BR112016016014B1 - Gene resistente a inseto derivado de ser humano e anticorpo de cadeia única de idiótipo de anti-toxina cry1b codificado pelo mesmo e sua aplicação - Google Patents

Gene resistente a inseto derivado de ser humano e anticorpo de cadeia única de idiótipo de anti-toxina cry1b codificado pelo mesmo e sua aplicação Download PDF

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Publication number
BR112016016014B1
BR112016016014B1 BR112016016014-2A BR112016016014A BR112016016014B1 BR 112016016014 B1 BR112016016014 B1 BR 112016016014B1 BR 112016016014 A BR112016016014 A BR 112016016014A BR 112016016014 B1 BR112016016014 B1 BR 112016016014B1
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BR
Brazil
Prior art keywords
human
cry1b
chain antibody
resistant gene
toxin
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Application number
BR112016016014-2A
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English (en)
Portuguese (pt)
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BR112016016014A2 (pt
Inventor
Xianjin LIU
Chongxin XU
Xiao Zhang
Yuan Liu
Yajing XIE
Cunzheng ZHANG
Xiangyang YU
Donglan WANG
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Jiangsu Academy Of Agricultural Sciences
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Application filed by Jiangsu Academy Of Agricultural Sciences filed Critical Jiangsu Academy Of Agricultural Sciences
Publication of BR112016016014A2 publication Critical patent/BR112016016014A2/pt
Publication of BR112016016014B1 publication Critical patent/BR112016016014B1/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/42—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against immunoglobulins
    • C07K16/4208—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig
    • C07K16/4233—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig against anti-bacterial Ig
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N63/00—Biocides, pest repellants or attractants, or plant growth regulators containing microorganisms, viruses, microbial fungi, animals or substances produced by, or obtained from, microorganisms, viruses, microbial fungi or animals, e.g. enzymes or fermentates
    • A01N63/50—Isolated enzymes; Isolated proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1267—Gram-positive bacteria
    • C07K16/1278—Bacillus (G)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
    • A01N47/40—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides
    • A01N47/42—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides containing —N=CX2 groups, e.g. isothiourea
    • A01N47/44—Guanidine; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Plant Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Dentistry (AREA)
  • Environmental Sciences (AREA)
  • Virology (AREA)
  • Peptides Or Proteins (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
BR112016016014-2A 2014-01-26 2015-01-09 Gene resistente a inseto derivado de ser humano e anticorpo de cadeia única de idiótipo de anti-toxina cry1b codificado pelo mesmo e sua aplicação BR112016016014B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201410037175.XA CN103773775B (zh) 2014-01-26 2014-01-26 一种人源抗虫基因及其编码的抗Cry1B毒素独特型单链抗体与应用
CN201410037175.X 2014-01-26
PCT/CN2015/070421 WO2015109952A1 (zh) 2014-01-26 2015-01-09 一种人源抗虫基因及其编码的抗Cry1B毒素独特型单链抗体与应用

Publications (2)

Publication Number Publication Date
BR112016016014A2 BR112016016014A2 (pt) 2017-12-12
BR112016016014B1 true BR112016016014B1 (pt) 2022-06-07

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Family Applications (1)

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BR112016016014-2A BR112016016014B1 (pt) 2014-01-26 2015-01-09 Gene resistente a inseto derivado de ser humano e anticorpo de cadeia única de idiótipo de anti-toxina cry1b codificado pelo mesmo e sua aplicação

Country Status (6)

Country Link
US (1) US9770038B2 (enExample)
EP (1) EP3098316B1 (enExample)
JP (1) JP6196382B2 (enExample)
CN (1) CN103773775B (enExample)
BR (1) BR112016016014B1 (enExample)
WO (1) WO2015109952A1 (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103773775B (zh) 2014-01-26 2015-11-18 江苏省农业科学院 一种人源抗虫基因及其编码的抗Cry1B毒素独特型单链抗体与应用
CN104498501B (zh) 2014-12-05 2017-07-18 江苏省农业科学院 一种人源杀虫基因及其编码杀虫肽与应用
CN104926940B (zh) * 2015-06-15 2018-02-09 江苏省农业科学院 一种人源杀虫蛋白及其制备方法与应用
CN105131123B (zh) * 2015-09-16 2018-11-27 江苏省农业科学院 一种具有杀虫活性的牛源化改型抗体及其制备方法与应用
CN105085683B (zh) * 2015-09-16 2018-11-27 江苏省农业科学院 一种具有杀虫活性的猪源化改型抗体及其制备方法与应用
US10981996B1 (en) 2020-06-01 2021-04-20 Abexxa Biologics, Inc. Antibodies targeting a complex comprising non-classical HLA-I and neoantigen and their methods of use
US10981997B1 (en) * 2020-06-01 2021-04-20 Abexxa Biologics, Inc. Antibodies targeting a complex comprising non-classical HLA-I and neoantigen and their methods of use
US11976120B2 (en) 2020-06-01 2024-05-07 Boehringer Ingelheim International Gmbh Antibodies targeting a complex comprising non-classical HLA-I and neoantigen and their methods of use
CN111909264B (zh) * 2020-08-05 2022-02-25 江苏省农业科学院 一种人源化抗金黄色葡萄球菌生物活性肽及其编码基因与应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE59205079D1 (de) * 1991-07-25 1996-02-29 Ciba Geigy Ag Immunologisches Nachweisverfahren
WO2007023782A1 (ja) * 2005-08-24 2007-03-01 Genecare Research Institute Co., Ltd. キラートキシン様タンパク質に対する中和抗体、およびその利用
PL1999141T3 (pl) * 2006-03-21 2011-10-31 Bayer Cropscience Nv Nowe geny kodujące białka owadobójcze
ATE528317T1 (de) * 2007-06-08 2011-10-15 Univ Mexico Nacional Autonoma Unterdrückung der resistenz von insekten gegen bacillus thuringiensis-cry-toxine unter verwendung von toxinen, die nicht den cadherin- rezeptor benötigen
CN103773776B (zh) 2014-01-26 2015-11-18 江苏省农业科学院 一种人源抗虫基因及其编码的抗Cry1C毒素独特型单链抗体与应用
CN103773775B (zh) 2014-01-26 2015-11-18 江苏省农业科学院 一种人源抗虫基因及其编码的抗Cry1B毒素独特型单链抗体与应用
CN103773774B (zh) 2014-01-26 2015-11-18 江苏省农业科学院 一种人源抗虫基因及其编码的抗Cry1Ab毒素独特型单链抗体与应用

Also Published As

Publication number Publication date
US9770038B2 (en) 2017-09-26
CN103773775B (zh) 2015-11-18
EP3098316A9 (en) 2017-06-28
EP3098316A4 (en) 2017-06-21
EP3098316A1 (en) 2016-11-30
CN103773775A (zh) 2014-05-07
EP3098316B1 (en) 2019-09-18
US20170035055A1 (en) 2017-02-09
JP6196382B2 (ja) 2017-09-13
JP2017505110A (ja) 2017-02-16
BR112016016014A2 (pt) 2017-12-12
WO2015109952A1 (zh) 2015-07-30

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