BR112016007727A8 - célula hospedeira, e, método para produzir uma proteína n-glicosilada. - Google Patents
célula hospedeira, e, método para produzir uma proteína n-glicosilada.Info
- Publication number
- BR112016007727A8 BR112016007727A8 BR112016007727A BR112016007727A BR112016007727A8 BR 112016007727 A8 BR112016007727 A8 BR 112016007727A8 BR 112016007727 A BR112016007727 A BR 112016007727A BR 112016007727 A BR112016007727 A BR 112016007727A BR 112016007727 A8 BR112016007727 A8 BR 112016007727A8
- Authority
- BR
- Brazil
- Prior art keywords
- producing
- host cell
- unglycosylated protein
- host cells
- protein
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/90—Stable introduction of foreign DNA into chromosome
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1048—Glycosyltransferases (2.4)
- C12N9/1051—Hexosyltransferases (2.4.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/025—Enterobacteriales, e.g. Enterobacter
- A61K39/0258—Escherichia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/025—Enterobacteriales, e.g. Enterobacter
- A61K39/0283—Shigella
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/104—Pseudomonadales, e.g. Pseudomonas
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/90—Stable introduction of foreign DNA into chromosome
- C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6037—Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2795/00—Bacteriophages
- C12N2795/00011—Details
- C12N2795/00041—Use of virus, viral particle or viral elements as a vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/30—Vector systems comprising sequences for excision in presence of a recombinase, e.g. loxP or FRT
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Mycology (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
são descritos aqui métodos para inserir sequências de ácido nucleico em células hospedeiras. também são descritos aqui células hospedeiras geneticamente estáveis compreendendo sequências de ácido nucleico inseridas e métodos para usar tais células hospedeiras na geração de proteínas.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361889672P | 2013-10-11 | 2013-10-11 | |
PCT/EP2014/071889 WO2015052344A1 (en) | 2013-10-11 | 2014-10-13 | Methods of host cell modification |
Publications (2)
Publication Number | Publication Date |
---|---|
BR112016007727A2 BR112016007727A2 (pt) | 2017-09-12 |
BR112016007727A8 true BR112016007727A8 (pt) | 2018-01-30 |
Family
ID=51726490
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112016007727A BR112016007727A8 (pt) | 2013-10-11 | 2014-10-13 | célula hospedeira, e, método para produzir uma proteína n-glicosilada. |
Country Status (13)
Country | Link |
---|---|
US (2) | US11220676B2 (pt) |
EP (1) | EP3055416B1 (pt) |
JP (1) | JP2016533719A (pt) |
KR (1) | KR20160062169A (pt) |
CN (1) | CN106062203B (pt) |
BR (1) | BR112016007727A8 (pt) |
CA (1) | CA2926523C (pt) |
EA (1) | EA201690529A1 (pt) |
ES (1) | ES2778074T3 (pt) |
IL (1) | IL244791A0 (pt) |
MX (1) | MX371513B (pt) |
SG (1) | SG11201602546RA (pt) |
WO (1) | WO2015052344A1 (pt) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MX365331B (es) | 2013-01-17 | 2019-05-29 | Arsanis Biosciences Gmbh | Anticuerpo específico contra e. coli mdr. |
