BR112016008125A2 - moléculas de ligação de domínio de fibronectina tipo iii modificadas com cisteína - Google Patents

moléculas de ligação de domínio de fibronectina tipo iii modificadas com cisteína

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Publication number
BR112016008125A2
BR112016008125A2 BR112016008125A BR112016008125A BR112016008125A2 BR 112016008125 A2 BR112016008125 A2 BR 112016008125A2 BR 112016008125 A BR112016008125 A BR 112016008125A BR 112016008125 A BR112016008125 A BR 112016008125A BR 112016008125 A2 BR112016008125 A2 BR 112016008125A2
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BR
Brazil
Prior art keywords
cysteine
domains
modified
binding molecules
monospecific
Prior art date
Application number
BR112016008125A
Other languages
English (en)
Other versions
BR112016008125B1 (pt
Inventor
O'neil Karyn
GOLDBERG Shalom
Jacobs Steven
Lin Tricia
Original Assignee
Janssen Biotech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Biotech Inc filed Critical Janssen Biotech Inc
Publication of BR112016008125A2 publication Critical patent/BR112016008125A2/pt
Publication of BR112016008125B1 publication Critical patent/BR112016008125B1/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2318/00—Antibody mimetics or scaffolds
    • C07K2318/20—Antigen-binding scaffold molecules wherein the scaffold is not an immunoglobulin variable region or antibody mimetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biotechnology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Endocrinology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Plant Pathology (AREA)
  • Peptides Or Proteins (AREA)

Abstract

moléculas monoespecíficas e biespecíficas contendo domínios de fn3 anti-egfr e/ou anti-c-metmodificadas com cisteína que compreendem um ou mais aminoácidos cisteína livres são produzidas por mutagenização de uma sequência de ácido nucleico de uma molé-cula parental e por substituição de um ou mais resíduos de aminoácido por cisteína para codificar as moléculas monoespecíficas e biespecífi-cas que contêm domínios de fn3 modificadas com cisteína; expressar as moléculas que contêm domínios de fn3 modificadas com cisteína; e recuperar a molécula que contém domínios de fn3 modificada com cisteína; as moléculas monoespecíficas ou biespecíficas que contêm domínios de fn3 modificadas com cisteína isoladas podem ser cova-lentemente ligadas a um marcador de detecção ou a uma porção de fármaco e usadas terapeuticamente.
BR112016008125-0A 2013-10-14 2014-10-13 Domínio proteico isolado de fibronectina tipo iii modificado com cisteína, seu método de produção e método para produzir uma molécula isolada de de fibronectina tipo iii biespecífica modificada com cisteína BR112016008125B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361890539P 2013-10-14 2013-10-14
US61/890,539 2013-10-14
PCT/US2014/060227 WO2015057545A2 (en) 2013-10-14 2014-10-13 Cysteine engineered fibronectin type iii domain binding molecules

Publications (2)

Publication Number Publication Date
BR112016008125A2 true BR112016008125A2 (pt) 2017-12-26
BR112016008125B1 BR112016008125B1 (pt) 2023-11-21

Family

ID=52809988

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112016008125-0A BR112016008125B1 (pt) 2013-10-14 2014-10-13 Domínio proteico isolado de fibronectina tipo iii modificado com cisteína, seu método de produção e método para produzir uma molécula isolada de de fibronectina tipo iii biespecífica modificada com cisteína

Country Status (12)

Country Link
US (3) US10196446B2 (pt)
EP (1) EP3057608A4 (pt)
JP (2) JP6585040B2 (pt)
KR (2) KR102478402B1 (pt)
CN (1) CN105899226B (pt)
AU (2) AU2014334627B2 (pt)
BR (1) BR112016008125B1 (pt)
CA (1) CA2926262A1 (pt)
EA (1) EA035745B1 (pt)
IL (1) IL244623B (pt)
MX (2) MX2016004862A (pt)
WO (1) WO2015057545A2 (pt)

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US10597438B2 (en) 2016-12-14 2020-03-24 Janssen Biotech, Inc. PD-L1 binding fibronectin type III domains
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US10329543B2 (en) 2017-10-23 2019-06-25 Poseida Therapeutics, Inc. Modified stem cell memory T cells, methods of making and methods of using same
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US11781138B2 (en) 2019-10-14 2023-10-10 Aro Biotherapeutics Company FN3 domain-siRNA conjugates and uses thereof
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Publication number Publication date
WO2015057545A2 (en) 2015-04-23
JP2017500003A (ja) 2017-01-05
JP6585040B2 (ja) 2019-10-02
AU2019253863A1 (en) 2019-11-14
MX2016004862A (es) 2016-08-01
WO2015057545A3 (en) 2015-06-11
US20150104808A1 (en) 2015-04-16
CA2926262A1 (en) 2015-04-23
US20210301025A1 (en) 2021-09-30
IL244623B (en) 2022-08-01
US11702475B2 (en) 2023-07-18
US11072663B2 (en) 2021-07-27
EP3057608A4 (en) 2017-10-11
IL244623A0 (en) 2016-04-21
EA201690773A1 (ru) 2016-08-31
KR20160067966A (ko) 2016-06-14
CN105899226B (zh) 2020-05-12
KR102478402B1 (ko) 2022-12-15
EA035745B1 (ru) 2020-08-05
US10196446B2 (en) 2019-02-05
KR20220136463A (ko) 2022-10-07
JP2020011969A (ja) 2020-01-23
CN105899226A (zh) 2016-08-24
AU2019253863B2 (en) 2022-03-10
US20190263915A1 (en) 2019-08-29
MX2019012876A (es) 2019-12-11
AU2014334627B2 (en) 2019-07-25
BR112016008125B1 (pt) 2023-11-21
AU2014334627A1 (en) 2016-04-07
EP3057608A2 (en) 2016-08-24

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