RU2016132972A - Монолиты с присоединенными распознающими соединениями, их система и их применение - Google Patents
Монолиты с присоединенными распознающими соединениями, их система и их применение Download PDFInfo
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- RU2016132972A RU2016132972A RU2016132972A RU2016132972A RU2016132972A RU 2016132972 A RU2016132972 A RU 2016132972A RU 2016132972 A RU2016132972 A RU 2016132972A RU 2016132972 A RU2016132972 A RU 2016132972A RU 2016132972 A RU2016132972 A RU 2016132972A
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- Prior art keywords
- nucleic acid
- column
- monolith
- acid tags
- attached
- Prior art date
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- 150000001875 compounds Chemical class 0.000 title claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 20
- 150000007523 nucleic acids Chemical class 0.000 claims 20
- 102000039446 nucleic acids Human genes 0.000 claims 20
- 108091034117 Oligonucleotide Proteins 0.000 claims 5
- 239000000203 mixture Substances 0.000 claims 5
- 238000000034 method Methods 0.000 claims 4
- 229920000642 polymer Polymers 0.000 claims 4
- 239000000654 additive Substances 0.000 claims 3
- 229920001577 copolymer Polymers 0.000 claims 3
- 239000003446 ligand Substances 0.000 claims 3
- DBCAQXHNJOFNGC-UHFFFAOYSA-N 4-bromo-1,1,1-trifluorobutane Chemical compound FC(F)(F)CCCBr DBCAQXHNJOFNGC-UHFFFAOYSA-N 0.000 claims 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims 2
- CERQOIWHTDAKMF-UHFFFAOYSA-M Methacrylate Chemical compound CC(=C)C([O-])=O CERQOIWHTDAKMF-UHFFFAOYSA-M 0.000 claims 2
- 239000004696 Poly ether ether ketone Substances 0.000 claims 2
- 239000003957 anion exchange resin Substances 0.000 claims 2
- 150000001540 azides Chemical class 0.000 claims 2
- 239000007795 chemical reaction product Substances 0.000 claims 2
- -1 cyclic olefin Chemical class 0.000 claims 2
- STVZJERGLQHEKB-UHFFFAOYSA-N ethylene glycol dimethacrylate Substances CC(=C)C(=O)OCCOC(=O)C(C)=C STVZJERGLQHEKB-UHFFFAOYSA-N 0.000 claims 2
- 229920002530 polyetherether ketone Polymers 0.000 claims 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N silicon dioxide Inorganic materials O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims 2
- 239000000126 substance Substances 0.000 claims 2
- 108010002156 Depsipeptides Proteins 0.000 claims 1
- JOYRKODLDBILNP-UHFFFAOYSA-N Ethyl urethane Chemical compound CCOC(N)=O JOYRKODLDBILNP-UHFFFAOYSA-N 0.000 claims 1
- 108091093037 Peptide nucleic acid Proteins 0.000 claims 1
- 108010043958 Peptoids Proteins 0.000 claims 1
- 239000004697 Polyetherimide Substances 0.000 claims 1
- 239000004743 Polypropylene Substances 0.000 claims 1
- 239000004793 Polystyrene Substances 0.000 claims 1
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 claims 1
- 229920004738 ULTEM® Polymers 0.000 claims 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims 1
- CKUAXEQHGKSLHN-UHFFFAOYSA-N [C].[N] Chemical compound [C].[N] CKUAXEQHGKSLHN-UHFFFAOYSA-N 0.000 claims 1
- HMDDXIMCDZRSNE-UHFFFAOYSA-N [C].[Si] Chemical compound [C].[Si] HMDDXIMCDZRSNE-UHFFFAOYSA-N 0.000 claims 1
- 229910052782 aluminium Inorganic materials 0.000 claims 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 claims 1
- 150000001408 amides Chemical class 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 239000004202 carbamide Substances 0.000 claims 1
- CREMABGTGYGIQB-UHFFFAOYSA-N carbon carbon Chemical compound C.C CREMABGTGYGIQB-UHFFFAOYSA-N 0.000 claims 1
- 239000011203 carbon fibre reinforced carbon Substances 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 claims 1
- 238000006352 cycloaddition reaction Methods 0.000 claims 1
- 238000010828 elution Methods 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 239000005350 fused silica glass Substances 0.000 claims 1
- 239000011521 glass Substances 0.000 claims 1
- 238000007373 indentation Methods 0.000 claims 1
- 230000004807 localization Effects 0.000 claims 1
- 239000002184 metal Substances 0.000 claims 1
- 229910052751 metal Inorganic materials 0.000 claims 1
- 150000002739 metals Chemical class 0.000 claims 1
- JRZJOMJEPLMPRA-UHFFFAOYSA-N olefin Natural products CCCCCCCC=C JRZJOMJEPLMPRA-UHFFFAOYSA-N 0.000 claims 1
- 150000002894 organic compounds Chemical class 0.000 claims 1
- 230000035699 permeability Effects 0.000 claims 1
