BR112016014413A2 - glicosiltransferase que glicosila o ácido flavoquermésico e/ou ácido quermésico - Google Patents

glicosiltransferase que glicosila o ácido flavoquermésico e/ou ácido quermésico

Info

Publication number
BR112016014413A2
BR112016014413A2 BR112016014413A BR112016014413A BR112016014413A2 BR 112016014413 A2 BR112016014413 A2 BR 112016014413A2 BR 112016014413 A BR112016014413 A BR 112016014413A BR 112016014413 A BR112016014413 A BR 112016014413A BR 112016014413 A2 BR112016014413 A2 BR 112016014413A2
Authority
BR
Brazil
Prior art keywords
acid
glycosyltransferase
flavoquermesic
glycosylates
kermesic
Prior art date
Application number
BR112016014413A
Other languages
English (en)
Other versions
BR112016014413A8 (pt
Inventor
Maya Kannangara Rubini
Bennedsen Mads
Madsen Bjørn
Binderup Kim
Thrane Ulf
John Normand Frandsen Rasmus
Hasbro Mortensen Uffe
Lindberg Møller Birger
Thyge Okkels Finn
Original Assignee
Danmarks Tekniske Universitet
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Danmarks Tekniske Universitet filed Critical Danmarks Tekniske Universitet
Publication of BR112016014413A2 publication Critical patent/BR112016014413A2/pt
Publication of BR112016014413A8 publication Critical patent/BR112016014413A8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • C12N15/815—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts for yeasts other than Saccharomyces
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1051—Hexosyltransferases (2.4.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/66—Preparation of oxygen-containing organic compounds containing the quinoid structure
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y204/00—Glycosyltransferases (2.4)

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Mycology (AREA)
  • Medicinal Chemistry (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Botany (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

a presente invenção refere-se a um polipeptídeo de glicosiltransferase isolado (gt) capaz de: (i): conjugar glicose ao ácido flavoquermésico (fk); e/ou (ii): conjugar glicose ao ácido quermésico (ka) e ao uso desta gt, por exemplo, para fazer ácido carmínico.
BR112016014413A 2013-12-18 2014-12-18 Glicosiltransferase que glicosila o ácido flavoquermésico e/ou ácido quermésico BR112016014413A8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP13198110 2013-12-18
PCT/EP2014/078540 WO2015091843A1 (en) 2013-12-18 2014-12-18 Glycosyltransferase glycosylating flavokermesic acid and/or kermesic acid

Publications (2)

Publication Number Publication Date
BR112016014413A2 true BR112016014413A2 (pt) 2018-02-20
BR112016014413A8 BR112016014413A8 (pt) 2022-07-12

Family

ID=49876386

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112016014413A BR112016014413A8 (pt) 2013-12-18 2014-12-18 Glicosiltransferase que glicosila o ácido flavoquermésico e/ou ácido quermésico

Country Status (10)

Country Link
US (2) US10100290B2 (pt)
EP (2) EP3330374B1 (pt)
CN (1) CN106062186A (pt)
BR (1) BR112016014413A8 (pt)
DK (2) DK3083950T3 (pt)
ES (2) ES2660301T3 (pt)
HK (1) HK1225409A1 (pt)
PL (1) PL3083950T3 (pt)
TR (1) TR201802540T4 (pt)
WO (1) WO2015091843A1 (pt)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL3083950T3 (pl) * 2013-12-18 2018-05-30 Københavns Universitet Glikozylotransferaza glikozylująca kwas flawokermesowy i/lub kermesowy
US20210261992A1 (en) * 2018-06-13 2021-08-26 Manus Bio, Inc. Enzymes, methods, and host cells for producing carminic acid
CN109913480B (zh) * 2019-03-21 2022-05-31 临沂大学 一种蝗虫尿苷二磷酸葡萄糖醛酸转移酶基因及其应用
CN111041056B (zh) * 2019-12-13 2021-08-24 中国科学院植物研究所 用莲类黄酮c-糖基转移酶ugt708n2合成类黄酮c-糖苷的方法
MX2020007632A (es) * 2020-07-16 2022-01-17 Carinlab S A P I De C V Pprocedimiento para obtencion de acido carminico.
JP2024505906A (ja) * 2021-01-27 2024-02-08 コリア アドバンスト インスティテュート オブ サイエンス アンド テクノロジー Ｃ－グリコシルトランスフェラーゼ変異体およびその用途

