SI3055291T1 - Postopki kemijske sinteze diaminofenotiazinijevih spojin, ki vključujejo metiltionijev klorid (MTC) - Google Patents
Postopki kemijske sinteze diaminofenotiazinijevih spojin, ki vključujejo metiltionijev klorid (MTC)Info
- Publication number
- SI3055291T1 SI3055291T1 SI201431094T SI201431094T SI3055291T1 SI 3055291 T1 SI3055291 T1 SI 3055291T1 SI 201431094 T SI201431094 T SI 201431094T SI 201431094 T SI201431094 T SI 201431094T SI 3055291 T1 SI3055291 T1 SI 3055291T1
- Authority
- SI
- Slovenia
- Prior art keywords
- mtc
- methods
- chemical synthesis
- compounds including
- methylthioninium chloride
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
- C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
- C07D279/18—[b, e]-condensed with two six-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
- C07C209/30—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of nitrogen-to-oxygen or nitrogen-to-nitrogen bonds
- C07C209/38—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of nitrogen-to-oxygen or nitrogen-to-nitrogen bonds by reduction of nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
- C07C209/68—Preparation of compounds containing amino groups bound to a carbon skeleton from amines, by reactions not involving amino groups, e.g. reduction of unsaturated amines, aromatisation, or substitution of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C381/00—Compounds containing carbon and sulfur and having functional groups not covered by groups C07C301/00 - C07C337/00
- C07C381/02—Thiosulfates
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1317702.7A GB201317702D0 (en) | 2013-10-07 | 2013-10-07 | Methods of chemical synthesis of diaminophenothiazinium compounds including methylthioninium chloride (MTC) |
| PCT/GB2014/053007 WO2015052496A1 (en) | 2013-10-07 | 2014-10-06 | Methods of chemical synthesis of diaminophenothiazinium compounds including methylthioninium chloride (mtc) |
| EP14789349.9A EP3055291B1 (en) | 2013-10-07 | 2014-10-06 | Methods of chemical synthesis of diaminophenothiazinium compounds including methylthioninium chloride (mtc) |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SI3055291T1 true SI3055291T1 (sl) | 2019-03-29 |
Family
ID=49630291
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI201431945T SI3415505T1 (sl) | 2013-10-07 | 2014-10-06 | Postopki kemijske sinteze diaminofenotiazinijevih spojin, ki vključujejo metiltioninijev klorid (MTC) |
| SI201431094T SI3055291T1 (sl) | 2013-10-07 | 2014-10-06 | Postopki kemijske sinteze diaminofenotiazinijevih spojin, ki vključujejo metiltionijev klorid (MTC) |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI201431945T SI3415505T1 (sl) | 2013-10-07 | 2014-10-06 | Postopki kemijske sinteze diaminofenotiazinijevih spojin, ki vključujejo metiltioninijev klorid (MTC) |
Country Status (21)
| Country | Link |
|---|---|
| US (3) | US9765042B2 (sl) |
| EP (3) | EP3415505B1 (sl) |
| JP (1) | JP6505091B2 (sl) |
| CN (3) | CN110092764B (sl) |
| AU (3) | AU2014333610B2 (sl) |
| BR (1) | BR122023024801A2 (sl) |
| CA (3) | CA3207522A1 (sl) |
| DK (2) | DK3055291T3 (sl) |
| ES (2) | ES2903529T3 (sl) |
| GB (1) | GB201317702D0 (sl) |
| HK (1) | HK1222175A1 (sl) |
| HR (2) | HRP20220102T1 (sl) |
| MX (3) | MX2020004348A (sl) |
| MY (1) | MY177815A (sl) |
| PL (2) | PL3055291T3 (sl) |
| PT (2) | PT3415505T (sl) |
| SG (3) | SG10201907363YA (sl) |
| SI (2) | SI3415505T1 (sl) |