- 239000004033 plastic Substances 0.000 claims 1
- 229920003023 plastic Polymers 0.000 claims 1
- 229920003229 poly(methyl methacrylate) Polymers 0.000 claims 1
- 239000004417 polycarbonate Substances 0.000 claims 1
- 229920000515 polycarbonate Polymers 0.000 claims 1
- 229920001601 polyetherimide Polymers 0.000 claims 1
- 239000004926 polymethyl methacrylate Substances 0.000 claims 1
- 229920001155 polypropylene Polymers 0.000 claims 1
- 229920002223 polystyrene Polymers 0.000 claims 1
- 238000011176 pooling Methods 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 239000010453 quartz Substances 0.000 claims 1
- OHRURASPPZQGQM-GCCNXGTGSA-N romidepsin Chemical compound O1C(=O)[C@H](C(C)C)NC(=O)C(=C/C)/NC(=O)[C@H]2CSSCC\C=C\[C@@H]1CC(=O)N[C@H](C(C)C)C(=O)N2 OHRURASPPZQGQM-GCCNXGTGSA-N 0.000 claims 1
- 229910001220 stainless steel Inorganic materials 0.000 claims 1
- 239000010935 stainless steel Substances 0.000 claims 1
- 150000003568 thioethers Chemical class 0.000 claims 1
- 239000010936 titanium Substances 0.000 claims 1
- 229910052719 titanium Inorganic materials 0.000 claims 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1068—Template (nucleic acid) mediated chemical library synthesis, e.g. chemical and enzymatical DNA-templated organic molecule synthesis, libraries prepared by non ribosomal polypeptide synthesis [NRPS], DNA/RNA-polymerase mediated polypeptide synthesis
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1065—Preparation or screening of tagged libraries, e.g. tagged microorganisms by STM-mutagenesis, tagged polynucleotides, gene tags
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1093—General methods of preparing gene libraries, not provided for in other subgroups
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
- C40B50/14—Solid phase synthesis, i.e. wherein one or more library building blocks are bound to a solid support during library creation; Particular methods of cleavage from the solid support
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00279—Features relating to reactor vessels
- B01J2219/00306—Reactor vessels in a multiple arrangement
- B01J2219/00313—Reactor vessels in a multiple arrangement the reactor vessels being formed by arrays of wells in blocks
- B01J2219/00315—Microtiter plates
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00351—Means for dispensing and evacuation of reagents
- B01J2219/00423—Means for dispensing and evacuation of reagents using filtration, e.g. through porous frits
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00497—Features relating to the solid phase supports
- B01J2219/005—Beads
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00497—Features relating to the solid phase supports
- B01J2219/00504—Pins
- B01J2219/00509—Microcolumns
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/0054—Means for coding or tagging the apparatus or the reagents
- B01J2219/00547—Bar codes
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/0054—Means for coding or tagging the apparatus or the reagents
- B01J2219/00572—Chemical means
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00592—Split-and-pool, mix-and-divide processes
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00596—Solid-phase processes
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00639—Making arrays on substantially continuous surfaces the compounds being trapped in or bound to a porous medium
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00639—Making arrays on substantially continuous surfaces the compounds being trapped in or bound to a porous medium
- B01J2219/00641—Making arrays on substantially continuous surfaces the compounds being trapped in or bound to a porous medium the porous medium being continuous, e.g. porous oxide substrates
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00718—Type of compounds synthesised
- B01J2219/0072—Organic compounds
- B01J2219/00722—Nucleotides
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
- C40B50/14—Solid phase synthesis, i.e. wherein one or more library building blocks are bound to a solid support during library creation; Particular methods of cleavage from the solid support
- C40B50/16—Solid phase synthesis, i.e. wherein one or more library building blocks are bound to a solid support during library creation; Particular methods of cleavage from the solid support involving encoding steps
