BR112016007618A2 - métodos de síntese química de compostos de diaminofenotiazínio incluindo cloreto de metiltionínio (mtc) - Google Patents

métodos de síntese química de compostos de diaminofenotiazínio incluindo cloreto de metiltionínio (mtc)

Info

Publication number
BR112016007618A2
BR112016007618A2 BR112016007618A BR112016007618A BR112016007618A2 BR 112016007618 A2 BR112016007618 A2 BR 112016007618A2 BR 112016007618 A BR112016007618 A BR 112016007618A BR 112016007618 A BR112016007618 A BR 112016007618A BR 112016007618 A2 BR112016007618 A2 BR 112016007618A2
Authority
BR
Brazil
Prior art keywords
mtc
chemical synthesis
synthesis methods
compounds including
methylthioninium chloride
Prior art date
Application number
BR112016007618A
Other languages
English (en)
Inventor
Peter Sinclair James
Mervyn David Storey John
Louise NICOLL Sarah
Original Assignee
Wista Lab Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wista Lab Ltd filed Critical Wista Lab Ltd
Priority to BR122023024801-5A priority Critical patent/BR122023024801A2/pt
Publication of BR112016007618A2 publication Critical patent/BR112016007618A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
    • C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
    • C07D279/18—[b, e]-condensed with two six-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/30—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of nitrogen-to-oxygen or nitrogen-to-nitrogen bonds
    • C07C209/38—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of nitrogen-to-oxygen or nitrogen-to-nitrogen bonds by reduction of nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/68—Preparation of compounds containing amino groups bound to a carbon skeleton from amines, by reactions not involving amino groups, e.g. reduction of unsaturated amines, aromatisation, or substitution of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C381/00—Compounds containing carbon and sulfur and having functional groups not covered by groups C07C301/00 - C07C337/00
    • C07C381/02—Thiosulfates
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

métodos de sintetizar e purificar certos compostos de 3,7-diamino-fenotiazín-5-io (referidos aqui como ?compostos de diaminofe-notiazínio?) incluindo cloreto de metiltionínio (mtc) (também conheci-do como azul de metileno) são fornecidos.
BR112016007618A 2013-10-07 2014-10-06 métodos de síntese química de compostos de diaminofenotiazínio incluindo cloreto de metiltionínio (mtc) BR112016007618A2 (pt)

Priority Applications (1)

Application Number Priority Date Filing Date Title
BR122023024801-5A BR122023024801A2 (pt) 2013-10-07 2014-10-06 Métodos para síntese química de compostos de diaminofenotiazínio incluindo cloreto de metiltionínio (mtc)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB1317702.7A GB201317702D0 (en) 2013-10-07 2013-10-07 Methods of chemical synthesis of diaminophenothiazinium compounds including methylthioninium chloride (MTC)
PCT/GB2014/053007 WO2015052496A1 (en) 2013-10-07 2014-10-06 Methods of chemical synthesis of diaminophenothiazinium compounds including methylthioninium chloride (mtc)

Publications (1)

Publication Number Publication Date
BR112016007618A2 true BR112016007618A2 (pt) 2017-08-01

Family

ID=49630291

Family Applications (2)

Application Number Title Priority Date Filing Date
BR122023024801-5A BR122023024801A2 (pt) 2013-10-07 2014-10-06 Métodos para síntese química de compostos de diaminofenotiazínio incluindo cloreto de metiltionínio (mtc)
BR112016007618A BR112016007618A2 (pt) 2013-10-07 2014-10-06 métodos de síntese química de compostos de diaminofenotiazínio incluindo cloreto de metiltionínio (mtc)

Family Applications Before (1)

Application Number Title Priority Date Filing Date
BR122023024801-5A BR122023024801A2 (pt) 2013-10-07 2014-10-06 Métodos para síntese química de compostos de diaminofenotiazínio incluindo cloreto de metiltionínio (mtc)

Country Status (21)

Country Link
US (3) US9765042B2 (pt)
EP (3) EP3055291B1 (pt)
JP (1) JP6505091B2 (pt)
CN (3) CN110092764B (pt)
AU (3) AU2014333610B2 (pt)
BR (2) BR122023024801A2 (pt)
CA (3) CA3131803C (pt)
DK (2) DK3415505T3 (pt)
ES (2) ES2713324T3 (pt)
GB (1) GB201317702D0 (pt)
HK (1) HK1222175A1 (pt)
HR (2) HRP20220102T1 (pt)
MX (3) MX2020004348A (pt)
MY (1) MY177815A (pt)
PL (2) PL3415505T3 (pt)
PT (2) PT3415505T (pt)
SG (3) SG10201907363YA (pt)
SI (2) SI3415505T1 (pt)
TR (1) TR201902152T4 (pt)
TW (2) TWI675829B (pt)
WO (1) WO2015052496A1 (pt)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105130926B (zh) * 2015-07-31 2018-02-13 江苏恒润制药有限公司 一种亚甲基蓝的制备方法
GB201621817D0 (en) * 2016-12-21 2017-02-01 Wista Lab Ltd Methods of chemical synthesis
US20220049102A1 (en) * 2019-09-21 2022-02-17 RK Pharma Solutions LLC Process for the Purification of Methylene Blue
CN114989113A (zh) * 2022-06-01 2022-09-02 山东科源制药股份有限公司 一种药用亚甲基蓝的精制方法