WO2015052344A1 (en) | 2013-10-11 | 2015-04-16 | Glycovaxyn Ag | Methods of host cell modification |
CA2940547C (en) | 2014-02-24 | 2021-01-05 | Glycovaxyn Ag | Novel polysaccharide and uses thereof |
BR112016023688B1 (pt) * | 2014-04-17 | 2024-01-09 | Glaxosmithkline Biologicals Sa | Bioconjugado e uso de um bioconjugado |
TWI715617B (zh) | 2015-08-24 | 2021-01-11 | 比利時商葛蘭素史密斯克藍生物品公司 | 對抗腸道外病原性大腸桿菌之免疫保護之方法及組合物 |
AR109621A1 (es) | 2016-10-24 | 2018-12-26 | Janssen Pharmaceuticals Inc | Formulaciones de vacunas contra glucoconjugados de expec |
GB201712678D0 (en) | 2017-08-07 | 2017-09-20 | Glaxosmithkline Biologicals Sa | Process for the manipulation of nucleic acids |
EP3492482A1 (en) | 2017-11-30 | 2019-06-05 | Vaxxilon AG | Vaccine against klebsiella pneumoniae |
CN108611306B (zh) * | 2018-04-03 | 2021-05-25 | 华南农业大学 | 一种研究慢生根瘤菌的基因功能的方法 |
CN108531439B (zh) * | 2018-04-16 | 2020-04-07 | 南京工业大学 | 一种大肠杆菌基因工程菌及其构建方法与应用 |
CN108774628B (zh) * | 2018-07-02 | 2022-03-25 | 南开大学 | 合成致新生儿脑膜炎大肠杆菌糖蛋白结合疫苗的大肠杆菌工程菌及用途 |
US11260119B2 (en) | 2018-08-24 | 2022-03-01 | Pfizer Inc. | Escherichia coli compositions and methods thereof |
EA202192390A1 (ru) | 2019-03-18 | 2021-12-03 | Янссен Фармасьютикалз, Инк. | Биоконъюгаты полисахаридных о-антигенов e.coli, способы их получения и способы их применения |
AU2020240075A1 (en) | 2019-03-18 | 2021-10-14 | Janssen Pharmaceuticals, Inc. | Methods of producing bioconjugates of e. coli o-antigen polysaccharides, compositions thereof, and methods of use thereof |
JP2021000041A (ja) * | 2019-06-24 | 2021-01-07 | トヨタ自動車株式会社 | 形質転換補助用プラスミド及びこれを用いた形質転換体の製造方法、並びに形質転換方法 |
EP4107170A2 (en) * | 2020-02-23 | 2022-12-28 | Pfizer Inc. | Escherichia coli compositions and methods thereof |
KR102160203B1 (ko) * | 2020-06-15 | 2020-09-25 | 서울시립대학교 산학협력단 | 데이노잔틴 고생산능을 갖는 변이 균주의 제조방법 및 온도제어를 이용한 데이노잔틴 대량생산 방법 |
CA3185639A1 (en) | 2020-06-25 | 2021-12-30 | Glaxosmithkline Biologicals Sa | Vaccine |
JP7517002B2 (ja) | 2020-09-10 | 2024-07-17 | トヨタ自動車株式会社 | 形質転換体の製造方法及び形質転換方法 |
WO2022058945A1 (en) | 2020-09-17 | 2022-03-24 | Janssen Pharmaceuticals, Inc. | Multivalent vaccine compositions and uses thereof |
IL302362A (en) * | 2020-10-27 | 2023-06-01 | Pfizer | ESCHERICHIA COLI preparations and their methods |
JP2022087881A (ja) * | 2020-12-02 | 2022-06-14 | トヨタ自動車株式会社 | 形質転換用プラスミド及びこれを用いた形質転換体の製造方法、並びに形質転換方法 |
JP2022099381A (ja) * | 2020-12-23 | 2022-07-05 | トヨタ自動車株式会社 | 形質転換補助用プラスミド及びこれを用いた形質転換体の製造方法、並びに形質転換方法 |
JP2022099419A (ja) * | 2020-12-23 | 2022-07-05 | トヨタ自動車株式会社 | 形質転換用プラスミド及びこれを用いた形質転換体の製造方法、並びに形質転換方法 |
CN113388596B (zh) * | 2021-08-16 | 2021-12-07 | 翌圣生物科技(上海)股份有限公司 | 高保真Pfu DNA聚合酶突变体、其编码DNA及其在NGS中的应用 |
JP2024139548A (ja) * | 2023-03-27 | 2024-10-09 | 株式会社豊田中央研究所 | 遺伝子発現方法 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2353814T3 (es) * | 2005-05-11 | 2011-03-07 | Eth Zuerich | Proteinas n-glicosiladas recombinantes de celulas procariotas. |
CN101983070B (zh) * | 2008-02-20 | 2016-03-30 | 格林考瓦因有限公司 | 由来源于原核细胞的重组n-糖基化蛋白制备生物共轭物 |
GB0915403D0 (en) | 2009-09-04 | 2009-10-07 | London School Hygiene & Tropical Medicine | Protein glycosylation |