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B70/00—Tags or labels specially adapted for combinatorial chemistry or libraries, e.g. fluorescent tags or bar codes
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Crystallography & Structural Chemistry (AREA)
- Bioinformatics & Computational Biology (AREA)
- Plant Pathology (AREA)
- General Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Structural Engineering (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Peptides Or Proteins (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461932747P | 2014-01-28 | 2014-01-28 | |
| US61/932,747 | 2014-01-28 | ||
| US201462006845P | 2014-06-02 | 2014-06-02 | |
| US62/006,845 | 2014-06-02 | ||
| PCT/US2015/013382 WO2015116739A1 (en) | 2014-01-28 | 2015-01-28 | Monoliths with attached recognition compounds, arrays thereof and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2016132972A true RU2016132972A (ru) | 2018-03-05 |
Family
ID=53678148
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2016132972A RU2016132972A (ru) | 2014-01-28 | 2015-01-28 | Монолиты с присоединенными распознающими соединениями, их система и их применение |
Country Status (15)
| Country | Link |
|---|---|
| US (3) | US10358641B2 (https=) |
| EP (1) | EP3099799B1 (https=) |
| JP (1) | JP6602772B2 (https=) |
| KR (1) | KR20160122174A (https=) |
| CN (1) | CN106459978B (https=) |
| AU (1) | AU2015211020A1 (https=) |
| BR (1) | BR112016017152A2 (https=) |
| CA (1) | CA2940526A1 (https=) |
| DK (1) | DK3099799T3 (https=) |
| ES (1) | ES2732054T3 (https=) |
| IL (1) | IL246784A0 (https=) |
| MX (1) | MX369674B (https=) |
| RU (1) | RU2016132972A (https=) |
| SG (2) | SG11201606921PA (https=) |
| WO (1) | WO2015116739A1 (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3079668A1 (en) | 2013-12-09 | 2016-10-19 | Durect Corporation | Pharmaceutically active agent complexes, polymer complexes, and compositions and methods involving the same |
| JP7033923B2 (ja) * | 2016-01-08 | 2022-03-11 | 株式会社ジーンデザイン | ゾル－ゲル法で作製される無機多孔質体を用いた核酸合成用担体 |
| JP2019523646A (ja) * | 2016-06-05 | 2019-08-29 | ダイス モレキュルズ エスヴィー， エルエルシーＤｉｃｅ Ｍｏｌｅｃｕｌｅｓ Ｓｖ， Ｌｌｃ | 経路決定の方法、組成物、およびその使用 |
| US11596919B2 (en) * | 2018-08-17 | 2023-03-07 | Sierra Biosystems, Inc. | Row-independent oligonucleotide synthesis |
| CN110724623A (zh) * | 2019-09-10 | 2020-01-24 | 深圳市百迈生命科学有限公司 | 1536孔固相合成与萃取板 |
Family Cites Families (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1123878A (en) | 1966-08-23 | 1968-08-14 | Ici Ltd | Synthesis of norbornene derivatives |
| US4889632A (en) | 1987-12-10 | 1989-12-26 | Ceskoslovenska Akademie Ved | Macroporous polymeric membranes for the separation of polymers and a method of their application |
| EP0554407A1 (en) | 1990-10-26 | 1993-08-11 | Genta Incorporated | Non-aromatic organic polymeric reagents for solid phase synthesis of oligomers |
| US5539082A (en) | 1993-04-26 | 1996-07-23 | Nielsen; Peter E. | Peptide nucleic acids |
| DK51092D0 (da) | 1991-05-24 | 1992-04-15 | Ole Buchardt | Oligonucleotid-analoge betegnet pna, monomere synthoner og fremgangsmaade til fremstilling deraf samt anvendelser deraf |
| US5281368A (en) | 1992-03-31 | 1994-01-25 | Exxon Chemical Patents Inc. | Norbornene polymerization initiators and process for preparing same |
| US5605793A (en) | 1994-02-17 | 1997-02-25 | Affymax Technologies N.V. | Methods for in vitro recombination |
| CN1268979A (zh) | 1997-07-22 | 2000-10-04 | 拉普吉恩公司 | 阵列单元的多功能性及其用途 |
| AU4437399A (en) | 1998-06-12 | 1999-12-30 | Waters Investments Limited | Novel ion exchange porous resins for solid phase extraction and chromatography |
| US6238565B1 (en) | 1998-09-16 | 2001-05-29 | Varian, Inc. | Monolithic matrix for separating bio-organic molecules |
| CA2346989A1 (en) | 1998-10-19 | 2000-04-27 | The Board Of Trustees Of The Leland Stanford Junior University | Dna-templated combinatorial library chemistry |
| US6919181B2 (en) | 2002-03-25 | 2005-07-19 | Agilent Technologies, Inc. | Methods for generating ligand arrays |
| US7473367B2 (en) | 2002-06-26 | 2009-01-06 | Dionex Corporation | Monolithic column |
| US20040200776A1 (en) * | 2003-01-17 | 2004-10-14 | Ivanov Alexander R. | Narrow I.D. monolithic capillary columns for high efficiency separation and high sensitivity analysis of biomolecules |