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US204796A (en) 1878-06-11 Improvement in the production of dye-stuffs from methyl-aniline
DE1886C (de) 1877-12-15 1877-12-15 Basf Ag Verfahren zur darstellung blauer farbstoffe aus dimethylanilin und anderen tertiaeren aromatischen monaminen
US4212971A (en) * 1979-03-08 1980-07-15 American Cyanamid Company Process for preparing methylene blue
CH640146A5 (de) * 1979-05-14 1983-12-30 Meyer Maschinenfabrik Ag Filtrationsverfahren.
US5344928A (en) 1991-04-26 1994-09-06 Takeda Chemical Industries, Ltd. Phenothiazine derivatives, their production and use
GB9506197D0 (en) 1995-03-27 1995-05-17 Hoffmann La Roche Inhibition of tau-tau association.
JP2001514617A (ja) 1997-01-21 2001-09-11 ジ・アメリカン・ナショナル・レッド・クロス 両親媒性フェノチアジン−５−イウム染料と光による全血および血液成分の細胞内および細胞外汚染除去
FR2810318B1 (fr) 2000-06-15 2005-09-23 Laurent Galey Derives de diamano-phenothiazine
GB0101049D0 (en) 2001-01-15 2001-02-28 Univ Aberdeen Materials and methods relating to protein aggregation in neurodegenerative disease
GB2373787A (en) 2001-03-08 2002-10-02 Univ Central Lancashire Phenothiazinium derivatives and their use to reduce pathogenic contaminants
WO2006032879A2 (en) 2004-09-23 2006-03-30 Wista Laboratories Ltd. Methods of chemical synthesis and purification of diaminophenothiazinium compounds including methylthioninium chloride (mtc)
JP5186212B2 (ja) * 2004-09-23 2013-04-17 ウィスタ ラボラトリーズ リミテッド メチルチオニニウム塩化物（ｍｔｃ）などのジアミノフェノチアジニウム化合物を化学合成および精製する方法
CN101460222B (zh) * 2006-03-29 2013-12-04 维斯塔实验室有限公司 锍化合物及其用途
CN103735554B (zh) * 2006-03-29 2018-03-20 维斯塔实验室有限公司 蛋白聚集抑制剂
CN101511803B (zh) * 2006-07-11 2012-10-31 维斯塔实验室有限公司 二氨基吩噻嗪*化合物的合成和/或纯化方法
CN100436431C (zh) * 2006-12-15 2008-11-26 贵州同济堂制药有限公司 药用亚甲蓝的合成方法
SI2430007T1 (sl) * 2009-05-12 2014-05-30 Wista Laboratories Ltd. Postopki kemijske sinteze diaminofenotiazinijevih spojin, ki vključujejo uporabo persulfatnih oksidantov

Also Published As

Publication number Publication date
CN110092764A (zh) 2019-08-06
EP4032880A3 (en) 2022-11-23
MY177815A (en) 2020-09-23
SG11201602650XA (en) 2016-05-30
PT3415505T (pt) 2022-01-07
EP3415505A2 (en) 2018-12-19
CA3207522A1 (en) 2015-04-16
AU2017206141B2 (en) 2019-05-02
SG10201907363YA (en) 2019-10-30
CA2925801A1 (en) 2015-04-16
AU2014333610A1 (en) 2016-05-12
JP6505091B2 (ja) 2019-04-24
GB201317702D0 (en) 2013-11-20
TWI626237B (zh) 2018-06-11
US10047062B2 (en) 2018-08-14
HK1222175A1 (zh) 2017-06-23
US20160251325A1 (en) 2016-09-01
US10421733B2 (en) 2019-09-24
MX363102B (es) 2019-03-08
HRP20220102T1 (hr) 2022-04-15
US20170342041A1 (en) 2017-11-30
CN105683171A (zh) 2016-06-15
SG10201913293PA (en) 2020-03-30
EP4032880A2 (en) 2022-07-27
WO2015052496A1 (en) 2015-04-16
TW201829390A (zh) 2018-08-16
CA3131803C (en) 2023-09-12
AU2019203490A1 (en) 2019-06-06
MX2016004229A (es) 2016-11-25
BR122023024801A2 (pt) 2023-12-26
AU2017206141A1 (en) 2017-08-03
AU2014333610B2 (en) 2017-04-27
PL3415505T3 (pl) 2022-03-07
SI3415505T1 (sl) 2022-05-31
TW201520202A (zh) 2015-06-01
DK3415505T3 (da) 2021-12-20
EP3055291A1 (en) 2016-08-17
JP2016531897A (ja) 2016-10-13
CN117209450A (zh) 2023-12-12
MX2020004348A (es) 2021-03-22
CA2925801C (en) 2021-11-09
EP3055291B1 (en) 2018-12-05
CA3131803A1 (en) 2015-04-16
US9765042B2 (en) 2017-09-19
PT3055291T (pt) 2019-03-06
MX2019002620A (es) 2019-08-01
TR201902152T4 (tr) 2019-03-21
DK3055291T3 (en) 2019-03-11
PL3055291T3 (pl) 2019-05-31
US20180327372A1 (en) 2018-11-15
SI3055291T1 (sl) 2019-03-29
CN110092764B (zh) 2023-09-15
EP3415505B1 (en) 2021-12-01
HRP20190374T1 (hr) 2019-04-19
AU2019203490B2 (en) 2021-01-21
TWI675829B (zh) 2019-11-01
CN105683171B (zh) 2019-03-22
EP3415505A3 (en) 2019-02-13
ES2903529T3 (es) 2022-04-04
ES2713324T3 (es) 2019-05-21

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B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]

Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS.

B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B15K Others concerning applications: alteration of classification

Free format text: A CLASSIFICACAO ANTERIOR ERA: C07D 279/18

Ipc: C07D 279/18 (2006.01), A61P 25/28 (2006.01), A61P

B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B154 Notification of filing of divisional application [chapter 15.50 patent gazette]

Free format text: O PEDIDO FOI DIVIDIDO NO BR122023024801-5 PROTOCOLO 870230104196 EM 27/11/2023 17:01.

B09A Decision: intention to grant [chapter 9.1 patent gazette]