PT3415505T - Métodos de síntese química de compostos de diaminofenotiazínio que incluem cloreto de metiltionínio (mtc) - Google Patents
Métodos de síntese química de compostos de diaminofenotiazínio que incluem cloreto de metiltionínio (mtc)Info
- Publication number
- PT3415505T PT3415505T PT181814054T PT18181405T PT3415505T PT 3415505 T PT3415505 T PT 3415505T PT 181814054 T PT181814054 T PT 181814054T PT 18181405 T PT18181405 T PT 18181405T PT 3415505 T PT3415505 T PT 3415505T
- Authority
- PT
- Portugal
- Prior art keywords
- mtc
- methods
- chemical synthesis
- compounds including
- methylthioninium chloride
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
- C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
- C07D279/18—[b, e]-condensed with two six-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
- C07C209/30—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of nitrogen-to-oxygen or nitrogen-to-nitrogen bonds
- C07C209/38—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of nitrogen-to-oxygen or nitrogen-to-nitrogen bonds by reduction of nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
- C07C209/68—Preparation of compounds containing amino groups bound to a carbon skeleton from amines, by reactions not involving amino groups, e.g. reduction of unsaturated amines, aromatisation, or substitution of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C381/00—Compounds containing carbon and sulfur and having functional groups not covered by groups C07C301/00 - C07C337/00
- C07C381/02—Thiosulfates
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB1317702.7A GB201317702D0 (en) | 2013-10-07 | 2013-10-07 | Methods of chemical synthesis of diaminophenothiazinium compounds including methylthioninium chloride (MTC) |
Publications (1)
Publication Number | Publication Date |
---|---|
PT3415505T true PT3415505T (pt) | 2022-01-07 |
Family
ID=49630291
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT181814054T PT3415505T (pt) | 2013-10-07 | 2014-10-06 | Métodos de síntese química de compostos de diaminofenotiazínio que incluem cloreto de metiltionínio (mtc) |
PT14789349T PT3055291T (pt) | 2013-10-07 | 2014-10-06 | Métodos de síntese química de compostos de diaminofenotiazínio que incluem cloreto de metiltionínio (mtc) |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT14789349T PT3055291T (pt) | 2013-10-07 | 2014-10-06 | Métodos de síntese química de compostos de diaminofenotiazínio que incluem cloreto de metiltionínio (mtc) |
Country Status (21)
Country | Link |
---|---|
US (3) | US9765042B2 (pt) |
EP (3) | EP3055291B1 (pt) |
JP (1) | JP6505091B2 (pt) |
CN (3) | CN110092764B (pt) |
AU (3) | AU2014333610B2 (pt) |
BR (1) | BR122023024801A2 (pt) |
CA (3) | CA3131803C (pt) |
DK (2) | DK3415505T3 (pt) |
ES (2) | ES2903529T3 (pt) |
GB (1) | GB201317702D0 (pt) |
HK (1) | HK1222175A1 (pt) |
HR (2) | HRP20220102T1 (pt) |
MX (3) | MX363102B (pt) |
MY (1) | MY177815A (pt) |
PL (2) | PL3415505T3 (pt) |
PT (2) | PT3415505T (pt) |
SG (3) | SG10201907363YA (pt) |
SI (2) | SI3415505T1 (pt) |
TR (1) | TR201902152T4 (pt) |
TW (2) | TWI675829B (pt) |
WO (1) | WO2015052496A1 (pt) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105130926B (zh) * | 2015-07-31 | 2018-02-13 | 江苏恒润制药有限公司 | 一种亚甲基蓝的制备方法 |
GB201621817D0 (en) * | 2016-12-21 | 2017-02-01 | Wista Lab Ltd | Methods of chemical synthesis |
US20220049102A1 (en) * | 2019-09-21 | 2022-02-17 | RK Pharma Solutions LLC | Process for the Purification of Methylene Blue |
CN114989113A (zh) * | 2022-06-01 | 2022-09-02 | 山东科源制药股份有限公司 | 一种药用亚甲基蓝的精制方法 |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US204796A (en) | 1878-06-11 | Improvement in the production of dye-stuffs from methyl-aniline | ||
DE1886C (de) | 1877-12-15 | 1877-12-15 | Basf Ag | Verfahren zur darstellung blauer farbstoffe aus dimethylanilin und anderen tertiaeren aromatischen monaminen |
US4212971A (en) * | 1979-03-08 | 1980-07-15 | American Cyanamid Company | Process for preparing methylene blue |
CH640146A5 (de) * | 1979-05-14 | 1983-12-30 | Meyer Maschinenfabrik Ag | Filtrationsverfahren. |
US5344928A (en) * | 1991-04-26 | 1994-09-06 | Takeda Chemical Industries, Ltd. | Phenothiazine derivatives, their production and use |
GB9506197D0 (en) | 1995-03-27 | 1995-05-17 | Hoffmann La Roche | Inhibition of tau-tau association. |
CA2278245A1 (en) | 1997-01-21 | 1998-07-23 | The American National Red Cross | Intracellular and extracellular decontamination of whole blood and blood components by amphiphilic phenothiazin-5-ium dyes plus light |