| TR (1) | TR201902152T4 (sl) |
| TW (2) | TWI675829B (sl) |
| WO (1) | WO2015052496A1 (sl) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105130926B (zh) * | 2015-07-31 | 2018-02-13 | 江苏恒润制药有限公司 | 一种亚甲基蓝的制备方法 |
| GB201621817D0 (en) * | 2016-12-21 | 2017-02-01 | Wista Lab Ltd | Methods of chemical synthesis |
| US20220049102A1 (en) * | 2019-09-21 | 2022-02-17 | RK Pharma Solutions LLC | Process for the Purification of Methylene Blue |
| CN114989113A (zh) * | 2022-06-01 | 2022-09-02 | 山东科源制药股份有限公司 | 一种药用亚甲基蓝的精制方法 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US204796A (en) | 1878-06-11 | Improvement in the production of dye-stuffs from methyl-aniline | ||
| DE1886C (de) | 1877-12-15 | 1877-12-15 | Basf Ag | Verfahren zur darstellung blauer farbstoffe aus dimethylanilin und anderen tertiaeren aromatischen monaminen |
| US4212971A (en) * | 1979-03-08 | 1980-07-15 | American Cyanamid Company | Process for preparing methylene blue |
| CH640146A5 (de) * | 1979-05-14 | 1983-12-30 | Meyer Maschinenfabrik Ag | Filtrationsverfahren. |
| US5344928A (en) * | 1991-04-26 | 1994-09-06 | Takeda Chemical Industries, Ltd. | Phenothiazine derivatives, their production and use |
| GB9506197D0 (en) | 1995-03-27 | 1995-05-17 | Hoffmann La Roche | Inhibition of tau-tau association. |
| JP2001514617A (ja) | 1997-01-21 | 2001-09-11 | ジ・アメリカン・ナショナル・レッド・クロス | 両親媒性フェノチアジン−５−イウム染料と光による全血および血液成分の細胞内および細胞外汚染除去 |
| FR2810318B1 (fr) | 2000-06-15 | 2005-09-23 | Laurent Galey | Derives de diamano-phenothiazine |
| GB0101049D0 (en) | 2001-01-15 | 2001-02-28 | Univ Aberdeen | Materials and methods relating to protein aggregation in neurodegenerative disease |
| GB2373787A (en) | 2001-03-08 | 2002-10-02 | Univ Central Lancashire | Phenothiazinium derivatives and their use to reduce pathogenic contaminants |
| CN101084204B (zh) * | 2004-09-23 | 2012-12-05 | 卫思道制药有限公司 | 包括亚甲蓝(mtc)在内的二氨基吩噻嗪鎓化合物的化学合成和纯化方法 |
| PL2322517T3 (pl) * | 2004-09-23 | 2019-09-30 | Wista Laboratories Ltd. | Sposoby syntezy chemicznej i oczyszczania związków diaminofenotiazyniowych, w tym chlorku metylotioniny (MTC) |
| SI2853293T1 (sl) * | 2006-03-29 | 2018-03-30 | Wista Laboratories Ltd. | Tioninijeve spojine in njihova uporaba |
| ES2667002T3 (es) * | 2006-03-29 | 2018-05-09 | Wista Laboratories Ltd. | Inhibidores de la agregación de proteínas |
| LT2457905T (lt) * | 2006-07-11 | 2016-11-10 | Wista Laboratories Ltd. | Diaminofenotiazino junginių sintezės ir (arba) gryninimo metodai |
| CN100436431C (zh) * | 2006-12-15 | 2008-11-26 | 贵州同济堂制药有限公司 | 药用亚甲蓝的合成方法 |
| DK2430007T3 (da) * | 2009-05-12 | 2014-05-12 | Wista Lab Ltd | Fremgangsmåde for kemisk syntese af diaminophenothiazinium forbindelser ved anvendelse af persulfat oxidanter |
-
2013
- 2013-10-07 GB GBGB1317702.7A patent/GB201317702D0/en not_active Ceased
-
2014
- 2014-10-06 ES ES18181405T patent/ES2903529T3/es active Active
- 2014-10-06 CA CA3207522A patent/CA3207522A1/en active Pending
- 2014-10-06 BR BR122023024801-5A patent/BR122023024801A2/pt active Search and Examination
- 2014-10-06 HR HRP20220102TT patent/HRP20220102T1/hr unknown
- 2014-10-06 CN CN201910293813.7A patent/CN110092764B/zh active Active
- 2014-10-06 SI SI201431945T patent/SI3415505T1/sl unknown
- 2014-10-06 AU AU2014333610A patent/AU2014333610B2/en active Active
- 2014-10-06 EP EP18181405.4A patent/EP3415505B1/en active Active
- 2014-10-06 CA CA2925801A patent/CA2925801C/en active Active