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU8295591A (en) 1990-07-17 1992-02-18 European Colour Plc Synthesis of carminic acid and principal intermediates
EP1234046B1 (en) * 1999-12-01 2008-11-12 Adelaide Research & Innovation Pty Ltd. Udp-glucose:aglycon-glucosyltransferase
EP1649029B1 (en) * 2003-06-19 2014-12-17 Evolva SA A method of producing a low molecular weight plant secondary metabolite in a yeast cell
DK2479263T3 (da) 2011-01-20 2014-02-03 Jennewein Biotechnologie Gmbh Nye fucosyltransferaser og deres anvendelser
JP6594205B2 (ja) * 2012-11-05 2019-10-23 エヴォルヴァ エスアー． バニリンシンターゼ
CN103352031B (zh) * 2013-04-26 2014-09-24 中山大学 一种糖基转移酶基因及应用
PL3083950T3 (pl) * 2013-12-18 2018-05-30 Københavns Universitet Glikozylotransferaza glikozylująca kwas flawokermesowy i/lub kermesowy
WO2016198564A1 (en) * 2015-06-10 2016-12-15 Danmarks Tekniske Universitet Use of octaketide synthases to produce kermesic acid and flavokermesic acid

Also Published As

Publication number Publication date
EP3083950A1 (en) 2016-10-26
ES2912660T3 (es) 2022-05-26
US10724012B2 (en) 2020-07-28
BR112016014413A8 (pt) 2022-07-12
WO2015091843A1 (en) 2015-06-25
EP3083950B1 (en) 2017-11-29
CN106062186A (zh) 2016-10-26
EP3330374A1 (en) 2018-06-06
ES2660301T3 (es) 2018-03-21
DK3083950T3 (en) 2018-02-05
US20160376569A1 (en) 2016-12-29
EP3330374B1 (en) 2022-02-02
US20190048328A1 (en) 2019-02-14
HK1225409A1 (zh) 2017-09-08
US10100290B2 (en) 2018-10-16
PL3083950T3 (pl) 2018-05-30
TR201802540T4 (tr) 2018-03-21
DK3330374T3 (da) 2022-03-07

Similar Documents

Publication Publication Date Title
BR112016014413A2 (pt) glicosiltransferase que glicosila o ácido flavoquermésico e/ou ácido quermésico
BR112019009019A2 (pt) esteroides e conjugados de proteínas dos mesmos
CL2018000108A1 (es) Moléculas de anticuerpo que se unen a cd22
BR112015023589A8 (pt) Método para a produção de um conjugado de imunoligante/carga útil, conjugado, uso de um conjugado, carga útil de baixo peso molecular e uso de uma carga útil
BR112015027327A2 (pt) composições e métodos para alterar a sinalização do mensageiro secundário
BR112018000768A2 (pt) anticorpos anti-pd-1, anticorpos anti-pd-1 ativáveis e métodos de uso dos mesmos
BR112017004949A2 (pt) receptor do antígeno quimérico, polinucleotídeo, vetor, célula, e, composição farmacêutica.
CR20150437A (es) Construcciones de anticuerpos para cdh19 y cd3
BR112015030514A2 (pt) Composições e métodos para conjugação de anticorpos ativáveis
BR112018001531A2 (pt) construtos de anticorpo para cd70 e cd3
BR112017003582A2 (pt) anticorpos, composições e usos
BR112016002614A2 (pt) imunocitoquina, ácido nucleico, vetor, célula hospedeira e composição farmacêutica
BR112016007112A2 (pt) Anticorpos que se ligam a angiopoietina 2 (ang-2) humana, usos de um anticorpo que se liga a angiopoietina 2 (ang-2) humana e combinação
BR112017018770A2 (pt) redução da tolerância imunológica induzida por pd-l1
BR112016024780A2 (pt) composições e métodos relacionados com construtos de fc manipulados
BR112018067525A2 (pt) anticorpos tendo especificidade para o btla e seus usos
CL2018000107A1 (es) Moléculas de anticuerpo que se unen a cd79
BR112015019985A2 (pt) Novo análogo de insulina e sua utilização
BR112014030098A2 (pt) métodos de rotulagem específica de sítio e moléculas produzidas pelos mesmos
UY36245A (es) Constructos de anticuerpos para cdh19 y cd3
BR112016005340A2 (pt) formulações de enzima com quebra controlada
CR20150247A (es) Anticuerpos de antihemaglutinina y métodos de uso
BR112016024494A2 (pt) análogos de peptídeo com sonda(s) de aminoácidos ramificados
BRPI0810096A8 (pt) Anticorpo anti-epcam e seus usos
BR112016001699A2 (pt) sistemas de exibição de projetor tendo direcionamento de feixe de espelho não mecânico

Legal Events

Date Code Title Description
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B350 Update of information on the portal [chapter 15.35 patent gazette]
B25A Requested transfer of rights approved

Owner name: DANMARKS TEKNISKE UNIVERSITET (DK) ; KOEBENHAVNS UNIVERSITET (DK) ; CHR. HANSEN NATURAL COLORS A/S (DK)

B25D Requested change of name of applicant approved

Owner name: DANMARKS TEKNISKE UNIVERSITET (DK) ; KOEBENHAVNS UNIVERSITET (DK) ; OTERRA A/S (DK)

B25G Requested change of headquarter approved

Owner name: DANMARKS TEKNISKE UNIVERSITET (DK) ; KOEBENHAVNS UNIVERSITET (DK) ; OTERRA A/S (DK)

B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]