DK2501406T3 (en) * | 2009-11-19 | 2018-02-26 | Glaxosmithkline Biologicals Sa | BIOSYNTHESE SYSTEM PRODUCING IMMUNOGENIC POLYSACCHARIDES IN PROCARYOTIC CELLS |
KR20130063510A (ko) * | 2010-05-06 | 2013-06-14 | 글리코박신 아게 | 캡슐형 그람-양성 세균 생체접합체 백신 |
US20140336366A1 (en) * | 2011-09-06 | 2014-11-13 | Glycovaxyn Ag | Bioconjugate vaccines made in prokaryotic cells |
KR20140091017A (ko) | 2011-10-28 | 2014-07-18 | 머크 샤프 앤드 돔 코포레이션 | Alg3 발현이 결핍된 피키아 파스토리스 균주에서 n-글리칸 점유율을 증가시키고 하이브리드 n-글리칸의 생산을 감소시키는 방법 |
WO2014037585A1 (en) * | 2012-09-10 | 2014-03-13 | Glycovaxyn Ag | Bioconjugates comprising modified antigens and uses thereof |
CA2887133C (en) * | 2012-10-12 | 2022-05-03 | Glycovaxyn Ag | Methods of host cell modification |
CN105008539B (zh) | 2012-11-07 | 2020-04-17 | 葛兰素史密丝克莱恩生物有限公司 | 通过酶缀合在大肠杆菌中生产重组疫苗 |
WO2015052344A1 (en) | 2013-10-11 | 2015-04-16 | Glycovaxyn Ag | Methods of host cell modification |
-
2014
- 2014-10-13 WO PCT/EP2014/071889 patent/WO2015052344A1/en active Application Filing
- 2014-10-13 SG SG11201602546RA patent/SG11201602546RA/en unknown
- 2014-10-13 CA CA2926523A patent/CA2926523C/en active Active
- 2014-10-13 BR BR112016007727A patent/BR112016007727A8/pt not_active Application Discontinuation
- 2014-10-13 US US15/028,483 patent/US11220676B2/en active Active
- 2014-10-13 JP JP2016521754A patent/JP2016533719A/ja active Pending
- 2014-10-13 ES ES14784209T patent/ES2778074T3/es active Active
- 2014-10-13 KR KR1020167012152A patent/KR20160062169A/ko not_active Application Discontinuation
- 2014-10-13 MX MX2016004575A patent/MX371513B/es active IP Right Grant
- 2014-10-13 CN CN201480066861.8A patent/CN106062203B/zh active Active
- 2014-10-13 EA EA201690529A patent/EA201690529A1/ru unknown
- 2014-10-13 EP EP14784209.0A patent/EP3055416B1/en active Active
-
2016
- 2016-03-28 IL IL244791A patent/IL244791A0/en unknown
-
2021
- 2021-12-03 US US17/541,454 patent/US20220186196A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
CN106062203B (zh) | 2020-08-07 |
CA2926523C (en) | 2023-09-26 |
US20170121691A1 (en) | 2017-05-04 |
KR20160062169A (ko) | 2016-06-01 |
IL244791A0 (en) | 2016-04-21 |
CN106062203A (zh) | 2016-10-26 |
EP3055416A1 (en) | 2016-08-17 |
JP2016533719A (ja) | 2016-11-04 |
MX2016004575A (es) | 2016-07-12 |
US11220676B2 (en) | 2022-01-11 |
ES2778074T3 (es) | 2020-08-07 |
BR112016007727A2 (pt) | 2017-09-12 |
CA2926523A1 (en) | 2015-04-16 |
MX371513B (es) | 2020-01-31 |
SG11201602546RA (en) | 2016-04-28 |
EP3055416B1 (en) | 2020-01-22 |
US20220186196A1 (en) | 2022-06-16 |
EA201690529A1 (ru) | 2016-11-30 |
WO2015052344A1 (en) | 2015-04-16 |
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B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
B25A | Requested transfer of rights approved |
Owner name: GLAXOSMITHKLINE BIOLOGICALS SA (BE) |
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B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
B350 | Update of information on the portal [chapter 15.35 patent gazette] | ||
B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
B09B | Patent application refused [chapter 9.2 patent gazette] | ||
B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL.MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL. |