| US20050095602A1 (en) * | 2003-11-04 | 2005-05-05 | West Jason A. | Microfluidic integrated microarrays for biological detection |
| EP1719816B1 (en) | 2004-02-12 | 2011-06-01 | GL Sciences Incorporated | Mechanism of separating and purifying dna |
| US7897378B2 (en) | 2004-03-18 | 2011-03-01 | Roche Molecular Systems, Inc. | Method and device for purifying nucleic acids |
| JP2006015333A (ja) | 2004-05-31 | 2006-01-19 | Showa Denko Kk | 有機ポリマーモノリス、その製造方法、およびその用途 |
| US20060078983A1 (en) * | 2004-08-27 | 2006-04-13 | Applera Corporation | Polymer monolith substrate |
| US20060099626A1 (en) * | 2004-10-27 | 2006-05-11 | Harbury Pehr B | DNA-templated combinatorial library device and method for use |
| US8394492B1 (en) | 2004-10-28 | 2013-03-12 | The United States Of America As Represented By The United States National Aeronautics And Space Administration | Surface modified aerogel monoliths |
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| DE102005059315A1 (de) | 2005-12-09 | 2007-06-14 | Qiagen Gmbh | Verfahren zur Anreicherung von kurzkettigen Nukleinsäuren |
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| EP2174916B9 (fr) | 2008-10-09 | 2017-11-22 | Université Des Sciences Et Technologies De Lille | Monolithes de silice de haute pureté et son procédé de synthèse |
| JP2012507513A (ja) * | 2008-11-06 | 2012-03-29 | エージェンシー フォー サイエンス，テクノロジー アンド リサーチ | バイオポリマー合成用器具 |
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| CA2786412C (en) | 2010-01-08 | 2018-02-06 | University Of Tasmania | Porous polymer monoliths, processes for preparation and use thereof |
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| US8603833B2 (en) | 2010-06-03 | 2013-12-10 | University Of South Florida | Germania-silica-based sol-gel monolith and uses thereof |
| MX2012013504A (es) | 2010-06-08 | 2013-01-24 | Firmenich & Cie | Biciclo-cetonas como ingredientes perfumantes. |
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| US20150315569A1 (en) | 2014-05-02 | 2015-11-05 | The Board Of Trustees Of The Leland Stanford Junior University | Method for screening a nucleic acid-programmed small molecule library |
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2015
- 2015-01-28 SG SG11201606921PA patent/SG11201606921PA/en unknown
- 2015-01-28 RU RU2016132972A patent/RU2016132972A/ru not_active Application Discontinuation
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- 2015-01-28 MX MX2016009798A patent/MX369674B/es active IP Right Grant
- 2015-01-28 SG SG10201803094QA patent/SG10201803094QA/en unknown
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- 2015-01-28 WO PCT/US2015/013382 patent/WO2015116739A1/en not_active Ceased
- 2015-01-28 CN CN201580017011.3A patent/CN106459978B/zh active Active
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- 2015-01-28 DK DK15743623.9T patent/DK3099799T3/da active
- 2015-01-28 CA CA2940526A patent/CA2940526A1/en not_active Abandoned
- 2015-01-28 KR KR1020167023649A patent/KR20160122174A/ko not_active Withdrawn
- 2015-01-28 AU AU2015211020A patent/AU2015211020A1/en not_active Abandoned
- 2015-01-28 EP EP15743623.9A patent/EP3099799B1/en active Active
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2016
- 2016-07-14 IL IL246784A patent/IL246784A0/en unknown
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| AU2015211020A2 (en) | 2016-08-25 |
| DK3099799T3 (da) | 2019-07-01 |
| KR20160122174A (ko) | 2016-10-21 |
| IL246784A0 (en) | 2016-08-31 |
| US20180179517A9 (en) | 2018-06-28 |
| US20190270985A1 (en) | 2019-09-05 |
| ES2732054T3 (es) | 2019-11-20 |
| HK1231511A1 (en) | 2017-12-22 |
| WO2015116739A1 (en) | 2015-08-06 |
| CN106459978B (zh) | 2020-05-19 |
| SG10201803094QA (en) | 2018-06-28 |
| CN106459978A (zh) | 2017-02-22 |
| US20150209753A1 (en) | 2015-07-30 |
| EP3099799A4 (en) | 2017-09-20 |
| US20170191056A1 (en) | 2017-07-06 |
| CA2940526A1 (en) | 2015-08-06 |
| SG11201606921PA (en) | 2016-10-28 |
| JP2017503522A (ja) | 2017-02-02 |
| EP3099799A1 (en) | 2016-12-07 |
| MX369674B (es) | 2019-11-15 |
| JP6602772B2 (ja) | 2019-11-06 |
| MX2016009798A (es) | 2017-02-28 |
| US10358641B2 (en) | 2019-07-23 |
| BR112016017152A2 (pt) | 2017-08-08 |
| AU2015211020A1 (en) | 2016-08-11 |
| EP3099799B1 (en) | 2019-05-15 |
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