FR2810318B1 (fr) | 2000-06-15 | 2005-09-23 | Laurent Galey | Derives de diamano-phenothiazine |
GB0101049D0 (en) | 2001-01-15 | 2001-02-28 | Univ Aberdeen | Materials and methods relating to protein aggregation in neurodegenerative disease |
GB2373787A (en) | 2001-03-08 | 2002-10-02 | Univ Central Lancashire | Phenothiazinium derivatives and their use to reduce pathogenic contaminants |
SI1799662T1 (sl) * | 2004-09-23 | 2013-08-30 | Wista Laboratories Ltd. | Postopki za kemijsko sintezo in čiščenje diaminofenotiazinijevih spojin, vključno metiltioninijevega klorida (MTC) |
JP5186212B2 (ja) * | 2004-09-23 | 2013-04-17 | ウィスタ ラボラトリーズ リミテッド | メチルチオニニウム塩化物(mtc)などのジアミノフェノチアジニウム化合物を化学合成および精製する方法 |
SI2853293T1 (en) * | 2006-03-29 | 2018-03-30 | Wista Laboratories Ltd. | Tioninium compounds and their use |
CA2645946C (en) * | 2006-03-29 | 2014-04-01 | Wista Laboratories Ltd. | Inhibitors of protein aggregation |
PL2057136T3 (pl) * | 2006-07-11 | 2013-10-31 | Wista Lab Ltd | Sposoby syntezy i/lub oczyszczania związków diaminofenotiazynowych |
CN100436431C (zh) * | 2006-12-15 | 2008-11-26 | 贵州同济堂制药有限公司 | 药用亚甲蓝的合成方法 |
WO2010130977A1 (en) * | 2009-05-12 | 2010-11-18 | Wista Laboratories Ltd. | Methods of chemical synthesis of diaminophenothiazinium compounds involving the use of persulfate oxidants |
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2013
- 2013-10-07 GB GBGB1317702.7A patent/GB201317702D0/en not_active Ceased
-
2014
- 2014-10-06 TW TW107113518A patent/TWI675829B/zh active
- 2014-10-06 AU AU2014333610A patent/AU2014333610B2/en active Active
- 2014-10-06 PT PT181814054T patent/PT3415505T/pt unknown
- 2014-10-06 SG SG10201907363Y patent/SG10201907363YA/en unknown
- 2014-10-06 MX MX2016004229A patent/MX363102B/es unknown
- 2014-10-06 EP EP14789349.9A patent/EP3055291B1/en active Active
- 2014-10-06 SG SG11201602650XA patent/SG11201602650XA/en unknown
- 2014-10-06 SI SI201431945T patent/SI3415505T1/sl unknown
- 2014-10-06 SG SG10201913293PA patent/SG10201913293PA/en unknown
- 2014-10-06 US US15/027,400 patent/US9765042B2/en active Active
- 2014-10-06 CN CN201910293813.7A patent/CN110092764B/zh active Active
- 2014-10-06 PL PL18181405T patent/PL3415505T3/pl unknown
- 2014-10-06 TW TW103134782A patent/TWI626237B/zh active
- 2014-10-06 EP EP18181405.4A patent/EP3415505B1/en active Active
- 2014-10-06 TR TR2019/02152T patent/TR201902152T4/tr unknown
- 2014-10-06 WO PCT/GB2014/053007 patent/WO2015052496A1/en active Application Filing
- 2014-10-06 MY MYPI2016701234A patent/MY177815A/en unknown
- 2014-10-06 CN CN201480054610.8A patent/CN105683171B/zh active Active
- 2014-10-06 ES ES18181405T patent/ES2903529T3/es active Active
- 2014-10-06 EP EP21203620.6A patent/EP4032880A3/en active Pending
- 2014-10-06 DK DK18181405.4T patent/DK3415505T3/da active
- 2014-10-06 PT PT14789349T patent/PT3055291T/pt unknown
- 2014-10-06 BR BR122023024801-5A patent/BR122023024801A2/pt active Search and Examination
- 2014-10-06 JP JP2016520050A patent/JP6505091B2/ja active Active
- 2014-10-06 HR HRP20220102TT patent/HRP20220102T1/hr unknown
- 2014-10-06 DK DK14789349.9T patent/DK3055291T3/en active
- 2014-10-06 CA CA3131803A patent/CA3131803C/en active Active
- 2014-10-06 CA CA2925801A patent/CA2925801C/en active Active
- 2014-10-06 CN CN202310997777.9A patent/CN117209450A/zh active Pending
- 2014-10-06 CA CA3207522A patent/CA3207522A1/en active Pending
- 2014-10-06 MX MX2020004348A patent/MX2020004348A/es unknown
- 2014-10-06 SI SI201431094T patent/SI3055291T1/sl unknown
- 2014-10-06 ES ES14789349T patent/ES2713324T3/es active Active
- 2014-10-06 PL PL14789349T patent/PL3055291T3/pl unknown
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2016
- 2016-04-01 MX MX2019002620A patent/MX2019002620A/es active IP Right Grant
- 2016-09-01 HK HK16110424.7A patent/HK1222175A1/zh unknown
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2017
- 2017-07-17 AU AU2017206141A patent/AU2017206141B2/en active Active
- 2017-08-10 US US15/674,229 patent/US10047062B2/en active Active
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2018
- 2018-07-20 US US16/040,964 patent/US10421733B2/en active Active
-
2019
- 2019-02-27 HR HRP20190374TT patent/HRP20190374T1/hr unknown
- 2019-05-17 AU AU2019203490A patent/AU2019203490B2/en active Active
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