- 2014-10-06 EP EP21203620.6A patent/EP4032880A3/en active Pending
- 2014-10-06 PT PT181814054T patent/PT3415505T/pt unknown
- 2014-10-06 PT PT14789349T patent/PT3055291T/pt unknown
- 2014-10-06 WO PCT/GB2014/053007 patent/WO2015052496A1/en active Application Filing
- 2014-10-06 TW TW107113518A patent/TWI675829B/zh active
- 2014-10-06 JP JP2016520050A patent/JP6505091B2/ja active Active
- 2014-10-06 SG SG10201907363Y patent/SG10201907363YA/en unknown
- 2014-10-06 DK DK14789349.9T patent/DK3055291T3/en active
- 2014-10-06 SI SI201431094T patent/SI3055291T1/sl unknown
- 2014-10-06 EP EP14789349.9A patent/EP3055291B1/en active Active
- 2014-10-06 TW TW103134782A patent/TWI626237B/zh active
- 2014-10-06 PL PL14789349T patent/PL3055291T3/pl unknown
- 2014-10-06 TR TR2019/02152T patent/TR201902152T4/tr unknown
- 2014-10-06 PL PL18181405T patent/PL3415505T3/pl unknown
- 2014-10-06 MX MX2020004348A patent/MX2020004348A/es unknown
- 2014-10-06 US US15/027,400 patent/US9765042B2/en active Active
- 2014-10-06 MX MX2016004229A patent/MX363102B/es unknown
- 2014-10-06 SG SG11201602650XA patent/SG11201602650XA/en unknown
- 2014-10-06 CN CN202310997777.9A patent/CN117209450A/zh active Pending
- 2014-10-06 ES ES14789349T patent/ES2713324T3/es active Active
- 2014-10-06 SG SG10201913293PA patent/SG10201913293PA/en unknown
- 2014-10-06 CN CN201480054610.8A patent/CN105683171B/zh active Active
- 2014-10-06 MY MYPI2016701234A patent/MY177815A/en unknown
- 2014-10-06 DK DK18181405.4T patent/DK3415505T3/da active
- 2014-10-06 CA CA3131803A patent/CA3131803C/en active Active
-
2016
- 2016-04-01 MX MX2019002620A patent/MX2019002620A/es active IP Right Grant
- 2016-09-01 HK HK16110424.7A patent/HK1222175A1/zh unknown
-
2017
- 2017-07-17 AU AU2017206141A patent/AU2017206141B2/en active Active
- 2017-08-10 US US15/674,229 patent/US10047062B2/en active Active
-
2018
- 2018-07-20 US US16/040,964 patent/US10421733B2/en active Active
-
2019
- 2019-02-27 HR HRP20190374TT patent/HRP20190374T1/hr unknown
- 2019-05-17 AU AU2019203490A patent/AU2019203490B2/en active Active
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HK1222859A1 (zh) | 化合物 | |
| HK1218142A1 (zh) | 正交合成測序 | |
| GB201421334D0 (en) | Synthesis of aeizeolite | |
| GB201209239D0 (en) | Methods of evolutionary synthesis including embodied chemical synthesis | |
| EP3663287C0 (en) | SYNTHESIS OF UROLITHINES ON A PROCESS SCALE | |
| GB201304245D0 (en) | Chemical compounds | |
| HK1214592A1 (zh) | 化合物 | |
| GB201322692D0 (en) | Production of encoded chemical libraries | |
| HRP20190374T1 (hr) | Postupci kemijske sinteze diaminofenotiazinskih spojeva uključujući metiltioninijev klorid (mtc) | |
| ZA201604296B (en) | Synthesis of zsm-48 crystals | |
| EP2970097A4 (en) | PROCESS FOR SYNTHESIS OF CHIRAL CYNURENINE COMPOUNDS | |
| GB2517001B (en) | Processes for the synthesis of morphinan-6-one compounds | |
| GB2539112B (en) | Chlorination of sucrose-6-esters | |
| GB201512678D0 (en) | Methods of chemical synthesis | |
| GB201322733D0 (en) | Chemical compounds | |
| GB201320732D0 (en) | Methods of chemical synthesis | |
| HK1216419A1 (zh) | 合成方法 | |
| HK1220194A1 (zh) | 去氮雜去鐵硫代黴素 類似物的多晶型形式 | |
| GB201313885D0 (en) | Chemical Compounds | |
| GB201306881D0 (en) | Chemical compounds | |
| SG10201701021XA (en) | Method of synthesis | |
| GB201322366D0 (en) | Chlorination of sucrose-6-esters | |
| GB201314779D0 (en) | Chlorination of sucrose-6-esters |