 Qiagen Gmbh Verfahren zur Anreicherung von kurzkettigen Nukleinsäuren
EP2041318A2 (en) 2006-06-26 2009-04-01 Blood Cell Storage, Inc. Device and method for extraction and analysis of nucleic acids from biological samples
GB0614727D0 (en) 2006-07-25 2006-09-06 Chromatide Ltd Solid support
CA2629589C (en) 2007-04-20 2016-03-29 F.Hoffmann-La Roche Ag Isolation and purification of nucleic acid molecules with a solid phase
TW200904950A (en) 2007-04-23 2009-02-01 Lg Chemical Ltd A retardation film, a method for preparing retardation film and polarizer comprising the retardation film
CN101861518B (zh) 2007-10-17 2012-05-30 株式会社岛津制作所 色谱分析用整体柱分离介质及其制造方法
EP2174916B9 (fr) 2008-10-09 2017-11-22 Université Des Sciences Et Technologies De Lille Monolithes de silice de haute pureté et son procédé de synthèse
WO2010053443A1 (en) 2008-11-06 2010-05-14 Agency For Science, Technology And Research Apparatus for biopolymer synthesis
EP2335820A1 (en) 2009-12-18 2011-06-22 Leopold-Franzens-Universität Innsbruck Method for covalently attaching polymeric monoliths to polyether ether ketone (PEEK) surfaces
CA2786412C (en) 2010-01-08 2018-02-06 University Of Tasmania Porous polymer monoliths, processes for preparation and use thereof
US20110240541A1 (en) 2010-04-06 2011-10-06 Binghe Gu Monolithic column technology for liquid chromatography
WO2011146179A2 (en) * 2010-05-18 2011-11-24 Abbott Laboratories Apparatus and process of purification of proteins
US8603833B2 (en) 2010-06-03 2013-12-10 University Of South Florida Germania-silica-based sol-gel monolith and uses thereof
EP2580309B1 (en) 2010-06-08 2014-07-16 Firmenich SA Bicyclo-ketones as perfuming ingredients
EP2405000A1 (en) 2010-07-06 2012-01-11 Alacris Theranostics GmbH Synthesis of chemical libraries
US20150315569A1 (en) 2014-05-02 2015-11-05 The Board Of Trustees Of The Leland Stanford Junior University Method for screening a nucleic acid-programmed small molecule library

Also Published As

Publication number Publication date
EP3099799A4 (en) 2017-09-20
EP3099799B1 (en) 2019-05-15
EP3099799A1 (en) 2016-12-07
DK3099799T3 (da) 2019-07-01
ES2732054T3 (es) 2019-11-20
MX2016009798A (es) 2017-02-28
MX369674B (es) 2019-11-15
US10358641B2 (en) 2019-07-23
US20150209753A1 (en) 2015-07-30
US20180179517A9 (en) 2018-06-28
JP2017503522A (ja) 2017-02-02
SG10201803094QA (en) 2018-06-28
AU2015211020A1 (en) 2016-08-11
AU2015211020A2 (en) 2016-08-25
US20170191056A1 (en) 2017-07-06
CN106459978A (zh) 2017-02-22
IL246784A0 (en) 2016-08-31
HK1231511A1 (en) 2017-12-22
CN106459978B (zh) 2020-05-19
CA2940526A1 (en) 2015-08-06
JP6602772B2 (ja) 2019-11-06
KR20160122174A (ko) 2016-10-21
WO2015116739A1 (en) 2015-08-06
RU2016132972A (ru) 2018-03-05
SG11201606921PA (en) 2016-10-28
US20190270985A1 (en) 2019-09-05

Similar Documents

Publication Publication Date Title
BR112018008867A8 (pt) anticorpos que se ligam especificamente a pd-1 e seus usos
MX2024010175A (es) Moleculas de anticuerpo contra april y usos de las mismas.
BR112017028318A2 (pt) compostos antibacterianos
BR112016022841A2 (pt) cadeia j modificada
CL2020000869A1 (es) Enantiómeros de tiazoles sustituidos compuestos antivirales.
BR112016021707A2 (pt) aparelhos, métodos e sistemas para fornecer força descendente para um implemento agrícola
BR112016028045A8 (pt) biopolímeros modificados, e seus métodos de produção
BR112017012141A2 (pt) composições inibidoras de nitrificação e métodos para preparação das mesmas
BR112017026206A2 (pt) molas não lineares e colchões que incluem as mesmas.
LT3371165T (lt) Btk inhibitorius, naudojamas vėžiui gydyti
IL255037B (en) T-slot cutter
BR112017018834A2 (pt) variantes de protoxina-ii e métodos de uso
BR112017008500A2 (pt) método para a produção de praziquantel e precursores do mesmo
BR112017002318A2 (pt) combinações de fármacos para tratar mieloma múltiplo.
MX395699B (es) Composiciones inhibidoras de nitrificacion y metodos para preparar las mismas.
BR112016017152A2 (pt) Monólitos com compostos de reconhecimento fixados, matrizes dos mesmos e usos dos mesmos
PL3291141T3 (pl) Sposób rozpoznawania wytłoczonych znaków, odpowiedni program komputerowy i urządzenie
DK3352804T3 (da) Artikel, der klæber til huden
DK3334705T3 (da) Cetylerede fedtsyrer, system til fremstillingen deraf og anvendelse deraf
BR112018005863A2 (pt) endófitos de brachiaria e métodos relacionados
BR112019006310A2 (pt) método para fabricar digliceróxido de cálcio
EA201790855A1 (ru) Трансдермальная терапевтическая система с высокой адгезивной способностью
ES1109280Y (es) Elemento portador de biomasa para sistemas de tratamiento biologico.
CL2017002653A1 (es) Procedimiento y reactor para fijar arsénico.
ITUB20152292A1 (it) Accorgimenti per incastonare pietre e solitari.

Legal Events

Date Code Title Description
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B11B Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements